Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02047:Lipo3'

184951

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lipo3

Ensembl Gene

ENSMUSG00000024766

Gene Name

lipase, member O3

Synonyms

Lipo1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

IGL02047

Quality Score

Status

Chromosome

Chromosomal Location

33532560-33568069 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 33534562 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Lysine at position 299 (I299K)

Ref Sequence

ENSEMBL: ENSMUSP00000108127 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025694] [ENSMUST00000112508]

AlphaFold

Q3UT41

Predicted Effect

probably benign
Transcript: ENSMUST00000025694
AA Change: I299K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000025694
Gene: ENSMUSG00000024766
AA Change: I299K

Domain	Start	End	E-Value	Type
Pfam:Abhydro_lipase	33	95	4.2e-24	PFAM
Pfam:Abhydrolase_1	76	213	7.3e-16	PFAM
Pfam:Abhydrolase_5	76	370	4.8e-12	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000112508
AA Change: I299K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000108127
Gene: ENSMUSG00000024766
AA Change: I299K

Domain	Start	End	E-Value	Type
Pfam:Abhydro_lipase	33	95	8.8e-24	PFAM
Pfam:Abhydrolase_5	76	370	5.2e-12	PFAM
Pfam:Abhydrolase_6	77	384	8.5e-10	PFAM
Pfam:Abhydrolase_1	109	384	2e-20	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133269

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145807

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A730049H05Rik	G	T	6: 92,808,909 (GRCm39)		probably benign	Het
Ank3	A	G	10: 69,728,324 (GRCm39)	N681S	possibly damaging	Het
Arpp19	T	G	9: 74,964,058 (GRCm39)	S137A	probably damaging	Het
Bmp2	T	C	2: 133,402,896 (GRCm39)	L149P	probably damaging	Het
Bpifb1	T	C	2: 154,044,536 (GRCm39)	M1T	probably null	Het
Btbd7	T	C	12: 102,760,038 (GRCm39)	S637G	probably benign	Het
Cyp51	T	A	5: 4,149,244 (GRCm39)	H211L	possibly damaging	Het
Cyth1	C	A	11: 118,059,958 (GRCm39)	Q333H	probably damaging	Het
Dennd5a	G	A	7: 109,533,991 (GRCm39)	T67M	possibly damaging	Het
Dse	A	T	10: 34,038,841 (GRCm39)	Y51*	probably null	Het
Dynlt3	A	T	X: 9,522,665 (GRCm39)	Y76*	probably null	Het
Fabp12	T	C	3: 10,312,778 (GRCm39)		probably benign	Het
Galr1	A	T	18: 82,424,118 (GRCm39)	L53Q	probably damaging	Het
Igkv4-70	A	T	6: 69,244,911 (GRCm39)	D103E	probably damaging	Het
Il2	T	C	3: 37,180,000 (GRCm39)	N19S	probably benign	Het
Jhy	T	C	9: 40,828,476 (GRCm39)	I477V	probably benign	Het
Kcnk4	A	G	19: 6,903,626 (GRCm39)	S308P	probably benign	Het
Mark3	T	A	12: 111,584,797 (GRCm39)	I131N	probably damaging	Het
Msr1	A	G	8: 40,077,001 (GRCm39)	V137A	probably benign	Het
Nf1	T	A	11: 79,316,361 (GRCm39)	V482E	probably benign	Het
Pcsk1	T	C	13: 75,246,108 (GRCm39)	V162A	probably benign	Het
Phf8-ps	C	T	17: 33,286,275 (GRCm39)	V176M	probably damaging	Het
Plekhb1	A	G	7: 100,304,506 (GRCm39)	V47A	probably damaging	Het
R3hcc1l	G	A	19: 42,552,258 (GRCm39)	M418I	probably benign	Het
Slc24a4	T	C	12: 102,220,882 (GRCm39)	F438L	probably damaging	Het
Slc38a5	G	T	X: 8,139,879 (GRCm39)	V127L	possibly damaging	Het
Szt2	A	G	4: 118,233,834 (GRCm39)		probably benign	Het
Tdh	A	T	14: 63,734,407 (GRCm39)	H80Q	probably benign	Het
Tshz3	A	C	7: 36,469,893 (GRCm39)	K627N	probably damaging	Het
Usp28	C	T	9: 48,946,941 (GRCm39)	P791S	probably damaging	Het
Wdr81	A	G	11: 75,336,332 (GRCm39)	Y1686H	probably damaging	Het
Xpot	G	T	10: 121,437,267 (GRCm39)		probably benign	Het
Zfand4	G	A	6: 116,291,889 (GRCm39)	G627R	probably damaging	Het

