Incidental Mutation 'IGL02012:Scrn3'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Scrn3
Ensembl Gene ENSMUSG00000008226
Gene Namesecernin 3
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.552) question?
Stock #IGL02012
Quality Score
Chromosomal Location73312601-73337818 bp(+) (GRCm38)
Type of Mutationcritical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 73318429 bp
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000107681 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090811] [ENSMUST00000112050]
Predicted Effect probably null
Transcript: ENSMUST00000090811
SMART Domains Protein: ENSMUSP00000088320
Gene: ENSMUSG00000008226

Pfam:Peptidase_C69 50 268 4.7e-13 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000112050
SMART Domains Protein: ENSMUSP00000107681
Gene: ENSMUSG00000008226

Pfam:Peptidase_C69 14 185 9.3e-13 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123621
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139926
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154158
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155019
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m A G 6: 121,674,861 N1296S probably damaging Het
Adprh A T 16: 38,445,852 D309E possibly damaging Het
AF529169 T C 9: 89,601,438 I635M probably benign Het
Armc1 A T 3: 19,157,537 C40S possibly damaging Het
BC100530 T G 16: 36,367,440 D21A possibly damaging Het
Cops8 T C 1: 90,612,234 V204A probably damaging Het
Dchs1 T G 7: 105,764,297 T1104P probably damaging Het
Ddi2 A T 4: 141,708,218 probably null Het
Ehbp1 G A 11: 22,101,218 P420S probably damaging Het
Eif1ad T G 19: 5,368,659 V80G probably damaging Het
Fat1 T C 8: 45,027,540 Y3004H possibly damaging Het
Fbxo11 C T 17: 88,012,651 R211Q probably benign Het
Foxf2 A G 13: 31,626,516 N146S probably damaging Het
Fsd2 A T 7: 81,549,914 N334K probably benign Het
Gm45234 C A 6: 124,746,048 probably benign Het
Itpr3 T A 17: 27,104,095 F1157I probably benign Het
Jph1 C A 1: 17,097,414 W64L probably benign Het
Lmo7 T C 14: 101,888,716 probably benign Het
Man2a1 T C 17: 64,666,899 I390T probably damaging Het
Marveld3 C T 8: 109,948,132 V351M probably damaging Het
Mycn A G 12: 12,937,103 L431P probably damaging Het
Naip5 T C 13: 100,223,339 N463S probably benign Het
Npnt A G 3: 132,908,397 C182R probably damaging Het
Obscn A G 11: 59,076,507 V3068A probably benign Het
Pggt1b A T 18: 46,262,955 S88T probably benign Het
Prx A G 7: 27,517,901 E748G probably damaging Het
Trmt10b G A 4: 45,315,045 R292H probably benign Het
Tuft1 A G 3: 94,622,155 probably benign Het
Wfdc8 T C 2: 164,603,150 probably benign Het
Other mutations in Scrn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02676:Scrn3 APN 2 73329871 missense probably benign
R2105:Scrn3 UTSW 2 73329852 missense probably damaging 0.96
R3973:Scrn3 UTSW 2 73335777 missense possibly damaging 0.66
R3974:Scrn3 UTSW 2 73335777 missense possibly damaging 0.66
R3975:Scrn3 UTSW 2 73335777 missense possibly damaging 0.66
R4206:Scrn3 UTSW 2 73319501 critical splice donor site probably null
R5340:Scrn3 UTSW 2 73335810 nonsense probably null
R5545:Scrn3 UTSW 2 73335781 missense possibly damaging 0.64
R5852:Scrn3 UTSW 2 73331005 missense probably damaging 1.00
R6819:Scrn3 UTSW 2 73319482 missense probably damaging 0.98
Posted On2014-05-07