Incidental Mutation 'IGL01988:Vmn1r6'
ID 181980
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r6
Ensembl Gene ENSMUSG00000115701
Gene Name vomeronasal 1 receptor 6
Synonyms V1rc20
Accession Numbers
Essential gene? Probably non essential (E-score: 0.131) question?
Stock # IGL01988
Quality Score
Status
Chromosome 6
Chromosomal Location 56979340-56980251 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 56979650 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 82 (T82I)
Ref Sequence ENSEMBL: ENSMUSP00000154199 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079669] [ENSMUST00000226689] [ENSMUST00000227131] [ENSMUST00000227188] [ENSMUST00000227631] [ENSMUST00000227847] [ENSMUST00000228285]
AlphaFold Q8R2D4
Predicted Effect possibly damaging
Transcript: ENSMUST00000079669
AA Change: T104I

PolyPhen 2 Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000078611
Gene: ENSMUSG00000115701
AA Change: T104I

DomainStartEndE-ValueType
Pfam:V1R 28 293 4.9e-54 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000226689
AA Change: T104I

PolyPhen 2 Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227131
AA Change: T104I

PolyPhen 2 Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect probably damaging
Transcript: ENSMUST00000227188
AA Change: T82I

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000227631
AA Change: T82I

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227847
AA Change: T104I

PolyPhen 2 Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228285
AA Change: T104I

PolyPhen 2 Score 0.899 (Sensitivity: 0.82; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9330159F19Rik T A 10: 29,101,107 (GRCm39) S493R probably benign Het
Abca17 T C 17: 24,553,229 (GRCm39) N161D probably damaging Het
Ace2 C A X: 162,946,988 (GRCm39) N290K possibly damaging Het
Adam26a G A 8: 44,022,207 (GRCm39) P428S possibly damaging Het
Adgrv1 T C 13: 81,705,428 (GRCm39) R1461G probably damaging Het
Arhgef10l T C 4: 140,305,672 (GRCm39) probably benign Het
Bicc1 A G 10: 70,792,006 (GRCm39) V334A probably damaging Het
C8a T C 4: 104,683,891 (GRCm39) Y408C probably damaging Het
Col24a1 T C 3: 145,229,922 (GRCm39) probably null Het
Copa T A 1: 171,945,831 (GRCm39) N931K probably benign Het
Cr1l A G 1: 194,799,858 (GRCm39) M272T probably damaging Het
Dcaf12 T C 4: 41,298,299 (GRCm39) N283S probably benign Het
Dnttip2 T A 3: 122,069,944 (GRCm39) S386R probably benign Het
Fbll1 G T 11: 35,688,728 (GRCm39) D178E probably benign Het
Fgd6 A G 10: 93,910,197 (GRCm39) probably benign Het
Fyn T A 10: 39,409,917 (GRCm39) L408* probably null Het
Gkn2 T C 6: 87,356,257 (GRCm39) V176A probably benign Het
Gm10764 G A 10: 87,126,953 (GRCm39) C120Y unknown Het
Gpr19 A T 6: 134,846,247 (GRCm39) F442I probably damaging Het
Herc1 A G 9: 66,395,357 (GRCm39) probably benign Het
Il7 A G 3: 7,669,126 (GRCm39) Y37H possibly damaging Het
Kcnj3 G A 2: 55,327,243 (GRCm39) D11N probably benign Het
Kif1c A G 11: 70,595,762 (GRCm39) D156G probably damaging Het
Lrch1 T C 14: 75,032,813 (GRCm39) probably benign Het
Nedd1 G T 10: 92,550,021 (GRCm39) T88K probably benign Het
Nlrc3 T G 16: 3,771,803 (GRCm39) S875R probably benign Het
Optc A G 1: 133,834,667 (GRCm39) probably null Het
Or4a78 T A 2: 89,497,424 (GRCm39) I269F probably benign Het
Pcdh17 T A 14: 84,684,062 (GRCm39) D176E probably damaging Het
Pde1b A G 15: 103,433,283 (GRCm39) probably null Het
Phf11a A T 14: 59,514,807 (GRCm39) D291E probably damaging Het
Slc30a8 A T 15: 52,198,601 (GRCm39) I349L probably benign Het
Spty2d1 T A 7: 46,647,358 (GRCm39) S524C probably damaging Het
Syndig1 T C 2: 149,845,090 (GRCm39) probably benign Het
Syvn1 G A 19: 6,102,437 (GRCm39) A502T probably benign Het
Tenm2 A G 11: 35,918,078 (GRCm39) L1894P probably damaging Het
Tmem176a T A 6: 48,819,554 (GRCm39) V11E possibly damaging Het
Tpr G T 1: 150,302,750 (GRCm39) probably null Het
Txnrd2 T C 16: 18,274,768 (GRCm39) probably benign Het
Ubqln3 G A 7: 103,792,089 (GRCm39) probably benign Het
Wdfy4 C T 14: 32,798,437 (GRCm39) E1990K possibly damaging Het
Zdhhc7 T C 8: 120,809,329 (GRCm39) R293G probably benign Het
Zeb1 T A 18: 5,759,037 (GRCm39) L148* probably null Het
Other mutations in Vmn1r6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00905:Vmn1r6 APN 6 56,979,789 (GRCm39) missense probably damaging 1.00
IGL01011:Vmn1r6 APN 6 56,979,529 (GRCm39) missense probably benign 0.00
IGL01147:Vmn1r6 APN 6 56,979,626 (GRCm39) missense probably damaging 1.00
IGL01475:Vmn1r6 APN 6 56,979,896 (GRCm39) missense probably damaging 1.00
IGL01638:Vmn1r6 APN 6 56,980,177 (GRCm39) nonsense probably null
IGL01860:Vmn1r6 APN 6 56,979,674 (GRCm39) nonsense probably null
IGL01876:Vmn1r6 APN 6 56,979,446 (GRCm39) missense probably benign 0.12
R0531:Vmn1r6 UTSW 6 56,979,583 (GRCm39) missense probably benign 0.00
R1495:Vmn1r6 UTSW 6 56,980,058 (GRCm39) missense possibly damaging 0.58
R1733:Vmn1r6 UTSW 6 56,979,607 (GRCm39) missense probably damaging 1.00
R2037:Vmn1r6 UTSW 6 56,980,109 (GRCm39) missense probably damaging 1.00
R3625:Vmn1r6 UTSW 6 56,979,920 (GRCm39) missense probably damaging 0.96
R4353:Vmn1r6 UTSW 6 56,979,677 (GRCm39) missense possibly damaging 0.63
R4484:Vmn1r6 UTSW 6 56,980,174 (GRCm39) missense probably benign
R4854:Vmn1r6 UTSW 6 56,979,683 (GRCm39) missense probably benign 0.00
R5237:Vmn1r6 UTSW 6 56,980,179 (GRCm39) missense probably damaging 1.00
R5341:Vmn1r6 UTSW 6 56,979,789 (GRCm39) missense probably damaging 1.00
R5611:Vmn1r6 UTSW 6 56,979,362 (GRCm39) missense probably damaging 1.00
R6795:Vmn1r6 UTSW 6 56,979,422 (GRCm39) missense possibly damaging 0.85
R8423:Vmn1r6 UTSW 6 56,979,495 (GRCm39) missense probably benign 0.30
R9249:Vmn1r6 UTSW 6 56,979,760 (GRCm39) missense probably benign
R9582:Vmn1r6 UTSW 6 56,979,925 (GRCm39) missense probably benign
Posted On 2014-05-07