Incidental Mutation 'IGL02015:Prmt2'
ID |
183716 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Prmt2
|
Ensembl Gene |
ENSMUSG00000020230 |
Gene Name |
protein arginine N-methyltransferase 2 |
Synonyms |
Hrmt1l1 |
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
IGL02015
|
Quality Score |
|
Status
|
|
Chromosome |
10 |
Chromosomal Location |
76043060-76073699 bp(-) (GRCm39) |
Type of Mutation |
nonsense |
DNA Base Change (assembly) |
G to A
at 76062089 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glutamine to Stop codon
at position 39
(Q39*)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000151456
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000020452]
[ENSMUST00000099571]
[ENSMUST00000099572]
[ENSMUST00000128099]
[ENSMUST00000137857]
[ENSMUST00000217726]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably null
Transcript: ENSMUST00000020452
AA Change: Q39*
|
SMART Domains |
Protein: ENSMUSP00000020452 Gene: ENSMUSG00000020230 AA Change: Q39*
Domain | Start | End | E-Value | Type |
low complexity region
|
30 |
43 |
N/A |
INTRINSIC |
SH3
|
45 |
100 |
4.22e-15 |
SMART |
Pfam:PrmA
|
122 |
253 |
2.5e-8 |
PFAM |
Pfam:PRMT5
|
123 |
427 |
2.4e-13 |
PFAM |
Pfam:Met_10
|
127 |
244 |
5.1e-8 |
PFAM |
Pfam:MTS
|
134 |
223 |
5.7e-11 |
PFAM |
Pfam:Methyltransf_31
|
147 |
294 |
1.5e-8 |
PFAM |
Pfam:Methyltransf_26
|
150 |
224 |
1.2e-9 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000099571
AA Change: Q39*
|
SMART Domains |
Protein: ENSMUSP00000097166 Gene: ENSMUSG00000020230 AA Change: Q39*
Domain | Start | End | E-Value | Type |
low complexity region
|
30 |
43 |
N/A |
INTRINSIC |
SH3
|
45 |
100 |
4.22e-15 |
SMART |
Pfam:PrmA
|
122 |
253 |
2.5e-8 |
PFAM |
Pfam:PRMT5
|
123 |
427 |
2.4e-13 |
PFAM |
Pfam:Met_10
|
127 |
244 |
5.1e-8 |
PFAM |
Pfam:MTS
|
134 |
223 |
5.7e-11 |
PFAM |
Pfam:Methyltransf_31
|
147 |
294 |
1.5e-8 |
PFAM |
Pfam:Methyltransf_26
|
150 |
224 |
1.2e-9 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000099572
AA Change: Q39*
|
SMART Domains |
Protein: ENSMUSP00000097167 Gene: ENSMUSG00000020230 AA Change: Q39*
Domain | Start | End | E-Value | Type |
low complexity region
|
30 |
43 |
N/A |
INTRINSIC |
SH3
|
45 |
100 |
4.22e-15 |
SMART |
Pfam:PrmA
|
124 |
253 |
3.1e-8 |
PFAM |
Pfam:PRMT5
|
124 |
451 |
1.2e-11 |
PFAM |
Pfam:MTS
|
137 |
223 |
3.3e-10 |
PFAM |
Pfam:Methyltransf_31
|
147 |
294 |
1.7e-8 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000128099
AA Change: Q39*
|
SMART Domains |
Protein: ENSMUSP00000137707 Gene: ENSMUSG00000020230 AA Change: Q39*
Domain | Start | End | E-Value | Type |
low complexity region
|
30 |
43 |
N/A |
INTRINSIC |
SH3
|
45 |
100 |
4.22e-15 |
SMART |
Pfam:PrmA
|
120 |
253 |
1.3e-9 |
PFAM |
Pfam:Met_10
|
122 |
235 |
3.8e-8 |
PFAM |
Pfam:TehB
|
122 |
235 |
6.9e-8 |
PFAM |
Pfam:MTS
|
133 |
223 |
2e-11 |
PFAM |
Pfam:Methyltransf_31
|
147 |
243 |
9.3e-9 |
PFAM |
Pfam:Methyltransf_26
|
150 |
224 |
4.6e-10 |
PFAM |
Pfam:Methyltransf_11
|
154 |
238 |
3.2e-6 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000137857
AA Change: Q39*
|
