Incidental Mutation 'IGL02034:Or10p22'
ID 184464
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10p22
Ensembl Gene ENSMUSG00000069430
Gene Name olfactory receptor family 10 subfamily P member 22
Synonyms GA_x6K02T2PULF-10675610-10676548, Olfr9, MOR269-3
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # IGL02034
Quality Score
Status
Chromosome 10
Chromosomal Location 128825543-128826769 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 128826570 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 263 (Q263L)
Ref Sequence ENSEMBL: ENSMUSP00000089622 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091996]
AlphaFold Q60885
Predicted Effect probably benign
Transcript: ENSMUST00000091996
AA Change: Q263L

PolyPhen 2 Score 0.195 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000089622
Gene: ENSMUSG00000069430
AA Change: Q263L

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2.6e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 305 6.9e-10 PFAM
Pfam:7tm_1 41 290 7.3e-15 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bcor A G X: 11,905,498 (GRCm39) S1556P possibly damaging Het
Brd10 A G 19: 29,694,259 (GRCm39) S1745P possibly damaging Het
Ccdc6 T A 10: 70,004,978 (GRCm39) I241N probably benign Het
Cd81 T C 7: 142,619,986 (GRCm39) I48T probably damaging Het
Cfap52 A G 11: 67,837,118 (GRCm39) probably null Het
Cfap54 T C 10: 92,897,347 (GRCm39) M264V probably damaging Het
Cmya5 G A 13: 93,221,043 (GRCm39) probably benign Het
Csn2 A G 5: 87,843,941 (GRCm39) probably benign Het
Cyfip1 G A 7: 55,548,101 (GRCm39) R567Q probably damaging Het
Ehbp1 A G 11: 22,235,486 (GRCm39) probably null Het
Ermp1 G A 19: 29,623,359 (GRCm39) probably benign Het
Erv3 C T 2: 131,697,934 (GRCm39) V142I possibly damaging Het
Fzd2 A G 11: 102,495,730 (GRCm39) N58S probably damaging Het
Gcm2 G A 13: 41,259,269 (GRCm39) R67C probably damaging Het
Gm17019 A G 5: 15,080,266 (GRCm39) I182T possibly damaging Het
Gpr45 T C 1: 43,072,478 (GRCm39) *374Q probably null Het
Haus8 T C 8: 71,708,202 (GRCm39) N165S probably damaging Het
Hoxd4 T A 2: 74,558,750 (GRCm39) L191Q probably damaging Het
I830077J02Rik A G 3: 105,834,565 (GRCm39) probably benign Het
Lpl T C 8: 69,333,424 (GRCm39) L7P possibly damaging Het
Lrp1b T A 2: 41,158,382 (GRCm39) K1612* probably null Het
Myh14 G T 7: 44,265,717 (GRCm39) A1546D possibly damaging Het
Nbea A G 3: 55,875,577 (GRCm39) S1698P probably damaging Het
Or4c112 C T 2: 88,854,015 (GRCm39) V111M probably benign Het
Or52e7 C A 7: 104,684,597 (GRCm39) T64N probably benign Het
Or5p51 G A 7: 107,444,385 (GRCm39) T185I probably benign Het
Otog A T 7: 45,945,417 (GRCm39) K40* probably null Het
Rgma C A 7: 73,067,181 (GRCm39) H145Q probably damaging Het
Rpgrip1l A T 8: 91,977,776 (GRCm39) probably null Het
Ssxb2 T A X: 8,324,743 (GRCm39) probably benign Het
Tmem175 C T 5: 108,790,002 (GRCm39) T118I probably damaging Het
Wdhd1 A G 14: 47,498,808 (GRCm39) V542A probably benign Het
Zfp977 G A 7: 42,230,136 (GRCm39) P130S probably damaging Het
Other mutations in Or10p22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02934:Or10p22 APN 10 128,825,958 (GRCm39) missense probably damaging 1.00
R0180:Or10p22 UTSW 10 128,826,703 (GRCm39) missense possibly damaging 0.87
R1716:Or10p22 UTSW 10 128,826,721 (GRCm39) makesense probably null
R5066:Or10p22 UTSW 10 128,826,660 (GRCm39) missense probably damaging 1.00
R5337:Or10p22 UTSW 10 128,826,548 (GRCm39) missense probably benign 0.03
R5980:Or10p22 UTSW 10 128,826,309 (GRCm39) missense probably damaging 0.98
R6815:Or10p22 UTSW 10 128,826,191 (GRCm39) missense probably benign 0.17
R6924:Or10p22 UTSW 10 128,825,960 (GRCm39) missense probably damaging 1.00
R8297:Or10p22 UTSW 10 128,826,708 (GRCm39) missense possibly damaging 0.87
R8312:Or10p22 UTSW 10 128,826,347 (GRCm39) missense probably benign 0.30
R8928:Or10p22 UTSW 10 128,826,317 (GRCm39) missense probably damaging 1.00
Posted On 2014-05-07