Incidental Mutation 'IGL01996:Trim45'
ID 182899
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim45
Ensembl Gene ENSMUSG00000033233
Gene Name tripartite motif-containing 45
Synonyms 4921530N01Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL01996
Quality Score
Status
Chromosome 3
Chromosomal Location 100829518-100844236 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 100835425 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 469 (Y469*)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037409] [ENSMUST00000094048] [ENSMUST00000106980] [ENSMUST00000134993]
AlphaFold Q6PFY8
Predicted Effect probably null
Transcript: ENSMUST00000037409
AA Change: Y469*
SMART Domains Protein: ENSMUSP00000043389
Gene: ENSMUSG00000033233
AA Change: Y469*

DomainStartEndE-ValueType
RING 29 97 5.35e-5 SMART
BBOX 130 176 1.03e-1 SMART
BBOX 186 227 4.34e-5 SMART
BBC 234 360 3.55e-9 SMART
IG_FLMN 398 500 7.63e-33 SMART
low complexity region 532 549 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000094048
AA Change: Y420*
SMART Domains Protein: ENSMUSP00000091590
Gene: ENSMUSG00000033233
AA Change: Y420*

DomainStartEndE-ValueType
BBOX 81 127 1.03e-1 SMART
BBOX 137 178 4.34e-5 SMART
BBC 185 311 3.55e-9 SMART
IG_FLMN 349 451 7.63e-33 SMART
low complexity region 483 500 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000106980
AA Change: Y469*
SMART Domains Protein: ENSMUSP00000102593
Gene: ENSMUSG00000033233
AA Change: Y469*

DomainStartEndE-ValueType
RING 29 97 5.35e-5 SMART
BBOX 130 176 1.03e-1 SMART
BBOX 186 227 4.34e-5 SMART
BBC 234 360 3.55e-9 SMART
IG_FLMN 398 500 7.63e-33 SMART
low complexity region 532 549 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000134993
AA Change: Y469*
SMART Domains Protein: ENSMUSP00000115669
Gene: ENSMUSG00000033233
AA Change: Y469*

DomainStartEndE-ValueType
RING 29 97 5.35e-5 SMART
BBOX 130 176 1.03e-1 SMART
BBOX 186 227 4.34e-5 SMART
BBC 234 360 3.55e-9 SMART
IG_FLMN 398 500 7.63e-33 SMART
Predicted Effect probably null
Transcript: ENSMUST00000163914
AA Change: Y469*
SMART Domains Protein: ENSMUSP00000129861
Gene: ENSMUSG00000033233
AA Change: Y469*

