Incidental Mutation 'IGL01980:Zfp738'
ID 182715
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp738
Ensembl Gene ENSMUSG00000048280
Gene Name zinc finger protein 738
Synonyms 6720487G11Rik, 3830402I07Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # IGL01980
Quality Score
Status
Chromosome 13
Chromosomal Location 67815560-67831631 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 67818096 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 632 (F632L)
Ref Sequence ENSEMBL: ENSMUSP00000121275 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110973] [ENSMUST00000125495] [ENSMUST00000137496] [ENSMUST00000175678] [ENSMUST00000175821]
AlphaFold B8JJX8
Predicted Effect probably benign
Transcript: ENSMUST00000110973
SMART Domains Protein: ENSMUSP00000106600
Gene: ENSMUSG00000048280

DomainStartEndE-ValueType
KRAB 2 62 1.97e-31 SMART
SCOP:d1fgja_ 76 119 1e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000125495
SMART Domains Protein: ENSMUSP00000135683
Gene: ENSMUSG00000048280

DomainStartEndE-ValueType
KRAB 5 65 1.97e-31 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000137496
AA Change: F632L

PolyPhen 2 Score 0.801 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000121275
Gene: ENSMUSG00000048280
AA Change: F632L

DomainStartEndE-ValueType
KRAB 15 75 1.97e-31 SMART
ZnF_C2H2 91 111 3.13e1 SMART
ZnF_C2H2 119 141 9.56e1 SMART
ZnF_C2H2 147 169 3.58e-2 SMART
ZnF_C2H2 175 197 3.21e-4 SMART
ZnF_C2H2 203 225 6.78e-3 SMART
ZnF_C2H2 231 253 8.34e-3 SMART
ZnF_C2H2 259 281 6.67e-2 SMART
ZnF_C2H2 287 309 1.12e-3 SMART
ZnF_C2H2 315 337 3.83e-2 SMART
ZnF_C2H2 343 365 8.34e-3 SMART
ZnF_C2H2 371 393 4.87e-4 SMART
ZnF_C2H2 427 449 9.58e-3 SMART
ZnF_C2H2 455 477 1.38e-3 SMART
ZnF_C2H2 483 505 3.89e-3 SMART
ZnF_C2H2 511 533 7.49e-5 SMART
ZnF_C2H2 539 561 5.5e-3 SMART
ZnF_C2H2 567 589 5.42e-2 SMART
ZnF_C2H2 595 617 7.78e-3 SMART
ZnF_C2H2 623 645 2.05e-2 SMART
ZnF_C2H2 651 673 2.57e-3 SMART
ZnF_C2H2 679 701 7.26e-3 SMART
ZnF_C2H2 735 757 5.42e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000175678
SMART Domains Protein: ENSMUSP00000134865
Gene: ENSMUSG00000048280

DomainStartEndE-ValueType
KRAB 15 75 1.97e-31 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000175821
SMART Domains Protein: ENSMUSP00000135050
Gene: ENSMUSG00000048280

