Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02055:Tmem86b'

185219

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem86b

Ensembl Gene

ENSMUSG00000045282

Gene Name

transmembrane protein 86B

Synonyms

C330014O21Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02055

Quality Score

Status

Chromosome

Chromosomal Location

4631039-4634211 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to C at 4631762 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000145838 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055085] [ENSMUST00000064099] [ENSMUST00000205360] [ENSMUST00000205402] [ENSMUST00000206610]

AlphaFold

Q497J1

Predicted Effect

probably benign
Transcript: ENSMUST00000055085

SMART Domains

Protein: ENSMUSP00000060237
Gene: ENSMUSG00000045282

Domain	Start	End	E-Value	Type
transmembrane domain	21	40	N/A	INTRINSIC
Pfam:YhhN	47	217	1.2e-41	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000064099

SMART Domains

Protein: ENSMUSP00000066736
Gene: ENSMUSG00000052296

Domain	Start	End	E-Value	Type
low complexity region	16	36	N/A	INTRINSIC
Pfam:SAPS	128	378	4.6e-69	PFAM
Pfam:SAPS	372	519	1.8e-39	PFAM
low complexity region	525	536	N/A	INTRINSIC
low complexity region	618	639	N/A	INTRINSIC
low complexity region	669	681	N/A	INTRINSIC
low complexity region	692	707	N/A	INTRINSIC
low complexity region	842	855	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000205360

Predicted Effect

probably benign
Transcript: ENSMUST00000205402

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206485

Predicted Effect

probably benign
Transcript: ENSMUST00000206610

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ap1b1	T	A	11: 4,974,452 (GRCm39)	C353*	probably null	Het
Asl	C	T	5: 130,041,891 (GRCm39)	G309R	possibly damaging	Het
B4galnt4	T	C	7: 140,650,731 (GRCm39)	F835S	probably damaging	Het
Bltp2	A	G	11: 78,177,457 (GRCm39)	T1921A	probably damaging	Het
Carmil2	A	G	8: 106,423,539 (GRCm39)		probably benign	Het
Ccnt2	C	A	1: 127,719,447 (GRCm39)	P116T	possibly damaging	Het
Clcn1	T	G	6: 42,284,489 (GRCm39)	M609R	probably damaging	Het
Csmd1	A	G	8: 16,119,015 (GRCm39)	I1858T	probably damaging	Het
Eefsec	T	C	6: 88,353,385 (GRCm39)	I95V	probably damaging	Het
Galk2	A	G	2: 125,773,324 (GRCm39)	K252R	probably benign	Het
Gbp2	A	T	3: 142,337,991 (GRCm39)	N369I	probably benign	Het
Glis2	G	T	16: 4,431,972 (GRCm39)		probably benign	Het
Igdcc3	T	C	9: 65,088,562 (GRCm39)	V388A	possibly damaging	Het
Klhl1	A	G	14: 96,517,539 (GRCm39)	F379S	possibly damaging	Het
Or5b12	T	A	19: 12,896,930 (GRCm39)	I248F	possibly damaging	Het
Pigm	C	T	1: 172,204,732 (GRCm39)	S156L	probably benign	Het
Pikfyve	T	C	1: 65,277,703 (GRCm39)		probably null	Het
Ppp6r3	A	G	19: 3,571,781 (GRCm39)	F123L	probably benign	Het
Pum1	C	A	4: 130,481,365 (GRCm39)	S637R	probably benign	Het
Rp1	A	G	1: 4,422,745 (GRCm39)	S112P	probably damaging	Het
Serpina3k	A	T	12: 104,307,295 (GRCm39)	K176*	probably null	Het
Smad4	A	G	18: 73,774,999 (GRCm39)		probably benign	Het
Tas2r140	T	A	6: 40,468,493 (GRCm39)	F108I	probably damaging	Het
Tbc1d20	G	A	2: 152,149,978 (GRCm39)	R73H	probably damaging	Het
Tmem131l	T	C	3: 83,817,673 (GRCm39)		probably null	Het
Trav6-4	G	A	14: 53,692,237 (GRCm39)	V115I	probably benign	Het
Trim37	T	G	11: 87,057,475 (GRCm39)	V303G	probably benign	Het
Trpc7	C	T	13: 57,035,357 (GRCm39)	R192Q	probably benign	Het
Ush1g	T	C	11: 115,208,925 (GRCm39)	D423G	possibly damaging	Het
Veph1	T	A	3: 66,113,048 (GRCm39)	D252V	possibly damaging	Het
Vmn1r181	T	G	7: 23,683,978 (GRCm39)	L148V	probably damaging	Het
Vmn1r42	T	C	6: 89,822,571 (GRCm39)		probably benign	Het
Vmn2r77	T	A	7: 86,450,763 (GRCm39)	H216Q	probably benign	Het
Zfp39	A	G	11: 58,782,156 (GRCm39)	V202A	probably benign	Het

Other mutations in Tmem86b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00793:Tmem86b	APN	7	4,631,756 (GRCm39)	splice site	probably benign
R1875:Tmem86b	UTSW	7	4,632,698 (GRCm39)	missense	possibly damaging	0.94
R1956:Tmem86b	UTSW	7	4,631,706 (GRCm39)	missense	probably benign	0.39
R3756:Tmem86b	UTSW	7	4,631,623 (GRCm39)	missense	probably damaging	1.00
R5049:Tmem86b	UTSW	7	4,631,465 (GRCm39)	missense	possibly damaging	0.84
R6362:Tmem86b	UTSW	7	4,632,835 (GRCm39)	start codon destroyed	probably null	0.00
R6518:Tmem86b	UTSW	7	4,632,608 (GRCm39)	nonsense	probably null
R7890:Tmem86b	UTSW	7	4,631,404 (GRCm39)	nonsense	probably null
R8143:Tmem86b	UTSW	7	4,631,484 (GRCm39)	missense	probably damaging	0.99
R8994:Tmem86b	UTSW	7	4,632,706 (GRCm39)	missense	unknown
R9186:Tmem86b	UTSW	7	4,632,725 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-05-07