Incidental Mutation 'IGL02060:Klra10'
| ID |
185357 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Klra10
|
| Ensembl Gene |
ENSMUSG00000072718 |
| Gene Name |
killer cell lectin-like receptor subfamily A, member 10 |
| Synonyms |
Ly49i2, Ly49J |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.051)
|
| Stock # |
IGL02060
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
6 |
| Chromosomal Location |
130246157-130258891 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 130249688 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 199
(Y199C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000107651
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000112020]
|
| AlphaFold |
Q9R1G6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112020
AA Change: Y199C
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000107651
Gene: ENSMUSG00000072718
AA Change: Y199C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
56 |
66 |
N/A |
INTRINSIC |
|
Blast:CLECT
|
73 |
117 |
2e-9 |
BLAST |
|
CLECT
|
143 |
258 |
6.43e-14 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 36 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4932438H23Rik |
T |
A |
16: 90,852,603 (GRCm39) |
I178F |
probably damaging |
Het |
| Aff1 |
T |
C |
5: 103,931,715 (GRCm39) |
V111A |
possibly damaging |
Het |
| Aox1 |
T |
G |
1: 58,137,114 (GRCm39) |
I1168R |
possibly damaging |
Het |
| Atf6 |
T |
C |
1: 170,646,989 (GRCm39) |
R295G |
probably damaging |
Het |
| Blm |
C |
A |
7: 80,164,328 (GRCm39) |
|
probably benign |
Het |
| Cse1l |
A |
T |
2: 166,772,573 (GRCm39) |
L413F |
probably damaging |
Het |
| Dip2c |
T |
C |
13: 9,672,666 (GRCm39) |
V1024A |
probably damaging |
Het |
| Fam13c |
A |
T |
10: 70,388,971 (GRCm39) |
E498V |
probably damaging |
Het |
| Fat4 |
A |
G |
3: 39,064,420 (GRCm39) |
E4792G |
probably damaging |
Het |
| Gramd1a |
A |
T |
7: 30,829,996 (GRCm39) |
L151* |
probably null |
Het |
| Igbp1b |
G |
T |
6: 138,634,982 (GRCm39) |
A154E |
probably damaging |
Het |
| Itga9 |
A |
G |
9: 118,490,500 (GRCm39) |
K277R |
probably damaging |
Het |
| Lgalsl2 |
A |
G |
7: 5,362,563 (GRCm39) |
T65A |
probably damaging |
Het |
| Mospd3 |
T |
C |
5: 137,598,266 (GRCm39) |
Y85C |
probably damaging |
Het |
| Nol6 |
C |
T |
4: 41,117,700 (GRCm39) |
A887T |
probably damaging |
Het |
| Or4a27 |
A |
T |
2: 88,559,907 (GRCm39) |
F12Y |
probably damaging |
Het |
| Or4z4 |
A |
G |
19: 12,076,824 (GRCm39) |
Y60H |
probably damaging |
Het |
| Or5p57 |
G |
T |
7: 107,665,878 (GRCm39) |
F42L |
probably benign |
Het |
| Or9g4 |
C |
T |
2: 85,505,178 (GRCm39) |
V106I |
probably benign |
Het |
| Pcdhb17 |
A |
G |
18: 37,619,469 (GRCm39) |
T420A |
probably damaging |
Het |
| Pgghg |
T |
C |
7: 140,526,546 (GRCm39) |
V646A |
probably benign |
Het |
| Prkg2 |
A |
G |
5: 99,172,374 (GRCm39) |
S114P |
probably benign |
Het |
| Rela |
G |
T |
19: 5,688,628 (GRCm39) |
K28N |
probably damaging |
Het |
| Rhbdf2 |
G |
T |
11: 116,491,452 (GRCm39) |
A598E |
probably damaging |
Het |
| Ryr2 |
C |
T |
13: 11,762,450 (GRCm39) |
D1454N |
probably damaging |
Het |
| Sdk1 |
C |
T |
5: 141,938,767 (GRCm39) |
L397F |
possibly damaging |
Het |
| Sh3pxd2a |
C |
T |
19: 47,361,817 (GRCm39) |
|
probably benign |
Het |
| Slc9a2 |
T |
A |
1: 40,795,453 (GRCm39) |
V518E |
probably damaging |
Het |
| Slco1a7 |
T |
A |
6: 141,700,134 (GRCm39) |
M133L |
probably benign |
Het |
