Incidental Mutation 'R1462:Ints10'
ID 186321
Institutional Source Beutler Lab
Gene Symbol Ints10
Ensembl Gene ENSMUSG00000031864
Gene Name integrator complex subunit 10
Synonyms 4921521J11Rik
MMRRC Submission 039516-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1462 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 69245729-69282062 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to A at 69260296 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000105871 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034328] [ENSMUST00000070713] [ENSMUST00000110241] [ENSMUST00000110242]
AlphaFold Q8K2A7
Predicted Effect probably benign
Transcript: ENSMUST00000034328
SMART Domains Protein: ENSMUSP00000034328
Gene: ENSMUSG00000031864

DomainStartEndE-ValueType
low complexity region 132 138 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000070713
SMART Domains Protein: ENSMUSP00000069908
Gene: ENSMUSG00000031864

DomainStartEndE-ValueType
low complexity region 132 138 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000110241
SMART Domains Protein: ENSMUSP00000105870
Gene: ENSMUSG00000031864

DomainStartEndE-ValueType
low complexity region 132 138 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000110242
SMART Domains Protein: ENSMUSP00000105871
Gene: ENSMUSG00000031864

DomainStartEndE-ValueType
low complexity region 132 138 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140309
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.0%
  • 20x: 92.0%
Validation Efficiency 99% (83/84)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 83 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930433I11Rik C A 7: 40,642,370 (GRCm39) S104* probably null Het
A430093F15Rik A T 19: 10,762,845 (GRCm39) probably benign Het
Abca13 T A 11: 9,433,924 (GRCm39) probably benign Het
Abca9 T C 11: 110,051,342 (GRCm39) D118G probably benign Het
Adamts16 A G 13: 70,984,253 (GRCm39) F137L probably benign Het
Adamts3 T C 5: 90,009,208 (GRCm39) I152V probably benign Het
Adcy4 T A 14: 56,015,765 (GRCm39) E441D possibly damaging Het
Adgra1 T A 7: 139,455,745 (GRCm39) Y458N probably damaging Het
Atpaf1 C T 4: 115,642,150 (GRCm39) probably benign Het
Bhlhe22 C G 3: 18,109,946 (GRCm39) S332C probably damaging Het
Card19 T A 13: 49,358,760 (GRCm39) Q71L probably benign Het
Ccdc12 T C 9: 110,485,662 (GRCm39) L11P probably damaging Het
Cdadc1 A G 14: 59,813,307 (GRCm39) Y367H probably damaging Het
Cdc5l G T 17: 45,719,288 (GRCm39) Q542K possibly damaging Het
Ceacam23 T G 7: 17,649,516 (GRCm39) noncoding transcript Het
Cep170 T C 1: 176,584,211 (GRCm39) K723E possibly damaging Het
Cep70 A G 9: 99,145,773 (GRCm39) I147V probably benign Het
Cfap58 A T 19: 47,950,869 (GRCm39) H410L probably damaging Het
Chat T C 14: 32,142,735 (GRCm39) K418R probably damaging Het
Cic T G 7: 24,971,032 (GRCm39) D254E probably damaging Het
Ckap4 T C 10: 84,363,431 (GRCm39) E544G probably damaging Het
Crnkl1 C T 2: 145,763,739 (GRCm39) A500T probably damaging Het
Cyp2c38 T C 19: 39,380,632 (GRCm39) N418D probably damaging Het
Daam1 A T 12: 71,990,916 (GRCm39) I177L unknown Het
Dnah1 T C 14: 30,990,738 (GRCm39) probably benign Het
Ercc5 A G 1: 44,219,784 (GRCm39) T1019A probably damaging Het