DomainStartEndE-ValueType
RING 29 97 5.35e-5 SMART
BBOX 130 176 1.03e-1 SMART
BBOX 186 227 4.34e-5 SMART
BBC 234 360 3.55e-9 SMART
IG_FLMN 398 500 7.63e-33 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110009E18Rik T C 1: 120,078,430 (GRCm39) V29A possibly damaging Het
Adarb1 A G 10: 77,158,051 (GRCm39) L132P probably damaging Het
Afg3l1 T G 8: 124,228,633 (GRCm39) M733R probably damaging Het
Aox1 C T 1: 58,121,225 (GRCm39) R899C probably benign Het
Arhgap44 T A 11: 64,896,322 (GRCm39) probably benign Het
Asns T C 6: 7,682,378 (GRCm39) D189G possibly damaging Het
Brap A G 5: 121,816,910 (GRCm39) probably benign Het
Ccdc138 T A 10: 58,397,852 (GRCm39) L564H probably damaging Het
Ccdc167 A G 17: 29,924,461 (GRCm39) probably null Het
Ccdc178 A G 18: 22,230,813 (GRCm39) Y353H probably damaging Het
Clca3b A T 3: 144,554,924 (GRCm39) S41R probably benign Het
Dpep3 T C 8: 106,701,358 (GRCm39) N397S probably damaging Het
Eif1 T C 11: 100,211,826 (GRCm39) I83T probably benign Het
Enah A T 1: 181,784,070 (GRCm39) W80R unknown Het
F2rl1 C T 13: 95,650,432 (GRCm39) C150Y probably damaging Het
Fbxw24 T C 9: 109,434,440 (GRCm39) R387G possibly damaging Het
Fsd1l A G 4: 53,647,760 (GRCm39) T68A probably benign Het
Greb1 T C 12: 16,740,846 (GRCm39) K1412R possibly damaging Het
Grin2b T C 6: 135,709,584 (GRCm39) S1321G probably damaging Het
H4c11 G A 13: 21,919,308 (GRCm39) G15S unknown Het
Itgb7 C T 15: 102,126,412 (GRCm39) G508D probably damaging Het
Kcnq3 A G 15: 65,895,545 (GRCm39) I333T probably damaging Het
Knl1 A G 2: 118,934,542 (GRCm39) D2115G probably damaging Het
Lmtk3 G A 7: 45,442,871 (GRCm39) probably null Het
Lrpprc A G 17: 85,080,698 (GRCm39) Y176H probably benign Het
Mier1 T C 4: 102,984,473 (GRCm39) S22P possibly damaging Het
Mme A T 3: 63,250,970 (GRCm39) N337I probably benign Het
Mthfd1 A G 12: 76,350,679 (GRCm39) Y687C probably damaging Het
Nrp2 T C 1: 62,788,419 (GRCm39) M373T probably damaging Het
Nudcd1 A T 15: 44,269,357 (GRCm39) F101Y probably benign Het
Nup133 T A 8: 124,673,334 (GRCm39) I66L probably benign Het
Or10j7 T C 1: 173,011,294 (GRCm39) T236A probably benign Het
Or11j4 T G 14: 50,631,116 (GRCm39) M301R probably damaging Het
Or1e19 T A 11: 73,316,794 (GRCm39) N5I probably damaging Het
Osbpl5 A G 7: 143,261,081 (GRCm39) probably null Het
Paqr8 T C 1: 21,005,628 (GRCm39) F261L probably damaging Het
Plxna2 A G 1: 194,482,084 (GRCm39) E1452G probably damaging Het
Polh T C 17: 46,483,927 (GRCm39) D446G probably benign Het
Psg19 A T 7: 18,523,986 (GRCm39) M353K possibly damaging Het
Sap25 T C 5: 137,640,080 (GRCm39) probably null Het
Sap30l C T 11: 57,700,777 (GRCm39) R144* probably null Het
Sema6b C T 17: 56,438,157 (GRCm39) V144M probably damaging Het
Sfmbt2 T C 2: 10,444,837 (GRCm39) Y228H probably benign Het
Shank2 A G 7: 143,965,230 (GRCm39) D946G probably damaging Het
Slc11a1 T A 1: 74,415,965 (GRCm39) L52Q possibly damaging Het
Sptlc3 T C 2: 139,423,424 (GRCm39) probably benign Het
Tgfb1i1 T C 7: 127,848,464 (GRCm39) probably benign Het
Tifa T C 3: 127,590,229 (GRCm39) probably benign Het
Tomm40l C T 1: 171,047,224 (GRCm39) V265M possibly damaging Het
Ttc21a G T 9: 119,787,182 (GRCm39) A730S probably damaging Het
Vmn1r18 A T 6: 57,367,001 (GRCm39) D184E possibly damaging Het
Vmn2r120 A T 17: 57,832,222 (GRCm39) I189N possibly damaging Het
Other mutations in Trim45
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00802:Trim45 APN 3 100,839,042 (GRCm39) intron probably benign
IGL01472:Trim45 APN 3 100,835,381 (GRCm39) missense probably benign 0.00
IGL02392:Trim45 APN 3 100,832,621 (GRCm39) missense probably benign 0.04
IGL03229:Trim45 APN 3 100,830,385 (GRCm39) missense probably damaging 1.00
IGL02837:Trim45 UTSW 3 100,838,943 (GRCm39) intron probably benign
R0021:Trim45 UTSW 3 100,832,736 (GRCm39) missense probably damaging 1.00
R0243:Trim45 UTSW 3 100,837,160 (GRCm39) missense probably benign 0.05
R0501:Trim45 UTSW 3 100,830,535 (GRCm39) missense probably damaging 1.00
R1222:Trim45 UTSW 3 100,834,614 (GRCm39) missense probably benign 0.14
R1418:Trim45 UTSW 3 100,834,614 (GRCm39) missense probably benign 0.14
R1813:Trim45 UTSW 3 100,830,283 (GRCm39) missense probably benign 0.16
R2148:Trim45 UTSW 3 100,839,360 (GRCm39) nonsense probably null
R2383:Trim45 UTSW 3 100,832,543 (GRCm39) missense probably damaging 0.97
R4368:Trim45 UTSW 3 100,830,502 (GRCm39) missense probably damaging 1.00
R4769:Trim45 UTSW 3 100,839,050 (GRCm39) intron probably benign
R4840:Trim45 UTSW 3 100,832,804 (GRCm39) missense possibly damaging 0.95
R5030:Trim45 UTSW 3 100,835,388 (GRCm39) missense probably damaging 1.00
R5272:Trim45 UTSW 3 100,837,235 (GRCm39) missense probably damaging 1.00
R5298:Trim45 UTSW 3 100,832,787 (GRCm39) missense probably damaging 1.00
R5498:Trim45 UTSW 3 100,832,457 (GRCm39) missense possibly damaging 0.67
R5589:Trim45 UTSW 3 100,837,257 (GRCm39) missense probably damaging 1.00
R6537:Trim45 UTSW 3 100,832,712 (GRCm39) missense probably benign 0.39
R6850:Trim45 UTSW 3 100,830,541 (GRCm39) nonsense probably null
R7009:Trim45 UTSW 3 100,839,195 (GRCm39) intron probably benign
R7122:Trim45 UTSW 3 100,839,353 (GRCm39) missense unknown
R7583:Trim45 UTSW 3 100,832,339 (GRCm39) missense probably damaging 1.00
R8358:Trim45 UTSW 3 100,834,634 (GRCm39) missense probably damaging 0.98
R8368:Trim45 UTSW 3 100,830,672 (GRCm39) missense possibly damaging 0.61
R8924:Trim45 UTSW 3 100,835,394 (GRCm39) missense probably damaging 1.00
R8998:Trim45 UTSW 3 100,838,960 (GRCm39) missense unknown
R8999:Trim45 UTSW 3 100,838,960 (GRCm39) missense unknown
R9069:Trim45 UTSW 3 100,832,440 (GRCm39) nonsense probably null
R9368:Trim45 UTSW 3 100,832,319 (GRCm39) missense possibly damaging 0.51
R9594:Trim45 UTSW 3 100,830,265 (GRCm39) missense probably benign 0.00
R9634:Trim45 UTSW 3 100,839,306 (GRCm39) missense unknown
R9651:Trim45 UTSW 3 100,832,705 (GRCm39) nonsense probably null
X0066:Trim45 UTSW 3 100,839,083 (GRCm39) intron probably benign
Z1088:Trim45 UTSW 3 100,832,956 (GRCm39) missense probably benign 0.11
Posted On 2014-05-07