Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01967:Mllt6'

181567

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mllt6

Ensembl Gene

ENSMUSG00000038437

Gene Name

myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6

Synonyms

Af17

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01967

Quality Score

Status

Chromosome

Chromosomal Location

97554240-97576289 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 97565603 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 630 (F630L)

Ref Sequence

ENSEMBL: ENSMUSP00000103212 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000044730] [ENSMUST00000107586]

AlphaFold

B1AR10

Predicted Effect

possibly damaging
Transcript: ENSMUST00000044730
AA Change: F600L

PolyPhen 2 Score 0.845 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000045445
Gene: ENSMUSG00000038437
AA Change: F600L

Domain	Start	End	E-Value	Type
PHD	7	55	5.92e-7	SMART
PHD	119	178	5e-5	SMART
low complexity region	190	224	N/A	INTRINSIC
low complexity region	271	284	N/A	INTRINSIC
low complexity region	290	330	N/A	INTRINSIC
low complexity region	358	380	N/A	INTRINSIC
low complexity region	398	412	N/A	INTRINSIC
low complexity region	487	498	N/A	INTRINSIC
low complexity region	502	516	N/A	INTRINSIC
low complexity region	520	536	N/A	INTRINSIC
low complexity region	559	573	N/A	INTRINSIC
low complexity region	579	601	N/A	INTRINSIC
low complexity region	649	666	N/A	INTRINSIC
coiled coil region	703	744	N/A	INTRINSIC
low complexity region	746	756	N/A	INTRINSIC
low complexity region	773	782	N/A	INTRINSIC
low complexity region	802	848	N/A	INTRINSIC
low complexity region	860	901	N/A	INTRINSIC
coiled coil region	915	942	N/A	INTRINSIC
low complexity region	995	1018	N/A	INTRINSIC
low complexity region	1026	1037	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000107586
AA Change: F630L

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000103212
Gene: ENSMUSG00000038437
AA Change: F630L

Domain	Start	End	E-Value	Type
PHD	7	55	5.92e-7	SMART
PHD	119	178	5e-5	SMART
low complexity region	190	224	N/A	INTRINSIC
low complexity region	271	284	N/A	INTRINSIC
low complexity region	290	330	N/A	INTRINSIC
low complexity region	336	356	N/A	INTRINSIC
low complexity region	388	410	N/A	INTRINSIC
low complexity region	428	442	N/A	INTRINSIC
low complexity region	517	528	N/A	INTRINSIC
low complexity region	532	546	N/A	INTRINSIC
low complexity region	550	566	N/A	INTRINSIC
low complexity region	589	603	N/A	INTRINSIC
low complexity region	609	631	N/A	INTRINSIC
low complexity region	679	696	N/A	INTRINSIC
coiled coil region	733	774	N/A	INTRINSIC
low complexity region	776	786	N/A	INTRINSIC
low complexity region	803	812	N/A	INTRINSIC
low complexity region	832	878	N/A	INTRINSIC
low complexity region	890	931	N/A	INTRINSIC
coiled coil region	945	972	N/A	INTRINSIC
low complexity region	1025	1048	N/A	INTRINSIC
low complexity region	1056	1067	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000134158

