Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02026:Or14j3'

184190

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or14j3

Ensembl Gene

ENSMUSG00000062629

Gene Name

olfactory receptor family 14 subfamily J member 3

Synonyms

MOR218-10, GA_x6K02T2PSCP-2049802-2048870, Olfr114

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

IGL02026

Quality Score

Status

Chromosome

Chromosomal Location

37900304-37901242 bp(-) (GRCm39)

Type of Mutation

utr 3 prime

DNA Base Change (assembly)

A to G at 37900298 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000149735 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076914] [ENSMUST00000214871] [ENSMUST00000216249]

AlphaFold

Q923Q8

Predicted Effect

probably benign
Transcript: ENSMUST00000076914

SMART Domains

Protein: ENSMUSP00000076181
Gene: ENSMUSG00000062629

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	2e-43	PFAM
Pfam:7TM_GPCR_Srsx	35	305	3.7e-6	PFAM
Pfam:7tm_1	41	290	3e-19	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214871

Predicted Effect

probably benign
Transcript: ENSMUST00000216249

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamdec1	A	T	14: 68,809,251 (GRCm39)	V237E	possibly damaging	Het
Amh	T	C	10: 80,641,242 (GRCm39)	L54P	probably damaging	Het
Aoc3	T	C	11: 101,228,421 (GRCm39)	S743P	probably benign	Het
Arhgap23	T	A	11: 97,342,407 (GRCm39)	W19R	probably damaging	Het
Atm	C	T	9: 53,353,717 (GRCm39)		probably null	Het
Ccdc47	T	C	11: 106,095,853 (GRCm39)	E281G	probably damaging	Het
Col7a1	A	C	9: 108,797,097 (GRCm39)	K1650N	probably damaging	Het
Cstdc5	C	A	16: 36,187,848 (GRCm39)	V6F	possibly damaging	Het
Evi2b	T	C	11: 79,406,613 (GRCm39)	S321G	probably damaging	Het
Fancm	T	G	12: 65,152,508 (GRCm39)	V988G	probably benign	Het
Gbp2	A	G	3: 142,339,241 (GRCm39)	Y431C	probably damaging	Het
Gclc	T	C	9: 77,699,342 (GRCm39)	V530A	probably benign	Het
Gm5885	T	C	6: 133,508,291 (GRCm39)		noncoding transcript	Het
Hlcs	A	T	16: 93,935,564 (GRCm39)	I576N	probably damaging	Het
Hnrnpul1	A	T	7: 25,444,587 (GRCm39)	F240L	probably damaging	Het
Itgb6	C	A	2: 60,458,410 (GRCm39)	V448F	possibly damaging	Het
Lama1	A	G	17: 68,116,287 (GRCm39)	T2385A	possibly damaging	Het
Lamc2	C	T	1: 153,020,482 (GRCm39)		probably benign	Het
Lrrc32	C	T	7: 98,148,767 (GRCm39)	R516C	probably benign	Het
Lrrtm3	T	C	10: 63,924,231 (GRCm39)	N312S	probably damaging	Het
Ltbp4	G	A	7: 27,026,842 (GRCm39)	R468*	probably null	Het
Man1a	T	C	10: 53,890,569 (GRCm39)	E373G	probably damaging	Het
Myo1h	A	T	5: 114,461,505 (GRCm39)	Q250L	probably null	Het
Myo9a	T	C	9: 59,813,245 (GRCm39)	V2077A	probably damaging	Het
Otud5	C	T	X: 7,738,232 (GRCm39)		probably benign	Het
Pcsk1	A	G	13: 75,260,772 (GRCm39)	S332G	probably benign	Het
Pde8b	A	G	13: 95,170,869 (GRCm39)	V549A	probably damaging	Het
Pgap1	A	T	1: 54,533,978 (GRCm39)	M645K	probably benign	Het
Pm20d1	A	T	1: 131,729,497 (GRCm39)	R175*	probably null	Het
Polr2b	A	G	5: 77,480,099 (GRCm39)	N585S	probably benign	Het
Recql	T	A	6: 142,312,394 (GRCm39)	K41*	probably null	Het
Sccpdh	A	T	1: 179,505,634 (GRCm39)	H138L	possibly damaging	Het
Sec31a	A	T	5: 100,517,485 (GRCm39)	S951T	probably benign	Het
Slc44a4	A	T	17: 35,140,832 (GRCm39)		probably benign	Het
Tchhl1	G	T	3: 93,377,862 (GRCm39)	A189S	probably damaging	Het
Tdrd12	G	A	7: 35,203,658 (GRCm39)		probably benign	Het
Tesl2	T	G	X: 23,824,233 (GRCm39)	H314P	probably damaging	Het
Trbv12-1	A	G	6: 41,090,928 (GRCm39)	D100G	probably damaging	Het
Ttll13	T	A	7: 79,910,127 (GRCm39)	S757T	probably benign	Het
Vipas39	T	A	12: 87,298,483 (GRCm39)		probably benign	Het
Vmn1r64	G	A	7: 5,886,649 (GRCm39)	P298L	possibly damaging	Het
Vmn1r81	A	G	7: 11,994,432 (GRCm39)	S59P	probably damaging	Het
Vsx1	A	T	2: 150,530,447 (GRCm39)	V145D	probably benign	Het
Wdfy4	T	A	14: 32,815,257 (GRCm39)	N1586I	probably damaging	Het
Zan	T	A	5: 137,403,726 (GRCm39)		probably benign	Het
Zfp318	C	T	17: 46,707,736 (GRCm39)	R265*	probably null	Het
Zzef1	T	A	11: 72,772,164 (GRCm39)	M1707K	probably benign	Het

