Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02027:Sgo2b'

184230

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Sgo2b

Ensembl Gene

ENSMUSG00000094443

Gene Name

shugoshin 2B

Synonyms

Gm4975, Sgol2b

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

IGL02027

Quality Score

Status

Chromosome

Chromosomal Location

64377728-64405204 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 64379863 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Proline to Serine at position 990 (P990S)

Ref Sequence

ENSEMBL: ENSMUSP00000136323 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000179944]

AlphaFold

J3QMK1

Predicted Effect

probably benign
Transcript: ENSMUST00000179944
AA Change: P990S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000136323
Gene: ENSMUSG00000094443
AA Change: P990S

Domain	Start	End	E-Value	Type
coiled coil region	54	113	N/A	INTRINSIC
low complexity region	122	135	N/A	INTRINSIC
low complexity region	163	172	N/A	INTRINSIC
low complexity region	400	414	N/A	INTRINSIC
internal_repeat_1	528	618	9.12e-8	PROSPERO
internal_repeat_1	713	809	9.12e-8	PROSPERO
low complexity region	1009	1024	N/A	INTRINSIC
low complexity region	1059	1081	N/A	INTRINSIC
low complexity region	1112	1126	N/A	INTRINSIC
low complexity region	1130	1148	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000210915

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adipor1	A	G	1: 134,358,923 (GRCm39)	T312A	probably benign	Het
Begain	T	G	12: 109,000,235 (GRCm39)	K384Q	possibly damaging	Het
C2cd6	T	C	1: 59,099,763 (GRCm39)	I393V	probably benign	Het
Catsperz	A	G	19: 6,902,664 (GRCm39)	V5A	probably benign	Het
Cbx1	T	A	11: 96,692,315 (GRCm39)	F67L	probably damaging	Het
Ccn2	A	G	10: 24,472,307 (GRCm39)	S117G	probably damaging	Het
Ccn3	T	C	15: 54,611,330 (GRCm39)	V155A	probably damaging	Het
Cerkl	T	C	2: 79,171,630 (GRCm39)		probably benign	Het
Cubn	G	T	2: 13,292,405 (GRCm39)	D3259E	probably damaging	Het
Cyp2u1	A	G	3: 131,091,600 (GRCm39)	Y307H	probably damaging	Het
Dcaf6	A	C	1: 165,251,910 (GRCm39)	D71E	probably damaging	Het
Dclk3	A	T	9: 111,296,911 (GRCm39)	K152*	probably null	Het
Fcgbp	G	A	7: 27,774,629 (GRCm39)	D68N	probably damaging	Het
Gm6576	A	G	15: 27,025,952 (GRCm39)		noncoding transcript	Het
Has2	T	C	15: 56,531,567 (GRCm39)	T383A	probably damaging	Het
Htr1f	T	A	16: 64,746,684 (GRCm39)	K203*	probably null	Het
Il36g	A	T	2: 24,082,797 (GRCm39)	I191L	probably benign	Het
Iqgap3	T	C	3: 87,994,649 (GRCm39)	I116T	possibly damaging	Het
Itga1	C	T	13: 115,126,591 (GRCm39)		probably null	Het
Kif5b	T	C	18: 6,209,089 (GRCm39)	D891G	possibly damaging	Het
Krt74	T	C	15: 101,665,229 (GRCm39)		noncoding transcript	Het
Lama3	A	G	18: 12,649,570 (GRCm39)	K1776E	probably damaging	Het
Lats1	T	C	10: 7,588,712 (GRCm39)	S1110P	probably benign	Het
Lipo3	T	A	19: 33,557,919 (GRCm39)	K158*	probably null	Het
Lrrc9	T	A	12: 72,517,108 (GRCm39)		probably benign	Het
Met	A	G	6: 17,563,726 (GRCm39)		probably benign	Het
Mmp13	A	G	9: 7,272,955 (GRCm39)	Y105C	probably damaging	Het
Mtus1	T	C	8: 41,446,638 (GRCm39)	E1151G	probably damaging	Het
Nptx1	T	C	11: 119,435,422 (GRCm39)	D298G	possibly damaging	Het
Odad4	C	T	11: 100,460,728 (GRCm39)	T495M	probably damaging	Het
Pdlim1	T	C	19: 40,231,910 (GRCm39)	N156S	probably benign	Het
Pdzk1	A	G	3: 96,761,989 (GRCm39)		probably benign	Het
Pex5	A	G	6: 124,375,847 (GRCm39)	S448P	probably benign	Het
Polr3e	G	T	7: 120,530,186 (GRCm39)	R124L	probably damaging	Het
Ppp2r2c	C	T	5: 37,109,816 (GRCm39)	R392C	probably damaging	Het
Prpf4b	T	C	13: 35,073,554 (GRCm39)	I543T	probably benign	Het
Prr27	A	G	5: 87,991,302 (GRCm39)	S305G	possibly damaging	Het
Repin1	A	G	6: 48,573,407 (GRCm39)	H56R	probably damaging	Het
Ryr2	A	T	13: 11,611,998 (GRCm39)	L408H	probably damaging	Het
Sbf2	T	A	7: 110,060,348 (GRCm39)	Q205H	probably damaging	Het
Slc33a1	G	T	3: 63,855,562 (GRCm39)	P361Q	probably damaging	Het
Tmem98	T	C	11: 80,706,483 (GRCm39)		probably benign	Het
Vmn1r16	T	C	6: 57,300,044 (GRCm39)	T193A	possibly damaging	Het
Vmn1r5	T	A	6: 56,962,640 (GRCm39)	I105K	probably damaging	Het
Zfp473	A	T	7: 44,387,462 (GRCm39)		probably benign	Het