SMART Domains |
Protein: ENSMUSP00000137725 Gene: ENSMUSG00000020230 AA Change: Q39*
Domain | Start | End | E-Value | Type |
low complexity region
|
30 |
43 |
N/A |
INTRINSIC |
SH3
|
45 |
100 |
4.22e-15 |
SMART |
Pfam:PrmA
|
120 |
253 |
1.5e-9 |
PFAM |
Pfam:Met_10
|
129 |
235 |
4.2e-7 |
PFAM |
Pfam:MTS
|
137 |
223 |
1.1e-10 |
PFAM |
Pfam:Methyltransf_31
|
147 |
243 |
9.2e-9 |
PFAM |
Pfam:Methyltransf_11
|
154 |
237 |
1.7e-6 |
PFAM |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000217726
AA Change: Q39*
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele display a hyperplastic response to vascular injury while mutant mouse embryonic fibroblasts show an earlier S phase entry following release of serum starvation. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 34 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Bcl9l |
C |
A |
9: 44,420,098 (GRCm39) |
|
probably null |
Het |
C1qtnf12 |
A |
G |
4: 156,047,201 (GRCm39) |
|
probably benign |
Het |
Csgalnact1 |
C |
A |
8: 68,854,144 (GRCm39) |
G219V |
probably damaging |
Het |
D430041D05Rik |
A |
G |
2: 104,060,749 (GRCm39) |
Y1382H |
probably damaging |
Het |
Fut1 |
A |
T |
7: 45,268,399 (GRCm39) |
M118L |
probably damaging |
Het |
Fzd5 |
A |
T |
1: 64,775,501 (GRCm39) |
C87S |
probably damaging |
Het |
Gmcl1 |
A |
G |
6: 86,684,439 (GRCm39) |
V361A |
possibly damaging |
Het |
Inpp4a |
T |
G |
1: 37,428,793 (GRCm39) |
F700V |
probably damaging |
Het |
Klk1b21 |
A |
T |
7: 43,753,782 (GRCm39) |
Q22L |
probably benign |
Het |
Lrp2 |
T |
A |
2: 69,357,922 (GRCm39) |
Q369L |
probably benign |
Het |
Mtor |
C |
T |
4: 148,624,570 (GRCm39) |
Q2117* |
probably null |
Het |
Naip2 |
A |
T |
13: 100,298,115 (GRCm39) |
S640R |
possibly damaging |
Het |
Nt5e |
T |
C |
9: 88,249,290 (GRCm39) |
I408T |
probably damaging |
Het |
Or10ab5 |
T |
A |
7: 108,245,220 (GRCm39) |
N188Y |
probably damaging |
Het |
Or51h5 |
G |
A |
7: 102,577,399 (GRCm39) |
R188H |
probably benign |
Het |
Or8d2 |
T |
C |
9: 38,760,090 (GRCm39) |
S227P |
probably damaging |
Het |
Plxna1 |
A |
G |
6: 89,319,433 (GRCm39) |
L590P |
probably damaging |
Het |
Ppp1r35 |
T |
C |
5: 137,778,293 (GRCm39) |
|
probably benign |
Het |
Ptprg |
A |
T |
14: 12,237,782 (GRCm38) |
N1413I |
possibly damaging |
Het |
Ranbp10 |
C |
A |
8: 106,506,622 (GRCm39) |
G233C |
probably damaging |
Het |
Rapgef2 |
A |
G |
3: 78,999,371 (GRCm39) |
|
probably benign |
Het |
Rilpl2 |
T |
C |
5: 124,607,876 (GRCm39) |
T115A |
probably benign |
Het |
Scaf4 |
T |
C |
16: 90,055,734 (GRCm39) |
S108G |
unknown |
Het |
Scn10a |
C |
T |
9: 119,494,017 (GRCm39) |
V430M |
probably benign |
Het |
Sf3b3 |
T |
C |
8: 111,542,922 (GRCm39) |
E845G |
possibly damaging |
Het |
Skint2 |
C |
T |
4: 112,481,325 (GRCm39) |
R63* |
probably null |
Het |
Slc35b4 |
A |
T |
6: 34,147,483 (GRCm39) |
V35D |
probably damaging |
Het |
Slc6a3 |
A |
T |
13: 73,692,833 (GRCm39) |
Y151F |
possibly damaging |
Het |
Susd1 |
G |
A |
4: 59,315,745 (GRCm39) |
T689I |
possibly damaging |
Het |
Tbx21 |
T |
C |
11: 96,989,740 (GRCm39) |
D484G |
probably benign |
