Incidental Mutation 'IGL01998:Crlf3'
ID 182983
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Crlf3
Ensembl Gene ENSMUSG00000017561
Gene Name cytokine receptor-like factor 3
Synonyms Creme9, cytor4
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01998
Quality Score
Status
Chromosome 11
Chromosomal Location 79937319-79971817 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) G to A at 79948845 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000137124 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061283] [ENSMUST00000103233] [ENSMUST00000177825] [ENSMUST00000178893] [ENSMUST00000179855]
AlphaFold Q9Z2L7
Predicted Effect probably benign
Transcript: ENSMUST00000061283
SMART Domains Protein: ENSMUSP00000060028
Gene: ENSMUSG00000017561

DomainStartEndE-ValueType
coiled coil region 10 43 N/A INTRINSIC
low complexity region 112 124 N/A INTRINSIC
FN3 179 260 1.66e0 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000092858
Predicted Effect probably benign
Transcript: ENSMUST00000103233
SMART Domains Protein: ENSMUSP00000099523
Gene: ENSMUSG00000017561

DomainStartEndE-ValueType
coiled coil region 10 43 N/A INTRINSIC
low complexity region 112 124 N/A INTRINSIC
FN3 179 260 1.66e0 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147164
Predicted Effect probably benign
Transcript: ENSMUST00000177825
SMART Domains Protein: ENSMUSP00000136473
Gene: ENSMUSG00000017561

DomainStartEndE-ValueType
coiled coil region 10 43 N/A INTRINSIC
low complexity region 112 124 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000178280
Predicted Effect probably benign
Transcript: ENSMUST00000178893
SMART Domains Protein: ENSMUSP00000137371
Gene: ENSMUSG00000017561

DomainStartEndE-ValueType
coiled coil region 10 39 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000179855
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a cytokine receptor-like factor that contains a fibronectin type 3 domain. The encoded protein may act as a negative regulator of the cell cycle. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased lean body mass, decreased platelet cell number and increased circulating fructosamine level. [provided by MGI curators]
Allele List at MGI

