Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01977:Or5m10'

181701

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5m10

Ensembl Gene

ENSMUSG00000050128

Gene Name

olfactory receptor family 5 subfamily M member 10

Synonyms

GA_x6K02T2Q125-47363965-47364900, MOR196-3, Olfr1023

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

IGL01977

Quality Score

Status

Chromosome

Chromosomal Location

85717146-85718081 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 85717711 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Phenylalanine at position 189 (C189F)

Ref Sequence

ENSEMBL: ENSMUSP00000149138 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000056408] [ENSMUST00000213441]

AlphaFold

A2ASU6

Predicted Effect

probably damaging
Transcript: ENSMUST00000056408
AA Change: C189F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000059849
Gene: ENSMUSG00000050128
AA Change: C189F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	2.6e-52	PFAM
Pfam:7TM_GPCR_Srsx	35	304	2.6e-7	PFAM
Pfam:7tm_1	41	290	2.4e-25	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000082871

Predicted Effect

probably damaging
Transcript: ENSMUST00000213441
AA Change: C189F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca7	T	A	10: 79,841,986 (GRCm39)	S1040T	probably benign	Het
Adam25	T	C	8: 41,208,134 (GRCm39)	Y467H	probably benign	Het
Ank1	A	G	8: 23,605,449 (GRCm39)	I1061V	probably benign	Het
Anxa10	T	C	8: 62,529,348 (GRCm39)	E123G	probably damaging	Het
Arhgap35	G	A	7: 16,297,128 (GRCm39)	L646F	probably damaging	Het
Atp8b5	A	G	4: 43,320,590 (GRCm39)		probably null	Het
Brap	A	G	5: 121,816,910 (GRCm39)		probably benign	Het
Carmil3	A	G	14: 55,730,993 (GRCm39)	T87A	probably damaging	Het
Ccdc172	A	G	19: 58,541,309 (GRCm39)	D256G	possibly damaging	Het
Cep350	C	T	1: 155,787,714 (GRCm39)	A1375T	probably benign	Het
Chrdl2	A	T	7: 99,671,263 (GRCm39)	Q127L	probably benign	Het
Cyp2c29	T	C	19: 39,279,341 (GRCm39)		probably benign	Het
Ddi1	C	A	9: 6,266,226 (GRCm39)	V48F	probably benign	Het
Ddrgk1	C	T	2: 130,497,166 (GRCm39)		probably benign	Het
Fastkd1	C	T	2: 69,524,932 (GRCm39)	V626I	possibly damaging	Het
Fgd5	A	G	6: 92,001,543 (GRCm39)	T755A	probably benign	Het
Fpgt	G	T	3: 154,793,655 (GRCm39)	T124K	probably damaging	Het
Gnl2	G	A	4: 124,941,405 (GRCm39)		probably null	Het
Got1	A	T	19: 43,504,284 (GRCm39)	S46T	probably benign	Het
Hbb-bt	G	T	7: 103,463,070 (GRCm39)	H3N	probably benign	Het
Ikbke	C	T	1: 131,199,838 (GRCm39)		probably benign	Het
Il2rb	A	G	15: 78,365,897 (GRCm39)	S467P	probably benign	Het
Kcnma1	A	G	14: 23,580,367 (GRCm39)		probably benign	Het
Ltbp2	T	C	12: 84,876,973 (GRCm39)	N391D	probably damaging	Het
Npr3	A	T	15: 11,858,804 (GRCm39)	I360N	probably damaging	Het
Nradd	G	A	9: 110,451,237 (GRCm39)	P44S	possibly damaging	Het
Or7h8	G	A	9: 20,123,755 (GRCm39)	V37I	possibly damaging	Het
Pcdh17	A	G	14: 84,770,537 (GRCm39)	E1005G	possibly damaging	Het
Pcdhb11	A	G	18: 37,555,344 (GRCm39)	T225A	possibly damaging	Het
Pja2	T	C	17: 64,604,821 (GRCm39)	D454G	probably benign	Het
Pon3	T	C	6: 5,221,670 (GRCm39)	Y320C	probably damaging	Het
Prl2a1	A	G	13: 27,990,261 (GRCm39)	D70G	probably damaging	Het
Proc	T	A	18: 32,260,472 (GRCm39)	T218S	probably benign	Het
Proz	G	T	8: 13,116,913 (GRCm39)	G155V	probably damaging	Het
Rab11fip3	T	C	17: 26,286,977 (GRCm39)	E392G	possibly damaging	Het
Rab3gap2	C	T	1: 184,999,220 (GRCm39)	R976*	probably null	Het
Shisa2	G	A	14: 59,867,435 (GRCm39)	C229Y	probably damaging	Het
Slc2a5	T	C	4: 150,226,675 (GRCm39)	V379A	probably damaging	Het
Slc31a2	A	T	4: 62,214,197 (GRCm39)	K47N	probably damaging	Het
Sult2a6	G	A	7: 13,987,411 (GRCm39)	T88I	probably benign	Het
Tbc1d14	T	C	5: 36,662,381 (GRCm39)	Y302C	probably damaging	Het
Thumpd3	C	A	6: 113,036,927 (GRCm39)	N275K	possibly damaging	Het
Tnks2	T	C	19: 36,849,990 (GRCm39)		probably null	Het
Tube1	G	A	10: 39,011,041 (GRCm39)		probably benign	Het
Umodl1	T	A	17: 31,192,742 (GRCm39)	Y290N	probably damaging	Het
Usp34	G	A	11: 23,402,661 (GRCm39)	E726K	probably damaging	Het
Vmn2r84	T	A	10: 130,229,935 (GRCm39)	D59V	probably benign	Het
Vps11	T	A	9: 44,267,516 (GRCm39)		probably benign	Het
Wdr19	T	C	5: 65,385,912 (GRCm39)	Y631H	probably benign	Het
Wdr62	G	A	7: 29,957,526 (GRCm39)	H88Y	probably damaging	Het
Wdr93	A	T	7: 79,402,253 (GRCm39)	N184I	probably damaging	Het
Wnk4	T	A	11: 101,156,240 (GRCm39)	F473Y	probably damaging	Het
Zbtb16	A	G	9: 48,568,483 (GRCm39)	W661R	probably damaging	Het

