Incidental Mutation 'IGL01961:Mideas'
ID 182413
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mideas
Ensembl Gene ENSMUSG00000042507
Gene Name mitotic deacetylase associated SANT domain protein
Synonyms C130039O16Rik, Elmsan1, 9430029N19Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.485) question?
Stock # IGL01961
Quality Score
Status
Chromosome 12
Chromosomal Location 84195950-84265655 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 84220388 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 189 (K189E)
Ref Sequence ENSEMBL: ENSMUSP00000152853 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046266] [ENSMUST00000110294] [ENSMUST00000220974]
AlphaFold E9Q2I4
Predicted Effect probably damaging
Transcript: ENSMUST00000046266
AA Change: K189E

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000048120
Gene: ENSMUSG00000042507
AA Change: K189E

DomainStartEndE-ValueType
low complexity region 28 39 N/A INTRINSIC
low complexity region 64 75 N/A INTRINSIC
low complexity region 107 117 N/A INTRINSIC
low complexity region 124 132 N/A INTRINSIC
low complexity region 247 265 N/A INTRINSIC
low complexity region 377 388 N/A INTRINSIC
low complexity region 556 567 N/A INTRINSIC
low complexity region 643 654 N/A INTRINSIC
ELM2 715 772 6.76e-14 SMART
low complexity region 798 814 N/A INTRINSIC
SANT 821 869 1.44e-5 SMART
low complexity region 906 926 N/A INTRINSIC
low complexity region 942 956 N/A INTRINSIC
ZnF_C2H2 1030 1052 4.72e-2 SMART
low complexity region 1053 1082 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000110294
AA Change: K189E

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000105923
Gene: ENSMUSG00000042507
AA Change: K189E

DomainStartEndE-ValueType
low complexity region 28 39 N/A INTRINSIC
low complexity region 64 75 N/A INTRINSIC
low complexity region 107 117 N/A INTRINSIC
low complexity region 124 132 N/A INTRINSIC
low complexity region 247 265 N/A INTRINSIC
low complexity region 377 388 N/A INTRINSIC
low complexity region 556 567 N/A INTRINSIC
low complexity region 643 654 N/A INTRINSIC
ELM2 715 772 6.76e-14 SMART
low complexity region 798 814 N/A INTRINSIC
SANT 821 869 1.44e-5 SMART
low complexity region 906 926 N/A INTRINSIC
low complexity region 942 956 N/A INTRINSIC
ZnF_C2H2 1030 1052 4.72e-2 SMART
low complexity region 1053 1082 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000220974
AA Change: K189E