DomainStartEndE-ValueType
KRAB 5 65 1.97e-31 SMART
ZnF_C2H2 81 101 3.13e1 SMART
ZnF_C2H2 109 131 9.56e1 SMART
ZnF_C2H2 137 159 3.58e-2 SMART
ZnF_C2H2 165 187 3.21e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225507
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd60 C T 2: 173,412,996 (GRCm39) C164Y probably benign Het
Atp13a2 C T 4: 140,733,463 (GRCm39) A979V probably benign Het
Col5a2 C T 1: 45,421,393 (GRCm39) probably benign Het
Col6a6 T C 9: 105,658,184 (GRCm39) N676S probably damaging Het
Cpa1 T C 6: 30,641,581 (GRCm39) F192L possibly damaging Het
Entpd6 T A 2: 150,604,286 (GRCm39) probably null Het
Fam185a A G 5: 21,664,171 (GRCm39) K302E probably damaging Het
Il12rb2 T C 6: 67,337,519 (GRCm39) K121E probably benign Het
Impg2 G A 16: 56,041,890 (GRCm39) C178Y probably damaging Het
Kdm3b G T 18: 34,967,289 (GRCm39) C1698F probably damaging Het
Llgl2 A G 11: 115,740,851 (GRCm39) D451G probably damaging Het
Mgat4b T A 11: 50,121,540 (GRCm39) L52Q probably damaging Het
Mmp9 C A 2: 164,792,836 (GRCm39) S363R probably benign Het
Mtfmt A G 9: 65,344,356 (GRCm39) Y94C probably benign Het
Myo7b G A 18: 32,094,953 (GRCm39) L1881F possibly damaging Het
Or51a10 A T 7: 103,699,300 (GRCm39) M87K probably benign Het
Or6c6 G T 10: 129,187,386 (GRCm39) probably benign Het
Pex5 T C 6: 124,375,339 (GRCm39) N524S probably damaging Het
Plppr1 A T 4: 49,319,992 (GRCm39) Y206F possibly damaging Het
Polr3e A G 7: 120,539,519 (GRCm39) probably benign Het
Rhbdd1 A G 1: 82,318,555 (GRCm39) probably benign Het
Rims4 A T 2: 163,707,702 (GRCm39) probably benign Het
Smarcal1 A T 1: 72,655,679 (GRCm39) K653* probably null Het
Stt3b C T 9: 115,105,767 (GRCm39) probably null Het
Syt8 C A 7: 141,993,877 (GRCm39) L343M probably damaging Het
Tbc1d23 G A 16: 57,009,615 (GRCm39) probably benign Het
Tfec T C 6: 16,845,465 (GRCm39) I65V probably damaging Het
Tmem236 A T 2: 14,223,716 (GRCm39) Q168H probably benign Het
Tmem25 G A 9: 44,709,568 (GRCm39) R78* probably null Het
Tnip2 A G 5: 34,654,212 (GRCm39) V288A probably benign Het
Ttc1 G A 11: 43,621,291 (GRCm39) probably benign Het
Tubb4b-ps1 A C 5: 7,229,843 (GRCm39) probably benign Het
Tut1 T C 19: 8,931,364 (GRCm39) C21R probably damaging Het
Ubr4 C A 4: 139,156,913 (GRCm39) Q2313K probably damaging Het
Unc5b T C 10: 60,615,966 (GRCm39) E119G probably damaging Het
Vmn1r23 T A 6: 57,903,475 (GRCm39) Q101L probably damaging Het
Vmn2r77 A G 7: 86,450,678 (GRCm39) D188G probably benign Het
Vmn2r79 A G 7: 86,686,290 (GRCm39) E557G possibly damaging Het
Other mutations in Zfp738
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01511:Zfp738 APN 13 67,831,520 (GRCm39) critical splice donor site probably null
IGL01734:Zfp738 APN 13 67,831,563 (GRCm39) utr 5 prime probably benign
IGL02052:Zfp738 APN 13 67,819,600 (GRCm39) missense possibly damaging 0.87
IGL02330:Zfp738 APN 13 67,819,550 (GRCm39) missense probably damaging 0.99
IGL02686:Zfp738 APN 13 67,821,771 (GRCm39) missense probably damaging 1.00
I2505:Zfp738 UTSW 13 67,821,186 (GRCm39) missense probably benign 0.36
R0219:Zfp738 UTSW 13 67,831,508 (GRCm39) intron probably benign
R0491:Zfp738 UTSW 13 67,818,140 (GRCm39) missense possibly damaging 0.87
R0722:Zfp738 UTSW 13 67,819,643 (GRCm39) missense probably benign 0.09
R1116:Zfp738 UTSW 13 67,818,362 (GRCm39) splice site probably null
R1425:Zfp738 UTSW 13 67,818,894 (GRCm39) missense possibly damaging 0.77
R1854:Zfp738 UTSW 13 67,818,476 (GRCm39) missense probably damaging 1.00
R2095:Zfp738 UTSW 13 67,819,422 (GRCm39) missense probably damaging 1.00
R2171:Zfp738 UTSW 13 67,819,096 (GRCm39) nonsense probably null
R2180:Zfp738 UTSW 13 67,819,313 (GRCm39) missense probably damaging 1.00
R2225:Zfp738 UTSW 13 67,818,431 (GRCm39) missense probably damaging 1.00
R2226:Zfp738 UTSW 13 67,818,431 (GRCm39) missense probably damaging 1.00
R2907:Zfp738 UTSW 13 67,818,231 (GRCm39) missense probably benign 0.33
R3605:Zfp738 UTSW 13 67,819,508 (GRCm39) nonsense probably null
R4731:Zfp738 UTSW 13 67,818,033 (GRCm39) missense probably damaging 1.00
R5037:Zfp738 UTSW 13 67,818,320 (GRCm39) missense probably damaging 1.00
R5223:Zfp738 UTSW 13 67,821,182 (GRCm39) missense probably damaging 0.99
R5259:Zfp738 UTSW 13 67,817,805 (GRCm39) missense probably benign
R5358:Zfp738 UTSW 13 67,819,131 (GRCm39) missense probably damaging 0.98
R6404:Zfp738 UTSW 13 67,819,179 (GRCm39) missense possibly damaging 0.89
R6874:Zfp738 UTSW 13 67,818,382 (GRCm39) missense possibly damaging 0.93
R7041:Zfp738 UTSW 13 67,818,420 (GRCm39) missense probably damaging 1.00
R7172:Zfp738 UTSW 13 67,818,527 (GRCm39) missense probably damaging 1.00
R7178:Zfp738 UTSW 13 67,821,147 (GRCm39) missense probably damaging 1.00
R7308:Zfp738 UTSW 13 67,817,672 (GRCm39) missense probably benign 0.00
R7386:Zfp738 UTSW 13 67,818,369 (GRCm39) missense probably damaging 1.00
R7453:Zfp738 UTSW 13 67,818,474 (GRCm39) missense probably benign 0.42
R7456:Zfp738 UTSW 13 67,817,619 (GRCm39) missense probably damaging 1.00
R7467:Zfp738 UTSW 13 67,821,080 (GRCm39) missense probably benign 0.03
R7615:Zfp738 UTSW 13 67,818,322 (GRCm39) missense probably damaging 0.96
R7663:Zfp738 UTSW 13 67,831,520 (GRCm39) critical splice donor site probably null
R7752:Zfp738 UTSW 13 67,821,110 (GRCm39) nonsense probably null
R7901:Zfp738 UTSW 13 67,821,110 (GRCm39) nonsense probably null
R8042:Zfp738 UTSW 13 67,819,010 (GRCm39) missense probably damaging 0.98
R8288:Zfp738 UTSW 13 67,818,908 (GRCm39) missense possibly damaging 0.88
R8340:Zfp738 UTSW 13 67,819,231 (GRCm39) missense probably damaging 0.98
R8735:Zfp738 UTSW 13 67,819,550 (GRCm39) missense probably damaging 0.99
R8846:Zfp738 UTSW 13 67,818,155 (GRCm39) missense probably benign 0.00
R8896:Zfp738 UTSW 13 67,817,910 (GRCm39) missense
R9124:Zfp738 UTSW 13 67,819,457 (GRCm39) missense possibly damaging 0.94
R9233:Zfp738 UTSW 13 67,819,017 (GRCm39) missense possibly damaging 0.88
R9513:Zfp738 UTSW 13 67,817,635 (GRCm39) nonsense probably null
Posted On 2014-05-07