Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02008:Gm1110'

183274

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm1110

Ensembl Gene

ENSMUSG00000079644

Gene Name

predicted gene 1110

Synonyms

LOC382064

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

IGL02008

Quality Score

Status

Chromosome

Chromosomal Location

26790863-26834407 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 26794526 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Valine at position 500 (D500V)

Ref Sequence

ENSEMBL: ENSMUSP00000110916 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000115261]

AlphaFold

F6Y113

Predicted Effect

probably benign
Transcript: ENSMUST00000115261
AA Change: D500V

PolyPhen 2 Score 0.087 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000110916
Gene: ENSMUSG00000079644
AA Change: D500V

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:Glyco_hydro_35	55	368	2e-93	PFAM
Pfam:Glyco_hydro_42	70	229	1e-12	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214847

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000217197

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	A	G	3: 121,969,750 (GRCm39)	T2252A	probably benign	Het
Abcc2	C	T	19: 43,810,189 (GRCm39)		probably benign	Het
Abcf1	T	C	17: 36,272,954 (GRCm39)	E231G	probably benign	Het
Astn2	T	C	4: 65,977,390 (GRCm39)	Y379C	probably damaging	Het
Atp8b1	G	T	18: 64,671,766 (GRCm39)		probably benign	Het
Atr	T	A	9: 95,763,473 (GRCm39)		probably benign	Het
Bdp1	A	G	13: 100,160,335 (GRCm39)	S2349P	possibly damaging	Het
Bmp2	T	C	2: 133,402,886 (GRCm39)	S146P	probably damaging	Het
Cacna1c	T	C	6: 118,692,885 (GRCm39)	S218G	probably null	Het
Cand2	T	C	6: 115,780,599 (GRCm39)	V1161A	probably damaging	Het
Clec16a	T	C	16: 10,398,824 (GRCm39)	V330A	probably damaging	Het
Cpsf1	A	T	15: 76,487,291 (GRCm39)	V161D	probably damaging	Het
Ctsh	A	G	9: 89,943,600 (GRCm39)	Y75C	probably damaging	Het
Cyp26c1	C	A	19: 37,677,371 (GRCm39)	L267M	probably damaging	Het
Cyp26c1	T	A	19: 37,677,372 (GRCm39)	L267Q	probably damaging	Het
Cyp2c50	G	A	19: 40,079,543 (GRCm39)	W212*	probably null	Het
Dnah5	T	A	15: 28,343,698 (GRCm39)	M2366K	probably damaging	Het
Ermp1	A	G	19: 29,590,320 (GRCm39)	M794T	probably damaging	Het
F11	G	T	8: 45,703,132 (GRCm39)	S186Y	probably damaging	Het
Fam184b	A	T	5: 45,690,165 (GRCm39)	F815I	possibly damaging	Het
Fezf2	T	C	14: 12,343,705 (GRCm38)	I347V	probably benign	Het
Fip1l1	C	T	5: 74,706,084 (GRCm39)	T114I	possibly damaging	Het
Gbp7	A	C	3: 142,252,211 (GRCm39)	D598A	probably benign	Het
Gm3248	T	A	14: 5,943,928 (GRCm38)	M99L	probably benign	Het
Gpi-ps	A	T	8: 5,689,896 (GRCm39)		noncoding transcript	Het