All alleles(39) : Targeted, other(2) Gene trapped(37)
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arpc3 T C 5: 122,541,470 (GRCm39) C78R probably damaging Het
Atp6v0b A G 4: 117,743,263 (GRCm39) probably null Het
B3gnt8 A G 7: 25,328,203 (GRCm39) Y211C probably damaging Het
Birc6 T C 17: 74,886,880 (GRCm39) I736T probably benign Het
Bltp1 T C 3: 37,011,165 (GRCm39) S1788P possibly damaging Het
Bpifb9a T C 2: 154,110,120 (GRCm39) probably null Het
C3ar1 A T 6: 122,827,899 (GRCm39) M106K probably damaging Het
C9orf72 A T 4: 35,194,179 (GRCm39) D205E probably benign Het
Cab39l T A 14: 59,734,344 (GRCm39) L21Q probably damaging Het
Casp1 A T 9: 5,303,043 (GRCm39) I166F probably damaging Het
Cd180 A G 13: 102,841,722 (GRCm39) E256G probably damaging Het
Clca4a T C 3: 144,663,887 (GRCm39) T519A probably damaging Het
Clstn3 A T 6: 124,435,622 (GRCm39) L233Q probably damaging Het
Depdc5 T C 5: 33,102,495 (GRCm39) probably benign Het
Drc7 T A 8: 95,785,821 (GRCm39) C226S probably damaging Het
Epha5 T A 5: 84,232,593 (GRCm39) D807V probably damaging Het
Fat2 A G 11: 55,187,021 (GRCm39) L1275P probably benign Het
Fv1 T C 4: 147,953,784 (GRCm39) C117R possibly damaging Het
Ighg2b C A 12: 113,270,709 (GRCm39) M140I unknown Het
Klra5 A T 6: 129,883,676 (GRCm39) Y60* probably null Het
Lmtk2 C T 5: 144,112,883 (GRCm39) T1201I probably damaging Het
Ncapd2 A T 6: 125,150,078 (GRCm39) S917T probably benign Het
Ncapd2 A T 6: 125,146,896 (GRCm39) L1230H probably damaging Het
Nfx1 T A 4: 41,004,353 (GRCm39) I708N probably damaging Het
Notch2 A T 3: 98,050,422 (GRCm39) D1899V probably damaging Het
Npepl1 T A 2: 173,957,993 (GRCm39) probably benign Het
Nps T A 7: 134,870,481 (GRCm39) probably benign Het
Nrg1 T C 8: 32,408,162 (GRCm39) S24G probably damaging Het
Or1j20 A G 2: 36,759,658 (GRCm39) N27D probably benign Het
Or2ag16 G A 7: 106,351,758 (GRCm39) T279M possibly damaging Het
Or2t48 A T 11: 58,420,403 (GRCm39) Y136* probably null Het
Or4k2 C A 14: 50,424,105 (GRCm39) V190L probably benign Het
Pigx G T 16: 31,903,428 (GRCm39) T211K probably benign Het
Pink1 A G 4: 138,048,053 (GRCm39) I223T probably damaging Het
Plat G A 8: 23,257,163 (GRCm39) A15T probably benign Het
Ptges2 G A 2: 32,291,542 (GRCm39) A310T possibly damaging Het
Rsl1d1 A G 16: 11,012,509 (GRCm39) S306P possibly damaging Het
Rxfp1 T C 3: 79,567,403 (GRCm39) K316E probably benign Het
Scn10a A G 9: 119,438,742 (GRCm39) I1708T probably damaging Het
Sdk2 A T 11: 113,729,358 (GRCm39) F1073Y probably damaging Het
Sp100 A G 1: 85,594,650 (GRCm39) D170G probably benign Het
Spock1 A T 13: 57,583,994 (GRCm39) probably benign Het
Strbp A G 2: 37,515,297 (GRCm39) L243P probably damaging Het
Tex55 A T 16: 38,648,586 (GRCm39) D174E probably benign Het
Tgm5 T A 2: 120,882,920 (GRCm39) T446S probably damaging Het
Tmem59l C T 8: 70,937,431 (GRCm39) V239I probably benign Het
Trav8-1 A T 14: 53,707,662 (GRCm39) T101S probably benign Het
Triml1 T C 8: 43,594,350 (GRCm39) D27G probably damaging Het
Vmn2r54 T C 7: 12,349,227 (GRCm39) E785G probably benign Het
Vps13c A G 9: 67,862,350 (GRCm39) probably null Het
Wwp2 C T 8: 108,276,153 (GRCm39) R64C probably damaging Het
Zfp608 T C 18: 55,024,890 (GRCm39) H1460R probably damaging Het
Other mutations in Crlf3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00690:Crlf3 APN 11 79,950,163 (GRCm39) missense probably damaging 1.00
IGL00835:Crlf3 APN 11 79,938,501 (GRCm39) missense probably benign 0.03
IGL01520:Crlf3 APN 11 79,950,972 (GRCm39) missense probably benign 0.01
IGL02622:Crlf3 APN 11 79,950,150 (GRCm39) missense probably damaging 1.00
IGL02748:Crlf3 APN 11 79,950,145 (GRCm39) missense probably damaging 0.98
R0064:Crlf3 UTSW 11 79,948,728 (GRCm39) missense possibly damaging 0.81
R0064:Crlf3 UTSW 11 79,948,728 (GRCm39) missense possibly damaging 0.81
R0076:Crlf3 UTSW 11 79,947,427 (GRCm39) unclassified probably benign
R0583:Crlf3 UTSW 11 79,950,107 (GRCm39) missense probably damaging 0.99
R1753:Crlf3 UTSW 11 79,948,698 (GRCm39) missense probably damaging 1.00
R2125:Crlf3 UTSW 11 79,950,081 (GRCm39) missense probably benign 0.21
R2571:Crlf3 UTSW 11 79,938,339 (GRCm39) missense probably benign 0.11
R5894:Crlf3 UTSW 11 79,948,678 (GRCm39) missense probably damaging 1.00
R6086:Crlf3 UTSW 11 79,939,436 (GRCm39) missense possibly damaging 0.81
R7214:Crlf3 UTSW 11 79,955,216 (GRCm39) missense possibly damaging 0.92
R7238:Crlf3 UTSW 11 79,947,351 (GRCm39) missense possibly damaging 0.94
R7511:Crlf3 UTSW 11 79,954,812 (GRCm39) splice site probably null
R8745:Crlf3 UTSW 11 79,955,100 (GRCm39) missense probably damaging 1.00
R8872:Crlf3 UTSW 11 79,938,440 (GRCm39) missense
R9297:Crlf3 UTSW 11 79,950,031 (GRCm39) missense probably damaging 1.00
X0064:Crlf3 UTSW 11 79,955,013 (GRCm39) splice site probably null
Posted On 2014-05-07