Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02009:Vmn2r6'

182266

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r6

Ensembl Gene

ENSMUSG00000090581

Gene Name

vomeronasal 2, receptor 6

Synonyms

EG667069, EG620718

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.241) question?

Stock #

IGL02009

Quality Score

Status

Chromosome

Chromosomal Location

64444916-64472855 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 64445323 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Leucine at position 712 (V712L)

Ref Sequence

ENSEMBL: ENSMUSP00000131831 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165012] [ENSMUST00000176481]

AlphaFold

H3BK29

Predicted Effect

possibly damaging
Transcript: ENSMUST00000165012
AA Change: V712L

PolyPhen 2 Score 0.606 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000131831
Gene: ENSMUSG00000090581
AA Change: V712L

Domain	Start	End	E-Value	Type
Pfam:ANF_receptor	1	416	1.4e-72	PFAM
Pfam:Peripla_BP_6	58	244	1.2e-10	PFAM
Pfam:NCD3G	458	511	1.8e-17	PFAM
Pfam:7tm_3	542	779	3.9e-76	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000176481
AA Change: V801L

PolyPhen 2 Score 0.114 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000135148
Gene: ENSMUSG00000090581
AA Change: V801L

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	88	505	9.8e-77	PFAM
Pfam:Peripla_BP_6	142	331	3.4e-10	PFAM
Pfam:NCD3G	547	600	5.4e-17	PFAM
Pfam:7tm_3	633	867	3.9e-47	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aldh1a3	T	C	7: 66,051,789 (GRCm39)	D388G	probably benign	Het
Ankhd1	C	A	18: 36,757,714 (GRCm39)	Q803K	probably damaging	Het
Arrdc3	A	G	13: 81,041,499 (GRCm39)	N180S	probably benign	Het
Atp11b	G	A	3: 35,868,301 (GRCm39)	E458K	probably benign	Het
Bend6	G	A	1: 33,901,827 (GRCm39)	A185V	probably benign	Het
Ccdc121	C	T	5: 31,644,835 (GRCm39)	T196I	probably benign	Het
Chd5	A	G	4: 152,450,670 (GRCm39)	D632G	probably damaging	Het
Clec4a1	A	T	6: 122,909,175 (GRCm39)	H181L	probably benign	Het
Cntnap5a	T	A	1: 116,085,224 (GRCm39)	D387E	probably benign	Het
Colq	G	A	14: 31,257,599 (GRCm39)	S256F	possibly damaging	Het
Cracd	A	G	5: 76,996,817 (GRCm39)	T92A	possibly damaging	Het
Ctdp1	A	G	18: 80,499,187 (GRCm39)	Y252H	probably damaging	Het
Cyp4f17	T	A	17: 32,743,854 (GRCm39)	L344Q	probably damaging	Het
Fam83b	A	G	9: 76,399,604 (GRCm39)	Y500H	probably damaging	Het
Gapvd1	G	A	2: 34,594,203 (GRCm39)	P949L	probably damaging	Het
Gp5	A	G	16: 30,128,482 (GRCm39)	I64T	probably benign	Het
Il31ra	A	G	13: 112,670,401 (GRCm39)	V248A	probably damaging	Het
Kdm4a	C	T	4: 118,017,366 (GRCm39)	A567T	probably benign	Het
Kpna7	T	C	5: 144,930,888 (GRCm39)		probably null	Het
Lrrc8c	G	A	5: 105,755,257 (GRCm39)	R344H	probably damaging	Het
Man1a	G	A	10: 53,801,621 (GRCm39)	L413F	probably damaging	Het
Man1a2	A	T	3: 100,591,978 (GRCm39)	D67E	probably damaging	Het
Mkln1	G	A	6: 31,426,455 (GRCm39)	S243N	probably benign	Het
Mmp19	T	A	10: 128,634,356 (GRCm39)	M299K	probably benign	Het
Msantd2	T	C	9: 37,434,686 (GRCm39)	F309L	possibly damaging	Het
Mstn	A	G	1: 53,101,309 (GRCm39)		probably benign	Het
Nat8f5	A	C	6: 85,794,408 (GRCm39)	I184R	probably benign	Het
Or5d43	C	T	2: 88,105,056 (GRCm39)	M112I	probably benign	Het
Or9m1b	G	T	2: 87,837,117 (GRCm39)	Q2K	probably benign	Het
Pigc	A	G	1: 161,798,134 (GRCm39)	K39E	possibly damaging	Het
Pms2	T	A	5: 143,862,582 (GRCm39)	L563Q	probably benign	Het
Rpap1	A	G	2: 119,610,594 (GRCm39)	S162P	possibly damaging	Het
Rpl3l	A	G	17: 24,951,407 (GRCm39)	K103E	probably damaging	Het
Slc45a1	A	T	4: 150,722,447 (GRCm39)	V479E	probably damaging	Het
Themis2	A	T	4: 132,512,753 (GRCm39)	L491Q	probably damaging	Het
Vmn2r17	A	T	5: 109,600,714 (GRCm39)	I671L	possibly damaging	Het
Zzz3	A	G	3: 152,133,752 (GRCm39)	D270G	possibly damaging	Het

