Incidental Mutation 'IGL02059:Gpr135'
ID185329
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr135
Ensembl Gene ENSMUSG00000043398
Gene NameG protein-coupled receptor 135
Synonyms
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.312) question?
Stock #IGL02059
Quality Score
Status
Chromosome12
Chromosomal Location72067976-72071125 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 72070084 bp
ZygosityHeterozygous
Amino Acid Change Valine to Aspartic acid at position 303 (V303D)
Ref Sequence ENSEMBL: ENSMUSP00000058762 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019862] [ENSMUST00000050649]
Predicted Effect probably benign
Transcript: ENSMUST00000019862
SMART Domains Protein: ENSMUSP00000019862
Gene: ENSMUSG00000019718

DomainStartEndE-ValueType
Pfam:Pro_racemase 22 352 8.7e-122 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000050649
AA Change: V303D

PolyPhen 2 Score 0.873 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000058762
Gene: ENSMUSG00000043398
AA Change: V303D

DomainStartEndE-ValueType
low complexity region 26 44 N/A INTRINSIC
low complexity region 65 88 N/A INTRINSIC
Pfam:7tm_1 89 350 7.5e-43 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 A C 11: 110,160,394 probably benign Het
Anks1 A G 17: 28,008,046 M558V possibly damaging Het
Arhgef1 T A 7: 24,912,552 probably benign Het
Atad3a G A 4: 155,754,750 probably benign Het
Bhmt2 A G 13: 93,666,663 Y121H probably benign Het
Cbx5 A G 15: 103,199,765 V151A probably damaging Het
Copa T A 1: 172,099,753 I231N probably damaging Het
Csf3r T A 4: 126,032,127 C168* probably null Het
Csgalnact1 C A 8: 68,401,492 G219V probably damaging Het
Dnah9 A T 11: 66,072,958 I1723N probably damaging Het
Epb42 G A 2: 121,024,707 P466S probably damaging Het
Fem1b C T 9: 62,796,164 V605I possibly damaging Het
Gclc T G 9: 77,787,816 S403A probably damaging Het
Gprin3 C A 6: 59,355,325 probably benign Het
Grik1 T A 16: 88,056,049 Q82L possibly damaging Het
Hacl1 T C 14: 31,632,934 N118D probably benign Het
Hdac9 A G 12: 34,431,968 V146A probably damaging Het
Hltf T C 3: 20,106,457 F763L probably benign Het
Impg2 C T 16: 56,259,972 S713L probably damaging Het
Ints7 T A 1: 191,615,760 M748K probably benign Het
Kalrn A G 16: 34,252,341 S724P possibly damaging Het
Kyat1 T C 2: 30,185,553 Q359R probably benign Het
Mtmr4 A G 11: 87,601,124 N206S possibly damaging Het
Nos3 T C 5: 24,368,998 I227T probably damaging Het
Olfr589 T C 7: 103,155,103 I215V probably benign Het
Pde1a A T 2: 79,897,077 H169Q possibly damaging Het
Ppp1r13b A T 12: 111,833,347 D665E probably damaging Het
Prickle4 G T 17: 47,690,249 L131M probably damaging Het
Prl6a1 T A 13: 27,315,365 Y39N probably benign Het
Slco6d1 T C 1: 98,446,806 V350A possibly damaging Het
Srsf7 T A 17: 80,202,692 S209C probably null Het
Syde2 C T 3: 146,002,172 A622V possibly damaging Het
Ugt1a6a T A 1: 88,138,681 S70T possibly damaging Het
Vmn2r39 T C 7: 9,023,644 I453V probably benign Het
Zc3h7a A G 16: 11,160,998 probably benign Het
Zeb1 G T 18: 5,766,892 V468F probably damaging Het
Zfp148 T A 16: 33,496,563 V493D probably damaging Het
Other mutations in Gpr135
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01458:Gpr135 APN 12 72069668 missense probably benign
IGL02219:Gpr135 APN 12 72070273 missense probably damaging 1.00
IGL02273:Gpr135 APN 12 72069958 missense probably damaging 0.96
R4688:Gpr135 UTSW 12 72070946 missense probably benign
R4791:Gpr135 UTSW 12 72069868 missense probably benign 0.12
R5001:Gpr135 UTSW 12 72070508 missense probably benign 0.10
R5811:Gpr135 UTSW 12 72069867 missense possibly damaging 0.87
R5857:Gpr135 UTSW 12 72070840 missense probably benign 0.25
Posted On2014-05-07