Incidental Mutation 'R0054:Or5ac23'
ID 18450
Institutional Source Beutler Lab
Gene Symbol Or5ac23
Ensembl Gene ENSMUSG00000094422
Gene Name olfactory receptor family 5 subfamily AC member 23
Synonyms Olfr205, MOR182-11P, GA_x54KRFPKG5P-55543875-55542958
MMRRC Submission 038348-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.099) question?
Stock # R0054 (G1)
Quality Score
Status Validated
Chromosome 16
Chromosomal Location 59148953-59149870 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 59149428 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 148 (Y148C)
Ref Sequence ENSEMBL: ENSMUSP00000149415 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074125] [ENSMUST00000213910]
AlphaFold Q7TS37
Predicted Effect possibly damaging
Transcript: ENSMUST00000074125
AA Change: Y148C

PolyPhen 2 Score 0.566 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000073762
Gene: ENSMUSG00000094422
AA Change: Y148C

DomainStartEndE-ValueType
Pfam:7tm_4 30 305 1.6e-49 PFAM
Pfam:7TM_GPCR_Srsx 34 302 1.6e-7 PFAM
Pfam:7tm_1 40 289 7.8e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213910
AA Change: Y148C

PolyPhen 2 Score 0.566 (Sensitivity: 0.88; Specificity: 0.91)
Meta Mutation Damage Score 0.2605 question?
Coding Region Coverage
  • 1x: 88.8%
  • 3x: 85.6%
  • 10x: 76.3%
  • 20x: 59.9%
Validation Efficiency 96% (91/95)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc9 A G 6: 142,547,500 (GRCm39) probably null Het
Apoa4 A G 9: 46,153,822 (GRCm39) D141G probably benign Het
Atg9a T C 1: 75,161,143 (GRCm39) Y701C probably damaging Het
Baz2b C T 2: 59,762,510 (GRCm39) R922Q probably damaging Het
Bmal2 T G 6: 146,731,216 (GRCm39) V507G probably benign Het
Brms1 T A 19: 5,096,727 (GRCm39) C136* probably null Het
Ccdc180 T A 4: 45,890,900 (GRCm39) V24E probably benign Het
Clec4f C T 6: 83,629,911 (GRCm39) V216M probably benign Het
Cpd C G 11: 76,681,664 (GRCm39) G1160R probably damaging Het
Creb5 A G 6: 53,424,642 (GRCm39) M128V probably benign Het
Ddb2 G T 2: 91,065,165 (GRCm39) Q87K probably benign Het
Defb41 A G 1: 18,321,471 (GRCm39) Y48H probably damaging Het
Dido1 T C 2: 180,303,267 (GRCm39) N1546D probably benign Het
Dmac1 A G 4: 75,196,337 (GRCm39) V51A possibly damaging Het
Dnajb11 C T 16: 22,681,369 (GRCm39) A49V probably damaging Het
Dnajc14 G A 10: 128,643,448 (GRCm39) D457N probably damaging Het
Eif3a C A 19: 60,755,264 (GRCm39) D973Y unknown Het
Farsb T A 1: 78,439,011 (GRCm39) K395* probably null Het
Fem1b A G 9: 62,704,082 (GRCm39) S393P probably damaging Het
Fsip2 A C 2: 82,817,299 (GRCm39) N4344T possibly damaging Het
Gphn A G 12: 78,684,277 (GRCm39) S558G probably damaging Het
Gpr142 C A 11: 114,689,755 (GRCm39) H2Q probably benign Het
Grhpr T C 4: 44,988,915 (GRCm39) probably benign Het
Grik3 C A 4: 125,517,368 (GRCm39) N70K probably damaging Het
Gsap T A 5: 21,455,933 (GRCm39) probably benign Het
Iars1 T A 13: 49,846,611 (GRCm39) C237S probably damaging Het
Ighv1-9 A T 12: 114,547,602 (GRCm39) F7L probably benign Het
Ints8 A G 4: 11,204,595 (GRCm39) probably benign Het
Kcnj16 G T 11: 110,915,549 (GRCm39) W70C probably damaging Het
Kpna6 T C 4: 129,551,251 (GRCm39) M85V probably benign Het
Kri1 G A 9: 21,186,661 (GRCm39) S447L probably damaging Het
Lrp1b A G 2: 40,632,829 (GRCm39) V3528A probably benign Het
Lrrc46 A T 11: 96,929,605 (GRCm39) L77Q probably damaging Het
Mrpl44 T C 1: 79,757,212 (GRCm39) L219S probably damaging Het
Ms4a14 T C 19: 11,281,303 (GRCm39) I418M probably benign Het
Myo7a T C 7: 97,714,905 (GRCm39) D112G probably damaging Het
