Incidental Mutation 'IGL02032:Olfr362'
ID184396
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr362
Ensembl Gene ENSMUSG00000075377
Gene Nameolfactory receptor 362
SynonymsMOR158-1, GA_x6K02T2NLDC-33797415-33796462
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.107) question?
Stock #IGL02032
Quality Score
Status
Chromosome2
Chromosomal Location37101706-37117910 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 37104761 bp
ZygosityHeterozygous
Amino Acid Change Serine to Arginine at position 296 (S296R)
Ref Sequence ENSEMBL: ENSMUSP00000150819 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100144] [ENSMUST00000213817] [ENSMUST00000215927]
Predicted Effect probably damaging
Transcript: ENSMUST00000100144
AA Change: S296R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097722
Gene: ENSMUSG00000075377
AA Change: S296R

DomainStartEndE-ValueType
Pfam:7tm_4 32 313 6.3e-50 PFAM
Pfam:7TM_GPCR_Srsx 36 164 1.6e-7 PFAM
Pfam:7tm_1 42 295 1.3e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000119049
Predicted Effect probably damaging
Transcript: ENSMUST00000213817
AA Change: S296R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000215927
AA Change: S296R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arap2 T A 5: 62,670,997 I944F probably damaging Het
Arhgef1 A G 7: 24,923,371 K614R probably benign Het
Cep170b T C 12: 112,737,333 probably null Het
Cps1 A T 1: 67,230,315 Y1491F probably benign Het
Dennd2d T C 3: 106,491,227 I176T probably damaging Het
Dnah1 T C 14: 31,274,369 Y2670C probably benign Het
Dock8 A T 19: 25,130,405 H833L probably damaging Het
Ell G A 8: 70,586,001 A463T probably benign Het
Emsy G T 7: 98,590,780 D1089E possibly damaging Het
Erc1 T G 6: 119,630,609 K677N probably damaging Het
Exd1 T G 2: 119,533,467 Q140P probably damaging Het
Fam114a1 T A 5: 65,015,371 V284E probably benign Het
Fbxo36 A G 1: 84,896,666 probably benign Het
Fig4 A T 10: 41,303,006 V16E probably benign Het
Gm4778 T C 3: 94,266,333 V212A probably damaging Het
Gm4788 G A 1: 139,774,546 P67S probably damaging Het
H2-M1 A T 17: 36,671,876 Y31N probably damaging Het
Lrp5 A G 19: 3,615,886 probably benign Het
Nol8 A G 13: 49,672,772 T1023A probably benign Het
Pygm A T 19: 6,388,087 T141S probably benign Het
Soat1 A G 1: 156,440,575 I254T probably benign Het
Stat5a A T 11: 100,861,828 D79V probably damaging Het
Ttn G T 2: 76,944,088 T2158N probably damaging Het
Usp29 A G 7: 6,962,018 K287E probably benign Het
Vav1 A T 17: 57,297,090 E164V possibly damaging Het
Vmn2r3 T A 3: 64,275,055 T408S possibly damaging Het
Vmn2r61 A T 7: 42,300,042 I629F probably damaging Het
Other mutations in Olfr362
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02141:Olfr362 APN 2 37105425 missense probably benign 0.00
IGL02444:Olfr362 APN 2 37104774 missense probably damaging 0.99
IGL02453:Olfr362 APN 2 37105197 missense probably benign 0.22
R0699:Olfr362 UTSW 2 37105062 missense possibly damaging 0.92
R1053:Olfr362 UTSW 2 37105464 missense probably damaging 1.00
R1387:Olfr362 UTSW 2 37104868 missense probably benign 0.24
R4914:Olfr362 UTSW 2 37105158 missense possibly damaging 0.67
R4918:Olfr362 UTSW 2 37105158 missense possibly damaging 0.67
R5009:Olfr362 UTSW 2 37105455 missense possibly damaging 0.92
R5114:Olfr362 UTSW 2 37104802 missense probably damaging 1.00
R5301:Olfr362 UTSW 2 37105198 missense probably benign 0.01
Posted On2014-05-07