Incidental Mutation 'IGL02047:Dynlt3'
ID 184963
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dynlt3
Ensembl Gene ENSMUSG00000031176
Gene Name dynein light chain Tctex-type 3
Synonyms 2310075M16Rik, Tcte1l
Accession Numbers
Essential gene? Not available question?
Stock # IGL02047
Quality Score
Status
Chromosome X
Chromosomal Location 9520509-9529222 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 9522665 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 76 (Y76*)
Ref Sequence ENSEMBL: ENSMUSP00000033519 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033519]
AlphaFold P56387
Predicted Effect probably null
Transcript: ENSMUST00000033519
AA Change: Y76*
SMART Domains Protein: ENSMUSP00000033519
Gene: ENSMUSG00000031176
AA Change: Y76*

DomainStartEndE-ValueType
Pfam:Tctex-1 17 113 5.9e-30 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125030
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140019
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154091
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A730049H05Rik G T 6: 92,808,909 (GRCm39) probably benign Het
Ank3 A G 10: 69,728,324 (GRCm39) N681S possibly damaging Het
Arpp19 T G 9: 74,964,058 (GRCm39) S137A probably damaging Het
Bmp2 T C 2: 133,402,896 (GRCm39) L149P probably damaging Het
Bpifb1 T C 2: 154,044,536 (GRCm39) M1T probably null Het
Btbd7 T C 12: 102,760,038 (GRCm39) S637G probably benign Het
Cyp51 T A 5: 4,149,244 (GRCm39) H211L possibly damaging Het
Cyth1 C A 11: 118,059,958 (GRCm39) Q333H probably damaging Het
Dennd5a G A 7: 109,533,991 (GRCm39) T67M possibly damaging Het
Dse A T 10: 34,038,841 (GRCm39) Y51* probably null Het
Fabp12 T C 3: 10,312,778 (GRCm39) probably benign Het
Galr1 A T 18: 82,424,118 (GRCm39) L53Q probably damaging Het
Igkv4-70 A T 6: 69,244,911 (GRCm39) D103E probably damaging Het
Il2 T C 3: 37,180,000 (GRCm39) N19S probably benign Het
Jhy T C 9: 40,828,476 (GRCm39) I477V probably benign Het
Kcnk4 A G 19: 6,903,626 (GRCm39) S308P probably benign Het
Lipo3 A T 19: 33,534,562 (GRCm39) I299K probably benign Het
Mark3 T A 12: 111,584,797 (GRCm39) I131N probably damaging Het
Msr1 A G 8: 40,077,001 (GRCm39) V137A probably benign Het
Nf1 T A 11: 79,316,361 (GRCm39) V482E probably benign Het
Pcsk1 T C 13: 75,246,108 (GRCm39) V162A probably benign Het
Phf8-ps C T 17: 33,286,275 (GRCm39) V176M probably damaging Het
Plekhb1 A G 7: 100,304,506 (GRCm39) V47A probably damaging Het
R3hcc1l G A 19: 42,552,258 (GRCm39) M418I probably benign Het
Slc24a4 T C 12: 102,220,882 (GRCm39) F438L probably damaging Het
Slc38a5 G T X: 8,139,879 (GRCm39) V127L possibly damaging Het
Szt2 A G 4: 118,233,834 (GRCm39) probably benign Het
Tdh A T 14: 63,734,407 (GRCm39) H80Q probably benign Het
Tshz3 A C 7: 36,469,893 (GRCm39) K627N probably damaging Het
Usp28 C T 9: 48,946,941 (GRCm39) P791S probably damaging Het
Wdr81 A G 11: 75,336,332 (GRCm39) Y1686H probably damaging Het
Xpot G T 10: 121,437,267 (GRCm39) probably benign Het
Zfand4 G A 6: 116,291,889 (GRCm39) G627R probably damaging Het
Posted On 2014-05-07