Incidental Mutation 'IGL01966:Gm12588'
ID181536
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm12588
Ensembl Gene
Gene Namepredicted gene 12588
Synonyms
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL01966
Quality Score
Status
Chromosome11
Chromosomal Location121905675-121943034 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 121906735 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Asparagine at position 96 (I96N)
Gene Model predicted gene model for transcript(s):
Predicted Effect probably benign
Transcript: ENSMUST00000142242
AA Change: I96N

PolyPhen 2 Score 0.160 (Sensitivity: 0.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000118445
Gene: ENSMUSG00000062632
AA Change: I96N

DomainStartEndE-ValueType
KRAB 4 60 1.43e-10 SMART
ZnF_C2H2 131 153 5.77e0 SMART
ZnF_C2H2 159 181 5.9e-3 SMART
ZnF_C2H2 187 209 2.09e-3 SMART
ZnF_C2H2 215 237 5.99e-4 SMART
ZnF_C2H2 243 265 2.43e-4 SMART
ZnF_C2H2 271 293 5.9e-3 SMART
ZnF_C2H2 299 321 2.95e-3 SMART
ZnF_C2H2 327 349 2.09e-3 SMART
ZnF_C2H2 355 377 2.79e-4 SMART
ZnF_C2H2 383 405 2.99e-4 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1500002C15Rik A G 4: 155,734,069 probably null Het
Acer2 T A 4: 86,917,578 *230R probably null Het
Adamts12 A G 15: 11,258,183 K527E probably damaging Het
Anks1b C A 10: 90,895,132 R937S probably damaging Het
C2cd5 G T 6: 143,012,041 C989* probably null Het
Col14a1 A G 15: 55,448,725 probably benign Het
Cramp1l T A 17: 24,982,943 T522S probably benign Het
Cyp2c70 A T 19: 40,153,572 probably benign Het
Elmod1 T A 9: 53,921,327 I224F probably benign Het
Emx2 T A 19: 59,459,589 I24N possibly damaging Het
Fam26e T C 10: 34,096,133 H102R probably benign Het
Fga A T 3: 83,029,154 I86F probably damaging Het
Fig4 C A 10: 41,232,102 probably null Het
Gm10234 T C 6: 95,322,137 probably null Het
Grm3 A G 5: 9,511,486 I788T probably damaging Het
Homer3 A G 8: 70,290,157 K173E probably damaging Het
Kansl1l A G 1: 66,738,068 V635A probably damaging Het
Kctd3 C T 1: 188,992,662 G241R probably damaging Het
Krt8 G T 15: 101,997,670 S423R probably benign Het
Lrrc24 C A 15: 76,718,311 A125S probably benign Het
Muc4 T C 16: 32,751,426 S435P possibly damaging Het
Nfkb2 G A 19: 46,309,690 G502D probably benign Het
Nlrp6 G A 7: 140,925,190 C750Y probably damaging Het
Olfr904 A T 9: 38,464,929 D296V possibly damaging Het
Oxsm T C 14: 16,242,520 N83S probably benign Het
Paqr3 A G 5: 97,099,643 L202P probably benign Het
Pcdh10 T A 3: 45,380,298 L349Q probably benign Het
Ptdss2 A G 7: 141,135,391 T29A possibly damaging Het
Rbbp8nl G A 2: 180,280,989 probably benign Het
Rc3h2 A G 2: 37,382,777 probably benign Het
Ric1 A T 19: 29,595,563 Y801F probably benign Het
Sgcz A T 8: 37,640,015 S114R probably damaging Het
Tenm4 A G 7: 96,553,550 D124G probably damaging Het
Zscan22 T G 7: 12,906,471 M214R probably benign Het
Other mutations in Gm12588
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01655:Gm12588 APN 11 121907951
IGL02234:Gm12588 APN 11 121908325
R2346:Gm12588 UTSW 11 121906168 missense probably benign 0.01
R3691:Gm12588 UTSW 11 121905925 missense possibly damaging 0.95
Posted On2014-05-07