Incidental Mutation 'IGL01985:Vmn2r10'
| ID |
181855 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r10
|
| Ensembl Gene |
ENSMUSG00000067010 |
| Gene Name |
vomeronasal 2, receptor 10 |
| Synonyms |
VR16, V2r16 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.079)
|
| Stock # |
IGL01985
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
5 |
| Chromosomal Location |
109141278-109154337 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 109154125 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 60
(S60P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000078162
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079163]
[ENSMUST00000176594]
|
| AlphaFold |
K7N621 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000079163
AA Change: S60P
PolyPhen 2
Score 0.207 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000078162
Gene: ENSMUSG00000067010
AA Change: S60P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
75 |
464 |
8.5e-29 |
PFAM |
|
Pfam:NCD3G
|
506 |
560 |
3.8e-17 |
PFAM |
|
Pfam:7tm_3
|
593 |
828 |
4e-55 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176594
AA Change: S60P
PolyPhen 2
Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000135274
Gene: ENSMUSG00000067010
AA Change: S60P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 43 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| AAdacl4fm3 |
G |
A |
4: 144,442,024 (GRCm39) |
Q76* |
probably null |
Het |
| Cass4 |
A |
C |
2: 172,269,126 (GRCm39) |
S403R |
probably damaging |
Het |
| Ccdc175 |
A |
T |
12: 72,175,052 (GRCm39) |
Y540* |
probably null |
Het |
| Cep164 |
C |
T |
9: 45,690,904 (GRCm39) |
E1266K |
probably damaging |
Het |
| Clec12b |
T |
A |
6: 129,359,334 (GRCm39) |
|
probably benign |
Het |
| Col6a5 |
T |
C |
9: 105,814,482 (GRCm39) |
K510R |
unknown |
Het |
| Crisp4 |
G |
A |
1: 18,204,289 (GRCm39) |
P101S |
probably damaging |
Het |
| Dapk1 |
T |
C |
13: 60,884,074 (GRCm39) |
L614P |
probably damaging |
Het |
| Dip2c |
T |
C |
13: 9,603,303 (GRCm39) |
|
probably benign |
Het |
| Dock7 |
A |
G |
4: 98,911,614 (GRCm39) |
F589L |
probably benign |
Het |
| Dvl2 |
T |
A |
11: 69,899,119 (GRCm39) |
V459E |
probably damaging |
Het |
| E2f6 |
T |
C |
12: 16,869,064 (GRCm39) |
|
probably null |
Het |
| Exph5 |
T |
C |
9: 53,287,869 (GRCm39) |
L1650P |
probably damaging |
Het |
| Farp2 |
A |
G |
1: 93,535,324 (GRCm39) |
Y691C |
probably damaging |
Het |
| Fshb |
T |
C |
2: 106,889,173 (GRCm39) |
T44A |
probably benign |
Het |
| Gm28044 |
T |
A |
13: 67,495,958 (GRCm39) |
K28* |
probably null |
Het |
| Il12b |
G |
A |
11: 44,298,881 (GRCm39) |
W112* |
probably null |
Het |
| Ino80 |
T |
C |
2: 119,263,802 (GRCm39) |
T621A |
probably damaging |
Het |
| Irx5 |
T |
A |
8: 93,086,155 (GRCm39) |
|
probably benign |
Het |
| Jmy |
T |
C |
13: 93,596,144 (GRCm39) |
H495R |
possibly damaging |
Het |
| Kif21a |
A |
T |
15: 90,875,970 (GRCm39) |
V321D |
probably damaging |
Het |
| Lrrc10 |
T |
A |
10: 116,881,921 (GRCm39) |
D198E |
probably damaging |
Het |
| Lrsam1 |
T |
C |
2: 32,818,103 (GRCm39) |
E651G |
probably benign |
Het |
| Mtarc1 |
A |
G |
1: 184,519,931 (GRCm39) |
V230A |
probably damaging |
Het |
| Mylk4 |
T |
A |
13: 32,901,564 (GRCm39) |
I475L |
possibly damaging |
Het |
| Myom3 |
G |
A |
4: 135,493,013 (GRCm39) |
|
probably null |
Het |
| Or5ac19 |
A |
T |
16: 59,089,442 (GRCm39) |
V196E |
probably benign |
Het |
| Pah |
G |
A |
10: 87,414,844 (GRCm39) |
V399M |
probably damaging |
Het |
| Pik3r4 |
G |
A |
9: 105,540,244 (GRCm39) |
E711K |
probably benign |
Het |
| Rbbp6 |
A |
G |
7: 122,570,296 (GRCm39) |
K38E |
probably damaging |
Het |
| Ror1 |
G |
A |
4: 100,283,161 (GRCm39) |
V409M |
possibly damaging |
Het |
| Slc6a11 |
T |
A |
6: 114,111,853 (GRCm39) |
V140D |
probably benign |
Het |
| Srebf2 |
G |
T |
15: 82,076,560 (GRCm39) |
A737S |
probably benign |
Het |
| Tcerg1 |
A |
G |
18: 42,663,721 (GRCm39) |
T303A |
unknown |
Het |
| Tmem74 |
A |
T |
15: 43,730,476 (GRCm39) |
I189N |
probably damaging |
Het |
| Tnr |
A |
G |
1: 159,746,607 (GRCm39) |
D1242G |
possibly damaging |
Het |
| U2surp |
A |
T |
9: 95,372,279 (GRCm39) |
F293L |
probably damaging |
Het |
| Uchl5 |
G |
A |
1: 143,661,864 (GRCm39) |
|
probably benign |
Het |
| Usp34 |
T |
A |
11: 23,402,565 (GRCm39) |
C2472S |
probably damaging |
Het |
| Usp42 |
G |
A |
5: 143,700,940 (GRCm39) |
R1028W |
probably damaging |
Het |
| Vmn2r31 |
G |
T |
7: 7,397,510 (GRCm39) |
D249E |
probably benign |
Het |
| Vnn1 |
C |
T |
10: 23,776,642 (GRCm39) |
T331I |
probably benign |
Het |
| Zmym6 |
G |
T |
4: 126,994,541 (GRCm39) |
V232F |
probably damaging |
Het |
|
| Other mutations in Vmn2r10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00816:Vmn2r10
|
APN |
5 |
109,150,451 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL01618:Vmn2r10
|
APN |
5 |
109,150,345 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01624:Vmn2r10
