Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01988:Gpr19'

181988

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr19

Ensembl Gene

ENSMUSG00000032641

Gene Name

G protein-coupled receptor 19

Synonyms

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01988

Quality Score

Status

Chromosome

Chromosomal Location

134846055-134875157 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 134846247 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Isoleucine at position 442 (F442I)

Ref Sequence

ENSEMBL: ENSMUSP00000149995 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046255] [ENSMUST00000066107] [ENSMUST00000111932] [ENSMUST00000116515] [ENSMUST00000165392] [ENSMUST00000203409] [ENSMUST00000203762] [ENSMUST00000204880] [ENSMUST00000215088]

AlphaFold

Q61121

Predicted Effect

probably damaging
Transcript: ENSMUST00000046255
AA Change: F393I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000047630
Gene: ENSMUSG00000032641
AA Change: F393I

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	76	345	1.7e-12	PFAM
Pfam:7tm_1	82	330	1.8e-50	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000066107
AA Change: F479I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000066287
Gene: ENSMUSG00000032641
AA Change: F479I

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	76	345	1.7e-12	PFAM
Pfam:7tm_1	82	330	5.3e-45	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000111932
AA Change: F387I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000107563
Gene: ENSMUSG00000032641
AA Change: F387I

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	70	339	2.6e-12	PFAM
Pfam:7tm_1	76	324	3.5e-50	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000116515
AA Change: F387I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000112214
Gene: ENSMUSG00000032641
AA Change: F387I

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	70	339	2.6e-12	PFAM
Pfam:7tm_1	76	324	3.5e-50	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000165392
AA Change: F387I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000127876
Gene: ENSMUSG00000032641
AA Change: F387I

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	70	339	2.6e-12	PFAM
Pfam:7tm_1	76	324	3.5e-50	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000203409

SMART Domains

Protein: ENSMUSP00000145128
Gene: ENSMUSG00000032641

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	70	132	9e-5	PFAM
Pfam:7tm_1	76	135	2.6e-16	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000203762

