Incidental Mutation 'IGL01963:Fndc4'
ID182481
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fndc4
Ensembl Gene ENSMUSG00000038552
Gene Namefibronectin type III domain containing 4
SynonymsFRCP1, 2810430J06Rik, 6330410H20Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.045) question?
Stock #IGL01963
Quality Score
Status
Chromosome5
Chromosomal Location31292242-31296080 bp(-) (GRCm38)
Type of Mutationcritical splice donor site (1 bp from exon)
DNA Base Change (assembly) C to T at 31295212 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000144195 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041266] [ENSMUST00000041565] [ENSMUST00000072228] [ENSMUST00000172435] [ENSMUST00000201166] [ENSMUST00000201417] [ENSMUST00000201675] [ENSMUST00000201809] [ENSMUST00000202158] [ENSMUST00000202615]
Predicted Effect probably null
Transcript: ENSMUST00000041266
SMART Domains Protein: ENSMUSP00000047185
Gene: ENSMUSG00000038552

DomainStartEndE-ValueType
FN3 43 123 4.35e-11 SMART
transmembrane domain 161 183 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000041565
SMART Domains Protein: ENSMUSP00000049335
Gene: ENSMUSG00000038564

DomainStartEndE-ValueType
WD40 2 44 6e-3 SMART
WD40 55 94 2.22e0 SMART
WD40 102 139 1.23e2 SMART
WD40 141 180 4.6e0 SMART
WD40 186 223 3.3e1 SMART
WD40 225 267 4.42e1 SMART
WD40 279 314 1.03e1 SMART
Blast:WD40 516 550 5e-13 BLAST
low complexity region 573 588 N/A INTRINSIC
internal_repeat_1 625 1026 1.7e-10 PROSPERO
Blast:TPR 1029 1062 2e-13 BLAST
low complexity region 1077 1091 N/A INTRINSIC
internal_repeat_1 1101 1498 1.7e-10 PROSPERO
Predicted Effect probably benign
Transcript: ENSMUST00000072228
SMART Domains Protein: ENSMUSP00000072084
Gene: ENSMUSG00000059434

DomainStartEndE-ValueType
PDB:4LC9|A 1 584 N/A PDB
Predicted Effect probably null
Transcript: ENSMUST00000172435
SMART Domains Protein: ENSMUSP00000127404
Gene: ENSMUSG00000038552

DomainStartEndE-ValueType
FN3 43 123 4.35e-11 SMART
transmembrane domain 161 183 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200845
Predicted Effect probably benign
Transcript: ENSMUST00000201166
SMART Domains Protein: ENSMUSP00000144202
Gene: ENSMUSG00000059434

DomainStartEndE-ValueType
PDB:4LC9|A 1 620 N/A PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201274
Predicted Effect probably null
Transcript: ENSMUST00000201417
SMART Domains Protein: ENSMUSP00000144142
Gene: ENSMUSG00000038552

DomainStartEndE-ValueType
signal peptide 1 40 N/A INTRINSIC
FN3 43 118 9.4e-8 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000201675
SMART Domains Protein: ENSMUSP00000144568
Gene: ENSMUSG00000059434

DomainStartEndE-ValueType
PDB:4LC9|A 1 120 7e-64 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000201809
SMART Domains Protein: ENSMUSP00000144425
Gene: ENSMUSG00000038564

DomainStartEndE-ValueType
WD40 2 44 3.8e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201906
Predicted Effect probably benign
Transcript: ENSMUST00000202158
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202312
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202456
Predicted Effect probably null
Transcript: ENSMUST00000202615
SMART Domains Protein: ENSMUSP00000144195
Gene: ENSMUSG00000038552

DomainStartEndE-ValueType
signal peptide 1 40 N/A INTRINSIC
FN3 43 123 2.2e-13 SMART
transmembrane domain 161 183 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202909
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous knockout mice suffer from increased severity of DSS-induced colitis with increased weight loss and decreased colon length. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610042L04Rik G A 14: 4,350,856 G130D probably damaging Het
Abca8b T A 11: 109,971,763 D392V probably damaging Het
Clptm1l T A 13: 73,617,569 probably benign Het
Creb3l1 G A 2: 91,993,333 T178I probably benign Het
Ctsd A G 7: 142,376,599 probably null Het
Dcstamp A T 15: 39,760,359 I401F possibly damaging Het
Dnah5 A G 15: 28,370,536 D2874G probably benign Het
Fgfr1op A T 17: 8,192,277 D354V probably damaging Het
Fli1 T A 9: 32,424,207 K310* probably null Het
Fuk A G 8: 110,893,402 F281S probably damaging Het
Gc G A 5: 89,422,122 probably benign Het
Krtap26-1 A G 16: 88,647,668 C22R probably damaging Het
Obscn C T 11: 59,020,541 G6422S probably benign Het
Olfr1444 T A 19: 12,862,382 F202L probably benign Het
Olfr418 T A 1: 173,270,352 M59K probably damaging Het
Olfr975 C A 9: 39,950,240 C177F probably damaging Het
Pgr C T 9: 8,922,668 P613L probably damaging Het
Pnpla8 C A 12: 44,296,033 A524E possibly damaging Het
Psma2 A T 13: 14,619,363 I105F probably damaging Het
Ptprg A G 14: 12,220,661 R458G probably damaging Het
Rbm44 A G 1: 91,163,108 I755V probably benign Het
Rev3l A G 10: 39,822,737 K1077E possibly damaging Het
Rps20 A C 4: 3,834,494 probably benign Het
Sel1l3 A C 5: 53,200,338 V104G probably damaging Het
Sirpb1c T C 3: 15,838,773 N89S probably benign Het
Slc25a16 G A 10: 62,930,441 probably null Het
Sulf1 C T 1: 12,818,507 R339C probably damaging Het
Tedc2 C T 17: 24,217,952 A270T probably benign Het
Trem3 T C 17: 48,247,852 S2P possibly damaging Het
Vps37a G T 8: 40,540,730 Q255H probably damaging Het
Zfp352 C T 4: 90,224,154 A177V possibly damaging Het
Other mutations in Fndc4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00484:Fndc4 APN 5 31293496 unclassified probably benign
IGL02507:Fndc4 APN 5 31294746 missense probably damaging 1.00
IGL02702:Fndc4 APN 5 31293735 missense probably damaging 1.00
IGL02748:Fndc4 APN 5 31294786 missense possibly damaging 0.95
R1489:Fndc4 UTSW 5 31293451 makesense probably null
R4085:Fndc4 UTSW 5 31293777 missense probably damaging 0.99
R5418:Fndc4 UTSW 5 31294634 missense probably benign 0.25
R7055:Fndc4 UTSW 5 31294178 missense probably benign 0.02
Posted On2014-05-07