Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01978:Svs3b'

181760

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Svs3b

Ensembl Gene

ENSMUSG00000050383

Gene Name

seminal vesicle secretory protein 3B

Synonyms

SVS III, 9530004A22Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.051) question?

Stock #

IGL01978

Quality Score

Status

Chromosome

Chromosomal Location

164096283-164098560 bp(-) (GRCm39)

Type of Mutation

start codon destroyed

DNA Base Change (assembly)

T to A at 164098541 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 1 (M1L)

Ref Sequence

ENSEMBL: ENSMUSP00000062011 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063132]

AlphaFold

Q8BZH8

Predicted Effect

probably benign
Transcript: ENSMUST00000063132
AA Change: M1L

PolyPhen 2 Score 0.163 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000062011
Gene: ENSMUSG00000050383
AA Change: M1L

Domain	Start	End	E-Value	Type
Pfam:Semenogelin	1	146	7.4e-10	PFAM
low complexity region	210	225	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9830107B12Rik	T	A	17: 48,453,164 (GRCm39)	T6S	probably damaging	Het
Acot5	T	C	12: 84,122,172 (GRCm39)	V252A	possibly damaging	Het
Bmper	A	T	9: 23,292,737 (GRCm39)	N349Y	probably damaging	Het
Brap	A	G	5: 121,816,910 (GRCm39)		probably benign	Het
Col9a2	G	A	4: 120,901,863 (GRCm39)	G139E	unknown	Het
Cplane1	A	T	15: 8,248,866 (GRCm39)	N1805I	probably damaging	Het
Cyp2j8	A	C	4: 96,392,246 (GRCm39)		probably null	Het
Dcbld2	A	G	16: 58,284,682 (GRCm39)	D612G	probably benign	Het
Dsc3	C	T	18: 20,107,253 (GRCm39)	R456Q	possibly damaging	Het
Fat2	T	C	11: 55,160,972 (GRCm39)	T3253A	probably benign	Het
Hoxc12	T	A	15: 102,845,299 (GRCm39)	H4Q	probably damaging	Het
Il6st	A	G	13: 112,633,891 (GRCm39)	E445G	possibly damaging	Het
Ipo8	T	C	6: 148,678,787 (GRCm39)	E937G	probably benign	Het
Kif5a	A	C	10: 127,081,608 (GRCm39)	D185E	probably benign	Het
Klhl38	T	C	15: 58,178,485 (GRCm39)	D495G	probably damaging	Het
Klra5	A	G	6: 129,888,393 (GRCm39)	V11A	probably benign	Het
Lrch1	G	A	14: 75,023,782 (GRCm39)	T581M	probably damaging	Het
Mecom	A	G	3: 30,017,315 (GRCm39)	I450T	probably damaging	Het
Mrgprb2	C	A	7: 48,202,312 (GRCm39)	V138L	probably damaging	Het
Muc15	G	A	2: 110,561,941 (GRCm39)	A126T	probably benign	Het
Mybpc1	A	T	10: 88,367,632 (GRCm39)	I522K	probably damaging	Het
Nectin1	G	A	9: 43,703,444 (GRCm39)	R234H	probably damaging	Het
Or5b98	T	C	19: 12,931,406 (GRCm39)	F151S	probably benign	Het
Or5h22	A	T	16: 58,894,630 (GRCm39)	I271K	probably benign	Het
Pdia6	T	A	12: 17,324,423 (GRCm39)	H91Q	possibly damaging	Het
Pfkfb4	A	T	9: 108,858,010 (GRCm39)	H445L	probably damaging	Het
Pkd1l1	T	C	11: 8,911,336 (GRCm39)	T314A	unknown	Het
Rb1cc1	A	G	1: 6,308,592 (GRCm39)	D159G	probably damaging	Het
Rhoh	T	A	5: 66,050,031 (GRCm39)	S100R	probably benign	Het
Rsbn1	T	A	3: 103,868,816 (GRCm39)	D618E	probably damaging	Het
Slc25a47	T	C	12: 108,817,116 (GRCm39)	V4A	probably damaging	Het
Thsd7a	T	C	6: 12,331,005 (GRCm39)	N1379S	probably benign	Het
Tmed3	T	C	9: 89,586,806 (GRCm39)	D58G	probably benign	Het
Trh	G	A	6: 92,219,596 (GRCm39)	A240V	probably benign	Het
Ubox5	A	T	2: 130,442,372 (GRCm39)	V105E	probably benign	Het
Vmn2r67	A	G	7: 84,800,649 (GRCm39)		probably null	Het
Vps13c	A	G	9: 67,837,925 (GRCm39)	H1825R	probably benign	Het
Wasf1	C	A	10: 40,812,197 (GRCm39)	P329T	unknown	Het
Wee2	T	C	6: 40,432,087 (GRCm39)	F219L	probably damaging	Het
Zp3r	T	C	1: 130,526,678 (GRCm39)	D175G	probably damaging	Het

Other mutations in Svs3b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00848:Svs3b	APN	2	164,098,021 (GRCm39)	missense	probably damaging	0.98
IGL01584:Svs3b	APN	2	164,097,943 (GRCm39)	missense	probably benign	0.35
IGL02279:Svs3b	APN	2	164,098,124 (GRCm39)	missense	possibly damaging	0.71
IGL03205:Svs3b	APN	2	164,098,181 (GRCm39)	missense	probably damaging	0.97
R0078:Svs3b	UTSW	2	164,097,881 (GRCm39)	missense	probably benign	0.14
R0097:Svs3b	UTSW	2	164,098,159 (GRCm39)	missense	probably damaging	0.98
R1920:Svs3b	UTSW	2	164,097,848 (GRCm39)	missense	probably benign	0.00
R1921:Svs3b	UTSW	2	164,097,848 (GRCm39)	missense	probably benign	0.00
R7938:Svs3b	UTSW	2	164,097,567 (GRCm39)	nonsense	probably null
R8118:Svs3b	UTSW	2	164,097,926 (GRCm39)	missense	probably damaging	0.97
R8209:Svs3b	UTSW	2	164,098,140 (GRCm39)	missense	possibly damaging	0.88
R8226:Svs3b	UTSW	2	164,098,140 (GRCm39)	missense	possibly damaging	0.88

Posted On

2014-05-07