Hspa9	G	A	18: 35,081,028 (GRCm39)	R218*	probably null	Het
Ikbip	G	A	10: 90,929,119 (GRCm39)		probably null	Het
Kcnb2	C	T	1: 15,781,033 (GRCm39)	T635M	probably benign	Het
Krtap29-1	T	A	11: 99,869,105 (GRCm39)	I259F	possibly damaging	Het
Lnpep	T	C	17: 17,791,219 (GRCm39)	T442A	probably benign	Het
Mgat1	T	A	11: 49,151,562 (GRCm39)	I15N	probably damaging	Het
Nlrp9c	A	T	7: 26,084,576 (GRCm39)	S334R	probably benign	Het
Notch2	A	T	3: 98,054,612 (GRCm39)	D2425V	probably damaging	Het
Ntn1	C	T	11: 68,104,089 (GRCm39)	V520M	probably damaging	Het
Or10d1b	A	G	9: 39,613,549 (GRCm39)	V172A	probably damaging	Het
Or4p18	T	A	2: 88,232,421 (GRCm39)	T286S	possibly damaging	Het
Or5d39	A	T	2: 87,979,922 (GRCm39)	V147E	probably damaging	Het
Or6c3b	T	A	10: 129,527,887 (GRCm39)	T8S	probably benign	Het
Or8g55	A	T	9: 39,784,781 (GRCm39)	D70V	probably damaging	Het
Or8k39	A	C	2: 86,563,521 (GRCm39)	I145R	possibly damaging	Het
Osr2	A	G	15: 35,302,138 (GRCm39)	H246R	probably damaging	Het
Papolg	T	C	11: 23,829,898 (GRCm39)	R224G	probably damaging	Het
Pax6	T	A	2: 105,522,623 (GRCm39)		probably null	Het
Pcyox1	A	G	6: 86,369,250 (GRCm39)	V192A	probably benign	Het
Phf1	C	T	17: 27,154,260 (GRCm39)	A159V	possibly damaging	Het
Ppfia4	G	A	1: 134,260,129 (GRCm39)	R45W	probably damaging	Het
Psmb9	T	A	17: 34,402,653 (GRCm39)	K109M	probably damaging	Het
Ptprt	T	A	2: 161,769,593 (GRCm39)	Y424F	probably benign	Het
Ptrh2	A	G	11: 86,580,592 (GRCm39)	I70V	probably benign	Het
Rnf213	G	A	11: 119,309,135 (GRCm39)		probably benign	Het
Rom1	T	A	19: 8,905,368 (GRCm39)	I271F	probably benign	Het
Satb2	T	A	1: 56,835,952 (GRCm39)	D731V	possibly damaging	Het
Serpinb7	G	T	1: 107,375,859 (GRCm39)	G159V	possibly damaging	Het
Slit1	T	C	19: 41,634,579 (GRCm39)	I393V	probably damaging	Het
Spata20	T	A	11: 94,374,289 (GRCm39)	D327V	probably damaging	Het
Spata31e3	G	A	13: 50,400,721 (GRCm39)	P535L	probably benign	Het
Spmap2l	A	T	5: 77,208,605 (GRCm39)	I378L	probably benign	Het
Tbc1d32	G	T	10: 56,027,871 (GRCm39)	Q744K	possibly damaging	Het
Tmem108	G	T	9: 103,366,439 (GRCm39)	N517K	possibly damaging	Het
Trp63	T	A	16: 25,681,211 (GRCm39)	N160K	probably damaging	Het
Ttll5	T	C	12: 85,980,385 (GRCm39)	S119P	probably damaging	Het
Ubqln3	T	A	7: 103,791,523 (GRCm39)	Q189L	probably damaging	Het
Vwa5a	G	A	9: 38,649,072 (GRCm39)	R638H	probably benign	Het
Wdr3	A	G	3: 100,058,298 (GRCm39)	S436P	probably damaging	Het
Zfp975	A	T	7: 42,312,215 (GRCm39)	C133S	probably damaging	Het
Zfp976	A	T	7: 42,263,656 (GRCm39)		probably benign	Het
Zmiz1	A	G	14: 25,657,303 (GRCm39)	M860V	probably damaging	Het
Zscan4d	T	C	7: 10,896,296 (GRCm39)	E358G	probably benign	Het

