Incidental Mutation 'IGL02051:Cacul1'
ID |
186113 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Cacul1
|
Ensembl Gene |
ENSMUSG00000033417 |
Gene Name |
CDK2 associated, cullin domain 1 |
Synonyms |
2700078E11Rik, 2810417M16Rik, 9830127L17Rik, D130033C15Rik |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.165)
|
Stock # |
IGL02051
|
Quality Score |
|
Status
|
|
Chromosome |
19 |
Chromosomal Location |
60513143-60569420 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 60531504 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Aspartic acid to Glycine
at position 255
(D255G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000127014
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000081790]
[ENSMUST00000111460]
[ENSMUST00000166712]
|
AlphaFold |
Q8R0X2 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000081790
AA Change: D255G
PolyPhen 2
Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000080480 Gene: ENSMUSG00000033417 AA Change: D255G
Domain | Start | End | E-Value | Type |
low complexity region
|
1 |
17 |
N/A |
INTRINSIC |
low complexity region
|
35 |
56 |
N/A |
INTRINSIC |
low complexity region
|
76 |
92 |
N/A |
INTRINSIC |
low complexity region
|
104 |
128 |
N/A |
INTRINSIC |
Pfam:Cullin
|
145 |
346 |
2.2e-13 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000111460
AA Change: D255G
PolyPhen 2
Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000107086 Gene: ENSMUSG00000033417 AA Change: D255G
Domain | Start | End | E-Value | Type |
low complexity region
|
1 |
17 |
N/A |
INTRINSIC |
low complexity region
|
35 |
56 |
N/A |
INTRINSIC |
low complexity region
|
76 |
92 |
N/A |
INTRINSIC |
low complexity region
|
104 |
128 |
N/A |
INTRINSIC |
Pfam:Cullin
|
145 |
294 |
2.4e-15 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000166712
AA Change: D255G
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000127014 Gene: ENSMUSG00000033417 AA Change: D255G
Domain | Start | End | E-Value | Type |
low complexity region
|
1 |
17 |
N/A |
INTRINSIC |
low complexity region
|
35 |
56 |
N/A |
INTRINSIC |
low complexity region
|
76 |
92 |
N/A |
INTRINSIC |
low complexity region
|
104 |
128 |
N/A |
INTRINSIC |
Pfam:Cullin
|
145 |
287 |
1.4e-15 |
PFAM |
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 21 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Chi3l1 |
T |
C |
1: 134,111,887 (GRCm39) |
S94P |
probably damaging |
Het |
Defa38 |
A |
G |
8: 21,585,275 (GRCm39) |
|
probably benign |
Het |
Dzip3 |
T |
C |
16: 48,792,617 (GRCm39) |
T223A |
probably benign |
Het |
Firrm |
T |
C |
1: 163,785,091 (GRCm39) |
T763A |
probably benign |
Het |
Gfra3 |
T |
C |
18: 34,828,894 (GRCm39) |
T167A |
possibly damaging |
Het |
Glb1l3 |
T |
C |
9: 26,736,464 (GRCm39) |
I533V |
probably benign |
Het |
Gm11437 |
T |
A |
11: 84,043,592 (GRCm39) |
Q233L |
probably benign |
Het |
Hif1an |
A |
G |
19: 44,551,829 (GRCm39) |
Y93C |
probably damaging |
Het |
Hspg2 |
A |
G |
4: 137,295,700 (GRCm39) |
|
probably benign |
Het |
Ints15 |
