Incidental Mutation 'IGL02066:Anp32a'
ID185665
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Anp32a
Ensembl Gene ENSMUSG00000032249
Gene Nameacidic (leucine-rich) nuclear phosphoprotein 32 family, member A
Synonymspp32, Anp32
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL02066
Quality Score
Status
Chromosome9
Chromosomal Location62341293-62378812 bp(+) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) G to A at 62377333 bp
ZygosityHeterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000085519] [ENSMUST00000128636] [ENSMUST00000135395]
Predicted Effect unknown
Transcript: ENSMUST00000085519
AA Change: D218N
SMART Domains Protein: ENSMUSP00000082652
Gene: ENSMUSG00000032249
AA Change: D218N

DomainStartEndE-ValueType
Pfam:LRR_4 64 107 5.2e-9 PFAM
Pfam:LRR_8 64 125 1.9e-9 PFAM
LRRcap 128 146 3.19e-2 SMART
coiled coil region 167 199 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126451
Predicted Effect probably benign
Transcript: ENSMUST00000128636
SMART Domains Protein: ENSMUSP00000123574
Gene: ENSMUSG00000032249

DomainStartEndE-ValueType
Pfam:LRR_8 67 128 3.1e-10 PFAM
Pfam:LRR_4 77 111 3e-8 PFAM
Pfam:LRR_6 90 110 7.2e-6 PFAM
Pfam:LRR_7 91 107 9.5e-4 PFAM
Pfam:LRR_1 92 115 1.7e-4 PFAM
LRRcap 131 149 3.19e-2 SMART
coiled coil region 170 198 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129026
Predicted Effect unknown
Transcript: ENSMUST00000135395
AA Change: D204N
SMART Domains Protein: ENSMUSP00000122165
Gene: ENSMUSG00000032249
AA Change: D204N

DomainStartEndE-ValueType
Pfam:LRR_8 50 111 4.9e-10 PFAM
Pfam:LRR_6 73 93 9e-6 PFAM
Pfam:LRR_7 74 90 1.2e-3 PFAM
Pfam:LRR_1 75 98 2.2e-4 PFAM
LRRcap 114 132 3.19e-2 SMART
coiled coil region 153 185 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136603
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138226
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141277
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145679
Predicted Effect probably benign
Transcript: ENSMUST00000156461
SMART Domains Protein: ENSMUSP00000115293
Gene: ENSMUSG00000032249

