Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01968:Mst1r'

181605

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mst1r

Ensembl Gene

ENSMUSG00000032584

Gene Name

macrophage stimulating 1 receptor (c-met-related tyrosine kinase)

Synonyms

Fv2, Ron, STK, friend virus susceptibility 2, CDw136, Fv-2, PTK8

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.261) question?

Stock #

IGL01968

Quality Score

Status

Chromosome

Chromosomal Location

107784072-107797582 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 107794005 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000035203 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035203] [ENSMUST00000035203] [ENSMUST00000195617]

AlphaFold

Q62190

Predicted Effect

probably null
Transcript: ENSMUST00000035203

SMART Domains

Protein: ENSMUSP00000035203
Gene: ENSMUSG00000032584

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Sema	57	510	9.03e-116	SMART
PSI	528	570	8.72e-4	SMART
IPT	570	684	1.63e-18	SMART
IPT	685	769	4.03e-23	SMART
IPT	771	873	8.41e-12	SMART
IPT	878	972	5.36e0	SMART
TyrKc	1059	1318	8.2e-134	SMART
low complexity region	1349	1360	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000035203

SMART Domains

Protein: ENSMUSP00000035203
Gene: ENSMUSG00000032584

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Sema	57	510	9.03e-116	SMART
PSI	528	570	8.72e-4	SMART
IPT	570	684	1.63e-18	SMART
IPT	685	769	4.03e-23	SMART
IPT	771	873	8.41e-12	SMART
IPT	878	972	5.36e0	SMART
TyrKc	1059	1318	8.2e-134	SMART
low complexity region	1349	1360	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000194527

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000195113

Predicted Effect

probably benign
Transcript: ENSMUST00000195617

SMART Domains

Protein: ENSMUSP00000142201
Gene: ENSMUSG00000032584

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Sema	57	442	3.5e-63	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: This gene encodes a precursor protein that is proteolytically cleaved to yield an alpha chain and a beta chain which form a membrane-spanning heterodimer. The encoded protein belongs to a family of cell-surface receptor tyrosine kinases involved in signaling from the cell surface to the intracellular environment. The binding of the encoded protein to its ligand, macrophage-stimulating protein, mediates several biological activities including wound healing, tumor immunity, macrophage activation and hematopoiesis as well as cell growth, motility, survival and adhesion. The protein encoded by this gene also functions in early development and the macrophage-mediated inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
PHENOTYPE: This locus controls susceptibility to splenomegaly or spleen focus formation induced by inoculation with Friend leukemia virus. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 18 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb4	A	G	5: 8,977,913 (GRCm39)	D497G	probably benign	Het
Adgra2	A	T	8: 27,611,263 (GRCm39)	R856*	probably null	Het
Cfap90	T	G	13: 68,759,363 (GRCm39)	H112Q	probably damaging	Het
Chodl	T	A	16: 78,738,557 (GRCm39)	S138T	probably damaging	Het
Dnah8	C	T	17: 30,875,572 (GRCm39)	R465*	probably null	Het
Fgfr2	A	G	7: 129,786,978 (GRCm39)	W358R	probably damaging	Het
Iqgap2	G	T	13: 95,772,090 (GRCm39)	A1363E	possibly damaging	Het
Malt1	T	A	18: 65,582,087 (GRCm39)	I317K	probably benign	Het
Mrps5	A	G	2: 127,433,827 (GRCm39)	N72S	probably null	Het
Nars1	A	T	18: 64,640,929 (GRCm39)	C176S	probably damaging	Het
Nt5el	T	A	13: 105,256,338 (GRCm39)	M469K	probably damaging	Het
Or4l1	A	T	14: 50,166,555 (GRCm39)	W149R	probably damaging	Het
Plxna4	T	G	6: 32,192,139 (GRCm39)	D817A	possibly damaging	Het
Plxnb1	C	T	9: 108,930,052 (GRCm39)	P303S	probably benign	Het
Prkd2	G	T	7: 16,603,501 (GRCm39)		probably null	Het
Sulf1	A	T	1: 12,888,675 (GRCm39)	H320L	probably damaging	Het
Use1	G	A	8: 71,819,711 (GRCm39)		probably benign	Het
Vmn2r6	T	C	3: 64,463,766 (GRCm39)	D356G	possibly damaging	Het