F13b T A 1: 139,435,374 (GRCm39) V173E probably damaging Het
Fam135b A G 15: 71,493,845 (GRCm39) probably benign Het
Fam20a A C 11: 109,568,143 (GRCm39) F316V probably damaging Het
Flrt2 T C 12: 95,746,112 (GRCm39) V150A probably damaging Het
Fnta A C 8: 26,489,599 (GRCm39) probably null Het
Ghsr A G 3: 27,426,025 (GRCm39) D27G probably benign Het
Glis3 G T 19: 28,239,918 (GRCm39) probably benign Het
Gtpbp1 A G 15: 79,592,086 (GRCm39) N96D probably damaging Het
H1f7 A T 15: 98,154,454 (GRCm39) W232R unknown Het
Hycc1 A G 5: 24,190,730 (GRCm39) probably benign Het
Ibtk A T 9: 85,606,198 (GRCm39) I443N probably damaging Het
Ifi207 T C 1: 173,552,513 (GRCm39) H968R probably damaging Het
Ifit2 A G 19: 34,550,586 (GRCm39) D42G probably null Het
Il17rc A T 6: 113,455,950 (GRCm39) D265V probably damaging Het
Itfg2 T C 6: 128,401,691 (GRCm39) D29G probably damaging Het
Itprid1 A G 6: 55,952,649 (GRCm39) H864R probably damaging Het
Kcng3 A T 17: 83,938,492 (GRCm39) C186S probably damaging Het
Lrrc1 A G 9: 77,349,547 (GRCm39) F295L probably benign Het
Mrps28 T A 3: 8,965,184 (GRCm39) H85L possibly damaging Het
Mtpn T A 6: 35,499,693 (GRCm39) K37M possibly damaging Het
Mug1 C T 6: 121,859,588 (GRCm39) H1196Y probably benign Het
Mup4 T C 4: 59,960,084 (GRCm39) H60R possibly damaging Het
Musk A G 4: 58,286,204 (GRCm39) probably benign Het
Mybl2 T C 2: 162,914,628 (GRCm39) S249P probably benign Het
Naip6 A G 13: 100,436,748 (GRCm39) Y592H possibly damaging Het
Nrp1 A G 8: 129,229,279 (GRCm39) N919S probably benign Het
Nudt9 C T 5: 104,212,904 (GRCm39) Q326* probably null Het
Or5w13 A T 2: 87,523,720 (GRCm39) C169S probably damaging Het
Or6c76b A G 10: 129,693,100 (GRCm39) T238A probably damaging Het
Or7g17 T A 9: 18,768,407 (GRCm39) M162K probably benign Het
Or9k7 T A 10: 130,046,592 (GRCm39) I136F probably benign Het
Pcsk4 T C 10: 80,161,815 (GRCm39) E142G probably damaging Het
Pde3a C A 6: 141,405,560 (GRCm39) P471T probably benign Het
Pign A T 1: 105,512,727 (GRCm39) V652E possibly damaging Het
Prkcb T A 7: 122,181,672 (GRCm39) M420K probably damaging Het
Prr14 T A 7: 127,073,160 (GRCm39) probably null Het
Rchy1 T A 5: 92,105,741 (GRCm39) Q69L probably damaging Het
Sccpdh A C 1: 179,509,125 (GRCm39) probably benign Het
Sec23ip T G 7: 128,367,862 (GRCm39) S625A probably benign Het
Smpdl3b A G 4: 132,473,925 (GRCm39) S47P probably damaging Het
Speer4a3 T A 5: 26,156,623 (GRCm39) I119F possibly damaging Het
Stil G A 4: 114,881,161 (GRCm39) M568I probably benign Het
Syt3 T A 7: 44,045,434 (GRCm39) V558E probably damaging Het
Sytl3 A G 17: 6,973,430 (GRCm39) probably benign Het
Szt2 A G 4: 118,231,164 (GRCm39) V2533A unknown Het
Tenm4 A G 7: 96,353,360 (GRCm39) Y384C probably damaging Het
Tfam T C 10: 71,071,380 (GRCm39) E94G probably damaging Het
Tmbim7 A G 5: 3,714,304 (GRCm39) T14A probably damaging Het
Tmtc2 A T 10: 105,409,566 (GRCm39) Y15* probably null Het
Uhrf1 C T 17: 56,625,035 (GRCm39) A526V probably damaging Het
Vmn2r67 T C 7: 84,805,046 (GRCm39) D22G probably benign Het
Vmn2r96 A G 17: 18,817,660 (GRCm39) I412M possibly damaging Het
Vmn2r-ps69 T A 7: 84,959,560 (GRCm39) noncoding transcript Het
Wdr17 A T 8: 55,123,363 (GRCm39) I479K probably damaging Het
Wt1 T C 2: 104,997,176 (GRCm39) V371A probably damaging Het