Other mutations in Vmn2r6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01547:Vmn2r6	APN	3	64,445,525 (GRCm39)	missense	probably damaging	1.00
IGL01968:Vmn2r6	APN	3	64,463,766 (GRCm39)	missense	possibly damaging	0.94
IGL02039:Vmn2r6	APN	3	64,463,610 (GRCm39)	missense	probably damaging	1.00
IGL02652:Vmn2r6	APN	3	64,463,749 (GRCm39)	missense	probably benign	0.24
IGL02737:Vmn2r6	APN	3	64,463,911 (GRCm39)	missense	possibly damaging	0.55
IGL02808:Vmn2r6	APN	3	64,463,917 (GRCm39)	missense	probably damaging	1.00
IGL03066:Vmn2r6	APN	3	64,472,574 (GRCm39)	missense	probably damaging	0.99
IGL03331:Vmn2r6	APN	3	64,445,428 (GRCm39)	missense	probably damaging	1.00
BB010:Vmn2r6	UTSW	3	64,467,224 (GRCm39)	missense	probably benign	0.02
BB020:Vmn2r6	UTSW	3	64,467,224 (GRCm39)	missense	probably benign	0.02
R0010:Vmn2r6	UTSW	3	64,466,966 (GRCm39)	nonsense	probably null
R0206:Vmn2r6	UTSW	3	64,447,333 (GRCm39)	missense	probably benign
R0206:Vmn2r6	UTSW	3	64,447,333 (GRCm39)	missense	probably benign
R0208:Vmn2r6	UTSW	3	64,447,333 (GRCm39)	missense	probably benign
R0427:Vmn2r6	UTSW	3	64,467,008 (GRCm39)	missense	probably damaging	1.00
R0466:Vmn2r6	UTSW	3	64,463,723 (GRCm39)	missense	probably damaging	1.00
R1018:Vmn2r6	UTSW	3	64,464,261 (GRCm39)	missense	probably benign	0.00
R1104:Vmn2r6	UTSW	3	64,445,487 (GRCm39)	missense	possibly damaging	0.93
R1186:Vmn2r6	UTSW	3	64,472,488 (GRCm39)	missense	probably benign	0.01
R1245:Vmn2r6	UTSW	3	64,464,211 (GRCm39)	missense	possibly damaging	0.53
R1295:Vmn2r6	UTSW	3	64,445,694 (GRCm39)	missense	probably damaging	1.00
R1473:Vmn2r6	UTSW	3	64,445,579 (GRCm39)	nonsense	probably null
R1498:Vmn2r6	UTSW	3	64,463,890 (GRCm39)	missense	probably damaging	1.00
R1925:Vmn2r6	UTSW	3	64,463,698 (GRCm39)	missense	possibly damaging	0.87
R2044:Vmn2r6	UTSW	3	64,445,262 (GRCm39)	missense	probably damaging	0.96
R2069:Vmn2r6	UTSW	3	64,463,519 (GRCm39)	missense	possibly damaging	0.89
R2253:Vmn2r6	UTSW	3	64,467,139 (GRCm39)	missense	probably damaging	1.00
R2261:Vmn2r6	UTSW	3	64,464,090 (GRCm39)	missense	probably benign	0.24
R2262:Vmn2r6	UTSW	3	64,464,090 (GRCm39)	missense	probably benign	0.24
R2350:Vmn2r6	UTSW	3	64,463,773 (GRCm39)	missense	probably benign	0.01
R2680:Vmn2r6	UTSW	3	64,445,707 (GRCm39)	missense	possibly damaging	0.91
R2846:Vmn2r6	UTSW	3	64,464,211 (GRCm39)	missense	possibly damaging	0.53
R2860:Vmn2r6	UTSW	3	64,454,760 (GRCm39)	missense	probably benign	0.00
R2861:Vmn2r6	UTSW	3	64,454,760 (GRCm39)	missense	probably benign	0.00
R3766:Vmn2r6	UTSW	3	64,463,929 (GRCm39)	missense	probably benign	0.19
R3870:Vmn2r6	UTSW	3	64,464,042 (GRCm39)	missense	probably damaging	0.96
R4018:Vmn2r6	UTSW	3	64,463,893 (GRCm39)	missense	probably benign	0.05
R4024:Vmn2r6	UTSW	3	64,445,671 (GRCm39)	missense	possibly damaging	0.73
R4026:Vmn2r6	UTSW	3	64,445,671 (GRCm39)	missense	possibly damaging	0.73
R4227:Vmn2r6	UTSW	3	64,445,369 (GRCm39)	missense	probably damaging	0.99
R4526:Vmn2r6	UTSW	3	64,445,145 (GRCm39)	missense	probably benign	0.32