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000143220

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000151729

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000155835

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000184494

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a gene trap allele exhibit no abnormal phenotype. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb5	A	G	12: 118,831,707 (GRCm39)	L1215P	probably damaging	Het
Abce1	T	C	8: 80,412,620 (GRCm39)	D569G	probably damaging	Het
Adnp	A	G	2: 168,025,339 (GRCm39)	V652A	possibly damaging	Het
Bco2	A	G	9: 50,446,809 (GRCm39)	I448T	probably damaging	Het
Cdh20	T	A	1: 104,868,762 (GRCm39)	H84Q	probably damaging	Het
Cep126	A	G	9: 8,095,209 (GRCm39)		probably null	Het
Clca4b	A	G	3: 144,633,951 (GRCm39)		probably benign	Het
Fat2	T	A	11: 55,202,649 (GRCm39)	N142Y	probably damaging	Het
Gnaq	C	T	19: 16,355,524 (GRCm39)	R247C	probably damaging	Het
Itprid1	A	T	6: 55,874,896 (GRCm39)	E282V	probably damaging	Het
Klf3	T	C	5: 64,979,430 (GRCm39)	S91P	probably damaging	Het
Lmtk2	C	A	5: 144,119,597 (GRCm39)	H1353N	probably benign	Het
Magi1	G	T	6: 93,685,115 (GRCm39)	H526Q	probably damaging	Het
Mecr	A	G	4: 131,589,192 (GRCm39)		probably null	Het
Nav1	T	C	1: 135,464,983 (GRCm39)	N274S	probably damaging	Het
Nmi	T	C	2: 51,846,052 (GRCm39)		probably null	Het
Or7e170	A	G	9: 19,794,885 (GRCm39)	S239P	probably damaging	Het
Perm1	G	T	4: 156,302,118 (GRCm39)	G221W	probably damaging	Het
Pikfyve	T	A	1: 65,303,524 (GRCm39)	N1681K	possibly damaging	Het
Ptch2	T	C	4: 116,971,430 (GRCm39)		probably benign	Het
Sc5d	A	T	9: 42,169,930 (GRCm39)	L97Q	possibly damaging	Het
Scaf8	T	A	17: 3,247,213 (GRCm39)	N845K	possibly damaging	Het
Sema7a	A	G	9: 57,863,678 (GRCm39)	K284E	probably damaging	Het
Slc16a3	G	A	11: 120,847,864 (GRCm39)	V351M	probably damaging	Het
Strn3	A	G	12: 51,699,596 (GRCm39)	I192T	probably damaging	Het
Syne2	A	C	12: 75,988,077 (GRCm39)	D1745A	probably damaging	Het
Ttc13	T	C	8: 125,439,386 (GRCm39)	T123A	probably damaging	Het
Zbtb18	T	A	1: 177,275,348 (GRCm39)	V236D	probably benign	Het
Zfp438	T	C	18: 5,214,049 (GRCm39)	E303G	probably benign	Het
Zfp644	T	C	5: 106,786,109 (GRCm39)	Q146R	probably damaging	Het
Zfp972	A	T	2: 177,563,495 (GRCm39)	N38K	probably damaging	Het