Het |
Tln2 |
C |
T |
9: 67,268,721 (GRCm39) |
|
probably benign |
Het |
Traf3 |
A |
G |
12: 111,219,174 (GRCm39) |
N242S |
probably benign |
Het |
Tut7 |
A |
G |
13: 59,937,072 (GRCm39) |
Y790H |
probably damaging |
Het |
Xiap |
T |
A |
X: 41,185,487 (GRCm39) |
|
probably benign |
Het |
|
Other mutations in Prmt2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01642:Prmt2
|
APN |
10 |
76,058,327 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01663:Prmt2
|
APN |
10 |
76,053,143 (GRCm39) |
splice site |
probably null |
|
IGL03094:Prmt2
|
APN |
10 |
76,046,224 (GRCm39) |
splice site |
probably benign |
|
R0352:Prmt2
|
UTSW |
10 |
76,044,337 (GRCm39) |
missense |
possibly damaging |
0.89 |
R0617:Prmt2
|
UTSW |
10 |
76,044,517 (GRCm39) |
intron |
probably benign |
|
R0831:Prmt2
|
UTSW |
10 |
76,043,641 (GRCm39) |
unclassified |
probably benign |
|
R0885:Prmt2
|
UTSW |
10 |
76,058,399 (GRCm39) |
missense |
probably damaging |
1.00 |
R1882:Prmt2
|
UTSW |
10 |
76,058,302 (GRCm39) |
missense |
probably benign |
0.00 |
R2022:Prmt2
|
UTSW |
10 |
76,061,292 (GRCm39) |
nonsense |
probably null |
|
R2312:Prmt2
|
UTSW |
10 |
76,062,089 (GRCm39) |
nonsense |
probably null |
|
R2401:Prmt2
|
UTSW |
10 |
76,061,249 (GRCm39) |
nonsense |
probably null |
|
R2408:Prmt2
|
UTSW |
10 |
76,044,301 (GRCm39) |
missense |
probably damaging |
0.98 |
R3753:Prmt2
|
UTSW |
10 |
76,061,137 (GRCm39) |
missense |
probably benign |
0.01 |
R4707:Prmt2
|
UTSW |
10 |
76,062,055 (GRCm39) |
missense |
probably damaging |
0.96 |
R4785:Prmt2
|
UTSW |
10 |
76,062,055 (GRCm39) |
missense |
probably damaging |
0.96 |
R4937:Prmt2
|
UTSW |
10 |
76,056,842 (GRCm39) |
missense |
probably damaging |
1.00 |
R5072:Prmt2
|
UTSW |
10 |
76,058,390 (GRCm39) |
missense |
probably damaging |
1.00 |
R5073:Prmt2
|
UTSW |
10 |
76,058,390 (GRCm39) |
missense |
probably damaging |
1.00 |
R5074:Prmt2
|
UTSW |
10 |
76,058,390 (GRCm39) |
missense |
probably damaging |
1.00 |
R5851:Prmt2
|
UTSW |
10 |
76,072,574 (GRCm39) |
missense |
possibly damaging |
0.61 |
R6084:Prmt2
|
UTSW |
10 |
76,046,278 (GRCm39) |
missense |
probably benign |
0.23 |
R6120:Prmt2
|
UTSW |
10 |
76,045,280 (GRCm39) |
missense |
possibly damaging |
0.51 |
R6239:Prmt2
|
UTSW |
10 |
76,058,425 (GRCm39) |
nonsense |
probably null |
|
R6317:Prmt2
|
UTSW |
10 |
76,058,351 (GRCm39) |
missense |
probably benign |
0.15 |
R6659:Prmt2
|
UTSW |
10 |
76,053,208 (GRCm39) |
missense |
possibly damaging |
0.85 |
R7174:Prmt2
|
UTSW |
10 |
76,061,173 (GRCm39) |
missense |
probably benign |
0.00 |
R7421:Prmt2
|
UTSW |
10 |
76,056,912 (GRCm39) |
missense |
probably benign |
0.00 |
R7485:Prmt2
|
UTSW |
10 |
76,056,838 (GRCm39) |
nonsense |
probably null |
|
R8326:Prmt2
|
UTSW |
10 |
76,053,247 (GRCm39) |
missense |
probably benign |
0.00 |
R9490:Prmt2
|
UTSW |
10 |
76,053,227 (GRCm39) |
missense |
probably damaging |
0.98 |
R9620:Prmt2
|
UTSW |
10 |
76,061,213 (GRCm39) |
missense |
probably damaging |
1.00 |
R9694:Prmt2
|
UTSW |
10 |
76,061,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Posted On |
2014-05-07 |