Incidental Mutation 'IGL01959:Nms'
ID 182342
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Nms
Ensembl Gene ENSMUSG00000067604
Gene Name neuromedin S
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # IGL01959
Quality Score
Status
Chromosome 1
Chromosomal Location 38978230-38989357 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 38981006 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000125166 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088029] [ENSMUST00000160214]
AlphaFold Q5H8A1
Predicted Effect probably benign
Transcript: ENSMUST00000088029
SMART Domains Protein: ENSMUSP00000085346
Gene: ENSMUSG00000067604

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
low complexity region 104 115 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000160214
SMART Domains Protein: ENSMUSP00000125166
Gene: ENSMUSG00000067604

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
low complexity region 96 107 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in the regulation of circadian rhythm, anorexigenic action, antidiuretic action, cardiovascular function and stimulation of oxytocin and vasopressin release. Mice lacking the encoded neuropeptide exhibit decreased heart rate without any accompanying changes in blood pressure. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate the mature peptide. [provided by RefSeq, Aug 2015]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9230009I02Rik T C 11: 50,982,645 (GRCm39) noncoding transcript Het
Aip A G 19: 4,171,397 (GRCm39) I13T probably damaging Het
Cacna2d1 C T 5: 16,417,895 (GRCm39) P140S probably benign Het
Cald1 A G 6: 34,730,403 (GRCm39) D40G probably damaging Het
Cep250 T A 2: 155,825,279 (GRCm39) V1052E possibly damaging Het
Chd1 A G 17: 15,962,435 (GRCm39) N731D probably damaging Het
Chml C T 1: 175,515,166 (GRCm39) V252I probably benign Het
Cog8 T C 8: 107,783,010 (GRCm39) Y93C probably damaging Het
Creld1 G A 6: 113,469,794 (GRCm39) A399T probably damaging Het
Cyp2a4 T A 7: 26,007,133 (GRCm39) V80E probably damaging Het
Cyp2c37 T A 19: 39,984,277 (GRCm39) L255* probably null Het
Cyp2d12 C A 15: 82,439,545 (GRCm39) probably benign Het
Dimt1 A G 13: 107,089,963 (GRCm39) I229V probably benign Het
Dsc1 G A 18: 20,230,282 (GRCm39) T341I probably damaging Het
Ercc3 T A 18: 32,390,411 (GRCm39) F567I probably damaging Het
Espl1 C A 15: 102,214,097 (GRCm39) probably benign Het
Fcrl2 T C 3: 87,166,939 (GRCm39) D18G probably damaging Het
Fnip1 T A 11: 54,381,738 (GRCm39) S296R possibly damaging Het
Fzd5 C A 1: 64,775,105 (GRCm39) A219S possibly damaging Het
Gbp7 A G 3: 142,247,108 (GRCm39) probably benign Het
Gm3298 T C 14: 5,018,731 (GRCm38) L162S probably damaging Het
Hspa1l A G 17: 35,196,111 (GRCm39) E50G probably damaging Het
Ipo9 T C 1: 135,348,093 (GRCm39) probably null Het
Kazn A G 4: 141,878,195 (GRCm39) L185P probably damaging Het
Kcnh8 T C 17: 53,141,635 (GRCm39) S293P probably damaging Het
Lrp1b T C 2: 41,202,539 (GRCm39) T1191A probably damaging Het
Mnat1 A G 12: 73,228,705 (GRCm39) probably benign Het
Msx2 C T 13: 53,622,638 (GRCm39) probably benign Het
Ndufs2 T G 1: 171,064,798 (GRCm39) I317L probably benign Het
Oosp3 T A 19: 11,678,286 (GRCm39) F87L probably benign Het
Pask A G 1: 93,262,329 (GRCm39) V177A probably benign Het
Poldip2 G T 11: 78,403,133 (GRCm39) probably benign Het
Prr14l A T 5: 32,987,549 (GRCm39) S649T possibly damaging Het
Slc6a18 T A 13: 73,825,984 (GRCm39) N22I probably damaging Het
Smco2 T A 6: 146,763,208 (GRCm39) S228T probably benign Het
Speer4a1 G A 5: 26,240,902 (GRCm39) Q197* probably null Het
Speg A G 1: 75,367,734 (GRCm39) K641R probably damaging Het
Strip2 G A 6: 29,928,553 (GRCm39) V286M probably damaging Het
Tnfrsf22 C T 7: 143,197,012 (GRCm39) probably null Het
Tnpo3 A G 6: 29,589,019 (GRCm39) probably benign Het
Top2b T A 14: 16,422,695 (GRCm38) N1377K probably benign Het
Trmt1 T A 8: 85,418,005 (GRCm39) probably null Het
Trpm1 A G 7: 63,858,723 (GRCm39) M266V possibly damaging Het
Vmn1r199 A G 13: 22,567,290 (GRCm39) T195A probably benign Het
Vmn2r10 A G 5: 109,145,571 (GRCm39) V512A probably benign Het
Zfp777 A G 6: 48,021,275 (GRCm39) F116L probably benign Het
Zp3r T A 1: 130,519,188 (GRCm39) K253* probably null Het
Other mutations in Nms
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01796:Nms APN 1 38,985,192 (GRCm39) missense possibly damaging 0.92
IGL02088:Nms APN 1 38,978,358 (GRCm39) utr 5 prime probably benign
IGL02810:Nms APN 1 38,987,725 (GRCm39) missense possibly damaging 0.94
IGL03001:Nms APN 1 38,980,993 (GRCm39) missense probably benign 0.12
alacrity UTSW 1 38,980,976 (GRCm39) missense probably benign 0.04
R1087:Nms UTSW 1 38,983,192 (GRCm39) critical splice donor site probably null
R3689:Nms UTSW 1 38,986,075 (GRCm39) splice site probably benign
R4426:Nms UTSW 1 38,978,377 (GRCm39) missense probably benign
R6910:Nms UTSW 1 38,980,976 (GRCm39) missense probably benign 0.04
R7258:Nms UTSW 1 38,986,051 (GRCm39) missense probably benign 0.01
R8848:Nms UTSW 1 38,978,391 (GRCm39) missense probably benign
R9108:Nms UTSW 1 38,985,147 (GRCm39) missense possibly damaging 0.78
R9493:Nms UTSW 1 38,980,982 (GRCm39) missense probably benign
Posted On 2014-05-07