|
APN |
5 |
109,154,112 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL01941:Vmn2r10
|
APN |
5 |
109,143,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01959:Vmn2r10
|
APN |
5 |
109,145,571 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01973:Vmn2r10
|
APN |
5 |
109,143,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02451:Vmn2r10
|
APN |
5 |
109,143,788 (GRCm39) |
nonsense |
probably null |
|
|
IGL02503:Vmn2r10
|
APN |
5 |
109,151,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03275:Vmn2r10
|
APN |
5 |
109,151,243 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0035:Vmn2r10
|
UTSW |
5 |
109,145,467 (GRCm39) |
splice site |
probably benign |
|
|
R0395:Vmn2r10
|
UTSW |
5 |
109,149,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0454:Vmn2r10
|
UTSW |
5 |
109,151,327 (GRCm39) |
missense |
probably benign |
0.25 |
|
R0648:Vmn2r10
|
UTSW |
5 |
109,143,782 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1251:Vmn2r10
|
UTSW |
5 |
109,143,890 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1580:Vmn2r10
|
UTSW |
5 |
109,154,117 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1845:Vmn2r10
|
UTSW |
5 |
109,149,861 (GRCm39) |
nonsense |
probably null |
|
|
R1986:Vmn2r10
|
UTSW |
5 |
109,154,120 (GRCm39) |
nonsense |
probably null |
|
|
R2137:Vmn2r10
|
UTSW |
5 |
109,151,410 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R2495:Vmn2r10
|
UTSW |
5 |
109,143,961 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3932:Vmn2r10
|
UTSW |
5 |
109,150,088 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R3933:Vmn2r10
|
UTSW |
5 |
109,150,088 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4899:Vmn2r10
|
UTSW |
5 |
109,151,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Vmn2r10
|
UTSW |
5 |
109,145,592 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5124:Vmn2r10
|
UTSW |
5 |
109,154,286 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5145:Vmn2r10
|
UTSW |
5 |
109,143,761 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R5156:Vmn2r10
|
UTSW |
5 |
109,143,466 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5265:Vmn2r10
|
UTSW |
5 |
109,143,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5311:Vmn2r10
|
UTSW |
5 |
109,154,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5321:Vmn2r10
|
UTSW |
5 |
109,143,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5666:Vmn2r10
|
UTSW |
5 |
109,146,910 (GRCm39) |
nonsense |
probably null |
|
|
R5670:Vmn2r10
|
UTSW |
5 |
109,146,910 (GRCm39) |
nonsense |
probably null |
|
|
R5872:Vmn2r10
|
UTSW |
5 |
109,151,377 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6004:Vmn2r10
|
UTSW |
5 |
109,146,944 (GRCm39) |
missense |
probably benign |
0.30 |
|
R6108:Vmn2r10
|
UTSW |
5 |
109,143,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6332:Vmn2r10
|
UTSW |
5 |
109,151,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6599:Vmn2r10
|
UTSW |
5 |
109,143,944 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6651:Vmn2r10
|
UTSW |
5 |
109,143,488 (GRCm39) |
missense |
probably null |
0.22 |
|
R6891:Vmn2r10
|
UTSW |
5 |
109,149,845 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7023:Vmn2r10
|
UTSW |
5 |
109,149,894 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7146:Vmn2r10
|
UTSW |
5 |
109,151,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7941:Vmn2r10
|
UTSW |
5 |
109,144,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8058:Vmn2r10
|
UTSW |
5 |
109,149,955 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8478:Vmn2r10
|
UTSW |
5 |
109,143,636 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8526:Vmn2r10
|
UTSW |
5 |
109,145,572 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R8698:Vmn2r10
|
UTSW |
5 |
109,151,390 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8796:Vmn2r10
|
UTSW |
5 |
109,143,917 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8854:Vmn2r10
|
UTSW |
5 |
109,144,126 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8871:Vmn2r10
|
UTSW |
5 |
109,146,899 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8893:Vmn2r10
|
UTSW |
5 |
109,143,677 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8907:Vmn2r10
|
UTSW |
5 |
109,149,791 (GRCm39) |
missense |
probably benign |
|
|
R8957:Vmn2r10
|
UTSW |
5 |
109,149,780 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8976:Vmn2r10
|
UTSW |
5 |
109,145,479 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9155:Vmn2r10
|
UTSW |
5 |
109,144,212 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9308:Vmn2r10
|
UTSW |
5 |
109,145,476 (GRCm39) |
nonsense |
probably null |
|
|
R9800:Vmn2r10
|
UTSW |
5 |
109,150,404 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1088:Vmn2r10
|
UTSW |
5 |
109,143,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r10
|
UTSW |
5 |
109,149,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2014-05-07 |
Incidental Mutation