Other mutations in Sgo2b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01017:Sgo2b	APN	8	64,379,557 (GRCm39)	missense	probably benign
IGL01343:Sgo2b	APN	8	64,380,349 (GRCm39)	nonsense	probably null
IGL02090:Sgo2b	APN	8	64,380,123 (GRCm39)	missense	probably damaging	0.99
IGL02121:Sgo2b	APN	8	64,384,316 (GRCm39)	missense	possibly damaging	0.94
IGL02206:Sgo2b	APN	8	64,394,118 (GRCm39)	missense	possibly damaging	0.94
IGL02554:Sgo2b	APN	8	64,379,571 (GRCm39)	missense	probably damaging	0.96
IGL02663:Sgo2b	APN	8	64,396,148 (GRCm39)	missense	probably damaging	0.97
IGL03149:Sgo2b	APN	8	64,379,617 (GRCm39)	missense	probably benign	0.14
floater	UTSW	8	64,391,451 (GRCm39)	nonsense	probably null
R0164:Sgo2b	UTSW	8	64,391,417 (GRCm39)	missense	possibly damaging	0.92
R0164:Sgo2b	UTSW	8	64,391,417 (GRCm39)	missense	possibly damaging	0.92
R0201:Sgo2b	UTSW	8	64,379,670 (GRCm39)	missense	probably benign
R0285:Sgo2b	UTSW	8	64,381,823 (GRCm39)	nonsense	probably null
R0325:Sgo2b	UTSW	8	64,381,410 (GRCm39)	missense	probably benign	0.20
R0727:Sgo2b	UTSW	8	64,380,816 (GRCm39)	missense	probably damaging	0.98
R0943:Sgo2b	UTSW	8	64,384,369 (GRCm39)	missense	possibly damaging	0.82
R1148:Sgo2b	UTSW	8	64,379,889 (GRCm39)	missense	probably damaging	0.99
R1266:Sgo2b	UTSW	8	64,381,455 (GRCm39)	missense	probably benign	0.00
R1484:Sgo2b	UTSW	8	64,384,507 (GRCm39)	missense	possibly damaging	0.77
R1493:Sgo2b	UTSW	8	64,379,889 (GRCm39)	missense	probably damaging	0.99
R1537:Sgo2b	UTSW	8	64,379,536 (GRCm39)	missense	possibly damaging	0.94
R1630:Sgo2b	UTSW	8	64,380,831 (GRCm39)	missense	possibly damaging	0.90
R1803:Sgo2b	UTSW	8	64,380,426 (GRCm39)	missense	probably benign	0.01
R1912:Sgo2b	UTSW	8	64,384,503 (GRCm39)	missense	probably damaging	0.98
R1993:Sgo2b	UTSW	8	64,379,867 (GRCm39)	missense	probably benign	0.36
R2042:Sgo2b	UTSW	8	64,381,561 (GRCm39)	missense	probably benign
R2130:Sgo2b	UTSW	8	64,380,181 (GRCm39)	missense	probably benign	0.09
R2146:Sgo2b	UTSW	8	64,381,057 (GRCm39)	missense	probably benign	0.00
R2881:Sgo2b	UTSW	8	64,380,570 (GRCm39)	missense	probably damaging	0.99
R3686:Sgo2b	UTSW	8	64,384,361 (GRCm39)	missense	probably benign	0.20
R3706:Sgo2b	UTSW	8	64,381,179 (GRCm39)	missense	probably damaging	0.98
R3889:Sgo2b	UTSW	8	64,380,777 (GRCm39)	missense	possibly damaging	0.82
R3894:Sgo2b	UTSW	8	64,381,767 (GRCm39)	missense	possibly damaging	0.91
R3895:Sgo2b	UTSW	8	64,381,767 (GRCm39)	missense	possibly damaging	0.91
R4058:Sgo2b	UTSW	8	64,379,981 (GRCm39)	missense	probably damaging	0.98
R4259:Sgo2b	UTSW	8	64,381,330 (GRCm39)	missense	probably benign	0.06
R4260:Sgo2b	UTSW	8	64,381,330 (GRCm39)	missense	probably benign	0.06