Ncoa3 A G 2: 165,897,098 (GRCm39) T630A possibly damaging Het
Nsl1 T C 1: 190,814,381 (GRCm39) L194P probably damaging Het
Or8u10 T C 2: 85,915,705 (GRCm39) K139E probably benign Het
Pde4d A G 13: 109,876,955 (GRCm39) S159G probably benign Het
Pi4ka T C 16: 17,142,978 (GRCm39) R845G probably null Het
Pld1 A G 3: 28,150,033 (GRCm39) probably benign Het
Psd T A 19: 46,311,781 (GRCm39) I300F probably damaging Het
Ptprz1 T A 6: 22,986,195 (GRCm39) W332R probably damaging Het
Rnf212 T A 5: 108,893,530 (GRCm39) M70L possibly damaging Het
Sema4f A G 6: 82,896,674 (GRCm39) probably benign Het
Sez6 C A 11: 77,844,699 (GRCm39) T7K possibly damaging Het
Skint2 T C 4: 112,502,660 (GRCm39) I290T probably benign Het
Slc5a3 T A 16: 91,874,522 (GRCm39) I193N probably damaging Het
Snip1 T A 4: 124,966,633 (GRCm39) Y354* probably null Het
Tmco5 A G 2: 116,717,768 (GRCm39) Y200C probably damaging Het
Tmem87b T A 2: 128,673,361 (GRCm39) probably benign Het
Trim60 T C 8: 65,453,973 (GRCm39) E92G probably benign Het
Ttn A T 2: 76,626,804 (GRCm39) D13067E possibly damaging Het
Ufl1 A T 4: 25,269,087 (GRCm39) I168N probably damaging Het
Zfp385c G A 11: 100,520,782 (GRCm39) P293S probably benign Het
Zfp473 T A 7: 44,383,899 (GRCm39) S144C probably damaging Het
Other mutations in Or5ac23
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02475:Or5ac23 APN 16 59,149,088 (GRCm39) missense probably benign 0.21
IGL03236:Or5ac23 APN 16 59,149,200 (GRCm39) missense probably damaging 0.97
R0054:Or5ac23 UTSW 16 59,149,428 (GRCm39) missense possibly damaging 0.57
R0167:Or5ac23 UTSW 16 59,149,337 (GRCm39) nonsense probably null
R0178:Or5ac23 UTSW 16 59,149,783 (GRCm39) missense probably damaging 1.00
R0371:Or5ac23 UTSW 16 59,149,585 (GRCm39) missense possibly damaging 0.60
R0577:Or5ac23 UTSW 16 59,149,061 (GRCm39) missense probably benign 0.01
R0597:Or5ac23 UTSW 16 59,149,123 (GRCm39) missense probably damaging 1.00
R0967:Or5ac23 UTSW 16 59,149,546 (GRCm39) missense possibly damaging 0.66
R1670:Or5ac23 UTSW 16 59,149,607 (GRCm39) missense probably benign 0.03
R1702:Or5ac23 UTSW 16 59,149,504 (GRCm39) missense probably benign 0.12
R1995:Or5ac23 UTSW 16 59,149,654 (GRCm39) missense probably damaging 1.00
R2239:Or5ac23 UTSW 16 59,149,738 (GRCm39) missense probably damaging 0.99
R4063:Or5ac23 UTSW 16 59,149,243 (GRCm39) missense probably benign 0.05
R4400:Or5ac23 UTSW 16 59,148,961 (GRCm39) missense probably benign
R4666:Or5ac23 UTSW 16 59,149,573 (GRCm39) missense possibly damaging 0.91
R4795:Or5ac23 UTSW 16 59,149,213 (GRCm39) missense probably benign 0.09
R5327:Or5ac23 UTSW 16 59,149,461 (GRCm39) missense probably benign 0.01
R5471:Or5ac23 UTSW 16 59,148,994 (GRCm39) missense probably damaging 1.00
R5770:Or5ac23 UTSW 16 59,149,514 (GRCm39) nonsense probably null
R6195:Or5ac23 UTSW 16 59,149,785 (GRCm39) missense possibly damaging 0.81
R6702:Or5ac23 UTSW 16 59,148,961 (GRCm39) missense probably benign
R7686:Or5ac23 UTSW 16 59,149,379 (GRCm39) missense probably damaging 1.00
R7908:Or5ac23 UTSW 16 59,149,606 (GRCm39) missense possibly damaging 0.48
R7911:Or5ac23 UTSW 16 59,149,606 (GRCm39) missense possibly damaging 0.48
R7912:Or5ac23 UTSW 16 59,149,606 (GRCm39) missense possibly damaging 0.48
R7913:Or5ac23 UTSW 16 59,149,606 (GRCm39) missense possibly damaging 0.48
R7998:Or5ac23 UTSW 16 59,149,633 (GRCm39) missense probably benign 0.09
R8772:Or5ac23 UTSW 16 59,149,051 (GRCm39) missense probably damaging 1.00
R9563:Or5ac23 UTSW 16 59,149,765 (GRCm39) missense probably benign 0.00
X0026:Or5ac23 UTSW 16 59,149,713 (GRCm39) missense probably benign 0.09
Posted On 2013-03-25