Other mutations in Mllt6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01745:Mllt6	APN	11	97,567,754 (GRCm39)	missense	probably damaging	1.00
IGL01808:Mllt6	APN	11	97,563,310 (GRCm39)	missense	possibly damaging	0.88
IGL02247:Mllt6	APN	11	97,561,158 (GRCm39)	missense	probably benign	0.01
IGL03161:Mllt6	APN	11	97,557,977 (GRCm39)	missense	probably benign	0.03
R0284:Mllt6	UTSW	11	97,569,431 (GRCm39)	missense	probably benign	0.02
R0718:Mllt6	UTSW	11	97,567,185 (GRCm39)	splice site	probably benign
R0783:Mllt6	UTSW	11	97,556,571 (GRCm39)	missense	probably damaging	0.99
R0811:Mllt6	UTSW	11	97,569,387 (GRCm39)	missense	probably damaging	0.97
R0812:Mllt6	UTSW	11	97,569,387 (GRCm39)	missense	probably damaging	0.97
R0904:Mllt6	UTSW	11	97,555,824 (GRCm39)	missense	probably damaging	1.00
R0960:Mllt6	UTSW	11	97,555,772 (GRCm39)	splice site	probably benign
R1445:Mllt6	UTSW	11	97,563,277 (GRCm39)	splice site	probably benign
R1523:Mllt6	UTSW	11	97,555,849 (GRCm39)	missense	probably damaging	1.00
R1781:Mllt6	UTSW	11	97,563,395 (GRCm39)	missense	probably benign
R1952:Mllt6	UTSW	11	97,568,048 (GRCm39)	missense	probably damaging	0.99
R2258:Mllt6	UTSW	11	97,555,802 (GRCm39)	missense	probably damaging	1.00
R2259:Mllt6	UTSW	11	97,555,802 (GRCm39)	missense	probably damaging	1.00
R2927:Mllt6	UTSW	11	97,571,602 (GRCm39)	missense	probably damaging	0.98
R4866:Mllt6	UTSW	11	97,565,285 (GRCm39)	missense	probably damaging	1.00
R4938:Mllt6	UTSW	11	97,569,233 (GRCm39)	missense	probably benign
R5039:Mllt6	UTSW	11	97,560,326 (GRCm39)	missense	possibly damaging	0.83
R5058:Mllt6	UTSW	11	97,560,326 (GRCm39)	missense	possibly damaging	0.83
R5064:Mllt6	UTSW	11	97,564,775 (GRCm39)	missense	probably damaging	1.00
R5076:Mllt6	UTSW	11	97,560,326 (GRCm39)	missense	possibly damaging	0.83
R5115:Mllt6	UTSW	11	97,560,326 (GRCm39)	missense	possibly damaging	0.83
R5379:Mllt6	UTSW	11	97,560,326 (GRCm39)	missense	possibly damaging	0.83
R5509:Mllt6	UTSW	11	97,560,326 (GRCm39)	missense	possibly damaging	0.83
R5510:Mllt6	UTSW	11	97,560,326 (GRCm39)	missense	possibly damaging	0.83
R5511:Mllt6	UTSW	11	97,560,326 (GRCm39)	missense	possibly damaging	0.83
R5603:Mllt6	UTSW	11	97,564,331 (GRCm39)	missense	probably damaging	1.00
R5816:Mllt6	UTSW	11	97,563,400 (GRCm39)	missense	probably damaging	0.97
R6030:Mllt6	UTSW	11	97,568,051 (GRCm39)	missense	probably damaging	0.99
R6030:Mllt6	UTSW	11	97,568,051 (GRCm39)	missense	probably damaging	0.99
R6051:Mllt6	UTSW	11	97,571,569 (GRCm39)	nonsense	probably null
R6180:Mllt6	UTSW	11	97,569,362 (GRCm39)	missense	possibly damaging	0.85
R6277:Mllt6	UTSW	11	97,564,774 (GRCm39)	missense	probably damaging	1.00
R6667:Mllt6	UTSW	11	97,567,760 (GRCm39)	missense	probably damaging	1.00
R6754:Mllt6	UTSW	11	97,565,273 (GRCm39)	missense	probably damaging	1.00
R6791:Mllt6	UTSW	11	97,571,428 (GRCm39)	missense	probably damaging	0.98
R7049:Mllt6	UTSW	11	97,564,637 (GRCm39)	missense	probably damaging	1.00
R7194:Mllt6	UTSW	11	97,564,394 (GRCm39)	missense	probably benign	0.23
R7387:Mllt6	UTSW	11	97,565,426 (GRCm39)	missense	probably benign	0.04
R7484:Mllt6	UTSW	11	97,563,442 (GRCm39)	missense	probably benign	0.18
R7685:Mllt6	UTSW	11	97,567,790 (GRCm39)	missense	probably damaging	0.99
R7853:Mllt6	UTSW	11	97,561,142 (GRCm39)	missense	probably benign
R7862:Mllt6	UTSW	11	97,556,631 (GRCm39)	missense	probably benign	0.03
R8004:Mllt6	UTSW	11	97,566,966 (GRCm39)	missense	possibly damaging	0.91
R8498:Mllt6	UTSW	11	97,567,688 (GRCm39)	missense	possibly damaging	0.86
R9044:Mllt6	UTSW	11	97,554,485 (GRCm39)	missense	probably damaging	1.00
R9297:Mllt6	UTSW	11	97,563,314 (GRCm39)	missense	probably damaging	0.96
R9457:Mllt6	UTSW	11	97,556,586 (GRCm39)	missense	probably benign	0.12
R9557:Mllt6	UTSW	11	97,564,310 (GRCm39)	missense	probably benign	0.04
Z1177:Mllt6	UTSW	11	97,567,251 (GRCm39)	missense	possibly damaging	0.73

Posted On

2014-05-07