Incidental Mutation 'IGL02036:Dpep3'
ID184526
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dpep3
Ensembl Gene ENSMUSG00000031898
Gene Namedipeptidase 3
SynonymsMBD-3, 1700018F16Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.127) question?
Stock #IGL02036
Quality Score
Status
Chromosome8
Chromosomal Location105973513-105979429 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 105973785 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Proline at position 430 (T430P)
Ref Sequence ENSEMBL: ENSMUSP00000034371 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034371]
Predicted Effect probably benign
Transcript: ENSMUST00000034371
AA Change: T430P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000034371
Gene: ENSMUSG00000031898
AA Change: T430P

DomainStartEndE-ValueType
signal peptide 1 40 N/A INTRINSIC
Pfam:Peptidase_M19 83 404 1.2e-110 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212917
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a membrane-bound glycoprotein from the family of dipeptidases involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family. Alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530053A07Rik G A 7: 28,137,525 V290M possibly damaging Het
Cep290 T A 10: 100,558,100 C2056* probably null Het
Cyp2c38 T A 19: 39,460,316 D143V probably null Het
Ddx10 T C 9: 53,204,183 K617R probably benign Het
Dgat2l6 T A X: 100,545,593 I336N probably damaging Het
Dopey1 A G 9: 86,531,765 I1906M probably benign Het
Dph1 T C 11: 75,184,165 probably null Het
Epha7 T C 4: 28,950,509 S775P probably damaging Het
F5 A G 1: 164,183,002 probably benign Het
Hdx T A X: 111,659,867 T342S probably benign Het
Inpp4a T C 1: 37,377,569 probably benign Het
Itgad A G 7: 128,189,821 T515A possibly damaging Het
Kcnc2 T A 10: 112,455,926 S340T possibly damaging Het
Krba1 C T 6: 48,415,642 T830I possibly damaging Het
Lrch1 G A 14: 74,795,293 probably benign Het
Mag C T 7: 30,908,452 V295M probably damaging Het
Mmp16 T A 4: 18,093,371 D375E probably benign Het
Olfr1216 A G 2: 89,013,479 V195A probably benign Het
Olfr314 T C 11: 58,787,097 Y288H probably damaging Het
Olfr90 A G 17: 37,085,667 F166S probably damaging Het
Pcyox1l T C 18: 61,707,536 probably benign Het
Secisbp2l A G 2: 125,758,207 S403P probably benign Het
Sh3tc2 T A 18: 62,014,907 H1229Q probably benign Het
Svep1 A C 4: 58,088,245 W1735G possibly damaging Het
Tbxas1 T A 6: 39,021,157 C220S probably benign Het
Vmn1r173 G T 7: 23,702,896 M185I probably benign Het
Ywhag A G 5: 135,911,494 V82A probably benign Het
Other mutations in Dpep3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00158:Dpep3 APN 8 105979147 missense probably benign 0.22
IGL01078:Dpep3 APN 8 105978228 missense probably damaging 1.00
IGL01543:Dpep3 APN 8 105976182 missense probably damaging 1.00
IGL01996:Dpep3 APN 8 105974726 missense probably damaging 1.00
R0422:Dpep3 UTSW 8 105976118 critical splice donor site probably null
R0627:Dpep3 UTSW 8 105978731 missense possibly damaging 0.56
R0747:Dpep3 UTSW 8 105977386 missense probably benign 0.12
R1116:Dpep3 UTSW 8 105978829 missense probably damaging 0.98
R1711:Dpep3 UTSW 8 105973693 missense probably benign 0.01
R2085:Dpep3 UTSW 8 105974714 missense probably damaging 1.00
R4385:Dpep3 UTSW 8 105978186 missense probably damaging 1.00
R4860:Dpep3 UTSW 8 105976189 missense probably benign 0.34
R4860:Dpep3 UTSW 8 105976189 missense probably benign 0.34
R5784:Dpep3 UTSW 8 105978743 missense probably benign 0.03
R6658:Dpep3 UTSW 8 105979096 missense probably benign
R6893:Dpep3 UTSW 8 105973842 missense probably benign
Posted On2014-05-07