DomainStartEndE-ValueType
Pfam:LRR_9 5 138 8e-13 PFAM
Pfam:LRR_4 60 104 9.7e-10 PFAM
Pfam:LRR_8 60 121 8.6e-10 PFAM
Pfam:LRR_4 84 129 2.8e-9 PFAM
Pfam:LRR_1 85 106 1.4e-3 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mutant mice are viable, fertile, behaviorally normal, and show no defects of the central nervous system. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610507B11Rik G A 11: 78,273,232 R1133H probably damaging Het
A2m T A 6: 121,649,895 C569S probably damaging Het
Adck5 T C 15: 76,595,206 V487A probably damaging Het
Agfg1 A G 1: 82,893,558 T483A probably damaging Het
Akr1c12 T C 13: 4,276,237 T82A probably damaging Het
Ano2 T A 6: 125,690,739 L6Q probably benign Het
Cep250 C A 2: 155,976,521 A871D probably damaging Het
Chl1 T C 6: 103,698,224 V624A probably benign Het
Clasp1 G A 1: 118,565,260 probably null Het
Clca3a2 T G 3: 144,813,455 D320A probably benign Het
Cnot9 A G 1: 74,527,053 Q201R possibly damaging Het
Cox4i2 C T 2: 152,760,682 R99C probably damaging Het
Csmd1 A T 8: 15,926,594 F2875I probably damaging Het
Dpagt1 A G 9: 44,331,906 Y246C probably damaging Het
Dsc1 A G 18: 20,108,803 probably benign Het
Eef1d G A 15: 75,896,855 T464I probably benign Het
Efna2 C T 10: 80,188,666 probably benign Het
Etaa1 C A 11: 17,946,687 V477L probably benign Het
Fam189b C T 3: 89,188,596 R545* probably null Het
Fam83d C T 2: 158,785,873 T494M probably benign Het
Fbxo24 C T 5: 137,612,870 V553M probably damaging Het
Gal3st2 A G 1: 93,873,657 T12A probably damaging Het
Gba2 G A 4: 43,570,175 T373I probably benign Het
Kitl T A 10: 100,076,882 C154S probably damaging Het
Lrp1b A T 2: 41,111,079 C2044* probably null Het
Lrp6 G T 6: 134,450,937 S1564* probably null Het
Manea A T 4: 26,340,965 probably benign Het
Myt1 T C 2: 181,797,189 L168P probably damaging Het
Notch1 T C 2: 26,460,396 E2244G possibly damaging Het
Nsd3 T G 8: 25,713,488 V1343G probably damaging Het
Nup155 T C 15: 8,157,766 probably benign Het
Obox6 T C 7: 15,834,703 I83V probably benign Het
Olfr358 A T 2: 37,005,309 F102I probably damaging Het
Olfr538 A T 7: 140,574,500 T116S possibly damaging Het
Pdgfra T C 5: 75,170,580 V282A possibly damaging Het
Pkd1l2 A G 8: 117,009,564 probably benign Het
Pmfbp1 A T 8: 109,541,733 I971F possibly damaging Het
Ppp6c T C 2: 39,199,671 T199A probably benign Het
Ptpa A G 2: 30,443,296 T3A possibly damaging Het
Rb1 A T 14: 73,198,534 M897K probably benign Het
Rptn A C 3: 93,397,129 S590R probably benign Het
Rreb1 A G 13: 37,931,506 D947G probably benign Het
Samd9l T C 6: 3,376,575 T229A probably damaging Het
Slc5a9 A T 4: 111,887,522 M423K probably damaging Het
Slc6a12 T A 6: 121,352,056 I111N probably damaging Het
Slc6a15 T A 10: 103,416,658 L561I probably damaging Het
Spag5 A G 11: 78,304,532 N222D probably benign Het
Spp2 G A 1: 88,417,243 M54I probably benign Het
Sptbn4 T C 7: 27,364,515 E847G possibly damaging Het
Timd2 T A 11: 46,678,223 N203Y probably damaging Het
Togaram1 G T 12: 64,983,421 D1000Y probably damaging Het
Usp47 C T 7: 112,064,397 R258C probably damaging Het
Uts2r A C 11: 121,160,697 D129A probably damaging Het
Vmn2r102 G A 17: 19,693,929 M585I probably benign Het
Vmn2r77 A T 7: 86,803,628 R518* probably null Het
Wdfy4 C T 14: 33,149,566 R296K probably benign Het
Xirp2 A T 2: 67,526,071 K3725N probably benign Het
Xntrpc T C 7: 102,077,829 S142P probably benign Het
Zfat T C 15: 68,180,829 H372R probably damaging Het
Other mutations in Anp32a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00655:Anp32a APN 9 62371712 splice site probably benign
IGL01799:Anp32a APN 9 62371810 missense probably benign 0.06
IGL02536:Anp32a APN 9 62371828 missense probably damaging 0.98
R1608:Anp32a UTSW 9 62372093 missense probably damaging 0.99
R2149:Anp32a UTSW 9 62371802 missense probably benign 0.19
R5287:Anp32a UTSW 9 62341993 missense possibly damaging 0.50
R5381:Anp32a UTSW 9 62372177 missense probably damaging 0.97
R5403:Anp32a UTSW 9 62341993 missense possibly damaging 0.50
R5427:Anp32a UTSW 9 62377316 unclassified probably benign
R6856:Anp32a UTSW 9 62372115 missense possibly damaging 0.95
R6906:Anp32a UTSW 9 62377569 unclassified probably benign
Posted On2014-05-07