Incidental Mutation 'R1651:Myo10'
ID 186419
Institutional Source Beutler Lab
Gene Symbol Myo10
Ensembl Gene ENSMUSG00000022272
Gene Name myosin X
Synonyms myosin-X, D15Ertd600e
MMRRC Submission 039687-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1651 (G1)
Quality Score 191
Status Validated
Chromosome 15
Chromosomal Location 25622636-25813759 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 25742455 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Asparagine at position 590 (H590N)
Ref Sequence ENSEMBL: ENSMUSP00000106087 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110457] [ENSMUST00000137601]
AlphaFold F8VQB6
Predicted Effect probably damaging
Transcript: ENSMUST00000110457
AA Change: H590N

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000106087
Gene: ENSMUSG00000022272
AA Change: H590N

DomainStartEndE-ValueType
MYSc 57 740 N/A SMART
IQ 741 763 1.27e-3 SMART
IQ 764 786 1.06e0 SMART
IQ 787 809 7.07e-2 SMART
Pfam:MYO10_CC 881 932 4.2e-22 PFAM
low complexity region 959 981 N/A INTRINSIC
low complexity region 1090 1102 N/A INTRINSIC
low complexity region 1147 1165 N/A INTRINSIC
PH 1217 1316 1.39e-21 SMART
PH 1397 1503 6.76e-11 SMART
MyTH4 1551 1699 4.12e-37 SMART
B41 1700 1962 1.72e-44 SMART
low complexity region 2050 2062 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000135981
SMART Domains Protein: ENSMUSP00000123057
Gene: ENSMUSG00000022272

DomainStartEndE-ValueType
PDB:2DFS|M 2 38 6e-7 PDB
Blast:MYSc 2 42 3e-19 BLAST
IQ 59 81 1.27e-3 SMART
IQ 82 104 1.06e0 SMART
IQ 105 127 7.07e-2 SMART
Pfam:MYO10_CC 199 242 1.7e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000137601
AA Change: H557N

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000118280
Gene: ENSMUSG00000022272
AA Change: H557N

