Incidental Mutation 'IGL01994:Zdhhc8'
ID 183641
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zdhhc8
Ensembl Gene ENSMUSG00000060166
Gene Name zinc finger, DHHC domain containing 8
Synonyms Op53c05, E330009O14Rik, D16H22S1738E
Accession Numbers
Essential gene? Possibly essential (E-score: 0.701) question?
Stock # IGL01994
Quality Score
Status
Chromosome 16
Chromosomal Location 18038617-18053000 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) G to T at 18045636 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000076957]
AlphaFold Q5Y5T5
Predicted Effect probably benign
Transcript: ENSMUST00000076957
SMART Domains Protein: ENSMUSP00000076224
Gene: ENSMUSG00000060166

DomainStartEndE-ValueType
transmembrane domain 15 34 N/A INTRINSIC
transmembrane domain 46 68 N/A INTRINSIC
Pfam:zf-DHHC 99 224 4.8e-36 PFAM
low complexity region 304 318 N/A INTRINSIC
low complexity region 404 417 N/A INTRINSIC
low complexity region 509 524 N/A INTRINSIC
low complexity region 551 563 N/A INTRINSIC
low complexity region 619 644 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000231412
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.[provided by RefSeq, May 2010]
PHENOTYPE: Homozygous null females display impaired prepulse inhibition and reduced exploration in new environments. Homozygous null males display normal prepulse inhibition and only a slight decrease in exploration. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actn2 A T 13: 12,305,563 (GRCm39) Y418N probably benign Het
Adam15 T C 3: 89,248,812 (GRCm39) probably benign Het
Adam32 C A 8: 25,392,812 (GRCm39) probably benign Het
Adamts12 T A 15: 11,345,680 (GRCm39) C1574S probably damaging Het
Adck1 T C 12: 88,397,926 (GRCm39) S187P possibly damaging Het
Atp13a3 A G 16: 30,156,336 (GRCm39) V949A possibly damaging Het
Atxn3 T C 12: 101,908,439 (GRCm39) T138A probably benign Het
Atxn7l2 C T 3: 108,110,859 (GRCm39) R559Q probably damaging Het
Bicra G T 7: 15,706,741 (GRCm39) S1233R possibly damaging Het
Cacybp G T 1: 160,034,206 (GRCm39) N101K probably damaging Het
Cops7b T C 1: 86,528,828 (GRCm39) L185P probably damaging Het
Cttnbp2 T C 6: 18,420,814 (GRCm39) D899G possibly damaging Het
Cyp4f37 C T 17: 32,844,150 (GRCm39) R85* probably null Het
Dnah3 T G 7: 119,550,437 (GRCm39) N3294T possibly damaging Het
Elmo1 T A 13: 20,526,634 (GRCm39) Y395N probably damaging Het
Fam234b T A 6: 135,202,203 (GRCm39) Y308* probably null Het
Fam43a A G 16: 30,419,481 (GRCm39) K22E probably damaging Het
Fcer2a T C 8: 3,738,302 (GRCm39) N123D possibly damaging Het
Gm11595 A G 11: 99,663,027 (GRCm39) C218R unknown Het
Gria4 T C 9: 4,537,726 (GRCm39) Y194C probably damaging Het
Grin2d T C 7: 45,507,396 (GRCm39) E435G probably damaging Het
Hectd1 T C 12: 51,844,725 (GRCm39) E506G probably damaging Het
Htt G A 5: 34,989,948 (GRCm39) S1160N possibly damaging Het
Ift140 A G 17: 25,267,417 (GRCm39) E605G probably damaging Het
Il17re T C 6: 113,445,411 (GRCm39) V374A probably benign Het
Ippk A G 13: 49,612,093 (GRCm39) Q439R possibly damaging Het
Itgam G A 7: 127,700,899 (GRCm39) V530M probably damaging Het
Kirrel3 A G 9: 34,931,429 (GRCm39) H47R possibly damaging Het
Klk1b24 A T 7: 43,841,057 (GRCm39) I162F probably damaging Het
Lama1 A T 17: 68,059,434 (GRCm39) T606S probably benign Het