R4704:Sgo2b	UTSW	8	64,380,824 (GRCm39)	missense	probably damaging	0.98
R4815:Sgo2b	UTSW	8	64,384,448 (GRCm39)	missense	probably benign
R4922:Sgo2b	UTSW	8	64,379,664 (GRCm39)	missense	possibly damaging	0.66
R5232:Sgo2b	UTSW	8	64,381,636 (GRCm39)	missense	possibly damaging	0.55
R5262:Sgo2b	UTSW	8	64,396,171 (GRCm39)	missense	probably damaging	0.99
R5444:Sgo2b	UTSW	8	64,379,590 (GRCm39)	missense	possibly damaging	0.90
R5677:Sgo2b	UTSW	8	64,380,008 (GRCm39)	missense	possibly damaging	0.77
R5959:Sgo2b	UTSW	8	64,380,322 (GRCm39)	missense	probably benign	0.01
R6004:Sgo2b	UTSW	8	64,379,707 (GRCm39)	nonsense	probably null
R6267:Sgo2b	UTSW	8	64,380,827 (GRCm39)	missense	probably benign
R6296:Sgo2b	UTSW	8	64,380,827 (GRCm39)	missense	probably benign
R6328:Sgo2b	UTSW	8	64,381,345 (GRCm39)	nonsense	probably null
R6517:Sgo2b	UTSW	8	64,384,528 (GRCm39)	missense	probably damaging	0.99
R6523:Sgo2b	UTSW	8	64,380,538 (GRCm39)	missense	probably benign	0.11
R6726:Sgo2b	UTSW	8	64,380,769 (GRCm39)	nonsense	probably null
R6957:Sgo2b	UTSW	8	64,384,489 (GRCm39)	small deletion	probably benign
R7031:Sgo2b	UTSW	8	64,393,078 (GRCm39)	missense	possibly damaging	0.94
R7034:Sgo2b	UTSW	8	64,379,868 (GRCm39)	missense	probably benign	0.36
R7145:Sgo2b	UTSW	8	64,381,218 (GRCm39)	missense	probably damaging	1.00
R7289:Sgo2b	UTSW	8	64,394,192 (GRCm39)	missense	probably damaging	0.97
R7366:Sgo2b	UTSW	8	64,391,451 (GRCm39)	nonsense	probably null
R7660:Sgo2b	UTSW	8	64,393,108 (GRCm39)	missense	probably benign	0.27
R7761:Sgo2b	UTSW	8	64,379,946 (GRCm39)	missense	probably benign
R7762:Sgo2b	UTSW	8	64,379,531 (GRCm39)	missense	probably benign	0.03
R7822:Sgo2b	UTSW	8	64,380,318 (GRCm39)	missense	probably damaging	0.98
R8111:Sgo2b	UTSW	8	64,396,138 (GRCm39)	missense	probably damaging	0.98
R8129:Sgo2b	UTSW	8	64,381,834 (GRCm39)	missense	possibly damaging	0.90
R8273:Sgo2b	UTSW	8	64,377,735 (GRCm39)	missense	unknown
R8856:Sgo2b	UTSW	8	64,393,091 (GRCm39)	missense	probably null	0.99
R9249:Sgo2b	UTSW	8	64,391,407 (GRCm39)	nonsense	probably null
R9428:Sgo2b	UTSW	8	64,393,067 (GRCm39)	missense	probably damaging	0.99
R9616:Sgo2b	UTSW	8	64,380,274 (GRCm39)	missense	probably benign
R9621:Sgo2b	UTSW	8	64,380,651 (GRCm39)	missense	probably damaging	0.99
RF014:Sgo2b	UTSW	8	64,384,439 (GRCm39)	missense	possibly damaging	0.94
RF055:Sgo2b	UTSW	8	64,396,203 (GRCm39)	missense	probably damaging	1.00
Z1088:Sgo2b	UTSW	8	64,381,456 (GRCm39)	missense	possibly damaging	0.61
Z1088:Sgo2b	UTSW	8	64,380,039 (GRCm39)	missense	probably damaging	1.00
Z1177:Sgo2b	UTSW	8	64,381,419 (GRCm39)	missense	possibly damaging	0.82
Z1177:Sgo2b	UTSW	8	64,380,473 (GRCm39)	missense	probably benign	0.03

Posted On

2014-05-07