Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02043:Or10a3n'

184813

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or10a3n

Ensembl Gene

ENSMUSG00000066239

Gene Name

olfactory receptor family 10 subfamily A member 3N

Synonyms

GA_x6K02T2PBJ9-11224559-11223615, MOR268-6, Olfr519

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL02043

Quality Score

Status

Chromosome

Chromosomal Location

108492668-108493612 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 108493046 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 189 (C189*)

Ref Sequence

ENSEMBL: ENSMUSP00000144271 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000084752] [ENSMUST00000202706]

AlphaFold

K7N645

Predicted Effect

probably null
Transcript: ENSMUST00000084752
AA Change: C194*

SMART Domains

Protein: ENSMUSP00000081804
Gene: ENSMUSG00000066239
AA Change: C194*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	36	313	1.3e-59	PFAM
Pfam:7TM_GPCR_Srsx	40	310	3.3e-6	PFAM
Pfam:7tm_1	46	305	3.7e-25	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000202706
AA Change: C189*

SMART Domains

Protein: ENSMUSP00000144271
Gene: ENSMUSG00000066239
AA Change: C189*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	4.1e-59	PFAM
Pfam:7TM_GPCR_Srsx	35	305	2.1e-5	PFAM
Pfam:7tm_1	41	300	1.2e-24	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atp1b2	T	C	11: 69,496,102 (GRCm39)	T33A	probably benign	Het
Brd2	A	T	17: 34,331,590 (GRCm39)		probably benign	Het
Carmil1	T	C	13: 24,208,299 (GRCm39)		probably benign	Het
Cdh9	A	T	15: 16,856,318 (GRCm39)	D786V	probably damaging	Het
Cep128	A	C	12: 91,233,504 (GRCm39)		probably benign	Het
Cep85	T	C	4: 133,883,038 (GRCm39)	T284A	probably benign	Het
Chrna1	C	T	2: 73,398,450 (GRCm39)	E330K	probably benign	Het
Clec2l	T	C	6: 38,653,785 (GRCm39)	Y104H	probably damaging	Het
Clybl	G	T	14: 122,616,664 (GRCm39)	K226N	probably damaging	Het
Cmip	T	A	8: 118,172,067 (GRCm39)	D467E	probably benign	Het
Cpne3	A	T	4: 19,543,340 (GRCm39)		probably null	Het
Crisp4	A	G	1: 18,204,324 (GRCm39)	V46A	probably damaging	Het
Csnk2a1	T	C	2: 152,116,070 (GRCm39)	Y261H	probably damaging	Het
Cul5	C	A	9: 53,569,973 (GRCm39)	G86V	probably benign	Het
Czib	T	G	4: 107,752,065 (GRCm39)		probably benign	Het
Depdc7	T	C	2: 104,560,626 (GRCm39)	T123A	probably benign	Het
Edem2	T	C	2: 155,547,661 (GRCm39)	T384A	probably damaging	Het
F8	C	T	X: 74,376,247 (GRCm39)	M377I	probably benign	Het
Fan1	T	A	7: 64,021,367 (GRCm39)		probably null	Het
Fez2	T	C	17: 78,689,051 (GRCm39)	D366G	probably damaging	Het
Gm4841	A	C	18: 60,404,037 (GRCm39)	S19A	probably benign	Het
Gm4862	T	A	3: 138,834,396 (GRCm39)		noncoding transcript	Het
Hk3	T	A	13: 55,162,908 (GRCm39)	Q44L	probably damaging	Het
Irgm1	C	A	11: 48,757,642 (GRCm39)	L56F	probably damaging	Het
Ldlr	A	G	9: 21,644,795 (GRCm39)	T108A	probably benign	Het
Lgr4	T	A	2: 109,841,635 (GRCm39)	M516K	probably damaging	Het
Lrp1b	T	C	2: 40,587,537 (GRCm39)	N3906S	probably null	Het
Lrrtm4	A	G	6: 79,998,845 (GRCm39)	N86D	possibly damaging	Het
Map3k2	A	G	18: 32,340,587 (GRCm39)	D198G	probably damaging	Het
Mapkapk3	C	T	9: 107,139,621 (GRCm39)		probably null	Het
Mvp	A	T	7: 126,592,790 (GRCm39)	Y374N	probably damaging	Het
Myo3a	T	C	2: 22,404,776 (GRCm39)	S711P	probably benign	Het
Myom3	A	G	4: 135,497,986 (GRCm39)	K189E	probably damaging	Het
Naip1	T	A	13: 100,563,304 (GRCm39)	K620N	probably benign	Het
Nlrp10	T	C	7: 108,524,709 (GRCm39)	E257G	probably damaging	Het
Nptn	T	G	9: 58,548,012 (GRCm39)	M139R	possibly damaging	Het
Nrk	T	G	X: 137,889,544 (GRCm39)	M1105R	possibly damaging	Het
Or10d4	T	G	9: 39,580,374 (GRCm39)	V7G	probably damaging	Het
Or1q1	T	A	2: 36,887,477 (GRCm39)	Y218*	probably null	Het
Pcdhb16	A	G	18: 37,612,248 (GRCm39)	T403A	probably benign	Het
Pcyt1b	A	G	X: 92,745,722 (GRCm39)	E50G	possibly damaging	Het
Pigg	C	T	5: 108,492,190 (GRCm39)	T892I	probably damaging	Het
Ppig	T	G	2: 69,566,327 (GRCm39)		probably null	Het
Prr12	A	G	7: 44,699,429 (GRCm39)		probably benign	Het
Slc5a5	G	T	8: 71,345,073 (GRCm39)	A78E	possibly damaging	Het
Slc7a2	T	G	8: 41,364,095 (GRCm39)	M436R	probably benign	Het
Sp7	T	A	15: 102,267,690 (GRCm39)	M39L	probably benign	Het
Spag8	T	A	4: 43,653,134 (GRCm39)		probably benign	Het
Svep1	A	G	4: 58,068,556 (GRCm39)	S3077P	probably benign	Het
Tmem30a	A	T	9: 79,681,371 (GRCm39)		probably benign	Het
Tmem63a	C	T	1: 180,800,353 (GRCm39)	T714I	probably benign	Het
Trank1	T	C	9: 111,193,028 (GRCm39)	L535P	probably damaging	Het
Tuba8	A	C	6: 121,197,470 (GRCm39)	N44T	probably benign	Het
Wnk1	A	G	6: 119,926,039 (GRCm39)		probably benign	Het
Zfp654	A	T	16: 64,605,391 (GRCm39)	I396K	probably benign	Het

