Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01985:Clec12b'

181890

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Clec12b

Ensembl Gene

ENSMUSG00000030158

Gene Name

C-type lectin domain family 12, member B

Synonyms

4933425B16Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.050) question?

Stock #

IGL01985

Quality Score

Status

Chromosome

Chromosomal Location

129352478-129362837 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 129359334 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000107713 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032261] [ENSMUST00000112082]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000032261

SMART Domains

Protein: ENSMUSP00000032261
Gene: ENSMUSG00000030158

Domain	Start	End	E-Value	Type
low complexity region	46	60	N/A	INTRINSIC
CLECT	142	263	6.62e-25	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000112082

SMART Domains

Protein: ENSMUSP00000107713
Gene: ENSMUSG00000030158

Domain	Start	End	E-Value	Type
low complexity region	46	60	N/A	INTRINSIC
CLECT	142	263	6.62e-25	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
AAdacl4fm3	G	A	4: 144,442,024 (GRCm39)	Q76*	probably null	Het
Cass4	A	C	2: 172,269,126 (GRCm39)	S403R	probably damaging	Het
Ccdc175	A	T	12: 72,175,052 (GRCm39)	Y540*	probably null	Het
Cep164	C	T	9: 45,690,904 (GRCm39)	E1266K	probably damaging	Het
Col6a5	T	C	9: 105,814,482 (GRCm39)	K510R	unknown	Het
Crisp4	G	A	1: 18,204,289 (GRCm39)	P101S	probably damaging	Het
Dapk1	T	C	13: 60,884,074 (GRCm39)	L614P	probably damaging	Het
Dip2c	T	C	13: 9,603,303 (GRCm39)		probably benign	Het
Dock7	A	G	4: 98,911,614 (GRCm39)	F589L	probably benign	Het
Dvl2	T	A	11: 69,899,119 (GRCm39)	V459E	probably damaging	Het
E2f6	T	C	12: 16,869,064 (GRCm39)		probably null	Het
Exph5	T	C	9: 53,287,869 (GRCm39)	L1650P	probably damaging	Het
Farp2	A	G	1: 93,535,324 (GRCm39)	Y691C	probably damaging	Het
Fshb	T	C	2: 106,889,173 (GRCm39)	T44A	probably benign	Het
Gm28044	T	A	13: 67,495,958 (GRCm39)	K28*	probably null	Het
Il12b	G	A	11: 44,298,881 (GRCm39)	W112*	probably null	Het
Ino80	T	C	2: 119,263,802 (GRCm39)	T621A	probably damaging	Het
Irx5	T	A	8: 93,086,155 (GRCm39)		probably benign	Het
Jmy	T	C	13: 93,596,144 (GRCm39)	H495R	possibly damaging	Het
Kif21a	A	T	15: 90,875,970 (GRCm39)	V321D	probably damaging	Het
Lrrc10	T	A	10: 116,881,921 (GRCm39)	D198E	probably damaging	Het
Lrsam1	T	C	2: 32,818,103 (GRCm39)	E651G	probably benign	Het
Mtarc1	A	G	1: 184,519,931 (GRCm39)	V230A	probably damaging	Het
Mylk4	T	A	13: 32,901,564 (GRCm39)	I475L	possibly damaging	Het
Myom3	G	A	4: 135,493,013 (GRCm39)		probably null	Het
Or5ac19	A	T	16: 59,089,442 (GRCm39)	V196E	probably benign	Het
Pah	G	A	10: 87,414,844 (GRCm39)	V399M	probably damaging	Het
Pik3r4	G	A	9: 105,540,244 (GRCm39)	E711K	probably benign	Het
Rbbp6	A	G	7: 122,570,296 (GRCm39)	K38E	probably damaging	Het
Ror1	G	A	4: 100,283,161 (GRCm39)	V409M	possibly damaging	Het
Slc6a11	T	A	6: 114,111,853 (GRCm39)	V140D	probably benign	Het
Srebf2	G	T	15: 82,076,560 (GRCm39)	A737S	probably benign	Het
Tcerg1	A	G	18: 42,663,721 (GRCm39)	T303A	unknown	Het
Tmem74	A	T	15: 43,730,476 (GRCm39)	I189N	probably damaging	Het
Tnr	A	G	1: 159,746,607 (GRCm39)	D1242G	possibly damaging	Het
U2surp	A	T	9: 95,372,279 (GRCm39)	F293L	probably damaging	Het
Uchl5	G	A	1: 143,661,864 (GRCm39)		probably benign	Het
Usp34	T	A	11: 23,402,565 (GRCm39)	C2472S	probably damaging	Het
Usp42	G	A	5: 143,700,940 (GRCm39)	R1028W	probably damaging	Het
Vmn2r10	A	G	5: 109,154,125 (GRCm39)	S60P	probably benign	Het
Vmn2r31	G	T	7: 7,397,510 (GRCm39)	D249E	probably benign	Het
Vnn1	C	T	10: 23,776,642 (GRCm39)	T331I	probably benign	Het
Zmym6	G	T	4: 126,994,541 (GRCm39)	V232F	probably damaging	Het

Other mutations in Clec12b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01014:Clec12b	APN	6	129,362,393 (GRCm39)	missense	probably damaging	0.98
IGL01328:Clec12b	APN	6	129,356,517 (GRCm39)	missense	probably damaging	1.00
IGL03101:Clec12b	APN	6	129,356,480 (GRCm39)	splice site	probably null
R0662:Clec12b	UTSW	6	129,353,200 (GRCm39)	missense	probably damaging	1.00
R0786:Clec12b	UTSW	6	129,357,651 (GRCm39)	missense	probably benign	0.07
R1468:Clec12b	UTSW	6	129,357,603 (GRCm39)	missense	probably damaging	0.98
R1468:Clec12b	UTSW	6	129,357,603 (GRCm39)	missense	probably damaging	0.98
R1513:Clec12b	UTSW	6	129,353,265 (GRCm39)	missense	probably damaging	1.00
R4757:Clec12b	UTSW	6	129,357,655 (GRCm39)	missense	probably damaging	1.00
R5566:Clec12b	UTSW	6	129,362,438 (GRCm39)	missense	probably damaging	0.99
R5643:Clec12b	UTSW	6	129,356,923 (GRCm39)	missense	probably benign
R5644:Clec12b	UTSW	6	129,356,923 (GRCm39)	missense	probably benign
R7351:Clec12b	UTSW	6	129,356,874 (GRCm39)	critical splice donor site	probably null
R7600:Clec12b	UTSW	6	129,353,226 (GRCm39)	missense	probably damaging	1.00
R8347:Clec12b	UTSW	6	129,357,450 (GRCm39)	critical splice donor site	probably null
R9076:Clec12b	UTSW	6	129,356,580 (GRCm39)	missense	possibly damaging	0.94

Posted On

2014-05-07