Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02073:Vmn1r17'

185881

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r17

Ensembl Gene

ENSMUSG00000115644

Gene Name

vomeronasal 1 receptor 17

Synonyms

V1rc16

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.218) question?

Stock #

IGL02073

Quality Score

Status

Chromosome

Chromosomal Location

57337452-57338363 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 57337787 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 193 (I193V)

Ref Sequence

ENSEMBL: ENSMUSP00000154129 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000176395] [ENSMUST00000227186] [ENSMUST00000227966] [ENSMUST00000228156] [ENSMUST00000228294] [ENSMUST00000228342]

AlphaFold

Q8R2D8

Predicted Effect

probably benign
Transcript: ENSMUST00000176395
AA Change: I193V

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000135746
Gene: ENSMUSG00000093411
AA Change: I193V

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	1.4e-53	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000227186
AA Change: I193V

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

Predicted Effect

probably benign
Transcript: ENSMUST00000227966
AA Change: I193V

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

Predicted Effect

probably benign
Transcript: ENSMUST00000228156
AA Change: I144V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Predicted Effect

probably benign
Transcript: ENSMUST00000228294
AA Change: I144V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Predicted Effect

probably benign
Transcript: ENSMUST00000228342
AA Change: I193V

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930566N20Rik	C	A	3: 156,914,039 (GRCm39)		probably benign	Het
6330409D20Rik	T	G	2: 32,630,698 (GRCm39)		probably benign	Het
Als2cl	A	G	9: 110,723,407 (GRCm39)	K659E	probably benign	Het
Bbx	G	A	16: 50,022,854 (GRCm39)	T702I	probably damaging	Het
Bcas3	A	G	11: 85,448,263 (GRCm39)	D405G	probably damaging	Het
Brpf3	A	G	17: 29,026,370 (GRCm39)	Y481C	probably benign	Het
Csnk1g1	T	A	9: 65,909,533 (GRCm39)	Y217N	probably damaging	Het
Cyp4f37	G	T	17: 32,846,825 (GRCm39)	V171L	possibly damaging	Het
Dock8	G	A	19: 25,178,350 (GRCm39)		probably null	Het
Extl3	C	A	14: 65,313,788 (GRCm39)	G465W	probably damaging	Het
Fbxo10	A	G	4: 45,046,349 (GRCm39)	I587T	possibly damaging	Het
Fstl5	A	C	3: 76,566,959 (GRCm39)		probably benign	Het
Gabbr2	T	C	4: 46,667,547 (GRCm39)	N866S	probably benign	Het
Gm4871	T	A	5: 144,969,388 (GRCm39)	K44*	probably null	Het
Hnrnpul1	T	C	7: 25,421,766 (GRCm39)		probably benign	Het
Jup	A	G	11: 100,274,215 (GRCm39)		probably benign	Het
Mccc2	A	T	13: 100,136,783 (GRCm39)	H57Q	probably benign	Het
Myo1a	A	T	10: 127,546,094 (GRCm39)	D239V	probably damaging	Het
Ncapd3	T	A	9: 26,974,612 (GRCm39)	S695T	probably benign	Het
Ncor1	A	T	11: 62,249,743 (GRCm39)	S1052T	probably damaging	Het
Or5k8	A	G	16: 58,644,169 (GRCm39)	I301T	probably benign	Het
Or7g12	T	A	9: 18,899,621 (GRCm39)	N112K	possibly damaging	Het
Or8c10	C	T	9: 38,279,603 (GRCm39)	H244Y	probably damaging	Het
Pcnx3	A	T	19: 5,729,414 (GRCm39)	I526K	probably damaging	Het
Pcnx4	A	G	12: 72,621,102 (GRCm39)	D974G	possibly damaging	Het
Peg3	T	C	7: 6,714,001 (GRCm39)	E407G	probably damaging	Het
Polk	A	G	13: 96,641,059 (GRCm39)	V166A	probably damaging	Het
Prkar2a	A	G	9: 108,610,322 (GRCm39)	I184V	probably damaging	Het
Ptpra	T	C	2: 30,333,362 (GRCm39)	S64P	probably damaging	Het
Rbsn	A	G	6: 92,166,340 (GRCm39)	L768P	probably damaging	Het
Ripk3	C	T	14: 56,023,482 (GRCm39)		probably null	Het
Rnf123	G	A	9: 107,945,501 (GRCm39)	R390*	probably null	Het
Sar1b	T	C	11: 51,680,020 (GRCm39)		probably benign	Het
Slx	A	T	X: 26,489,755 (GRCm39)	W89R	probably benign	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Svep1	T	C	4: 58,070,104 (GRCm39)	I2561V	probably benign	Het
Tasor2	T	C	13: 3,624,721 (GRCm39)	D1743G	probably benign	Het
Tm7sf3	A	G	6: 146,525,208 (GRCm39)	L79P	possibly damaging	Het
Trub1	A	T	19: 57,441,379 (GRCm39)	M1L	probably benign	Het
Unc80	A	G	1: 66,651,386 (GRCm39)	D1577G	possibly damaging	Het
Vat1	A	T	11: 101,351,405 (GRCm39)	M312K	possibly damaging	Het
Vps13b	A	G	15: 35,875,732 (GRCm39)	I2706V	possibly damaging	Het
Wls	T	C	3: 159,612,890 (GRCm39)		probably null	Het
Zfp955b	A	G	17: 33,519,564 (GRCm39)	T11A	possibly damaging	Het

