Incidental Mutation 'IGL01978:Mrgprb2'
ID 181775
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mrgprb2
Ensembl Gene ENSMUSG00000050425
Gene Name MAS-related GPR, member B2
Synonyms 4833406I20Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01978
Quality Score
Status
Chromosome 7
Chromosomal Location 48200713-48207834 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 48202312 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 138 (V138L)
Ref Sequence ENSEMBL: ENSMUSP00000061878 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052730]
AlphaFold Q3KNA1
Predicted Effect probably damaging
Transcript: ENSMUST00000052730
AA Change: V138L

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000061878
Gene: ENSMUSG00000050425
AA Change: V138L

DomainStartEndE-ValueType
Pfam:7tm_1 54 286 2.1e-7 PFAM
low complexity region 293 308 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired mast cell activation and inflammatory response after 48/80 treatment. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9830107B12Rik T A 17: 48,453,164 (GRCm39) T6S probably damaging Het
Acot5 T C 12: 84,122,172 (GRCm39) V252A possibly damaging Het
Bmper A T 9: 23,292,737 (GRCm39) N349Y probably damaging Het
Brap A G 5: 121,816,910 (GRCm39) probably benign Het
Col9a2 G A 4: 120,901,863 (GRCm39) G139E unknown Het
Cplane1 A T 15: 8,248,866 (GRCm39) N1805I probably damaging Het
Cyp2j8 A C 4: 96,392,246 (GRCm39) probably null Het
Dcbld2 A G 16: 58,284,682 (GRCm39) D612G probably benign Het
Dsc3 C T 18: 20,107,253 (GRCm39) R456Q possibly damaging Het
Fat2 T C 11: 55,160,972 (GRCm39) T3253A probably benign Het
Hoxc12 T A 15: 102,845,299 (GRCm39) H4Q probably damaging Het
Il6st A G 13: 112,633,891 (GRCm39) E445G possibly damaging Het
Ipo8 T C 6: 148,678,787 (GRCm39) E937G probably benign Het
Kif5a A C 10: 127,081,608 (GRCm39) D185E probably benign Het
Klhl38 T C 15: 58,178,485 (GRCm39) D495G probably damaging Het
Klra5 A G 6: 129,888,393 (GRCm39) V11A probably benign Het
Lrch1 G A 14: 75,023,782 (GRCm39) T581M probably damaging Het
Mecom A G 3: 30,017,315 (GRCm39) I450T probably damaging Het
Muc15 G A 2: 110,561,941 (GRCm39) A126T probably benign Het
Mybpc1 A T 10: 88,367,632 (GRCm39) I522K probably damaging Het
Nectin1 G A 9: 43,703,444 (GRCm39) R234H probably damaging Het
Or5b98 T C 19: 12,931,406 (GRCm39) F151S probably benign Het
Or5h22 A T 16: 58,894,630 (GRCm39) I271K probably benign Het
Pdia6 T A 12: 17,324,423 (GRCm39) H91Q possibly damaging Het
Pfkfb4 A T 9: 108,858,010 (GRCm39) H445L probably damaging Het
Pkd1l1 T C 11: 8,911,336 (GRCm39) T314A unknown Het
Rb1cc1 A G 1: 6,308,592 (GRCm39) D159G probably damaging Het
Rhoh T A 5: 66,050,031 (GRCm39) S100R probably benign Het
Rsbn1 T A 3: 103,868,816 (GRCm39) D618E probably damaging Het
Slc25a47 T C 12: 108,817,116 (GRCm39) V4A probably damaging Het
Svs3b T A 2: 164,098,541 (GRCm39) M1L probably benign Het
Thsd7a T C 6: 12,331,005 (GRCm39) N1379S probably benign Het
