Incidental Mutation 'IGL02027:Prr27'
ID |
184204 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Prr27
|
Ensembl Gene |
ENSMUSG00000002240 |
Gene Name |
proline rich 27 |
Synonyms |
4930432K09Rik |
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
IGL02027
|
Quality Score |
|
Status
|
|
Chromosome |
5 |
Chromosomal Location |
87973556-87994245 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 87991302 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Glycine
at position 305
(S305G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000098617
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000002310]
[ENSMUST00000101056]
|
AlphaFold |
Q3SYJ2 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000002310
AA Change: S297G
PolyPhen 2
Score 0.904 (Sensitivity: 0.82; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000002310 Gene: ENSMUSG00000002240 AA Change: S297G
Domain | Start | End | E-Value | Type |
low complexity region
|
49 |
57 |
N/A |
INTRINSIC |
low complexity region
|
104 |
130 |
N/A |
INTRINSIC |
low complexity region
|
137 |
153 |
N/A |
INTRINSIC |
low complexity region
|
179 |
194 |
N/A |
INTRINSIC |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000101056
AA Change: S305G
PolyPhen 2
Score 0.904 (Sensitivity: 0.82; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000098617 Gene: ENSMUSG00000002240 AA Change: S305G
Domain | Start | End | E-Value | Type |
low complexity region
|
57 |
65 |
N/A |
INTRINSIC |
low complexity region
|
112 |
138 |
N/A |
INTRINSIC |
low complexity region
|
145 |
161 |
N/A |
INTRINSIC |
low complexity region
|
187 |
202 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000197636
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 45 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adipor1 |
A |
G |
1: 134,358,923 (GRCm39) |
T312A |
probably benign |
Het |
Begain |
T |
G |
12: 109,000,235 (GRCm39) |
K384Q |
possibly damaging |
Het |
C2cd6 |
T |
C |
1: 59,099,763 (GRCm39) |
I393V |
probably benign |
Het |
Catsperz |
A |
G |
19: 6,902,664 (GRCm39) |
V5A |
probably benign |
Het |
Cbx1 |
T |
A |
11: 96,692,315 (GRCm39) |
F67L |
probably damaging |
Het |
Ccn2 |
A |
G |
10: 24,472,307 (GRCm39) |
S117G |
probably damaging |
Het |
Ccn3 |
T |
C |
15: 54,611,330 (GRCm39) |
V155A |
probably damaging |
Het |
Cerkl |
T |
C |
2: 79,171,630 (GRCm39) |
|
probably benign |
Het |
Cubn |
G |
T |
2: 13,292,405 (GRCm39) |
D3259E |
probably damaging |
Het |
Cyp2u1 |
A |
G |
3: 131,091,600 (GRCm39) |
Y307H |
probably damaging |
Het |
Dcaf6 |
A |
C |
1: 165,251,910 (GRCm39) |
D71E |
probably damaging |
Het |
Dclk3 |
A |
T |
9: 111,296,911 (GRCm39) |
K152* |
probably null |
Het |
Fcgbp |
G |
A |
7: 27,774,629 (GRCm39) |
D68N |
probably damaging |
Het |
Gm6576 |
A |
G |
15: 27,025,952 (GRCm39) |
|
noncoding transcript |
Het |