Other mutations in Lipo3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01521:Lipo3	APN	19	33,763,083 (GRCm39)	missense	probably damaging	1.00
IGL01697:Lipo3	APN	19	33,536,965 (GRCm39)	missense	probably damaging	1.00
IGL01916:Lipo3	APN	19	33,762,182 (GRCm39)	missense	probably damaging	1.00
IGL02027:Lipo3	APN	19	33,557,919 (GRCm39)	nonsense	probably null
IGL02586:Lipo3	APN	19	33,559,539 (GRCm39)	missense	possibly damaging	0.95
IGL03005:Lipo3	APN	19	33,763,136 (GRCm39)	missense	possibly damaging	0.65
IGL03111:Lipo3	APN	19	33,559,637 (GRCm39)	missense	probably damaging	0.96
IGL03404:Lipo3	APN	19	33,560,440 (GRCm39)	splice site	probably benign
R0122:Lipo3	UTSW	19	33,600,086 (GRCm39)	intron	probably benign
R0128:Lipo3	UTSW	19	33,534,506 (GRCm39)	critical splice donor site	probably null
R0540:Lipo3	UTSW	19	33,536,967 (GRCm39)	missense	possibly damaging	0.62
R0551:Lipo3	UTSW	19	33,557,951 (GRCm39)	missense	probably damaging	1.00
R0568:Lipo3	UTSW	19	33,559,442 (GRCm39)	splice site	probably benign
R0646:Lipo3	UTSW	19	33,762,169 (GRCm39)	nonsense	probably null
R0669:Lipo3	UTSW	19	33,537,025 (GRCm39)	missense	probably benign	0.05
R1704:Lipo3	UTSW	19	33,757,743 (GRCm39)	missense	possibly damaging	0.87
R1772:Lipo3	UTSW	19	33,764,821 (GRCm39)	missense	probably benign	0.45
R1862:Lipo3	UTSW	19	33,762,092 (GRCm39)	missense	probably damaging	1.00
R1863:Lipo3	UTSW	19	33,762,092 (GRCm39)	missense	probably damaging	1.00
R2911:Lipo3	UTSW	19	33,556,767 (GRCm39)	missense	probably benign	0.00
R3801:Lipo3	UTSW	19	33,762,257 (GRCm39)	missense	probably damaging	0.99
R3802:Lipo3	UTSW	19	33,762,257 (GRCm39)	missense	probably damaging	0.99
R3803:Lipo3	UTSW	19	33,762,257 (GRCm39)	missense	probably damaging	0.99
R3973:Lipo3	UTSW	19	33,535,723 (GRCm39)	missense	probably damaging	1.00
R4020:Lipo3	UTSW	19	33,764,804 (GRCm39)	missense	probably benign	0.00
R4648:Lipo3	UTSW	19	33,760,860 (GRCm39)	missense	probably damaging	1.00
R4660:Lipo3	UTSW	19	33,598,360 (GRCm39)	intron	probably benign
R4775:Lipo3	UTSW	19	33,757,795 (GRCm39)	missense	probably damaging	1.00
R4787:Lipo3	UTSW	19	33,757,749 (GRCm39)	missense	probably benign	0.00
R4820:Lipo3	UTSW	19	33,560,497 (GRCm39)	missense	probably damaging	1.00
R4830:Lipo3	UTSW	19	33,753,987 (GRCm39)	missense	probably damaging	0.99
R4951:Lipo3	UTSW	19	33,759,621 (GRCm39)	missense	probably benign	0.01
R5117:Lipo3	UTSW	19	33,536,952 (GRCm39)	missense	probably benign
R5258:Lipo3	UTSW	19	33,591,243 (GRCm39)	intron	probably benign
R5799:Lipo3	UTSW	19	33,755,093 (GRCm39)	intron	probably benign
R5853:Lipo3	UTSW	19	33,759,630 (GRCm39)	missense	probably benign	0.37
R6235:Lipo3	UTSW	19	33,760,963 (GRCm39)	missense	probably damaging	0.96
R6296:Lipo3	UTSW	19	33,757,737 (GRCm39)	missense	probably benign	0.10
R6383:Lipo3	UTSW	19	33,533,831 (GRCm39)	missense	probably benign	0.02
R6659:Lipo3	UTSW	19	33,533,828 (GRCm39)	missense	possibly damaging	0.55
R6913:Lipo3	UTSW	19	33,757,705 (GRCm39)	missense	probably benign	0.00
R6915:Lipo3	UTSW	19	33,562,293 (GRCm39)	missense	probably damaging	1.00
R7092:Lipo3	UTSW	19	33,591,092 (GRCm39)	splice site	probably null
R7444:Lipo3	UTSW	19	33,535,663 (GRCm39)	critical splice donor site	probably null
R7532:Lipo3	UTSW	19	33,560,464 (GRCm39)	missense	possibly damaging	0.90
R7672:Lipo3	UTSW	19	33,757,785 (GRCm39)	missense	probably benign	0.23
R7796:Lipo3	UTSW	19	33,759,634 (GRCm39)	missense	possibly damaging	0.75
R7945:Lipo3	UTSW	19	33,533,831 (GRCm39)	missense	probably benign	0.02
R8683:Lipo3	UTSW	19	33,759,604 (GRCm39)	missense	probably benign	0.04
R8936:Lipo3	UTSW	19	33,557,880 (GRCm39)	missense	probably damaging	1.00
R9062:Lipo3	UTSW	19	33,757,714 (GRCm39)	missense	probably damaging	1.00
R9086:Lipo3	UTSW	19	33,534,529 (GRCm39)	missense	probably benign	0.44
R9432:Lipo3	UTSW	19	33,533,864 (GRCm39)	missense	probably damaging	1.00
R9615:Lipo3	UTSW	19	33,754,047 (GRCm39)	missense	probably benign	0.02
R9620:Lipo3	UTSW	19	33,559,629 (GRCm39)	nonsense	probably null
Z1176:Lipo3	UTSW	19	33,562,328 (GRCm39)	missense	probably null	0.97

Posted On

2014-05-07