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 15 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Catsperg2 A G 7: 29,421,097 (GRCm39) probably benign Het
Gm9958 C A 5: 90,515,837 (GRCm39) probably benign Het
Kdelr2 T C 5: 143,406,556 (GRCm39) V202A probably benign Het
Mlh3 T C 12: 85,313,118 (GRCm39) R1023G probably benign Het
Pcdhb7 A G 18: 37,475,526 (GRCm39) K221E probably damaging Het
Ptprq A G 10: 107,479,515 (GRCm39) S1171P probably damaging Het
Sez6l G A 5: 112,619,597 (GRCm39) T345M probably damaging Het
Skint7 T C 4: 111,834,660 (GRCm39) Y15H probably benign Het
Strip2 T C 6: 29,928,426 (GRCm39) probably benign Het
Syne1 C A 10: 4,993,723 (GRCm39) R8339M possibly damaging Het
Tmtc3 A T 10: 100,282,893 (GRCm39) D887E probably benign Het
Ush1g A G 11: 115,209,361 (GRCm39) S278P probably benign Het
Wars1 A T 12: 108,832,096 (GRCm39) M323K probably damaging Het
Zc3h11a G A 1: 133,554,805 (GRCm39) R392W probably benign Het
Zswim8 T C 14: 20,762,402 (GRCm39) F305L possibly damaging Het
Other mutations in Mideas
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00334:Mideas APN 12 84,219,629 (GRCm39) nonsense probably null
IGL00913:Mideas APN 12 84,219,632 (GRCm39) missense probably benign
IGL00944:Mideas APN 12 84,207,322 (GRCm39) splice site probably benign
IGL01108:Mideas APN 12 84,220,465 (GRCm39) missense probably damaging 1.00
IGL01952:Mideas APN 12 84,220,040 (GRCm39) missense probably benign 0.00
IGL02188:Mideas APN 12 84,209,100 (GRCm39) missense probably benign 0.00
IGL02700:Mideas APN 12 84,199,636 (GRCm39) missense probably benign 0.06
R0645:Mideas UTSW 12 84,205,077 (GRCm39) missense possibly damaging 0.71
R1387:Mideas UTSW 12 84,199,705 (GRCm39) missense probably damaging 0.98
R1740:Mideas UTSW 12 84,219,676 (GRCm39) missense probably damaging 0.99
R1769:Mideas UTSW 12 84,205,124 (GRCm39) splice site probably benign
R1795:Mideas UTSW 12 84,205,748 (GRCm39) critical splice donor site probably null
R2146:Mideas UTSW 12 84,219,809 (GRCm39) missense probably damaging 0.99
R2872:Mideas UTSW 12 84,203,245 (GRCm39) missense probably benign 0.00
R2872:Mideas UTSW 12 84,203,245 (GRCm39) missense probably benign 0.00
R2940:Mideas UTSW 12 84,203,245 (GRCm39) missense probably benign 0.00
R3408:Mideas UTSW 12 84,203,245 (GRCm39) missense probably benign 0.00
R3689:Mideas UTSW 12 84,203,245 (GRCm39) missense probably benign 0.00
R3691:Mideas UTSW 12 84,203,245 (GRCm39) missense probably benign 0.00
R3840:Mideas UTSW 12 84,218,383 (GRCm39) missense probably damaging 0.99
R4364:Mideas UTSW 12 84,203,245 (GRCm39) missense probably benign 0.00
R4366:Mideas UTSW 12 84,203,245 (GRCm39) missense probably benign 0.00
R4392:Mideas UTSW 12 84,219,885 (GRCm39) missense probably benign 0.06
R4439:Mideas UTSW 12 84,203,245 (GRCm39) missense probably benign 0.00
R4440:Mideas UTSW 12 84,203,245 (GRCm39) missense probably benign 0.00
R4496:Mideas UTSW 12 84,203,245 (GRCm39) missense probably benign 0.00
R5227:Mideas UTSW 12 84,199,661 (GRCm39) missense probably benign 0.10
R6921:Mideas UTSW 12 84,203,233 (GRCm39) missense probably damaging 0.99
R7675:Mideas UTSW 12 84,220,574 (GRCm39) missense probably damaging 1.00
R8956:Mideas UTSW 12 84,209,102 (GRCm39) missense probably benign
R8990:Mideas UTSW 12 84,218,380 (GRCm39) missense probably benign
R9058:Mideas UTSW 12 84,220,642 (GRCm39) missense probably damaging 0.98
R9106:Mideas UTSW 12 84,199,327 (GRCm39) missense probably damaging 0.99
R9205:Mideas UTSW 12 84,199,661 (GRCm39) missense probably benign 0.00
R9369:Mideas UTSW 12 84,219,670 (GRCm39) missense probably benign
R9643:Mideas UTSW 12 84,219,885 (GRCm39) missense probably benign 0.06
R9794:Mideas UTSW 12 84,220,576 (GRCm39) missense probably damaging 0.98
Z1176:Mideas UTSW 12 84,220,275 (GRCm39) missense probably damaging 0.98
Z1176:Mideas UTSW 12 84,220,273 (GRCm39) missense probably damaging 0.99
Z1177:Mideas UTSW 12 84,209,132 (GRCm39) nonsense probably null
Z1177:Mideas UTSW 12 84,199,765 (GRCm39) missense probably benign 0.01
Posted On 2014-05-07