Other mutations in Or5m10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01536:Or5m10	APN	2	85,717,944 (GRCm39)	missense	probably damaging	1.00
IGL01622:Or5m10	APN	2	85,717,306 (GRCm39)	missense	probably benign	0.01
IGL01623:Or5m10	APN	2	85,717,306 (GRCm39)	missense	probably benign	0.01
IGL02057:Or5m10	APN	2	85,717,275 (GRCm39)	missense	probably benign	0.00
IGL02555:Or5m10	APN	2	85,717,742 (GRCm39)	missense	probably benign	0.34
IGL03133:Or5m10	APN	2	85,717,478 (GRCm39)	missense	probably damaging	1.00
IGL03180:Or5m10	APN	2	85,717,740 (GRCm39)	missense	probably benign	0.00
R0415:Or5m10	UTSW	2	85,717,782 (GRCm39)	missense	possibly damaging	0.94
R1476:Or5m10	UTSW	2	85,717,592 (GRCm39)	nonsense	probably null
R1544:Or5m10	UTSW	2	85,717,615 (GRCm39)	missense	probably damaging	1.00
R2058:Or5m10	UTSW	2	85,717,296 (GRCm39)	missense	possibly damaging	0.48
R4096:Or5m10	UTSW	2	85,717,767 (GRCm39)	missense	probably damaging	0.98
R5055:Or5m10	UTSW	2	85,717,585 (GRCm39)	missense	probably benign	0.12
R5703:Or5m10	UTSW	2	85,717,783 (GRCm39)	missense	probably benign	0.06
R6297:Or5m10	UTSW	2	85,717,159 (GRCm39)	missense	probably benign	0.35
R7041:Or5m10	UTSW	2	85,717,965 (GRCm39)	missense	probably benign	0.01
R7070:Or5m10	UTSW	2	85,718,034 (GRCm39)	missense	probably benign	0.13
R7563:Or5m10	UTSW	2	85,717,482 (GRCm39)	missense	probably damaging	0.98
R7777:Or5m10	UTSW	2	85,717,951 (GRCm39)	missense	possibly damaging	0.83
R7913:Or5m10	UTSW	2	85,718,074 (GRCm39)	missense	probably damaging	0.96
R9060:Or5m10	UTSW	2	85,717,920 (GRCm39)	missense	probably benign	0.06
R9789:Or5m10	UTSW	2	85,717,338 (GRCm39)	missense	probably damaging	1.00
S24628:Or5m10	UTSW	2	85,717,782 (GRCm39)	missense	possibly damaging	0.94

Posted On

2014-05-07