Incidental Mutation 'IGL02015:Prmt2'
ID 183716
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prmt2
Ensembl Gene ENSMUSG00000020230
Gene Name protein arginine N-methyltransferase 2
Synonyms Hrmt1l1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02015
Quality Score
Status
Chromosome 10
Chromosomal Location 76043060-76073699 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 76062089 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 39 (Q39*)
Ref Sequence ENSEMBL: ENSMUSP00000151456 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020452] [ENSMUST00000099571] [ENSMUST00000099572] [ENSMUST00000128099] [ENSMUST00000137857] [ENSMUST00000217726]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000020452
AA Change: Q39*
SMART Domains Protein: ENSMUSP00000020452
Gene: ENSMUSG00000020230
AA Change: Q39*

DomainStartEndE-ValueType
low complexity region 30 43 N/A INTRINSIC
SH3 45 100 4.22e-15 SMART
Pfam:PrmA 122 253 2.5e-8 PFAM
Pfam:PRMT5 123 427 2.4e-13 PFAM
Pfam:Met_10 127 244 5.1e-8 PFAM
Pfam:MTS 134 223 5.7e-11 PFAM
Pfam:Methyltransf_31 147 294 1.5e-8 PFAM
Pfam:Methyltransf_26 150 224 1.2e-9 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000099571
AA Change: Q39*
SMART Domains Protein: ENSMUSP00000097166
Gene: ENSMUSG00000020230
AA Change: Q39*

DomainStartEndE-ValueType
low complexity region 30 43 N/A INTRINSIC
SH3 45 100 4.22e-15 SMART
Pfam:PrmA 122 253 2.5e-8 PFAM
Pfam:PRMT5 123 427 2.4e-13 PFAM
Pfam:Met_10 127 244 5.1e-8 PFAM
Pfam:MTS 134 223 5.7e-11 PFAM
Pfam:Methyltransf_31 147 294 1.5e-8 PFAM
Pfam:Methyltransf_26 150 224 1.2e-9 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000099572
AA Change: Q39*
SMART Domains Protein: ENSMUSP00000097167
Gene: ENSMUSG00000020230
AA Change: Q39*

DomainStartEndE-ValueType
low complexity region 30 43 N/A INTRINSIC
SH3 45 100 4.22e-15 SMART
Pfam:PrmA 124 253 3.1e-8 PFAM
Pfam:PRMT5 124 451 1.2e-11 PFAM
Pfam:MTS 137 223 3.3e-10 PFAM
Pfam:Methyltransf_31 147 294 1.7e-8 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000128099
AA Change: Q39*
SMART Domains Protein: ENSMUSP00000137707
Gene: ENSMUSG00000020230
AA Change: Q39*

DomainStartEndE-ValueType
low complexity region 30 43 N/A INTRINSIC
SH3 45 100 4.22e-15 SMART
Pfam:PrmA 120 253 1.3e-9 PFAM
Pfam:Met_10 122 235 3.8e-8 PFAM
Pfam:TehB 122 235 6.9e-8 PFAM
Pfam:MTS 133 223 2e-11 PFAM
Pfam:Methyltransf_31 147 243 9.3e-9 PFAM
Pfam:Methyltransf_26 150 224 4.6e-10 PFAM
Pfam:Methyltransf_11 154 238 3.2e-6 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000137857
AA Change: Q39*
SMART Domains Protein: ENSMUSP00000137725
Gene: ENSMUSG00000020230
AA Change: Q39*

