Incidental Mutation 'IGL02036:Olfr90'
ID184529
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr90
Ensembl Gene ENSMUSG00000056600
Gene Nameolfactory receptor 90
SynonymsMOR256-21, GA_x6K02T2PSCP-1526227-1525295
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.044) question?
Stock #IGL02036
Quality Score
Status
Chromosome17
Chromosomal Location37083871-37088499 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 37085667 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Serine at position 166 (F166S)
Ref Sequence ENSEMBL: ENSMUSP00000150119 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070808] [ENSMUST00000207101] [ENSMUST00000215195] [ENSMUST00000216376] [ENSMUST00000216488] [ENSMUST00000217372] [ENSMUST00000217397]
Predicted Effect probably damaging
Transcript: ENSMUST00000070808
AA Change: F166S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000065322
Gene: ENSMUSG00000056600
AA Change: F166S

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srbc 21 157 9e-8 PFAM
Pfam:7tm_4 29 306 5.3e-52 PFAM
Pfam:7tm_1 39 288 6.1e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207101
Predicted Effect probably damaging
Transcript: ENSMUST00000215195
AA Change: F166S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215502
Predicted Effect probably benign
Transcript: ENSMUST00000216376
Predicted Effect probably damaging
Transcript: ENSMUST00000216488
AA Change: F166S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000217372
Predicted Effect probably damaging
Transcript: ENSMUST00000217397
AA Change: F166S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9530053A07Rik G A 7: 28,137,525 V290M possibly damaging Het
Cep290 T A 10: 100,558,100 C2056* probably null Het
Cyp2c38 T A 19: 39,460,316 D143V probably null Het
Ddx10 T C 9: 53,204,183 K617R probably benign Het
Dgat2l6 T A X: 100,545,593 I336N probably damaging Het
Dopey1 A G 9: 86,531,765 I1906M probably benign Het
Dpep3 T G 8: 105,973,785 T430P probably benign Het
Dph1 T C 11: 75,184,165 probably null Het
Epha7 T C 4: 28,950,509 S775P probably damaging Het
F5 A G 1: 164,183,002 probably benign Het
Hdx T A X: 111,659,867 T342S probably benign Het
Inpp4a T C 1: 37,377,569 probably benign Het
Itgad A G 7: 128,189,821 T515A possibly damaging Het
Kcnc2 T A 10: 112,455,926 S340T possibly damaging Het
Krba1 C T 6: 48,415,642 T830I possibly damaging Het
Lrch1 G A 14: 74,795,293 probably benign Het
Mag C T 7: 30,908,452 V295M probably damaging Het
Mmp16 T A 4: 18,093,371 D375E probably benign Het
Olfr1216 A G 2: 89,013,479 V195A probably benign Het
Olfr314 T C 11: 58,787,097 Y288H probably damaging Het
Pcyox1l T C 18: 61,707,536 probably benign Het
Secisbp2l A G 2: 125,758,207 S403P probably benign Het
Sh3tc2 T A 18: 62,014,907 H1229Q probably benign Het
Svep1 A C 4: 58,088,245 W1735G possibly damaging Het
Tbxas1 T A 6: 39,021,157 C220S probably benign Het
Vmn1r173 G T 7: 23,702,896 M185I probably benign Het
Ywhag A G 5: 135,911,494 V82A probably benign Het
Other mutations in Olfr90
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01628:Olfr90 APN 17 37085300 nonsense probably null
IGL01893:Olfr90 APN 17 37085868 missense probably damaging 0.99
IGL02851:Olfr90 APN 17 37086156 unclassified probably null
R1701:Olfr90 UTSW 17 37085731 missense probably benign 0.17
R1934:Olfr90 UTSW 17 37086014 missense possibly damaging 0.69
R3773:Olfr90 UTSW 17 37086065 nonsense probably null
R4570:Olfr90 UTSW 17 37085579 missense probably damaging 1.00
R4571:Olfr90 UTSW 17 37085579 missense probably damaging 1.00
R4888:Olfr90 UTSW 17 37085451 missense probably damaging 1.00
R4914:Olfr90 UTSW 17 37085991 missense probably damaging 1.00
R5014:Olfr90 UTSW 17 37085554 missense probably benign 0.01
R6381:Olfr90 UTSW 17 37086085 missense probably benign 0.00
Posted On2014-05-07