Tmed3 T C 9: 89,586,806 (GRCm39) D58G probably benign Het
Trh G A 6: 92,219,596 (GRCm39) A240V probably benign Het
Ubox5 A T 2: 130,442,372 (GRCm39) V105E probably benign Het
Vmn2r67 A G 7: 84,800,649 (GRCm39) probably null Het
Vps13c A G 9: 67,837,925 (GRCm39) H1825R probably benign Het
Wasf1 C A 10: 40,812,197 (GRCm39) P329T unknown Het
Wee2 T C 6: 40,432,087 (GRCm39) F219L probably damaging Het
Zp3r T C 1: 130,526,678 (GRCm39) D175G probably damaging Het
Other mutations in Mrgprb2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01311:Mrgprb2 APN 7 48,201,746 (GRCm39) missense probably benign 0.29
IGL01509:Mrgprb2 APN 7 48,202,674 (GRCm39) missense possibly damaging 0.70
IGL02307:Mrgprb2 APN 7 48,202,644 (GRCm39) missense probably benign 0.01
IGL02726:Mrgprb2 APN 7 48,202,618 (GRCm39) missense probably damaging 0.97
IGL03393:Mrgprb2 APN 7 48,202,650 (GRCm39) missense probably benign 0.13
R0190:Mrgprb2 UTSW 7 48,202,525 (GRCm39) missense possibly damaging 0.95
R0334:Mrgprb2 UTSW 7 48,202,077 (GRCm39) missense probably damaging 1.00
R0514:Mrgprb2 UTSW 7 48,201,718 (GRCm39) missense probably benign 0.05
R2177:Mrgprb2 UTSW 7 48,202,128 (GRCm39) missense probably benign 0.11
R2932:Mrgprb2 UTSW 7 48,202,194 (GRCm39) missense probably benign 0.17
R3417:Mrgprb2 UTSW 7 48,202,281 (GRCm39) missense probably damaging 0.98
R3953:Mrgprb2 UTSW 7 48,202,116 (GRCm39) missense possibly damaging 0.78
R5673:Mrgprb2 UTSW 7 48,202,121 (GRCm39) missense probably benign 0.00
R5733:Mrgprb2 UTSW 7 48,202,261 (GRCm39) missense probably benign 0.01
R5890:Mrgprb2 UTSW 7 48,201,707 (GRCm39) makesense probably null
R5915:Mrgprb2 UTSW 7 48,202,554 (GRCm39) missense probably benign 0.14
R6147:Mrgprb2 UTSW 7 48,202,113 (GRCm39) missense possibly damaging 0.64
R6381:Mrgprb2 UTSW 7 48,202,138 (GRCm39) missense probably benign 0.01
R6414:Mrgprb2 UTSW 7 48,202,129 (GRCm39) missense probably benign 0.01
R6965:Mrgprb2 UTSW 7 48,202,597 (GRCm39) missense probably damaging 0.97
R7017:Mrgprb2 UTSW 7 48,202,585 (GRCm39) missense probably benign 0.08
R7341:Mrgprb2 UTSW 7 48,202,644 (GRCm39) missense probably benign 0.01
R7399:Mrgprb2 UTSW 7 48,201,890 (GRCm39) missense probably damaging 1.00
R8168:Mrgprb2 UTSW 7 48,201,767 (GRCm39) missense probably benign 0.26
R8189:Mrgprb2 UTSW 7 48,202,502 (GRCm39) nonsense probably null
R8738:Mrgprb2 UTSW 7 48,202,648 (GRCm39) missense probably benign 0.04
R9160:Mrgprb2 UTSW 7 48,201,982 (GRCm39) missense possibly damaging 0.82
R9210:Mrgprb2 UTSW 7 48,202,392 (GRCm39) missense possibly damaging 0.91
R9212:Mrgprb2 UTSW 7 48,202,392 (GRCm39) missense possibly damaging 0.91
R9308:Mrgprb2 UTSW 7 48,202,655 (GRCm39) missense possibly damaging 0.86
R9562:Mrgprb2 UTSW 7 48,202,674 (GRCm39) missense possibly damaging 0.70
R9565:Mrgprb2 UTSW 7 48,202,674 (GRCm39) missense possibly damaging 0.70
R9763:Mrgprb2 UTSW 7 48,202,174 (GRCm39) missense probably benign 0.00
Z1177:Mrgprb2 UTSW 7 48,202,721 (GRCm39) start codon destroyed probably null
Posted On 2014-05-07