Incidental Mutation 'IGL01961:Wars1'
ID 182410
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wars1
Ensembl Gene ENSMUSG00000021266
Gene Name tryptophanyl-tRNA synthetase1
Synonyms Wars
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL01961
Quality Score
Status
Chromosome 12
Chromosomal Location 108825956-108860095 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 108832096 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 323 (M323K)
Ref Sequence ENSEMBL: ENSMUSP00000125320 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109848] [ENSMUST00000160477] [ENSMUST00000161154] [ENSMUST00000161410]
AlphaFold P32921
Predicted Effect probably damaging
Transcript: ENSMUST00000109848
AA Change: M323K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000105474
Gene: ENSMUSG00000021266
AA Change: M323K

DomainStartEndE-ValueType
WHEP-TRS 16 72 3.01e-23 SMART
Pfam:tRNA-synt_1b 155 447 5.8e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157592
Predicted Effect probably benign
Transcript: ENSMUST00000160477
Predicted Effect probably damaging
Transcript: ENSMUST00000161154
AA Change: M323K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000124625
Gene: ENSMUSG00000021266
AA Change: M323K

DomainStartEndE-ValueType
WHEP-TRS 16 72 3.01e-23 SMART
Pfam:tRNA-synt_1b 155 446 1.4e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000161410
AA Change: M323K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000125320
Gene: ENSMUSG00000021266
AA Change: M323K

DomainStartEndE-ValueType
WHEP-TRS 16 72 3.01e-23 SMART
Pfam:tRNA-synt_1b 155 447 5.8e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162952
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 15 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Catsperg2 A G 7: 29,421,097 (GRCm39) probably benign Het
Gm9958 C A 5: 90,515,837 (GRCm39) probably benign Het
Kdelr2 T C 5: 143,406,556 (GRCm39) V202A probably benign Het
Mideas T C 12: 84,220,388 (GRCm39) K189E probably damaging Het
Mlh3 T C 12: 85,313,118 (GRCm39) R1023G probably benign Het
Pcdhb7 A G 18: 37,475,526 (GRCm39) K221E probably damaging Het
Ptprq A G 10: 107,479,515 (GRCm39) S1171P probably damaging Het
Sez6l G A 5: 112,619,597 (GRCm39) T345M probably damaging Het
Skint7 T C 4: 111,834,660 (GRCm39) Y15H probably benign Het
Strip2 T C 6: 29,928,426 (GRCm39) probably benign Het
Syne1 C A 10: 4,993,723 (GRCm39) R8339M possibly damaging Het
Tmtc3 A T 10: 100,282,893 (GRCm39) D887E probably benign Het
Ush1g A G 11: 115,209,361 (GRCm39) S278P probably benign Het
Zc3h11a G A 1: 133,554,805 (GRCm39) R392W probably benign Het
Zswim8 T C 14: 20,762,402 (GRCm39) F305L possibly damaging Het
Other mutations in Wars1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02327:Wars1 APN 12 108,832,227 (GRCm39) critical splice acceptor site probably null
IGL02864:Wars1 APN 12 108,848,791 (GRCm39) missense probably benign
IGL02962:Wars1 APN 12 108,841,706 (GRCm39) missense probably damaging 0.99
R0271:Wars1 UTSW 12 108,841,119 (GRCm39) missense probably benign
R0485:Wars1 UTSW 12 108,841,083 (GRCm39) missense probably damaging 1.00
R0669:Wars1 UTSW 12 108,831,944 (GRCm39) missense probably benign 0.00
R1144:Wars1 UTSW 12 108,854,291 (GRCm39) nonsense probably null
R1581:Wars1 UTSW 12 108,841,635 (GRCm39) nonsense probably null
R1730:Wars1 UTSW 12 108,841,667 (GRCm39) missense probably damaging 1.00
R1783:Wars1 UTSW 12 108,841,667 (GRCm39) missense probably damaging 1.00
R1990:Wars1 UTSW 12 108,854,359 (GRCm39) missense possibly damaging 0.94
R5382:Wars1 UTSW 12 108,848,706 (GRCm39) missense probably benign
R5703:Wars1 UTSW 12 108,841,047 (GRCm39) missense probably damaging 1.00
R6299:Wars1 UTSW 12 108,827,309 (GRCm39) missense probably benign 0.00
R7186:Wars1 UTSW 12 108,846,982 (GRCm39) missense probably damaging 0.99
R7508:Wars1 UTSW 12 108,848,801 (GRCm39) missense probably benign 0.01
R7919:Wars1 UTSW 12 108,847,030 (GRCm39) missense probably benign 0.11
R8530:Wars1 UTSW 12 108,848,818 (GRCm39) missense probably damaging 0.99
R9132:Wars1 UTSW 12 108,827,199 (GRCm39) missense probably benign 0.41
Posted On 2014-05-07