Incidental Mutation 'IGL02039:Ifitm3'
ID184668
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifitm3
Ensembl Gene ENSMUSG00000025492
Gene Nameinterferon induced transmembrane protein 3
Synonymsmil-1, Fgls, 1110004C05Rik, fragilis, IP15
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02039
Quality Score
Status
Chromosome7
Chromosomal Location141009586-141010770 bp(-) (GRCm38)
Type of Mutationutr 5 prime
DNA Base Change (assembly) C to A at 141010650 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000026565 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026565]
Predicted Effect probably benign
Transcript: ENSMUST00000026565
SMART Domains Protein: ENSMUSP00000026565
Gene: ENSMUSG00000025492

DomainStartEndE-ValueType
Pfam:CD225 47 130 7.6e-33 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012]
PHENOTYPE: Mice homozygous for a reporter allele are viable and fertile with no detectable defects in embryogenesis or germ cell development but show increased susceptibility to respiratory syncytial virus and influenza A virus infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T A 11: 9,297,193 Y2313* probably null Het
Arhgef12 A G 9: 42,972,267 I1323T probably benign Het
C87436 A G 6: 86,453,695 M366V probably benign Het
Cep290 T C 10: 100,514,602 probably null Het
Cpsf3 T C 12: 21,301,456 M326T probably damaging Het
Cpxm2 A G 7: 132,047,753 V64A probably damaging Het
Csnka2ip G A 16: 64,478,594 S25F probably damaging Het
Cyfip1 T C 7: 55,875,021 F168L possibly damaging Het
Dhx8 T C 11: 101,764,027 probably null Het
Dnah2 T A 11: 69,499,212 I736F probably damaging Het
Erf T C 7: 25,244,544 E454G possibly damaging Het
Flnc T C 6: 29,450,719 V1482A probably benign Het
Fmn1 T C 2: 113,365,080 L375P unknown Het
Foxm1 T C 6: 128,369,360 Y85H probably damaging Het
Frem3 A G 8: 80,612,971 E631G probably damaging Het
Fsip1 T C 2: 118,240,414 D265G probably damaging Het
Gprc5c C T 11: 114,864,486 Q330* probably null Het
Grin1 C T 2: 25,305,342 V246M probably damaging Het
Igdcc3 G A 9: 65,183,880 V648I probably benign Het
Ighv5-2 A G 12: 113,578,594 I87T probably benign Het
Imp4 G A 1: 34,443,768 probably null Het
Ino80 T C 2: 119,380,073 N1327D probably damaging Het
Kif5a T C 10: 127,233,867 I830V possibly damaging Het
Mgea5 A T 19: 45,773,703 V237E probably damaging Het
Muc5b A G 7: 141,871,164 Y4696C possibly damaging Het
Nrl T C 14: 55,522,110 E120G probably benign Het
Nsmaf T A 4: 6,424,995 probably benign Het
Nup35 T C 2: 80,642,775 M64T probably benign Het
Nxpe2 T A 9: 48,319,659 N470I probably benign Het
Olfr109 T A 17: 37,466,449 I81N possibly damaging Het
Olfr1502 C T 19: 13,862,719 Q309* probably null Het
Os9 G A 10: 127,096,291 P604S possibly damaging Het
Pitpnm1 A G 19: 4,105,032 T287A probably benign Het
Pkd2l2 G T 18: 34,435,368 probably null Het
Pola2 A T 19: 5,948,469 I355N probably damaging Het
Pp2d1 T A 17: 53,515,994 R15* probably null Het
Prpf40a T C 2: 53,144,803 D749G probably damaging Het
Rhoh T C 5: 65,892,638 S84P probably damaging Het
Slc12a7 T C 13: 73,809,094 probably null Het
Slc37a2 A G 9: 37,233,684 I454T probably damaging Het
Smarca2 A G 19: 26,716,137 D28G probably damaging Het
Socs4 T C 14: 47,290,193 I195T probably benign Het
Svep1 A G 4: 58,123,980 probably null Het
Thbd T C 2: 148,406,542 T469A probably benign Het
Thoc5 T C 11: 4,922,027 probably null Het
Vmn1r173 G T 7: 23,702,896 M185I probably benign Het
Vmn1r59 T C 7: 5,454,381 S127G probably benign Het
Vmn2r6 T C 3: 64,556,189 E408G probably damaging Het
Yars A T 4: 129,215,259 I428F probably damaging Het
Zglp1 T C 9: 21,067,039 E14G possibly damaging Het
Other mutations in Ifitm3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02478:Ifitm3 APN 7 141009874 missense possibly damaging 0.68
IGL02889:Ifitm3 APN 7 141009879 missense probably damaging 1.00
I0000:Ifitm3 UTSW 7 141010528 missense possibly damaging 0.85
R1069:Ifitm3 UTSW 7 141009900 splice site probably benign
R4019:Ifitm3 UTSW 7 141009859 missense possibly damaging 0.71
R4991:Ifitm3 UTSW 7 141010459 missense probably damaging 1.00
R5288:Ifitm3 UTSW 7 141010641 missense probably benign 0.00
R5385:Ifitm3 UTSW 7 141010641 missense probably benign 0.00
R5386:Ifitm3 UTSW 7 141010641 missense probably benign 0.00
R5543:Ifitm3 UTSW 7 141009817 missense unknown
R7071:Ifitm3 UTSW 7 141010524 missense probably benign 0.03
Posted On2014-05-07