Has2 |
T |
C |
15: 56,531,567 (GRCm39) |
T383A |
probably damaging |
Het |
Htr1f |
T |
A |
16: 64,746,684 (GRCm39) |
K203* |
probably null |
Het |
Il36g |
A |
T |
2: 24,082,797 (GRCm39) |
I191L |
probably benign |
Het |
Iqgap3 |
T |
C |
3: 87,994,649 (GRCm39) |
I116T |
possibly damaging |
Het |
Itga1 |
C |
T |
13: 115,126,591 (GRCm39) |
|
probably null |
Het |
Kif5b |
T |
C |
18: 6,209,089 (GRCm39) |
D891G |
possibly damaging |
Het |
Krt74 |
T |
C |
15: 101,665,229 (GRCm39) |
|
noncoding transcript |
Het |
Lama3 |
A |
G |
18: 12,649,570 (GRCm39) |
K1776E |
probably damaging |
Het |
Lats1 |
T |
C |
10: 7,588,712 (GRCm39) |
S1110P |
probably benign |
Het |
Lipo3 |
T |
A |
19: 33,557,919 (GRCm39) |
K158* |
probably null |
Het |
Lrrc9 |
T |
A |
12: 72,517,108 (GRCm39) |
|
probably benign |
Het |
Met |
A |
G |
6: 17,563,726 (GRCm39) |
|
probably benign |
Het |
Mmp13 |
A |
G |
9: 7,272,955 (GRCm39) |
Y105C |
probably damaging |
Het |
Mtus1 |
T |
C |
8: 41,446,638 (GRCm39) |
E1151G |
probably damaging |
Het |
Nptx1 |
T |
C |
11: 119,435,422 (GRCm39) |
D298G |
possibly damaging |
Het |
Odad4 |
C |
T |
11: 100,460,728 (GRCm39) |
T495M |
probably damaging |
Het |
Pdlim1 |
T |
C |
19: 40,231,910 (GRCm39) |
N156S |
probably benign |
Het |
Pdzk1 |
A |
G |
3: 96,761,989 (GRCm39) |
|
probably benign |
Het |
Pex5 |
A |
G |
6: 124,375,847 (GRCm39) |
S448P |
probably benign |
Het |
Polr3e |
G |
T |
7: 120,530,186 (GRCm39) |
R124L |
probably damaging |
Het |
Ppp2r2c |
C |
T |
5: 37,109,816 (GRCm39) |
R392C |
probably damaging |
Het |
Prpf4b |
T |
C |
13: 35,073,554 (GRCm39) |
I543T |
probably benign |
Het |
Repin1 |
A |
G |
6: 48,573,407 (GRCm39) |
H56R |
probably damaging |
Het |
Ryr2 |
A |
T |
13: 11,611,998 (GRCm39) |
L408H |
probably damaging |
Het |
Sbf2 |
T |
A |
7: 110,060,348 (GRCm39) |
Q205H |
probably damaging |
Het |
Sgo2b |
G |
A |
8: 64,379,863 (GRCm39) |
P990S |
probably benign |
Het |
Slc33a1 |
G |
T |
3: 63,855,562 (GRCm39) |
P361Q |
probably damaging |
Het |
Tmem98 |
T |
C |
11: 80,706,483 (GRCm39) |
|
probably benign |
Het |
Vmn1r16 |
T |
C |
6: 57,300,044 (GRCm39) |
T193A |
possibly damaging |
Het |
Vmn1r5 |
T |
A |
6: 56,962,640 (GRCm39) |
I105K |
probably damaging |
Het |
Zfp473 |
A |
T |
7: 44,387,462 (GRCm39) |
|
probably benign |
Het |
|
Other mutations in Prr27 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02617:Prr27
|
APN |
5 |
87,990,518 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02995:Prr27
|
APN |
5 |
87,990,675 (GRCm39) |
missense |
probably benign |
|
IGL03270:Prr27
|
APN |
5 |
87,983,537 (GRCm39) |
utr 5 prime |
probably benign |
|
R0531:Prr27
|
UTSW |
5 |
87,990,537 (GRCm39) |
missense |
probably benign |
0.02 |
R0637:Prr27
|
UTSW |
5 |
87,999,005 (GRCm39) |
unclassified |
probably benign |
|
R1498:Prr27
|
UTSW |
5 |
87,998,600 (GRCm39) |