Other mutations in Gm1110

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00591:Gm1110	APN	9	26,792,170 (GRCm39)	nonsense	probably null
IGL01089:Gm1110	APN	9	26,793,156 (GRCm39)	missense	probably benign
IGL01631:Gm1110	APN	9	26,809,212 (GRCm39)	critical splice donor site	probably null
IGL02331:Gm1110	APN	9	26,824,583 (GRCm39)	critical splice donor site	probably null
IGL02335:Gm1110	APN	9	26,793,059 (GRCm39)	missense	probably benign	0.00
IGL02550:Gm1110	APN	9	26,793,130 (GRCm39)	missense	probably benign	0.09
IGL02614:Gm1110	APN	9	26,832,010 (GRCm39)	missense	probably benign	0.11
IGL03409:Gm1110	APN	9	26,807,916 (GRCm39)	missense	probably benign	0.21
PIT4458001:Gm1110	UTSW	9	26,792,124 (GRCm39)	missense	probably benign	0.00
R0189:Gm1110	UTSW	9	26,794,514 (GRCm39)	missense	probably null	0.99
R0271:Gm1110	UTSW	9	26,831,962 (GRCm39)	missense	probably damaging	1.00
R1034:Gm1110	UTSW	9	26,832,646 (GRCm39)	missense	probably damaging	1.00
R1229:Gm1110	UTSW	9	26,793,102 (GRCm39)	missense	probably benign
R1355:Gm1110	UTSW	9	26,795,057 (GRCm39)	missense	probably benign	0.01
R1566:Gm1110	UTSW	9	26,792,166 (GRCm39)	missense	probably damaging	1.00
R1574:Gm1110	UTSW	9	26,792,422 (GRCm39)	splice site	probably benign
R1916:Gm1110	UTSW	9	26,800,934 (GRCm39)	missense	probably damaging	1.00
R2011:Gm1110	UTSW	9	26,805,554 (GRCm39)	missense	probably benign	0.01
R2214:Gm1110	UTSW	9	26,813,786 (GRCm39)	missense	probably benign	0.37
R2567:Gm1110	UTSW	9	26,831,992 (GRCm39)	missense	probably benign
R2967:Gm1110	UTSW	9	26,792,339 (GRCm39)	missense	probably benign	0.05
R4271:Gm1110	UTSW	9	26,806,944 (GRCm39)	critical splice donor site	probably null
R4683:Gm1110	UTSW	9	26,831,890 (GRCm39)	missense	probably damaging	0.99
R4945:Gm1110	UTSW	9	26,831,891 (GRCm39)	missense	possibly damaging	0.46
R5015:Gm1110	UTSW	9	26,793,162 (GRCm39)	missense	probably benign	0.01
R5089:Gm1110	UTSW	9	26,793,683 (GRCm39)	missense	probably damaging	0.96
R5225:Gm1110	UTSW	9	26,813,774 (GRCm39)	missense	probably damaging	1.00
R5239:Gm1110	UTSW	9	26,804,866 (GRCm39)	missense	probably benign	0.00
R5395:Gm1110	UTSW	9	26,800,928 (GRCm39)	missense	probably benign
R5783:Gm1110	UTSW	9	26,793,632 (GRCm39)	missense	probably benign
R6045:Gm1110	UTSW	9	26,794,505 (GRCm39)	critical splice donor site	probably null
R6245:Gm1110	UTSW	9	26,832,043 (GRCm39)	missense	probably benign	0.04
R6357:Gm1110	UTSW	9	26,825,424 (GRCm39)	splice site	probably null
R6863:Gm1110	UTSW	9	26,792,360 (GRCm39)	missense	probably damaging	1.00
R7336:Gm1110	UTSW	9	26,825,653 (GRCm39)	missense	probably damaging	0.99
R7454:Gm1110	UTSW	9	26,831,945 (GRCm39)	missense	probably benign
R7555:Gm1110	UTSW	9	26,804,924 (GRCm39)	missense	probably benign	0.05
R7579:Gm1110	UTSW	9	26,795,122 (GRCm39)	missense	possibly damaging	0.93
R7990:Gm1110	UTSW	9	26,792,137 (GRCm39)	missense	possibly damaging	0.66
R8062:Gm1110	UTSW	9	26,793,117 (GRCm39)	missense	probably damaging	0.99
R8108:Gm1110	UTSW	9	26,831,957 (GRCm39)	missense	probably damaging	1.00
R8323:Gm1110	UTSW	9	26,813,719 (GRCm39)	critical splice donor site	probably null
R8354:Gm1110	UTSW	9	26,794,577 (GRCm39)	missense	probably benign	0.00
R8354:Gm1110	UTSW	9	26,794,576 (GRCm39)	missense	probably benign	0.01
R8454:Gm1110	UTSW	9	26,794,577 (GRCm39)	missense	probably benign	0.00
R8454:Gm1110	UTSW	9	26,794,576 (GRCm39)	missense	probably benign	0.01
R8494:Gm1110	UTSW	9	26,792,154 (GRCm39)	missense	probably benign	0.04
R8978:Gm1110	UTSW	9	26,807,095 (GRCm39)	splice site	probably benign
R9321:Gm1110	UTSW	9	26,831,891 (GRCm39)	missense	probably benign	0.00
R9513:Gm1110	UTSW	9	26,795,083 (GRCm39)	missense	possibly damaging	0.95
R9545:Gm1110	UTSW	9	26,800,977 (GRCm39)	missense	probably benign	0.00
R9758:Gm1110	UTSW	9	26,800,894 (GRCm39)	nonsense	probably null
RF002:Gm1110	UTSW	9	26,831,936 (GRCm39)	missense	probably damaging	1.00
X0063:Gm1110	UTSW	9	26,805,576 (GRCm39)	missense	probably benign	0.01
Z1088:Gm1110	UTSW	9	26,824,606 (GRCm39)	missense	probably benign	0.01

Posted On

2014-05-07