Lama2 C T 10: 27,343,199 (GRCm39) probably null Het
Lrp2 A G 2: 69,313,945 (GRCm39) I2262T probably benign Het
Mamdc4 A T 2: 25,458,546 (GRCm39) I317N possibly damaging Het
Mtmr3 G T 11: 4,437,938 (GRCm39) H839N probably benign Het
Ncr1 G T 7: 4,344,253 (GRCm39) V177F probably benign Het
Nop58 T C 1: 59,743,242 (GRCm39) S219P probably damaging Het
Nrg3 T C 14: 38,734,043 (GRCm39) Y281C probably damaging Het
Nsf A G 11: 103,819,608 (GRCm39) S54P probably damaging Het
Or56b6 A T 7: 104,925,153 (GRCm39) noncoding transcript Het
Or6k8-ps1 T A 1: 173,979,102 (GRCm39) S7T probably benign Het
Plxnc1 T C 10: 94,685,801 (GRCm39) K730R probably damaging Het
Polr2g A T 19: 8,771,740 (GRCm39) probably benign Het
Rps13 A G 7: 115,932,925 (GRCm39) probably benign Het
Scgb2b7 A G 7: 31,403,409 (GRCm39) I99T probably benign Het
Slc22a27 G T 19: 7,887,108 (GRCm39) H260Q possibly damaging Het
Spata18 G T 5: 73,814,944 (GRCm39) probably null Het
Tns2 A G 15: 102,019,814 (GRCm39) E560G possibly damaging Het
Trbv16 T C 6: 41,128,715 (GRCm39) probably benign Het
Ubr3 T A 2: 69,851,520 (GRCm39) I1829N probably damaging Het
Vcl C T 14: 21,053,311 (GRCm39) T442I probably damaging Het
Vmn2r102 T A 17: 19,880,731 (GRCm39) I24N probably benign Het
Vmn2r114 T C 17: 23,529,451 (GRCm39) D217G probably damaging Het
Vmn2r58 A G 7: 41,486,394 (GRCm39) Y834H probably damaging Het
Other mutations in Zdhhc8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00338:Zdhhc8 APN 16 18,043,060 (GRCm39) missense possibly damaging 0.66
IGL02102:Zdhhc8 APN 16 18,043,063 (GRCm39) missense possibly damaging 0.95
IGL02706:Zdhhc8 APN 16 18,042,758 (GRCm39) missense probably damaging 1.00
IGL03287:Zdhhc8 APN 16 18,042,964 (GRCm39) missense probably benign 0.01
IGL03296:Zdhhc8 APN 16 18,044,587 (GRCm39) missense possibly damaging 0.94
R0066:Zdhhc8 UTSW 16 18,043,064 (GRCm39) missense probably benign 0.00
R0066:Zdhhc8 UTSW 16 18,043,064 (GRCm39) missense probably benign 0.00
R0491:Zdhhc8 UTSW 16 18,046,254 (GRCm39) missense probably damaging 0.99
R0838:Zdhhc8 UTSW 16 18,042,430 (GRCm39) missense probably damaging 0.99
R1567:Zdhhc8 UTSW 16 18,044,984 (GRCm39) missense probably benign 0.36
R2057:Zdhhc8 UTSW 16 18,046,210 (GRCm39) missense probably damaging 1.00
R3913:Zdhhc8 UTSW 16 18,044,587 (GRCm39) missense possibly damaging 0.94
R4690:Zdhhc8 UTSW 16 18,044,605 (GRCm39) missense probably damaging 0.96
R4902:Zdhhc8 UTSW 16 18,045,030 (GRCm39) missense probably benign
R5111:Zdhhc8 UTSW 16 18,044,612 (GRCm39) missense probably benign 0.00
R5825:Zdhhc8 UTSW 16 18,046,538 (GRCm39) missense probably null 0.99
R6111:Zdhhc8 UTSW 16 18,042,762 (GRCm39) missense probably damaging 1.00
R6152:Zdhhc8 UTSW 16 18,041,202 (GRCm39) missense possibly damaging 0.90
R7296:Zdhhc8 UTSW 16 18,052,790 (GRCm39) missense probably benign 0.00
R7450:Zdhhc8 UTSW 16 18,043,035 (GRCm39) missense probably benign 0.00
R7540:Zdhhc8 UTSW 16 18,045,674 (GRCm39) missense probably damaging 1.00
R9015:Zdhhc8 UTSW 16 18,041,141 (GRCm39) missense probably damaging 1.00
R9256:Zdhhc8 UTSW 16 18,042,686 (GRCm39) missense probably damaging 1.00
R9448:Zdhhc8 UTSW 16 18,039,558 (GRCm39) missense
R9520:Zdhhc8 UTSW 16 18,045,044 (GRCm39) missense probably benign
Posted On 2014-05-07