R4570:Vmn2r6	UTSW	3	64,467,068 (GRCm39)	missense	probably benign	0.31
R4894:Vmn2r6	UTSW	3	64,454,829 (GRCm39)	missense	probably benign
R4934:Vmn2r6	UTSW	3	64,463,766 (GRCm39)	missense	probably damaging	0.99
R5057:Vmn2r6	UTSW	3	64,445,207 (GRCm39)	missense	probably damaging	1.00
R5059:Vmn2r6	UTSW	3	64,445,044 (GRCm39)	missense	possibly damaging	0.89
R5148:Vmn2r6	UTSW	3	64,464,015 (GRCm39)	missense	probably damaging	0.99
R5155:Vmn2r6	UTSW	3	64,445,935 (GRCm39)	missense	probably benign	0.44
R5179:Vmn2r6	UTSW	3	64,445,411 (GRCm39)	missense	probably benign	0.00
R5256:Vmn2r6	UTSW	3	64,464,263 (GRCm39)	missense	probably benign	0.33
R5861:Vmn2r6	UTSW	3	64,463,454 (GRCm39)	missense	probably benign	0.00
R5950:Vmn2r6	UTSW	3	64,472,652 (GRCm39)	missense	probably benign	0.05
R6081:Vmn2r6	UTSW	3	64,463,953 (GRCm39)	missense	probably benign	0.25
R6173:Vmn2r6	UTSW	3	64,467,176 (GRCm39)	missense	probably damaging	1.00
R6190:Vmn2r6	UTSW	3	64,445,424 (GRCm39)	missense	probably benign	0.04
R6240:Vmn2r6	UTSW	3	64,464,226 (GRCm39)	missense	probably damaging	1.00
R6433:Vmn2r6	UTSW	3	64,454,801 (GRCm39)	nonsense	probably null
R6645:Vmn2r6	UTSW	3	64,464,297 (GRCm39)	missense	probably damaging	1.00
R6791:Vmn2r6	UTSW	3	64,445,580 (GRCm39)	missense	probably damaging	1.00
R7265:Vmn2r6	UTSW	3	64,464,195 (GRCm39)	missense	probably benign	0.00
R7503:Vmn2r6	UTSW	3	64,447,372 (GRCm39)	nonsense	probably null
R7562:Vmn2r6	UTSW	3	64,463,941 (GRCm39)	missense	probably benign	0.00
R7584:Vmn2r6	UTSW	3	64,472,683 (GRCm39)	missense	probably benign	0.07
R7611:Vmn2r6	UTSW	3	64,472,563 (GRCm39)	missense	probably damaging	0.98
R7759:Vmn2r6	UTSW	3	64,463,991 (GRCm39)	missense	probably damaging	1.00
R7834:Vmn2r6	UTSW	3	64,445,443 (GRCm39)	missense	probably damaging	1.00
R7933:Vmn2r6	UTSW	3	64,467,224 (GRCm39)	missense	probably benign	0.02
R7982:Vmn2r6	UTSW	3	64,467,241 (GRCm39)	missense	probably damaging	1.00
R8024:Vmn2r6	UTSW	3	64,467,245 (GRCm39)	missense	probably benign	0.40
R8074:Vmn2r6	UTSW	3	64,455,064 (GRCm39)	intron	probably benign
R8169:Vmn2r6	UTSW	3	64,447,310 (GRCm39)	missense	probably benign	0.01
R8337:Vmn2r6	UTSW	3	64,463,526 (GRCm39)	nonsense	probably null
R8736:Vmn2r6	UTSW	3	64,467,221 (GRCm39)	missense	probably damaging	1.00
R8962:Vmn2r6	UTSW	3	64,463,576 (GRCm39)	missense	probably damaging	1.00
R9139:Vmn2r6	UTSW	3	64,464,277 (GRCm39)	missense	probably benign	0.12
R9206:Vmn2r6	UTSW	3	64,467,032 (GRCm39)	missense	probably damaging	0.97
R9295:Vmn2r6	UTSW	3	64,463,484 (GRCm39)	missense	probably benign	0.00
R9332:Vmn2r6	UTSW	3	64,454,671 (GRCm39)	missense	probably benign	0.01
R9616:Vmn2r6	UTSW	3	64,445,724 (GRCm39)	missense	probably damaging	1.00
R9663:Vmn2r6	UTSW	3	64,463,549 (GRCm39)	missense	possibly damaging	0.90
R9685:Vmn2r6	UTSW	3	64,464,081 (GRCm39)	missense	probably benign	0.19
X0020:Vmn2r6	UTSW	3	64,445,871 (GRCm39)	missense	probably benign
X0066:Vmn2r6	UTSW	3	64,454,799 (GRCm39)	missense	probably damaging	1.00
Z1176:Vmn2r6	UTSW	3	64,463,746 (GRCm39)	missense	probably damaging	0.98

Posted On

2014-05-07