Incidental Mutation 'IGL02055:Zfp39'
ID185191
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp39
Ensembl Gene ENSMUSG00000037001
Gene Namezinc finger protein 39
SynonymsZfp-39, CTfin33
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.183) question?
Stock #IGL02055
Quality Score
Status
Chromosome11
Chromosomal Location58888153-58904225 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 58891330 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 202 (V202A)
Ref Sequence ENSEMBL: ENSMUSP00000099764 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102703]
Predicted Effect probably benign
Transcript: ENSMUST00000102703
AA Change: V202A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000099764
Gene: ENSMUSG00000037001
AA Change: V202A

DomainStartEndE-ValueType
KRAB 59 119 8.23e-34 SMART
low complexity region 171 180 N/A INTRINSIC
ZnF_C2H2 298 320 9.58e-3 SMART
ZnF_C2H2 326 347 2.2e2 SMART
ZnF_C2H2 353 373 1.18e2 SMART
ZnF_C2H2 409 431 8.34e-3 SMART
ZnF_C2H2 437 459 7.26e-3 SMART
ZnF_C2H2 465 487 1.53e-1 SMART
ZnF_C2H2 493 515 9.08e-4 SMART
ZnF_C2H2 521 543 2.61e-4 SMART
ZnF_C2H2 549 571 1.12e-3 SMART
ZnF_C2H2 577 599 4.94e-5 SMART
ZnF_C2H2 605 627 5.14e-3 SMART
ZnF_C2H2 633 655 1.38e-3 SMART
ZnF_C2H2 661 683 6.78e-3 SMART
ZnF_C2H2 689 711 5.14e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132394
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a Kruppel-associated box (KRAB) zinc-finger protein, which belongs to a large group of transcriptional regulators in mammals. These proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation and apoptosis, and in regulating viral replication and transcription. A pseudogene of this gene was identified on chromosome 1. [provided by RefSeq, May 2016]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610507B11Rik A G 11: 78,286,631 T1921A probably damaging Het
Ap1b1 T A 11: 5,024,452 C353* probably null Het
Asl C T 5: 130,013,050 G309R possibly damaging Het
B4galnt4 T C 7: 141,070,818 F835S probably damaging Het
Carmil2 A G 8: 105,696,907 probably benign Het
Ccnt2 C A 1: 127,791,710 P116T possibly damaging Het
Clcn1 T G 6: 42,307,555 M609R probably damaging Het
Csmd1 A G 8: 16,069,001 I1858T probably damaging Het
Eefsec T C 6: 88,376,403 I95V probably damaging Het
Galk2 A G 2: 125,931,404 K252R probably benign Het
Gbp2 A T 3: 142,632,230 N369I probably benign Het
Glis2 G T 16: 4,614,108 probably benign Het
Igdcc3 T C 9: 65,181,280 V388A possibly damaging Het
Klhl1 A G 14: 96,280,103 F379S possibly damaging Het
Olfr1448 T A 19: 12,919,566 I248F possibly damaging Het
Pigm C T 1: 172,377,165 S156L probably benign Het
Pikfyve T C 1: 65,238,544 probably null Het
Ppp6r3 A G 19: 3,521,781 F123L probably benign Het
Pum1 C A 4: 130,754,054 S637R probably benign Het
Rp1 A G 1: 4,352,522 S112P probably damaging Het
Serpina3k A T 12: 104,341,036 K176* probably null Het
Smad4 A G 18: 73,641,928 probably benign Het
Tas2r137 T A 6: 40,491,559 F108I probably damaging Het
Tbc1d20 G A 2: 152,308,058 R73H probably damaging Het
Tmem131l T C 3: 83,910,366 probably null Het
Tmem86b A C 7: 4,628,763 probably benign Het
Trav6-4 G A 14: 53,454,780 V115I probably benign Het
Trim37 T G 11: 87,166,649 V303G probably benign Het
Trpc7 C T 13: 56,887,544 R192Q probably benign Het
Ush1g T C 11: 115,318,099 D423G possibly damaging Het
Veph1 T A 3: 66,205,627 D252V possibly damaging Het
Vmn1r181 T G 7: 23,984,553 L148V probably damaging Het
Vmn1r42 T C 6: 89,845,589 probably benign Het
Vmn2r77 T A 7: 86,801,555 H216Q probably benign Het
Other mutations in Zfp39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00791:Zfp39 APN 11 58893059 splice site probably benign
IGL01597:Zfp39 APN 11 58891543 missense probably damaging 0.96
IGL02456:Zfp39 APN 11 58902800 nonsense probably null
IGL02873:Zfp39 APN 11 58891022 missense probably benign 0.12
H8562:Zfp39 UTSW 11 58900686 missense probably damaging 1.00
R0462:Zfp39 UTSW 11 58890406 missense probably benign 0.03
R0513:Zfp39 UTSW 11 58889987 missense probably benign 0.09
R1185:Zfp39 UTSW 11 58902844 missense possibly damaging 0.91
R1185:Zfp39 UTSW 11 58902844 missense possibly damaging 0.91
R1185:Zfp39 UTSW 11 58902844 missense possibly damaging 0.91
R1401:Zfp39 UTSW 11 58890323 missense probably benign 0.01
R1797:Zfp39 UTSW 11 58900660 missense probably damaging 0.96
R2146:Zfp39 UTSW 11 58890332 missense probably benign 0.05
R3903:Zfp39 UTSW 11 58890175 missense probably benign 0.44
R4303:Zfp39 UTSW 11 58890017 missense probably damaging 1.00
R4706:Zfp39 UTSW 11 58902807 missense probably benign 0.41
R4957:Zfp39 UTSW 11 58891231 missense possibly damaging 0.63
R5092:Zfp39 UTSW 11 58891202 missense possibly damaging 0.71
R5158:Zfp39 UTSW 11 58889845 missense possibly damaging 0.81
R5292:Zfp39 UTSW 11 58900589 missense probably damaging 0.97
R5697:Zfp39 UTSW 11 58889835 missense probably benign 0.08
R5906:Zfp39 UTSW 11 58902891 missense probably benign
R5925:Zfp39 UTSW 11 58891273 missense possibly damaging 0.94
R6174:Zfp39 UTSW 11 58891387 missense probably benign 0.01
R6177:Zfp39 UTSW 11 58891061 missense probably benign 0.27
R6968:Zfp39 UTSW 11 58891480 missense probably benign 0.00
R7045:Zfp39 UTSW 11 58890443 missense unknown
R7139:Zfp39 UTSW 11 58890559 missense probably damaging 1.00
Posted On2014-05-07