Predicted Effect

probably benign
Transcript: ENSMUST00000204880

SMART Domains

Protein: ENSMUSP00000144918
Gene: ENSMUSG00000032641

Domain	Start	End	E-Value	Type
transmembrane domain	59	76	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000215088
AA Change: F442I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous mutation of this gene results in increased anxiety-like behavior. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9330159F19Rik	T	A	10: 29,101,107 (GRCm39)	S493R	probably benign	Het
Abca17	T	C	17: 24,553,229 (GRCm39)	N161D	probably damaging	Het
Ace2	C	A	X: 162,946,988 (GRCm39)	N290K	possibly damaging	Het
Adam26a	G	A	8: 44,022,207 (GRCm39)	P428S	possibly damaging	Het
Adgrv1	T	C	13: 81,705,428 (GRCm39)	R1461G	probably damaging	Het
Arhgef10l	T	C	4: 140,305,672 (GRCm39)		probably benign	Het
Bicc1	A	G	10: 70,792,006 (GRCm39)	V334A	probably damaging	Het
C8a	T	C	4: 104,683,891 (GRCm39)	Y408C	probably damaging	Het
Col24a1	T	C	3: 145,229,922 (GRCm39)		probably null	Het
Copa	T	A	1: 171,945,831 (GRCm39)	N931K	probably benign	Het
Cr1l	A	G	1: 194,799,858 (GRCm39)	M272T	probably damaging	Het
Dcaf12	T	C	4: 41,298,299 (GRCm39)	N283S	probably benign	Het
Dnttip2	T	A	3: 122,069,944 (GRCm39)	S386R	probably benign	Het
Fbll1	G	T	11: 35,688,728 (GRCm39)	D178E	probably benign	Het
Fgd6	A	G	10: 93,910,197 (GRCm39)		probably benign	Het
Fyn	T	A	10: 39,409,917 (GRCm39)	L408*	probably null	Het
Gkn2	T	C	6: 87,356,257 (GRCm39)	V176A	probably benign	Het
Gm10764	G	A	10: 87,126,953 (GRCm39)	C120Y	unknown	Het
Herc1	A	G	9: 66,395,357 (GRCm39)		probably benign	Het
Il7	A	G	3: 7,669,126 (GRCm39)	Y37H	possibly damaging	Het
Kcnj3	G	A	2: 55,327,243 (GRCm39)	D11N	probably benign	Het
Kif1c	A	G	11: 70,595,762 (GRCm39)	D156G	probably damaging	Het
Lrch1	T	C	14: 75,032,813 (GRCm39)		probably benign	Het
Nedd1	G	T	10: 92,550,021 (GRCm39)	T88K	probably benign	Het
Nlrc3	T	G	16: 3,771,803 (GRCm39)	S875R	probably benign	Het
Optc	A	G	1: 133,834,667 (GRCm39)		probably null	Het
Or4a78	T	A	2: 89,497,424 (GRCm39)	I269F	probably benign	Het
Pcdh17	T	A	14: 84,684,062 (GRCm39)	D176E	probably damaging	Het
Pde1b	A	G	15: 103,433,283 (GRCm39)		probably null	Het
Phf11a	A	T	14: 59,514,807 (GRCm39)	D291E	probably damaging	Het
Slc30a8	A	T	15: 52,198,601 (GRCm39)	I349L	probably benign	Het
Spty2d1	T	A	7: 46,647,358 (GRCm39)	S524C	probably damaging	Het
Syndig1	T	C	2: 149,845,090 (GRCm39)		probably benign	Het
Syvn1	G	A	19: 6,102,437 (GRCm39)	A502T	probably benign	Het
Tenm2	A	G	11: 35,918,078 (GRCm39)	L1894P	probably damaging	Het
Tmem176a	T	A	6: 48,819,554 (GRCm39)	V11E	possibly damaging	Het
Tpr	G	T	1: 150,302,750 (GRCm39)		probably null	Het
Txnrd2	T	C	16: 18,274,768 (GRCm39)		probably benign	Het
Ubqln3	G	A	7: 103,792,089 (GRCm39)		probably benign	Het
Vmn1r6	C	T	6: 56,979,650 (GRCm39)	T82I	probably damaging	Het
Wdfy4	C	T	14: 32,798,437 (GRCm39)	E1990K	possibly damaging	Het
Zdhhc7	T	C	8: 120,809,329 (GRCm39)	R293G	probably benign	Het
Zeb1	T	A	18: 5,759,037 (GRCm39)	L148*	probably null	Het

Other mutations in Gpr19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01310:Gpr19	APN	6	134,846,705 (GRCm39)	missense	probably damaging	0.99
IGL01373:Gpr19	APN	6	134,847,284 (GRCm39)	missense	possibly damaging	0.81
R1530:Gpr19	UTSW	6	134,846,961 (GRCm39)	missense	probably damaging	0.97
R1548:Gpr19	UTSW	6	134,847,047 (GRCm39)	missense	possibly damaging	0.92
R1699:Gpr19	UTSW	6	134,847,192 (GRCm39)	missense	possibly damaging	0.93
R2131:Gpr19	UTSW	6	134,847,405 (GRCm39)	start codon destroyed	probably null	0.99
R5016:Gpr19	UTSW	6	134,846,880 (GRCm39)	nonsense	probably null
R6605:Gpr19	UTSW	6	134,847,398 (GRCm39)	missense	probably benign	0.02
R7080:Gpr19	UTSW	6	134,847,419 (GRCm39)	missense	probably damaging	0.99
R7746:Gpr19	UTSW	6	134,846,355 (GRCm39)	missense	probably damaging	1.00
R8014:Gpr19	UTSW	6	134,846,436 (GRCm39)	missense	probably damaging	1.00
R9176:Gpr19	UTSW	6	134,846,718 (GRCm39)	missense	probably damaging	0.99
R9408:Gpr19	UTSW	6	134,864,704 (GRCm39)	missense	unknown

Posted On

2014-05-07