Other mutations in Or10a3n

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01634:Or10a3n	APN	7	108,493,292 (GRCm39)	missense	probably benign	0.22
PIT4382001:Or10a3n	UTSW	7	108,493,309 (GRCm39)	missense	probably damaging	1.00
R1183:Or10a3n	UTSW	7	108,492,948 (GRCm39)	missense	probably damaging	1.00
R1596:Or10a3n	UTSW	7	108,493,086 (GRCm39)	missense	probably damaging	1.00
R1647:Or10a3n	UTSW	7	108,492,972 (GRCm39)	missense	probably damaging	1.00
R1648:Or10a3n	UTSW	7	108,492,972 (GRCm39)	missense	probably damaging	1.00
R3952:Or10a3n	UTSW	7	108,493,189 (GRCm39)	missense	probably benign	0.00
R4611:Or10a3n	UTSW	7	108,493,324 (GRCm39)	missense	probably damaging	1.00
R4723:Or10a3n	UTSW	7	108,493,028 (GRCm39)	missense	probably benign	0.09
R5838:Or10a3n	UTSW	7	108,493,292 (GRCm39)	missense	probably benign	0.22
R6483:Or10a3n	UTSW	7	108,493,318 (GRCm39)	missense	possibly damaging	0.76
R6516:Or10a3n	UTSW	7	108,492,972 (GRCm39)	missense	probably damaging	1.00
R7353:Or10a3n	UTSW	7	108,493,429 (GRCm39)	missense	probably damaging	1.00
R7748:Or10a3n	UTSW	7	108,493,285 (GRCm39)	missense	probably benign	0.22
R7975:Or10a3n	UTSW	7	108,493,019 (GRCm39)	nonsense	probably null
R8823:Or10a3n	UTSW	7	108,493,155 (GRCm39)	missense	probably benign	0.00
R8913:Or10a3n	UTSW	7	108,492,736 (GRCm39)	missense	probably damaging	0.99
R8914:Or10a3n	UTSW	7	108,492,736 (GRCm39)	missense	probably damaging	0.99
R9066:Or10a3n	UTSW	7	108,493,253 (GRCm39)	nonsense	probably null
R9093:Or10a3n	UTSW	7	108,493,609 (GRCm39)	missense	probably benign	0.05
R9763:Or10a3n	UTSW	7	108,493,210 (GRCm39)	missense	probably benign	0.01
Z1088:Or10a3n	UTSW	7	108,492,980 (GRCm39)	missense	probably damaging	0.99

Posted On

2014-05-07