DomainStartEndE-ValueType
MYSc 24 707 N/A SMART
IQ 708 730 1.27e-3 SMART
IQ 731 753 1.06e0 SMART
IQ 754 776 7.07e-2 SMART
Meta Mutation Damage Score 0.0726 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.0%
Validation Efficiency 97% (66/68)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]
PHENOTYPE: Homozygous null mutations are semi-lethal with over half of homozygous embryos exhibiting exencephaly. Surviving mutants show decreased body weight, white spotting, syndactyly, persistence of hyaloid vascular system and other eye defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd12 T A 2: 150,690,341 (GRCm39) Q118L probably benign Het
Acss1 A T 2: 150,480,357 (GRCm39) V238D possibly damaging Het
Adgrv1 T C 13: 81,635,972 (GRCm39) I3512M probably benign Het
Arhgap32 A G 9: 32,171,096 (GRCm39) Q1292R probably damaging Het
Bpnt2 A G 4: 4,792,737 (GRCm39) F123L probably damaging Het
Caskin1 C T 17: 24,721,186 (GRCm39) R509C possibly damaging Het
Cd47 T C 16: 49,714,591 (GRCm39) V147A possibly damaging Het
Cdc20b T A 13: 113,215,258 (GRCm39) Y275* probably null Het
Chd4 A G 6: 125,100,547 (GRCm39) D1745G possibly damaging Het
Crmp1 T A 5: 37,430,783 (GRCm39) S250T probably damaging Het
Crybg2 A G 4: 133,802,214 (GRCm39) K1125E probably benign Het
Crybg2 C A 4: 133,802,136 (GRCm39) P1099T possibly damaging Het
Csf1r T A 18: 61,243,473 (GRCm39) I163N possibly damaging Het
Dicer1 T C 12: 104,675,064 (GRCm39) T733A probably damaging Het
Edar A G 10: 58,441,875 (GRCm39) V339A possibly damaging Het
Efcab3 A G 11: 104,611,492 (GRCm39) R445G probably benign Het
Efcab6 A G 15: 83,755,194 (GRCm39) I1374T possibly damaging Het
Erbb2 G A 11: 98,324,283 (GRCm39) R757K probably damaging Het
Fam98a A G 17: 75,854,710 (GRCm39) V33A probably benign Het
Farp2 T C 1: 93,531,191 (GRCm39) probably null Het
Fcmr A G 1: 130,805,988 (GRCm39) T315A probably benign Het
Gdf9 G A 11: 53,324,576 (GRCm39) R115Q probably damaging Het
Gm22697+Rbm27 AGGTCCAGGCCCAGGCCCTGGTCCTGGCCCTGGCCCTGGTCCCGGCCCAGGCCC AGGTCCCGGCCCAGGCCC 18: 42,434,948 (GRCm39) probably benign Het
H2-M10.1 A G 17: 36,636,648 (GRCm39) V52A probably damaging Het
Hspg2 T A 4: 137,260,748 (GRCm39) C1582* probably null Het
Icam2 C T 11: 106,268,782 (GRCm39) V229M probably damaging Het
Itga7 C T 10: 128,784,693 (GRCm39) P735L probably benign Het
Kbtbd3 C A 9: 4,330,589 (GRCm39) P321Q possibly damaging Het
Kcnma1 T A 14: 23,364,262 (GRCm39) T997S probably damaging Het
Kifc5b T C 17: 27,144,504 (GRCm39) F541S probably damaging Het
Klhdc9 C A 1: 171,188,016 (GRCm39) V72L probably benign Het
Krt84 G A 15: 101,434,398 (GRCm39) S523F possibly damaging Het
Lrrtm4 A G 6: 79,999,511 (GRCm39) T308A probably benign Het
Map1b T C 13: 99,569,091 (GRCm39) E1210G unknown Het
Mocs3 A G 2: 168,073,489 (GRCm39) Y312C probably damaging Het
Mrps7 G T 11: 115,495,581 (GRCm39) E40* probably null Het
Msantd5f1 A T 4: 73,605,621 (GRCm39) N344I possibly damaging Het
Msln T C 17: 25,972,382 (GRCm39) H50R probably benign Het
Myb A G 10: 21,002,097 (GRCm39) F748S probably damaging Het
Naip5 T C 13: 100,358,419 (GRCm39) E939G probably benign Het
Nbeal1 T A 1: 60,239,278 (GRCm39) V107E probably damaging Het
Nrcam A T 12: 44,623,462 (GRCm39) N1011I probably damaging Het
Or14c44 A G 7: 86,057,078 (GRCm39) probably benign Het
Or1ak2 T C 2: 36,827,335 (GRCm39) L68P probably damaging Het
Or4c118 A C 2: 88,975,346 (GRCm39) V7G probably damaging Het
Pcgf6 A T 19: 47,037,441 (GRCm39) C153S probably damaging Het
Phrf1 T C 7: 140,817,434 (GRCm39) V81A probably benign Het
Ppp4r4 A G 12: 103,550,331 (GRCm39) N36D probably benign Het
Prkch A G 12: 73,805,775 (GRCm39) T517A possibly damaging Het
Rasal1 A T 5: 120,790,910 (GRCm39) K33* probably null Het
Rp1l1 G A 14: 64,268,442 (GRCm39) E1343K probably damaging Het
Serpinb6e T C 13: 34,020,406 (GRCm39) D234G probably benign Het
Setd2 A G 9: 110,378,932 (GRCm39) S632G probably benign Het
Smyd3 T G 1: 178,871,441 (GRCm39) I313L probably benign Het
Tdrd9 C A 12: 111,991,140 (GRCm39) D543E probably damaging Het
Tet1 A G 10: 62,715,453 (GRCm39) L114P probably damaging Het
Tmprss11c G A 5: 86,387,283 (GRCm39) P212S probably damaging Het
Tmx2 A T 2: 84,506,461 (GRCm39) M77K probably damaging Het