A |
G |
5: 143,293,737 (GRCm39) |
C247R |
probably damaging |
Het |
Mak |
G |
A |
13: 41,195,558 (GRCm39) |
A385V |
probably benign |
Het |
Mical2 |
G |
T |
7: 111,980,597 (GRCm39) |
K190N |
probably benign |
Het |
Moxd1 |
A |
G |
10: 24,128,916 (GRCm39) |
|
probably null |
Het |
Ptpn5 |
A |
G |
7: 46,732,507 (GRCm39) |
|
probably null |
Het |
Ryr1 |
A |
G |
7: 28,771,083 (GRCm39) |
Y2614H |
probably benign |
Het |
Sema3e |
T |
A |
5: 14,274,324 (GRCm39) |
Y192N |
possibly damaging |
Het |
Smpd4 |
T |
C |
16: 17,444,382 (GRCm39) |
L145P |
probably damaging |
Het |
Tesk2 |
A |
G |
4: 116,608,381 (GRCm39) |
E101G |
probably damaging |
Het |
Vmn1r68 |
A |
T |
7: 10,261,948 (GRCm39) |
V50E |
probably benign |
Het |
Vpreb3 |
G |
A |
10: 75,784,244 (GRCm39) |
|
probably null |
Het |
Vps72 |
T |
C |
3: 95,030,040 (GRCm39) |
L353P |
possibly damaging |
Het |
|
Other mutations in Cacul1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02614:Cacul1
|
APN |
19 |
60,551,661 (GRCm39) |
missense |
possibly damaging |
0.72 |
IGL03329:Cacul1
|
APN |
19 |
60,531,489 (GRCm39) |
missense |
probably damaging |
1.00 |
R0012:Cacul1
|
UTSW |
19 |
60,552,691 (GRCm39) |
missense |
probably damaging |
1.00 |
R0323:Cacul1
|
UTSW |
19 |
60,531,498 (GRCm39) |
missense |
probably benign |
0.38 |
R0400:Cacul1
|
UTSW |
19 |
60,551,591 (GRCm39) |
splice site |
probably benign |
|
R0472:Cacul1
|
UTSW |
19 |
60,531,464 (GRCm39) |
missense |
probably damaging |
1.00 |
R0853:Cacul1
|
UTSW |
19 |
60,522,664 (GRCm39) |
missense |
probably damaging |
1.00 |
R1169:Cacul1
|
UTSW |
19 |
60,568,846 (GRCm39) |
missense |
probably damaging |
0.99 |
R1490:Cacul1
|
UTSW |
19 |
60,568,837 (GRCm39) |
missense |
probably damaging |
0.99 |
R1840:Cacul1
|
UTSW |
19 |
60,522,688 (GRCm39) |
nonsense |
probably null |
|
R5140:Cacul1
|
UTSW |
19 |
60,551,619 (GRCm39) |
missense |
probably benign |
0.00 |
R5858:Cacul1
|
UTSW |
19 |
60,517,482 (GRCm39) |
utr 3 prime |
probably benign |
|
R5888:Cacul1
|
UTSW |
19 |
60,525,902 (GRCm39) |
missense |
possibly damaging |
0.62 |
R6629:Cacul1
|
UTSW |
19 |
60,568,805 (GRCm39) |
missense |
probably benign |
0.06 |
R6853:Cacul1
|
UTSW |
19 |
60,517,904 (GRCm39) |
nonsense |
probably null |
|
R6859:Cacul1
|
UTSW |
19 |
60,522,683 (GRCm39) |
missense |
probably damaging |
1.00 |
R7486:Cacul1
|
UTSW |
19 |
60,568,868 (GRCm39) |
missense |
probably benign |
0.08 |
R8262:Cacul1
|
UTSW |
19 |
60,517,475 (GRCm39) |
makesense |
probably null |
|
R8358:Cacul1
|
UTSW |
19 |
60,551,673 (GRCm39) |
missense |
possibly damaging |
0.75 |
R8889:Cacul1
|
UTSW |
19 |
60,568,960 (GRCm39) |
missense |
probably damaging |
0.99 |
R9357:Cacul1
|
UTSW |
19 |
60,533,942 (GRCm39) |
missense |
probably benign |
0.00 |
R9555:Cacul1
|
UTSW |
19 |
60,533,887 (GRCm39) |
nonsense |
probably null |
|
R9755:Cacul1
|
UTSW |
19 |
60,533,955 (GRCm39) |
missense |
probably damaging |
0.98 |
X0027:Cacul1
|
UTSW |
19 |
60,531,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Posted On |
2014-05-07 |