Other mutations in Mst1r

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00429:Mst1r	APN	9	107,790,449 (GRCm39)	splice site	probably benign
IGL01327:Mst1r	APN	9	107,785,043 (GRCm39)	missense	probably benign	0.03
IGL01572:Mst1r	APN	9	107,788,791 (GRCm39)	missense	probably damaging	1.00
IGL01983:Mst1r	APN	9	107,794,475 (GRCm39)	missense	probably damaging	0.99
IGL02096:Mst1r	APN	9	107,794,478 (GRCm39)	missense	probably damaging	0.97
IGL02203:Mst1r	APN	9	107,785,068 (GRCm39)	missense	probably damaging	1.00
IGL02203:Mst1r	APN	9	107,790,348 (GRCm39)	missense	possibly damaging	0.61
IGL02332:Mst1r	APN	9	107,785,025 (GRCm39)	nonsense	probably null
IGL02402:Mst1r	APN	9	107,794,026 (GRCm39)	missense	probably damaging	0.99
IGL02404:Mst1r	APN	9	107,790,266 (GRCm39)	splice site	probably benign
IGL02942:Mst1r	APN	9	107,790,352 (GRCm39)	missense	possibly damaging	0.89
IGL02951:Mst1r	APN	9	107,785,403 (GRCm39)	missense	possibly damaging	0.88
IGL02975:Mst1r	APN	9	107,790,379 (GRCm39)	missense	probably benign	0.20
IGL03005:Mst1r	APN	9	107,791,748 (GRCm39)	nonsense	probably null
IGL03304:Mst1r	APN	9	107,785,137 (GRCm39)	missense	probably damaging	1.00
R0386:Mst1r	UTSW	9	107,794,003 (GRCm39)	splice site	probably null
R0833:Mst1r	UTSW	9	107,791,975 (GRCm39)	missense	probably benign	0.00
R0833:Mst1r	UTSW	9	107,790,366 (GRCm39)	missense	probably benign
R1139:Mst1r	UTSW	9	107,797,168 (GRCm39)	missense	possibly damaging	0.93
R1371:Mst1r	UTSW	9	107,794,424 (GRCm39)	missense	probably damaging	1.00
R1477:Mst1r	UTSW	9	107,785,523 (GRCm39)	missense	probably benign
R1479:Mst1r	UTSW	9	107,790,544 (GRCm39)	splice site	probably benign
R1541:Mst1r	UTSW	9	107,794,562 (GRCm39)	missense	probably damaging	0.99
R1698:Mst1r	UTSW	9	107,797,179 (GRCm39)	missense	probably benign	0.06
R1891:Mst1r	UTSW	9	107,790,661 (GRCm39)	missense	probably damaging	1.00
R1971:Mst1r	UTSW	9	107,790,411 (GRCm39)	missense	probably benign	0.06
R1974:Mst1r	UTSW	9	107,793,132 (GRCm39)	critical splice donor site	probably null
R1974:Mst1r	UTSW	9	107,791,962 (GRCm39)	missense	probably damaging	1.00
R2144:Mst1r	UTSW	9	107,790,367 (GRCm39)	missense	probably benign
R2221:Mst1r	UTSW	9	107,785,547 (GRCm39)	missense	probably damaging	1.00
R2356:Mst1r	UTSW	9	107,795,069 (GRCm39)	missense	probably damaging	1.00
R3913:Mst1r	UTSW	9	107,791,945 (GRCm39)	missense	probably benign
R4768:Mst1r	UTSW	9	107,788,849 (GRCm39)	missense	probably damaging	1.00
R4793:Mst1r	UTSW	9	107,797,124 (GRCm39)	missense	probably damaging	0.96
R5141:Mst1r	UTSW	9	107,789,440 (GRCm39)	missense	probably damaging	0.99
R5191:Mst1r	UTSW	9	107,788,750 (GRCm39)	missense	probably damaging	0.98
R5238:Mst1r	UTSW	9	107,784,773 (GRCm39)	missense	probably damaging	1.00
R6024:Mst1r	UTSW	9	107,785,350 (GRCm39)	missense	probably benign	0.00
R6220:Mst1r	UTSW	9	107,784,547 (GRCm39)	missense	probably benign	0.11
R6256:Mst1r	UTSW	9	107,794,465 (GRCm39)	missense	probably damaging	1.00
R6361:Mst1r	UTSW	9	107,793,052 (GRCm39)	missense	probably benign
R6522:Mst1r	UTSW	9	107,790,438 (GRCm39)	missense	probably benign	0.00
R6559:Mst1r	UTSW	9	107,785,470 (GRCm39)	missense	possibly damaging	0.91
R6863:Mst1r	UTSW	9	107,797,225 (GRCm39)	missense	probably benign
R6868:Mst1r	UTSW	9	107,793,132 (GRCm39)	critical splice donor site	probably null
R6873:Mst1r	UTSW	9	107,788,843 (GRCm39)	missense	possibly damaging	0.90
R6978:Mst1r	UTSW	9	107,789,793 (GRCm39)	missense	probably benign	0.23
R7168:Mst1r	UTSW	9	107,785,392 (GRCm39)	missense	probably benign	0.01
R7299:Mst1r	UTSW	9	107,791,989 (GRCm39)	missense	possibly damaging	0.46
R7301:Mst1r	UTSW	9	107,791,989 (GRCm39)	missense	possibly damaging	0.46
R7405:Mst1r	UTSW	9	107,792,321 (GRCm39)	missense	possibly damaging	0.87
R7615:Mst1r	UTSW	9	107,797,211 (GRCm39)	missense	probably benign	0.05
R7684:Mst1r	UTSW	9	107,788,762 (GRCm39)	missense	probably benign	0.01
R7741:Mst1r	UTSW	9	107,784,319 (GRCm39)	start gained	probably benign
R7916:Mst1r	UTSW	9	107,784,777 (GRCm39)	missense	probably damaging	1.00
R7987:Mst1r	UTSW	9	107,789,997 (GRCm39)	splice site	probably null
R8177:Mst1r	UTSW	9	107,784,784 (GRCm39)	missense	probably damaging	1.00
R8356:Mst1r	UTSW	9	107,794,463 (GRCm39)	missense	probably damaging	1.00
R8494:Mst1r	UTSW	9	107,791,718 (GRCm39)	missense	possibly damaging	0.90
R8692:Mst1r	UTSW	9	107,792,050 (GRCm39)	missense	possibly damaging	0.82
R8979:Mst1r	UTSW	9	107,792,478 (GRCm39)	missense	probably damaging	0.98
R9012:Mst1r	UTSW	9	107,791,960 (GRCm39)	missense	probably benign	0.01
X0026:Mst1r	UTSW	9	107,790,402 (GRCm39)	missense	probably damaging	0.97

Posted On

2014-05-07