unclassified |
probably benign |
|
R1599:Prr27
|
UTSW |
5 |
87,991,084 (GRCm39) |
missense |
probably benign |
0.00 |
R1744:Prr27
|
UTSW |
5 |
87,990,906 (GRCm39) |
missense |
possibly damaging |
0.46 |
R1980:Prr27
|
UTSW |
5 |
87,991,261 (GRCm39) |
missense |
probably benign |
0.03 |
R4033:Prr27
|
UTSW |
5 |
87,991,164 (GRCm39) |
nonsense |
probably null |
|
R4304:Prr27
|
UTSW |
5 |
87,990,766 (GRCm39) |
missense |
probably benign |
0.00 |
R4306:Prr27
|
UTSW |
5 |
87,990,766 (GRCm39) |
missense |
probably benign |
0.00 |
R4307:Prr27
|
UTSW |
5 |
87,990,766 (GRCm39) |
missense |
probably benign |
0.00 |
R4308:Prr27
|
UTSW |
5 |
87,990,766 (GRCm39) |
missense |
probably benign |
0.00 |
R4347:Prr27
|
UTSW |
5 |
87,990,531 (GRCm39) |
missense |
possibly damaging |
0.46 |
R4675:Prr27
|
UTSW |
5 |
87,991,100 (GRCm39) |
missense |
possibly damaging |
0.94 |
R4826:Prr27
|
UTSW |
5 |
87,998,825 (GRCm39) |
unclassified |
probably benign |
|
R4908:Prr27
|
UTSW |
5 |
87,990,888 (GRCm39) |
missense |
probably benign |
0.01 |
R5361:Prr27
|
UTSW |
5 |
87,991,203 (GRCm39) |
missense |
probably damaging |
0.96 |
R5426:Prr27
|
UTSW |
5 |
87,998,744 (GRCm39) |
unclassified |
probably benign |
|
R7268:Prr27
|
UTSW |
5 |
87,991,135 (GRCm39) |
missense |
probably damaging |
0.99 |
R7785:Prr27
|
UTSW |
5 |
87,991,131 (GRCm39) |
missense |
probably benign |
|
R8087:Prr27
|
UTSW |
5 |
87,994,168 (GRCm39) |
missense |
probably benign |
0.00 |
R8250:Prr27
|
UTSW |
5 |
87,990,556 (GRCm39) |
missense |
possibly damaging |
0.89 |
R8270:Prr27
|
UTSW |
5 |
87,994,171 (GRCm39) |
missense |
possibly damaging |
0.82 |
R8375:Prr27
|
UTSW |
5 |
87,990,710 (GRCm39) |
nonsense |
probably null |
|
R9070:Prr27
|
UTSW |
5 |
87,990,994 (GRCm39) |
missense |
probably benign |
|
R9071:Prr27
|
UTSW |
5 |
87,990,994 (GRCm39) |
missense |
probably benign |
|
R9101:Prr27
|
UTSW |
5 |
87,991,330 (GRCm39) |
missense |
probably damaging |
0.99 |
R9186:Prr27
|
UTSW |
5 |
87,990,994 (GRCm39) |
missense |
probably benign |
|
R9188:Prr27
|
UTSW |
5 |
87,990,994 (GRCm39) |
missense |
probably benign |
|
R9189:Prr27
|
UTSW |
5 |
87,990,994 (GRCm39) |
missense |
probably benign |
|
R9318:Prr27
|
UTSW |
5 |
87,990,994 (GRCm39) |
missense |
probably benign |
|
R9367:Prr27
|
UTSW |
5 |
87,990,994 (GRCm39) |
missense |
probably benign |
|
R9590:Prr27
|
UTSW |
5 |
87,990,994 (GRCm39) |
missense |
probably benign |
|
R9592:Prr27
|
UTSW |
5 |
87,990,994 (GRCm39) |
missense |
probably benign |
|
R9593:Prr27
|
UTSW |
5 |
87,990,994 (GRCm39) |
missense |
probably benign |
|
R9760:Prr27
|
UTSW |
5 |
87,990,994 (GRCm39) |
missense |
probably benign |
|
R9762:Prr27
|
UTSW |
5 |
87,990,994 (GRCm39) |
missense |
probably benign |
|
Z1088:Prr27
|
UTSW |
5 |
87,990,505 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Posted On |
2014-05-07 |