Incidental Mutation 'IGL02027:Vmn1r16'
ID184193
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r16
Ensembl Gene ENSMUSG00000115792
Gene Namevomeronasal 1 receptor 16
SynonymsV1rc29
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.269) question?
Stock #IGL02027
Quality Score
Status
Chromosome6
Chromosomal Location57318052-57329494 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 57323059 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 193 (T193A)
Ref Sequence ENSEMBL: ENSMUSP00000154566 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000177267] [ENSMUST00000227168] [ENSMUST00000227283] [ENSMUST00000228356]
Predicted Effect possibly damaging
Transcript: ENSMUST00000177267
AA Change: T193A

PolyPhen 2 Score 0.487 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000134873
Gene: ENSMUSG00000093523
AA Change: T193A

DomainStartEndE-ValueType
Pfam:V1R 28 293 3.4e-57 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000227168
AA Change: T193A

PolyPhen 2 Score 0.487 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000227283
AA Change: T193A

PolyPhen 2 Score 0.487 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect probably benign
Transcript: ENSMUST00000228356
AA Change: T193A

PolyPhen 2 Score 0.403 (Sensitivity: 0.89; Specificity: 0.89)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adipor1 A G 1: 134,431,185 T312A probably benign Het
Begain T G 12: 109,034,309 K384Q possibly damaging Het
C2cd6 T C 1: 59,060,604 I393V probably benign Het
Catsperz A G 19: 6,925,296 V5A probably benign Het
Cbx1 T A 11: 96,801,489 F67L probably damaging Het
Cerkl T C 2: 79,341,286 probably benign Het
Ctgf A G 10: 24,596,409 S117G probably damaging Het
Cubn G T 2: 13,287,594 D3259E probably damaging Het
Cyp2u1 A G 3: 131,297,951 Y307H probably damaging Het
Dcaf6 A C 1: 165,424,341 D71E probably damaging Het
Dclk3 A T 9: 111,467,843 K152* probably null Het
Fcgbp G A 7: 28,075,204 D68N probably damaging Het
Gm6576 A G 15: 27,025,866 noncoding transcript Het
Has2 T C 15: 56,668,171 T383A probably damaging Het
Htr1f T A 16: 64,926,321 K203* probably null Het
Il1f9 A T 2: 24,192,785 I191L probably benign Het
Iqgap3 T C 3: 88,087,342 I116T possibly damaging Het
Itga1 C T 13: 114,990,055 probably null Het
Kif5b T C 18: 6,209,089 D891G possibly damaging Het
Krt74 T C 15: 101,756,794 noncoding transcript Het
Lama3 A G 18: 12,516,513 K1776E probably damaging Het
Lats1 T C 10: 7,712,948 S1110P probably benign Het
Lipo3 T A 19: 33,580,519 K158* probably null Het
Lrrc9 T A 12: 72,470,334 probably benign Het
Met A G 6: 17,563,727 probably benign Het
Mmp13 A G 9: 7,272,955 Y105C probably damaging Het
Mtus1 T C 8: 40,993,601 E1151G probably damaging Het
Nov T C 15: 54,747,934 V155A probably damaging Het
Nptx1 T C 11: 119,544,596 D298G possibly damaging Het
Pdlim1 T C 19: 40,243,466 N156S probably benign Het
Pdzk1 A G 3: 96,854,673 probably benign Het
Pex5 A G 6: 124,398,888 S448P probably benign Het
Polr3e G T 7: 120,930,963 R124L probably damaging Het
Ppp2r2c C T 5: 36,952,472 R392C probably damaging Het
Prpf4b T C 13: 34,889,571 I543T probably benign Het
Prr27 A G 5: 87,843,443 S305G possibly damaging Het
Repin1 A G 6: 48,596,473 H56R probably damaging Het
Ryr2 A T 13: 11,597,112 L408H probably damaging Het
Sbf2 T A 7: 110,461,141 Q205H probably damaging Het
Sgo2b G A 8: 63,926,829 P990S probably benign Het
Slc33a1 G T 3: 63,948,141 P361Q probably damaging Het
Tmem98 T C 11: 80,815,657 probably benign Het
Ttc25 C T 11: 100,569,902 T495M probably damaging Het
Vmn1r5 T A 6: 56,985,655 I105K probably damaging Het
Zfp473 A T 7: 44,738,038 probably benign Het
Other mutations in Vmn1r16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01350:Vmn1r16 APN 6 57322731 missense possibly damaging 0.74
IGL02804:Vmn1r16 APN 6 57323482 missense probably benign 0.18
IGL03329:Vmn1r16 APN 6 57323618 missense probably damaging 0.99
IGL03392:Vmn1r16 APN 6 57322894 missense probably damaging 1.00
I1329:Vmn1r16 UTSW 6 57323534 missense probably damaging 0.97
PIT4581001:Vmn1r16 UTSW 6 57322873 missense probably benign 0.12
R0750:Vmn1r16 UTSW 6 57322827 missense probably benign 0.00
R1137:Vmn1r16 UTSW 6 57323236 missense probably damaging 1.00
R1239:Vmn1r16 UTSW 6 57323633 start codon destroyed probably null 1.00
R1796:Vmn1r16 UTSW 6 57323271 missense probably benign 0.03
R1858:Vmn1r16 UTSW 6 57322899 missense probably damaging 1.00
R1895:Vmn1r16 UTSW 6 57322900 missense probably benign 0.31
R1946:Vmn1r16 UTSW 6 57322900 missense probably benign 0.31
R3832:Vmn1r16 UTSW 6 57323227 missense probably benign 0.00
R4801:Vmn1r16 UTSW 6 57323190 missense probably benign 0.03
R4802:Vmn1r16 UTSW 6 57323190 missense probably benign 0.03
R6658:Vmn1r16 UTSW 6 57323106 nonsense probably null
R6981:Vmn1r16 UTSW 6 57323488 missense probably benign 0.30
R6991:Vmn1r16 UTSW 6 57322884 nonsense probably null
X0061:Vmn1r16 UTSW 6 57323364 missense probably damaging 1.00
Posted On2014-05-07