DomainStartEndE-ValueType
low complexity region 30 43 N/A INTRINSIC
SH3 45 100 4.22e-15 SMART
Pfam:PrmA 120 253 1.5e-9 PFAM
Pfam:Met_10 129 235 4.2e-7 PFAM
Pfam:MTS 137 223 1.1e-10 PFAM
Pfam:Methyltransf_31 147 243 9.2e-9 PFAM
Pfam:Methyltransf_11 154 237 1.7e-6 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000217726
AA Change: Q39*
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele display a hyperplastic response to vascular injury while mutant mouse embryonic fibroblasts show an earlier S phase entry following release of serum starvation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bcl9l C A 9: 44,420,098 (GRCm39) probably null Het
C1qtnf12 A G 4: 156,047,201 (GRCm39) probably benign Het
Csgalnact1 C A 8: 68,854,144 (GRCm39) G219V probably damaging Het
D430041D05Rik A G 2: 104,060,749 (GRCm39) Y1382H probably damaging Het
Fut1 A T 7: 45,268,399 (GRCm39) M118L probably damaging Het
Fzd5 A T 1: 64,775,501 (GRCm39) C87S probably damaging Het
Gmcl1 A G 6: 86,684,439 (GRCm39) V361A possibly damaging Het
Inpp4a T G 1: 37,428,793 (GRCm39) F700V probably damaging Het
Klk1b21 A T 7: 43,753,782 (GRCm39) Q22L probably benign Het
Lrp2 T A 2: 69,357,922 (GRCm39) Q369L probably benign Het
Mtor C T 4: 148,624,570 (GRCm39) Q2117* probably null Het
Naip2 A T 13: 100,298,115 (GRCm39) S640R possibly damaging Het
Nt5e T C 9: 88,249,290 (GRCm39) I408T probably damaging Het
Or10ab5 T A 7: 108,245,220 (GRCm39) N188Y probably damaging Het
Or51h5 G A 7: 102,577,399 (GRCm39) R188H probably benign Het
Or8d2 T C 9: 38,760,090 (GRCm39) S227P probably damaging Het
Plxna1 A G 6: 89,319,433 (GRCm39) L590P probably damaging Het
Ppp1r35 T C 5: 137,778,293 (GRCm39) probably benign Het
Ptprg A T 14: 12,237,782 (GRCm38) N1413I possibly damaging Het
Ranbp10 C A 8: 106,506,622 (GRCm39) G233C probably damaging Het
Rapgef2 A G 3: 78,999,371 (GRCm39) probably benign Het
Rilpl2 T C 5: 124,607,876 (GRCm39) T115A probably benign Het
Scaf4 T C 16: 90,055,734 (GRCm39) S108G unknown Het
Scn10a C T 9: 119,494,017 (GRCm39) V430M probably benign Het
Sf3b3 T C 8: 111,542,922 (GRCm39) E845G possibly damaging Het
Skint2 C T 4: 112,481,325 (GRCm39) R63* probably null Het
Slc35b4 A T 6: 34,147,483 (GRCm39) V35D probably damaging Het
Slc6a3 A T 13: 73,692,833 (GRCm39) Y151F possibly damaging Het
Susd1 G A 4: 59,315,745 (GRCm39) T689I possibly damaging Het
Tbx21 T C 11: 96,989,740 (GRCm39) D484G probably benign Het
Tln2 C T 9: 67,268,721 (GRCm39) probably benign Het
Traf3 A G 12: 111,219,174 (GRCm39) N242S probably benign Het
Tut7 A G 13: 59,937,072 (GRCm39) Y790H probably damaging Het
Xiap T A X: 41,185,487 (GRCm39) probably benign Het
Other mutations in Prmt2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01642:Prmt2 APN 10 76,058,327 (GRCm39) missense probably damaging 1.00
IGL01663:Prmt2 APN 10 76,053,143 (GRCm39) splice site probably null
IGL03094:Prmt2 APN 10 76,046,224 (GRCm39) splice site probably benign
R0352:Prmt2 UTSW 10 76,044,337 (GRCm39) missense possibly damaging 0.89
R0617:Prmt2 UTSW 10 76,044,517 (GRCm39) intron probably benign
R0831:Prmt2 UTSW 10 76,043,641 (GRCm39) unclassified probably benign
R0885:Prmt2 UTSW 10 76,058,399 (GRCm39) missense probably damaging 1.00
R1882:Prmt2 UTSW 10 76,058,302 (GRCm39) missense probably benign 0.00
R2022:Prmt2 UTSW 10 76,061,292 (GRCm39) nonsense probably null
R2312:Prmt2 UTSW 10 76,062,089 (GRCm39) nonsense probably null
R2401:Prmt2 UTSW 10 76,061,249 (GRCm39) nonsense probably null
R2408:Prmt2 UTSW 10 76,044,301 (GRCm39) missense probably damaging 0.98
R3753:Prmt2 UTSW 10 76,061,137 (GRCm39) missense probably benign 0.01
R4707:Prmt2 UTSW 10 76,062,055 (GRCm39) missense probably damaging 0.96
R4785:Prmt2 UTSW 10 76,062,055 (GRCm39) missense probably damaging 0.96
R4937:Prmt2 UTSW 10 76,056,842 (GRCm39) missense probably damaging 1.00
R5072:Prmt2 UTSW 10 76,058,390 (GRCm39) missense probably damaging 1.00
R5073:Prmt2 UTSW 10 76,058,390 (GRCm39) missense probably damaging 1.00
R5074:Prmt2 UTSW 10 76,058,390 (GRCm39) missense probably damaging 1.00
R5851:Prmt2 UTSW 10 76,072,574 (GRCm39) missense possibly damaging 0.61
R6084:Prmt2 UTSW 10 76,046,278 (GRCm39) missense probably benign 0.23
R6120:Prmt2 UTSW 10 76,045,280 (GRCm39) missense possibly damaging 0.51
R6239:Prmt2 UTSW 10 76,058,425 (GRCm39) nonsense probably null
R6317:Prmt2 UTSW 10 76,058,351 (GRCm39) missense probably benign 0.15
R6659:Prmt2 UTSW 10 76,053,208 (GRCm39) missense possibly damaging 0.85
R7174:Prmt2 UTSW 10 76,061,173 (GRCm39) missense probably benign 0.00
R7421:Prmt2 UTSW 10 76,056,912 (GRCm39) missense probably benign 0.00
R7485:Prmt2 UTSW 10 76,056,838 (GRCm39) nonsense probably null
R8326:Prmt2 UTSW 10 76,053,247 (GRCm39) missense probably benign 0.00
R9490:Prmt2 UTSW 10 76,053,227 (GRCm39) missense probably damaging 0.98
R9620:Prmt2 UTSW 10 76,061,213 (GRCm39) missense probably damaging 1.00
R9694:Prmt2 UTSW 10 76,061,213 (GRCm39) missense probably damaging 1.00
Posted On 2014-05-07