Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01980:Tubb4b-ps1'

182714

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tubb4b-ps1

Ensembl Gene

ENSMUSG00000095159

Gene Name

tubulin, beta 4B class IVB, pseudogene 1

Synonyms

Tubb2c-ps1, Tubb2c2, ENSMUSG00000056506

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL01980

Quality Score

Status

Chromosome

Chromosomal Location

7229365-7230700 bp(+) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

A to C at 7229843 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000143568 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000200317]

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000082917

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000179460

SMART Domains

Protein: ENSMUSP00000136922
Gene: ENSMUSG00000095159

Domain	Start	End	E-Value	Type
Tubulin	47	243	6.6e-61	SMART
Tubulin_C	245	382	4.17e-49	SMART
low complexity region	427	444	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000200317

SMART Domains

Protein: ENSMUSP00000143568
Gene: ENSMUSG00000092094

Domain	Start	End	E-Value	Type
ZnF_C2H2	56	80	2e-2	SMART
low complexity region	958	970	N/A	INTRINSIC
low complexity region	1155	1179	N/A	INTRINSIC
low complexity region	1196	1207	N/A	INTRINSIC
low complexity region	1215	1234	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd60	C	T	2: 173,412,996 (GRCm39)	C164Y	probably benign	Het
Atp13a2	C	T	4: 140,733,463 (GRCm39)	A979V	probably benign	Het
Col5a2	C	T	1: 45,421,393 (GRCm39)		probably benign	Het
Col6a6	T	C	9: 105,658,184 (GRCm39)	N676S	probably damaging	Het
Cpa1	T	C	6: 30,641,581 (GRCm39)	F192L	possibly damaging	Het
Entpd6	T	A	2: 150,604,286 (GRCm39)		probably null	Het
Fam185a	A	G	5: 21,664,171 (GRCm39)	K302E	probably damaging	Het
Il12rb2	T	C	6: 67,337,519 (GRCm39)	K121E	probably benign	Het
Impg2	G	A	16: 56,041,890 (GRCm39)	C178Y	probably damaging	Het
Kdm3b	G	T	18: 34,967,289 (GRCm39)	C1698F	probably damaging	Het
Llgl2	A	G	11: 115,740,851 (GRCm39)	D451G	probably damaging	Het
Mgat4b	T	A	11: 50,121,540 (GRCm39)	L52Q	probably damaging	Het
Mmp9	C	A	2: 164,792,836 (GRCm39)	S363R	probably benign	Het
Mtfmt	A	G	9: 65,344,356 (GRCm39)	Y94C	probably benign	Het
Myo7b	G	A	18: 32,094,953 (GRCm39)	L1881F	possibly damaging	Het
Or51a10	A	T	7: 103,699,300 (GRCm39)	M87K	probably benign	Het
Or6c6	G	T	10: 129,187,386 (GRCm39)		probably benign	Het
Pex5	T	C	6: 124,375,339 (GRCm39)	N524S	probably damaging	Het
Plppr1	A	T	4: 49,319,992 (GRCm39)	Y206F	possibly damaging	Het
Polr3e	A	G	7: 120,539,519 (GRCm39)		probably benign	Het
Rhbdd1	A	G	1: 82,318,555 (GRCm39)		probably benign	Het
Rims4	A	T	2: 163,707,702 (GRCm39)		probably benign	Het
Smarcal1	A	T	1: 72,655,679 (GRCm39)	K653*	probably null	Het
Stt3b	C	T	9: 115,105,767 (GRCm39)		probably null	Het
Syt8	C	A	7: 141,993,877 (GRCm39)	L343M	probably damaging	Het
Tbc1d23	G	A	16: 57,009,615 (GRCm39)		probably benign	Het
Tfec	T	C	6: 16,845,465 (GRCm39)	I65V	probably damaging	Het
Tmem236	A	T	2: 14,223,716 (GRCm39)	Q168H	probably benign	Het
Tmem25	G	A	9: 44,709,568 (GRCm39)	R78*	probably null	Het
Tnip2	A	G	5: 34,654,212 (GRCm39)	V288A	probably benign	Het
Ttc1	G	A	11: 43,621,291 (GRCm39)		probably benign	Het
Tut1	T	C	19: 8,931,364 (GRCm39)	C21R	probably damaging	Het
Ubr4	C	A	4: 139,156,913 (GRCm39)	Q2313K	probably damaging	Het
Unc5b	T	C	10: 60,615,966 (GRCm39)	E119G	probably damaging	Het
Vmn1r23	T	A	6: 57,903,475 (GRCm39)	Q101L	probably damaging	Het
Vmn2r77	A	G	7: 86,450,678 (GRCm39)	D188G	probably benign	Het
Vmn2r79	A	G	7: 86,686,290 (GRCm39)	E557G	possibly damaging	Het
Zfp738	A	G	13: 67,818,096 (GRCm39)	F632L	possibly damaging	Het

Other mutations in Tubb4b-ps1

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL00973:Tubb4b-ps1	APN	5	7,229,408 (GRCm39)	intron	probably benign
IGL01861:Tubb4b-ps1	APN	5	7,229,374 (GRCm39)	intron	probably benign
IGL02336:Tubb4b-ps1	APN	5	7,229,952 (GRCm39)	intron	probably benign
IGL03152:Tubb4b-ps1	APN	5	7,230,001 (GRCm39)	intron	probably benign
IGL03166:Tubb4b-ps1	APN	5	7,229,965 (GRCm39)	intron	probably benign
IGL03279:Tubb4b-ps1	APN	5	7,229,630 (GRCm39)	intron	probably benign

Posted On

2014-05-07