Zfp536 G T 7: 37,178,735 (GRCm39) S226Y probably damaging Het
Zfp827 T C 8: 79,803,108 (GRCm39) V560A probably benign Het
Other mutations in Ints10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00743:Ints10 APN 8 69,271,985 (GRCm39) missense probably damaging 1.00
IGL00964:Ints10 APN 8 69,264,638 (GRCm39) missense probably damaging 1.00
IGL02326:Ints10 APN 8 69,257,485 (GRCm39) missense probably damaging 0.99
R0012:Ints10 UTSW 8 69,260,127 (GRCm39) missense probably benign 0.01
R0112:Ints10 UTSW 8 69,279,954 (GRCm39) missense probably damaging 0.99
R1302:Ints10 UTSW 8 69,279,964 (GRCm39) missense probably damaging 1.00
R1540:Ints10 UTSW 8 69,249,365 (GRCm39) splice site probably benign
R1592:Ints10 UTSW 8 69,255,555 (GRCm39) missense possibly damaging 0.69
R1845:Ints10 UTSW 8 69,247,323 (GRCm39) missense probably damaging 1.00
R2144:Ints10 UTSW 8 69,249,457 (GRCm39) missense probably damaging 1.00
R2323:Ints10 UTSW 8 69,271,997 (GRCm39) missense probably benign 0.09
R3765:Ints10 UTSW 8 69,277,771 (GRCm39) missense possibly damaging 0.78
R3910:Ints10 UTSW 8 69,266,272 (GRCm39) missense probably damaging 0.96
R3912:Ints10 UTSW 8 69,266,272 (GRCm39) missense probably damaging 0.96
R3913:Ints10 UTSW 8 69,266,272 (GRCm39) missense probably damaging 0.96
R4050:Ints10 UTSW 8 69,280,003 (GRCm39) missense probably damaging 1.00
R4151:Ints10 UTSW 8 69,247,250 (GRCm39) splice site probably null
R4607:Ints10 UTSW 8 69,263,271 (GRCm39) missense probably damaging 1.00
R4608:Ints10 UTSW 8 69,263,271 (GRCm39) missense probably damaging 1.00
R4881:Ints10 UTSW 8 69,263,256 (GRCm39) missense probably benign 0.08
R4911:Ints10 UTSW 8 69,279,964 (GRCm39) missense probably damaging 0.98
R5255:Ints10 UTSW 8 69,246,624 (GRCm39) start gained probably benign
R5331:Ints10 UTSW 8 69,273,472 (GRCm39) splice site probably null
R5461:Ints10 UTSW 8 69,246,693 (GRCm39) missense possibly damaging 0.59
R5740:Ints10 UTSW 8 69,257,574 (GRCm39) missense probably damaging 0.96
R5741:Ints10 UTSW 8 69,257,574 (GRCm39) missense probably damaging 0.96
R6128:Ints10 UTSW 8 69,274,904 (GRCm39) critical splice donor site probably null
R6465:Ints10 UTSW 8 69,260,188 (GRCm39) missense probably benign
R6868:Ints10 UTSW 8 69,250,450 (GRCm39) missense probably damaging 1.00
R6983:Ints10 UTSW 8 69,246,703 (GRCm39) missense probably damaging 1.00
R7076:Ints10 UTSW 8 69,249,403 (GRCm39) nonsense probably null
R7216:Ints10 UTSW 8 69,274,809 (GRCm39) missense probably damaging 0.96
R7652:Ints10 UTSW 8 69,277,771 (GRCm39) missense possibly damaging 0.78
R8134:Ints10 UTSW 8 69,255,638 (GRCm39) nonsense probably null
R8176:Ints10 UTSW 8 69,255,603 (GRCm39) missense probably damaging 1.00
R8185:Ints10 UTSW 8 69,249,370 (GRCm39) missense possibly damaging 0.51
R8964:Ints10 UTSW 8 69,264,631 (GRCm39) missense probably benign
R9015:Ints10 UTSW 8 69,260,139 (GRCm39) missense probably benign 0.00
R9256:Ints10 UTSW 8 69,261,129 (GRCm39) missense possibly damaging 0.93
R9320:Ints10 UTSW 8 69,279,951 (GRCm39) missense probably damaging 0.98
R9372:Ints10 UTSW 8 69,271,967 (GRCm39) missense probably damaging 1.00
X0027:Ints10 UTSW 8 69,261,126 (GRCm39) missense probably damaging 0.96
Predicted Primers
Posted On 2014-05-09