Other mutations in Or14j3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01534:Or14j3	APN	17	37,900,963 (GRCm39)	missense	possibly damaging	0.93
IGL01624:Or14j3	APN	17	37,900,816 (GRCm39)	missense	probably benign	0.00
IGL02608:Or14j3	APN	17	37,901,110 (GRCm39)	missense	probably damaging	1.00
IGL02632:Or14j3	APN	17	37,901,232 (GRCm39)	missense	probably benign	0.00
IGL02990:Or14j3	APN	17	37,900,559 (GRCm39)	missense	probably benign	0.00
R0114:Or14j3	UTSW	17	37,900,306 (GRCm39)	makesense	probably null
R1156:Or14j3	UTSW	17	37,900,408 (GRCm39)	missense	possibly damaging	0.93
R1366:Or14j3	UTSW	17	37,900,655 (GRCm39)	missense	probably benign	0.03
R3413:Or14j3	UTSW	17	37,900,587 (GRCm39)	missense	probably benign	0.00
R3701:Or14j3	UTSW	17	37,900,717 (GRCm39)	nonsense	probably null
R6122:Or14j3	UTSW	17	37,900,817 (GRCm39)	missense	probably benign	0.12
R6639:Or14j3	UTSW	17	37,900,822 (GRCm39)	missense	probably damaging	1.00
R7066:Or14j3	UTSW	17	37,901,034 (GRCm39)	missense	probably damaging	1.00
R7316:Or14j3	UTSW	17	37,901,026 (GRCm39)	missense	probably damaging	0.99
R8340:Or14j3	UTSW	17	37,901,034 (GRCm39)	missense	probably damaging	1.00
R8483:Or14j3	UTSW	17	37,900,866 (GRCm39)	missense	possibly damaging	0.52
R8555:Or14j3	UTSW	17	37,900,540 (GRCm39)	missense	possibly damaging	0.95
R9442:Or14j3	UTSW	17	37,900,633 (GRCm39)	missense	possibly damaging	0.95
R9617:Or14j3	UTSW	17	37,901,053 (GRCm39)	nonsense	probably null
R9718:Or14j3	UTSW	17	37,900,914 (GRCm39)	missense	probably benign	0.00

Posted On

2014-05-07