Other mutations in Vmn1r17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00943:Vmn1r17	APN	6	57,338,185 (GRCm39)	missense	possibly damaging	0.48
IGL03117:Vmn1r17	APN	6	57,337,501 (GRCm39)	missense	probably benign	0.08
IGL03168:Vmn1r17	APN	6	57,337,583 (GRCm39)	missense	probably benign	0.01
R0472:Vmn1r17	UTSW	6	57,338,304 (GRCm39)	missense	probably benign
R0590:Vmn1r17	UTSW	6	57,337,999 (GRCm39)	missense	probably benign	0.01
R0648:Vmn1r17	UTSW	6	57,337,460 (GRCm39)	missense	probably damaging	0.98
R1025:Vmn1r17	UTSW	6	57,338,240 (GRCm39)	missense	probably benign	0.05
R1545:Vmn1r17	UTSW	6	57,338,317 (GRCm39)	missense	probably benign	0.01
R2035:Vmn1r17	UTSW	6	57,337,573 (GRCm39)	missense	probably benign	0.13
R2507:Vmn1r17	UTSW	6	57,338,244 (GRCm39)	missense	probably damaging	0.99
R2508:Vmn1r17	UTSW	6	57,337,855 (GRCm39)	missense	possibly damaging	0.76
R3084:Vmn1r17	UTSW	6	57,337,768 (GRCm39)	missense	probably damaging	0.99
R3688:Vmn1r17	UTSW	6	57,337,544 (GRCm39)	missense	probably damaging	0.99
R3696:Vmn1r17	UTSW	6	57,337,523 (GRCm39)	missense	possibly damaging	0.74
R4436:Vmn1r17	UTSW	6	57,337,719 (GRCm39)	missense	possibly damaging	0.91
R4741:Vmn1r17	UTSW	6	57,338,337 (GRCm39)	nonsense	probably null
R4989:Vmn1r17	UTSW	6	57,337,460 (GRCm39)	missense	possibly damaging	0.47
R5013:Vmn1r17	UTSW	6	57,337,828 (GRCm39)	missense	probably benign	0.05
R5133:Vmn1r17	UTSW	6	57,337,828 (GRCm39)	missense	probably benign	0.05
R5134:Vmn1r17	UTSW	6	57,337,828 (GRCm39)	missense	probably benign	0.05
R5162:Vmn1r17	UTSW	6	57,337,828 (GRCm39)	missense	probably benign	0.05
R5184:Vmn1r17	UTSW	6	57,337,828 (GRCm39)	missense	probably benign	0.05
R5185:Vmn1r17	UTSW	6	57,337,828 (GRCm39)	missense	probably benign	0.05
R5831:Vmn1r17	UTSW	6	57,337,999 (GRCm39)	missense	probably benign	0.01
R6487:Vmn1r17	UTSW	6	57,338,209 (GRCm39)	missense	possibly damaging	0.94
R7436:Vmn1r17	UTSW	6	57,337,862 (GRCm39)	missense	probably benign	0.03
R7600:Vmn1r17	UTSW	6	57,337,906 (GRCm39)	missense	probably benign	0.01
R8944:Vmn1r17	UTSW	6	57,338,142 (GRCm39)	missense	probably benign	0.00

Posted On

2014-05-07