Incidental Mutation 'IGL02024:Ifi208'
ID184077
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifi208
Ensembl Gene ENSMUSG00000066677
Gene Nameinterferon activated gene 208
SynonymsPydc3, E430029J22Rik, Pyr-rv1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.075) question?
Stock #IGL02024
Quality Score
Status
Chromosome1
Chromosomal Location173673675-173698395 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 173683290 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 337 (Y337C)
Ref Sequence ENSEMBL: ENSMUSP00000128958 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085876] [ENSMUST00000169857]
Predicted Effect probably damaging
Transcript: ENSMUST00000085876
AA Change: Y337C

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000083039
Gene: ENSMUSG00000066677
AA Change: Y337C

DomainStartEndE-ValueType
PYRIN 10 88 3.23e-20 SMART
low complexity region 101 112 N/A INTRINSIC
low complexity region 211 222 N/A INTRINSIC
low complexity region 488 504 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000169857
AA Change: Y337C

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000128958
Gene: ENSMUSG00000066677
AA Change: Y337C

DomainStartEndE-ValueType
PYRIN 10 88 3.23e-20 SMART
low complexity region 101 112 N/A INTRINSIC
low complexity region 211 222 N/A INTRINSIC
Pfam:HERV-K_REC 502 580 3.5e-9 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182880
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930415L06Rik G A X: 89,931,523 T356I probably benign Het
Aass G A 6: 23,113,706 H246Y probably damaging Het
Abat G A 16: 8,611,136 A322T probably damaging Het
Bcat1 A G 6: 145,032,838 V152A probably damaging Het
Btaf1 A G 19: 36,992,426 probably benign Het
Elavl2 T C 4: 91,253,539 T291A probably benign Het
Ezh1 G T 11: 101,199,340 H529Q probably damaging Het
Fcgbp G A 7: 28,106,374 C2026Y probably damaging Het
Fcgrt T A 7: 45,095,258 H258L probably damaging Het
Galnt6 C T 15: 100,703,493 D302N probably benign Het
Gldc T A 19: 30,100,827 R923S probably damaging Het
Hspg2 G T 4: 137,540,073 A2033S probably damaging Het
Htr2c T A X: 147,075,925 M77K probably damaging Het
Ints11 G T 4: 155,888,515 W554L probably damaging Het
Itgbl1 T A 14: 123,857,492 C186S probably damaging Het
Lipf A G 19: 33,976,595 Y362C probably damaging Het
Map2k7 T A 8: 4,247,663 S421R possibly damaging Het
Mroh9 T G 1: 163,062,502 N222T possibly damaging Het
Msl3 C A X: 168,670,251 R89L probably benign Het
Nrip1 T A 16: 76,291,675 D998V probably benign Het
Nrk T A X: 138,995,929 I1265N probably damaging Het
Ntn5 A G 7: 45,691,406 probably benign Het
Olfr1153 A T 2: 87,896,899 R233S possibly damaging Het
Olfr743 A G 14: 50,533,850 N146S probably benign Het
Olfr750 T G 14: 51,071,309 E28A probably benign Het
Plch2 T C 4: 155,043,138 probably benign Het
Porcn C T X: 8,201,662 V233I probably benign Het
Ppp2r2a T C 14: 67,038,912 K48R probably benign Het
Rccd1 A T 7: 80,319,007 D268E probably benign Het
Sacs C A 14: 61,189,678 S178R probably damaging Het
Samd12 T A 15: 53,658,466 D116V probably damaging Het
Slc12a8 A G 16: 33,608,198 E46G probably damaging Het
Slc30a10 A T 1: 185,455,241 I60F possibly damaging Het
Slc6a8 C T X: 73,678,977 probably benign Het
Sos2 A G 12: 69,618,048 probably benign Het
Tbc1d31 T C 15: 57,919,942 V79A probably benign Het
Tmem184c A T 8: 77,604,814 V102E probably benign Het
Ttc19 G T 11: 62,313,113 R300I probably damaging Het
Unc5d T A 8: 28,652,827 I866F probably benign Het
Vmn1r7 A T 6: 57,024,889 C129S probably benign Het
Vps41 T A 13: 18,791,657 probably benign Het
Vwa8 C T 14: 79,094,284 A1275V possibly damaging Het
Other mutations in Ifi208
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00093:Ifi208 APN 1 173679038 critical splice donor site probably null
IGL00725:Ifi208 APN 1 173682861 missense possibly damaging 0.86
IGL01952:Ifi208 APN 1 173679031 missense possibly damaging 0.93
IGL02637:Ifi208 APN 1 173678942 missense probably benign 0.15
IGL02829:Ifi208 APN 1 173682840 missense probably damaging 0.99
IGL03216:Ifi208 APN 1 173678941 missense possibly damaging 0.68
IGL03398:Ifi208 APN 1 173683251 missense probably damaging 0.96
FR4304:Ifi208 UTSW 1 173677698 small deletion probably benign
FR4340:Ifi208 UTSW 1 173677698 small deletion probably benign
FR4342:Ifi208 UTSW 1 173677698 small deletion probably benign
R0022:Ifi208 UTSW 1 173683046 missense possibly damaging 0.91
R0468:Ifi208 UTSW 1 173683481 missense probably benign 0.08
R0734:Ifi208 UTSW 1 173683335 missense probably damaging 0.98
R0780:Ifi208 UTSW 1 173682696 missense probably benign 0.06
R1070:Ifi208 UTSW 1 173683044 missense probably damaging 0.99
R1339:Ifi208 UTSW 1 173683238 missense probably damaging 0.99
R1473:Ifi208 UTSW 1 173695654 missense possibly damaging 0.53
R1755:Ifi208 UTSW 1 173677910 missense possibly damaging 0.86
R3012:Ifi208 UTSW 1 173695570 critical splice acceptor site probably null
R3692:Ifi208 UTSW 1 173682872 missense possibly damaging 0.93
R4175:Ifi208 UTSW 1 173682701 missense probably benign 0.01
R4235:Ifi208 UTSW 1 173682911 missense probably benign 0.06
R4749:Ifi208 UTSW 1 173695614 missense possibly damaging 0.70
R4815:Ifi208 UTSW 1 173682837 missense probably damaging 0.96
R5116:Ifi208 UTSW 1 173677983 intron probably benign
R5138:Ifi208 UTSW 1 173690673 missense probably null 0.29
R5210:Ifi208 UTSW 1 173683265 missense probably benign
R5304:Ifi208 UTSW 1 173683608 missense probably benign
R6126:Ifi208 UTSW 1 173677708 missense possibly damaging 0.91
R6558:Ifi208 UTSW 1 173683023 missense probably damaging 0.99
R6915:Ifi208 UTSW 1 173682878 missense probably damaging 1.00
Posted On2014-05-07