Incidental Mutation 'IGL01997:Cyp3a25'
ID182099
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp3a25
Ensembl Gene ENSMUSG00000029630
Gene Namecytochrome P450, family 3, subfamily a, polypeptide 25
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.098) question?
Stock #IGL01997
Quality Score
Status
Chromosome5
Chromosomal Location145977194-146009618 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 145994956 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Lysine at position 114 (M114K)
Ref Sequence ENSEMBL: ENSMUSP00000123615 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068317] [ENSMUST00000138870] [ENSMUST00000145062]
Predicted Effect possibly damaging
Transcript: ENSMUST00000068317
AA Change: M114K

PolyPhen 2 Score 0.538 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000065585
Gene: ENSMUSG00000029630
AA Change: M114K

DomainStartEndE-ValueType
Pfam:p450 38 493 9.4e-129 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138870
SMART Domains Protein: ENSMUSP00000116077
Gene: ENSMUSG00000029630

DomainStartEndE-ValueType
Pfam:p450 38 126 2e-13 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000145062
AA Change: M114K

PolyPhen 2 Score 0.915 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000123615
Gene: ENSMUSG00000029630
AA Change: M114K

DomainStartEndE-ValueType
Pfam:p450 38 148 3.9e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153808
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahctf1 G A 1: 179,755,462 T83I probably damaging Het
Aoah A T 13: 20,999,938 M391L probably benign Het
Apc A G 18: 34,315,423 T1757A probably benign Het
B4galt5 A G 2: 167,301,341 Y388H probably benign Het
Dcbld1 A G 10: 52,317,110 E246G probably damaging Het
Fstl4 T A 11: 53,163,054 Y404* probably null Het
Gnat3 G T 5: 17,999,723 E125* probably null Het
Hspa5 C T 2: 34,772,315 probably benign Het
Krt72 A G 15: 101,784,880 S200P probably damaging Het
Mab21l3 G A 3: 101,818,639 T347I probably damaging Het
Map2k7 A G 8: 4,243,442 E104G probably benign Het
Map3k9 T C 12: 81,772,697 D261G probably damaging Het
Mepe C T 5: 104,337,600 P202L probably damaging Het
Mill1 G A 7: 18,255,889 G32D probably damaging Het
Mmp20 T G 9: 7,639,260 M143R probably benign Het
Mms19 A T 19: 41,956,531 L302H probably damaging Het
Myh13 T A 11: 67,367,166 I1728K probably benign Het
Nsun2 C T 13: 69,623,246 P290L probably damaging Het
Nwd2 A T 5: 63,804,595 R507S probably damaging Het
Os9 T A 10: 127,119,443 H147L probably benign Het
Piezo1 T C 8: 122,488,331 probably benign Het
Plekhf1 A T 7: 38,221,328 V272D probably damaging Het
Pnisr T C 4: 21,871,537 I419T possibly damaging Het
Ppp1r3d G T 2: 178,413,654 T185K possibly damaging Het
Ppp2r2a C T 14: 67,016,519 S400N probably benign Het
Rpl21 T C 5: 146,835,608 I96T probably benign Het
S1pr3 C T 13: 51,419,715 R311W probably damaging Het
Senp5 T C 16: 31,963,470 K736R probably damaging Het
Slfn9 T C 11: 82,987,677 I209V possibly damaging Het
Traf3ip1 T A 1: 91,507,570 probably null Het
Tyk2 A G 9: 21,110,494 F879L probably damaging Het
Vmn2r53 T C 7: 12,582,446 D482G possibly damaging Het
Vmn2r65 A G 7: 84,940,770 F646S probably damaging Het
Vps13b T A 15: 35,709,224 S1772R probably damaging Het
Vwde C T 6: 13,215,706 C117Y probably damaging Het
Zfyve26 T C 12: 79,244,400 I2144V probably benign Het
Other mutations in Cyp3a25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00091:Cyp3a25 APN 5 146001463 nonsense probably null
IGL00430:Cyp3a25 APN 5 145993360 missense probably damaging 1.00
IGL00803:Cyp3a25 APN 5 146001443 splice site probably benign
IGL00928:Cyp3a25 APN 5 145986954 missense possibly damaging 0.94
IGL01557:Cyp3a25 APN 5 145984901 missense probably damaging 1.00
IGL02140:Cyp3a25 APN 5 146009463 splice site probably benign
IGL02267:Cyp3a25 APN 5 145998552 missense possibly damaging 0.48
IGL02272:Cyp3a25 APN 5 145993265 intron probably benign
IGL02327:Cyp3a25 APN 5 145986921 missense possibly damaging 0.50
IGL02411:Cyp3a25 APN 5 146001447 critical splice donor site probably benign
IGL02504:Cyp3a25 APN 5 145993331 missense probably benign 0.03
IGL02653:Cyp3a25 APN 5 146003110 missense possibly damaging 0.95
R0378:Cyp3a25 UTSW 5 145986842 missense probably damaging 1.00
R0403:Cyp3a25 UTSW 5 145998513 missense probably damaging 1.00
R0685:Cyp3a25 UTSW 5 145998546 missense probably damaging 1.00
R0725:Cyp3a25 UTSW 5 145994936 missense probably damaging 1.00
R0798:Cyp3a25 UTSW 5 145991533 missense probably damaging 0.98
R1061:Cyp3a25 UTSW 5 145986833 missense probably benign
R1519:Cyp3a25 UTSW 5 146001447 critical splice donor site probably null
R1628:Cyp3a25 UTSW 5 146001463 nonsense probably null
R1822:Cyp3a25 UTSW 5 145984953 missense probably damaging 1.00
R1824:Cyp3a25 UTSW 5 145984953 missense probably damaging 1.00
R1864:Cyp3a25 UTSW 5 145994929 missense probably damaging 0.98
R2062:Cyp3a25 UTSW 5 145986969 splice site probably benign
R2401:Cyp3a25 UTSW 5 145986968 critical splice acceptor site probably null
R2516:Cyp3a25 UTSW 5 146003027 splice site probably null
R3080:Cyp3a25 UTSW 5 145998531 missense probably benign 0.33
R3236:Cyp3a25 UTSW 5 146003128 splice site probably benign
R3694:Cyp3a25 UTSW 5 145989976 splice site probably null
R3730:Cyp3a25 UTSW 5 146003081 missense probably damaging 1.00
R4112:Cyp3a25 UTSW 5 146003031 missense probably benign 0.18
R4258:Cyp3a25 UTSW 5 145991438 missense probably damaging 1.00
R4651:Cyp3a25 UTSW 5 145994891 missense probably benign 0.01
R4788:Cyp3a25 UTSW 5 145985082 nonsense probably null
R4899:Cyp3a25 UTSW 5 145977671 missense possibly damaging 0.59
R4926:Cyp3a25 UTSW 5 145991456 missense probably damaging 1.00
R4952:Cyp3a25 UTSW 5 145991524 missense probably benign 0.01
R5270:Cyp3a25 UTSW 5 145981502 missense probably benign 0.36
R5595:Cyp3a25 UTSW 5 145994863 critical splice donor site probably null
R5659:Cyp3a25 UTSW 5 145991546 missense possibly damaging 0.69
R5787:Cyp3a25 UTSW 5 145998503 missense probably benign 0.14
R6307:Cyp3a25 UTSW 5 145994956 missense possibly damaging 0.92
R6380:Cyp3a25 UTSW 5 145998547 missense probably damaging 0.99
Posted On2014-05-07