Incidental Mutation 'IGL02059:Vmn2r39'
ID185319
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r39
Ensembl Gene ENSMUSG00000096658
Gene Namevomeronasal 2, receptor 39
SynonymsEG545909
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.095) question?
Stock #IGL02059
Quality Score
Status
Chromosome7
Chromosomal Location9013875-9030798 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 9023644 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 453 (I453V)
Ref Sequence ENSEMBL: ENSMUSP00000134010 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000174388]
Predicted Effect probably benign
Transcript: ENSMUST00000174388
AA Change: I453V

PolyPhen 2 Score 0.192 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000134010
Gene: ENSMUSG00000096658
AA Change: I453V

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 469 9.1e-32 PFAM
Pfam:NCD3G 512 565 7.9e-21 PFAM
Pfam:7tm_3 598 833 2.6e-55 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 A C 11: 110,160,394 probably benign Het
Anks1 A G 17: 28,008,046 M558V possibly damaging Het
Arhgef1 T A 7: 24,912,552 probably benign Het
Atad3a G A 4: 155,754,750 probably benign Het
Bhmt2 A G 13: 93,666,663 Y121H probably benign Het
Cbx5 A G 15: 103,199,765 V151A probably damaging Het
Copa T A 1: 172,099,753 I231N probably damaging Het
Csf3r T A 4: 126,032,127 C168* probably null Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Dnah9 A T 11: 66,072,958 I1723N probably damaging Het
Epb42 G A 2: 121,024,707 P466S probably damaging Het
Fem1b C T 9: 62,796,164 V605I possibly damaging Het
Gclc T G 9: 77,787,816 S403A probably damaging Het
Gpr135 A T 12: 72,070,084 V303D possibly damaging Het
Gprin3 C A 6: 59,355,325 probably benign Het
Grik1 T A 16: 88,056,049 Q82L possibly damaging Het
Hacl1 T C 14: 31,632,934 N118D probably benign Het
Hdac9 A G 12: 34,431,968 V146A probably damaging Het
Hltf T C 3: 20,106,457 F763L probably benign Het
Impg2 C T 16: 56,259,972 S713L probably damaging Het
Ints7 T A 1: 191,615,760 M748K probably benign Het
Kalrn A G 16: 34,252,341 S724P possibly damaging Het
Kyat1 T C 2: 30,185,553 Q359R probably benign Het
Mtmr4 A G 11: 87,601,124 N206S possibly damaging Het
Nos3 T C 5: 24,368,998 I227T probably damaging Het
Olfr589 T C 7: 103,155,103 I215V probably benign Het
Pde1a A T 2: 79,897,077 H169Q possibly damaging Het
Ppp1r13b A T 12: 111,833,347 D665E probably damaging Het
Prickle4 G T 17: 47,690,249 L131M probably damaging Het
Prl6a1 T A 13: 27,315,365 Y39N probably benign Het
Slco6d1 T C 1: 98,446,806 V350A possibly damaging Het
Srsf7 T A 17: 80,202,692 S209C probably null Het
Syde2 C T 3: 146,002,172 A622V possibly damaging Het
Ugt1a6a T A 1: 88,138,681 S70T possibly damaging Het
Zc3h7a A G 16: 11,160,998 probably benign Het
Zeb1 G T 18: 5,766,892 V468F probably damaging Het
Zfp148 T A 16: 33,496,563 V493D probably damaging Het
Other mutations in Vmn2r39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03017:Vmn2r39 APN 7 9014941 missense probably damaging 1.00
R1314:Vmn2r39 UTSW 7 9014982 missense probably damaging 1.00
R1358:Vmn2r39 UTSW 7 9023688 missense possibly damaging 0.63
R1480:Vmn2r39 UTSW 7 9014956 missense probably damaging 1.00
R4119:Vmn2r39 UTSW 7 9023674 missense probably benign 0.01
R4120:Vmn2r39 UTSW 7 9023674 missense probably benign 0.01
R4720:Vmn2r39 UTSW 7 9023470 critical splice donor site probably null
R4990:Vmn2r39 UTSW 7 9023676 missense probably benign
R5079:Vmn2r39 UTSW 7 9023490 missense probably benign 0.05
R5695:Vmn2r39 UTSW 7 9025151 missense possibly damaging 0.87
R6131:Vmn2r39 UTSW 7 9014964 missense probably damaging 1.00
R6561:Vmn2r39 UTSW 7 9015093 missense probably damaging 1.00
Posted On2014-05-07