| Snapc1 |
A |
G |
12: 74,014,810 (GRCm39) |
Y105C |
probably damaging |
Het |
| Sult2a8 |
A |
G |
7: 14,159,326 (GRCm39) |
S98P |
probably damaging |
Het |
| Tmem30c |
T |
A |
16: 57,111,261 (GRCm39) |
M4L |
probably benign |
Het |
| Trim71 |
T |
C |
9: 114,342,321 (GRCm39) |
I654V |
possibly damaging |
Het |
| Uroc1 |
A |
G |
6: 90,315,237 (GRCm39) |
S133G |
probably benign |
Het |
| Vmn2r100 |
A |
G |
17: 19,741,516 (GRCm39) |
N76S |
possibly damaging |
Het |
| Zcchc14 |
T |
C |
8: 122,330,634 (GRCm39) |
S910G |
probably damaging |
Het |
|
| Other mutations in Klra10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01505:Klra10
|
APN |
6 |
130,249,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02249:Klra10
|
APN |
6 |
130,256,367 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02681:Klra10
|
APN |
6 |
130,256,382 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02684:Klra10
|
APN |
6 |
130,258,845 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
FR4342:Klra10
|
UTSW |
6 |
130,249,710 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0324:Klra10
|
UTSW |
6 |
130,249,613 (GRCm39) |
splice site |
probably null |
|
|
R1072:Klra10
|
UTSW |
6 |
130,258,811 (GRCm39) |
missense |
probably benign |
0.11 |
|
R1466:Klra10
|
UTSW |
6 |
130,256,394 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1466:Klra10
|
UTSW |
6 |
130,256,394 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1466:Klra10
|
UTSW |
6 |
130,256,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1466:Klra10
|
UTSW |
6 |
130,256,278 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2125:Klra10
|
UTSW |
6 |
130,256,241 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2266:Klra10
|
UTSW |
6 |
130,246,264 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2427:Klra10
|
UTSW |
6 |
130,256,298 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4260:Klra10
|
UTSW |
6 |
130,249,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4495:Klra10
|
UTSW |
6 |
130,256,311 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5897:Klra10
|
UTSW |
6 |
130,258,792 (GRCm39) |
nonsense |
probably null |
|
|
R6123:Klra10
|
UTSW |
6 |
130,256,339 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6221:Klra10
|
UTSW |
6 |
130,246,235 (GRCm39) |
missense |
probably benign |
|
|
R6478:Klra10
|
UTSW |
6 |
130,249,507 (GRCm39) |
splice site |
probably null |
|
|
R6520:Klra10
|
UTSW |
6 |
130,252,755 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6551:Klra10
|
UTSW |
6 |
130,252,718 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7445:Klra10
|
UTSW |
6 |
130,252,819 (GRCm39) |
missense |
probably benign |
0.38 |
|
R7453:Klra10
|
UTSW |
6 |
130,257,327 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7744:Klra10
|
UTSW |
6 |
130,249,724 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8079:Klra10
|
UTSW |
6 |
130,252,738 (GRCm39) |
missense |
probably benign |
|
|
R8320:Klra10
|
UTSW |
6 |
130,246,211 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8963:Klra10
|
UTSW |
6 |
130,249,617 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9419:Klra10
|
UTSW |
6 |
130,256,435 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9725:Klra10
|
UTSW |
6 |
130,252,849 (GRCm39) |
missense |
probably benign |
|
|
RF060:Klra10
|
UTSW |
6 |
130,252,784 (GRCm39) |
small deletion |
probably benign |
|
|
| Posted On |
2014-05-07 |
Incidental Mutation