Traf3 T G 12: 111,228,470 (GRCm39) D560E probably damaging Het
Trappc12 C T 12: 28,741,776 (GRCm39) M711I probably benign Het
Trim2 A G 3: 84,074,957 (GRCm39) probably null Het
Vmn2r18 A G 5: 151,485,464 (GRCm39) S677P probably damaging Het
Wdr7 T A 18: 63,853,847 (GRCm39) L60* probably null Het
Wdr93 T C 7: 79,399,830 (GRCm39) F140L probably benign Het
Zfp638 A G 6: 83,931,719 (GRCm39) T802A probably benign Het
Other mutations in Myo10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00557:Myo10 APN 15 25,776,466 (GRCm39) missense probably damaging 1.00
IGL01068:Myo10 APN 15 25,739,395 (GRCm39) missense possibly damaging 0.93
IGL01352:Myo10 APN 15 25,701,783 (GRCm39) missense probably damaging 1.00
IGL01388:Myo10 APN 15 25,736,703 (GRCm39) missense possibly damaging 0.55
IGL01460:Myo10 APN 15 25,714,194 (GRCm39) missense probably benign 0.00
IGL01553:Myo10 APN 15 25,776,415 (GRCm39) missense probably damaging 1.00
IGL01732:Myo10 APN 15 25,732,149 (GRCm39) missense probably benign 0.10
IGL01992:Myo10 APN 15 25,799,634 (GRCm39) missense possibly damaging 0.92
IGL02000:Myo10 APN 15 25,808,152 (GRCm39) missense probably damaging 1.00
IGL02045:Myo10 APN 15 25,726,574 (GRCm39) missense probably benign 0.03
IGL02307:Myo10 APN 15 25,776,401 (GRCm39) splice site probably benign
IGL02511:Myo10 APN 15 25,723,975 (GRCm39) missense probably damaging 0.97
IGL03240:Myo10 APN 15 25,701,688 (GRCm39) missense probably damaging 1.00
least UTSW 15 25,726,561 (GRCm39) nonsense probably null
R0037:Myo10 UTSW 15 25,666,618 (GRCm39) intron probably benign
R0153:Myo10 UTSW 15 25,781,324 (GRCm39) missense possibly damaging 0.84
R0282:Myo10 UTSW 15 25,793,253 (GRCm39) missense probably damaging 1.00
R0360:Myo10 UTSW 15 25,804,454 (GRCm39) missense probably damaging 1.00
R0585:Myo10 UTSW 15 25,736,541 (GRCm39) missense probably damaging 1.00
R0617:Myo10 UTSW 15 25,738,091 (GRCm39) missense probably damaging 1.00
R0729:Myo10 UTSW 15 25,722,243 (GRCm39) splice site probably benign
R0771:Myo10 UTSW 15 25,778,264 (GRCm39) missense probably damaging 1.00
R0960:Myo10 UTSW 15 25,801,275 (GRCm39) missense probably damaging 1.00
R1562:Myo10 UTSW 15 25,780,497 (GRCm39) missense possibly damaging 0.81
R1789:Myo10 UTSW 15 25,726,611 (GRCm39) critical splice donor site probably null
R1816:Myo10 UTSW 15 25,800,286 (GRCm39) missense probably damaging 1.00
R1835:Myo10 UTSW 15 25,805,673 (GRCm39) missense possibly damaging 0.53
R1908:Myo10 UTSW 15 25,801,308 (GRCm39) missense probably damaging 1.00
R2082:Myo10 UTSW 15 25,786,079 (GRCm39) missense probably damaging 1.00
R2101:Myo10 UTSW 15 25,722,345 (GRCm39) missense probably benign 0.26
R2129:Myo10 UTSW 15 25,781,885 (GRCm39) missense probably benign 0.09
R2141:Myo10 UTSW 15 25,714,194 (GRCm39) missense probably benign
R2142:Myo10 UTSW 15 25,714,194 (GRCm39) missense probably benign
R2920:Myo10 UTSW 15 25,801,226 (GRCm39) missense probably damaging 1.00
R2938:Myo10 UTSW 15 25,795,803 (GRCm39) missense probably damaging 0.99
R3723:Myo10 UTSW 15 25,803,374 (GRCm39) missense probably damaging 1.00
R3852:Myo10 UTSW 15 25,779,712 (GRCm39) missense probably damaging 1.00
R4162:Myo10 UTSW 15 25,726,501 (GRCm39) splice site probably null
R4163:Myo10 UTSW 15 25,726,501 (GRCm39) splice site probably null
R4164:Myo10 UTSW 15 25,726,501 (GRCm39) splice site probably null
R4177:Myo10 UTSW 15 25,734,137 (GRCm39) missense possibly damaging 0.81
R4409:Myo10 UTSW 15 25,807,955 (GRCm39) missense probably damaging 1.00
R4667:Myo10 UTSW 15 25,793,239 (GRCm39) missense possibly damaging 0.91
R4905:Myo10 UTSW 15 25,800,298 (GRCm39) missense probably damaging 0.99
R4933:Myo10 UTSW 15 25,781,204 (GRCm39) missense probably damaging 0.96
R4968:Myo10 UTSW 15 25,808,270 (GRCm39) missense probably damaging 1.00
R5081:Myo10 UTSW 15 25,786,026 (GRCm39) missense probably damaging 1.00
R5123:Myo10 UTSW 15 25,726,569 (GRCm39) missense possibly damaging 0.94
R5310:Myo10 UTSW 15 25,778,164 (GRCm39) splice site probably null
R6073:Myo10 UTSW 15 25,736,728 (GRCm39) missense probably damaging 1.00
R6117:Myo10 UTSW 15 25,805,745 (GRCm39) missense probably benign 0.00
R6185:Myo10 UTSW 15 25,726,596 (GRCm39) missense probably damaging 0.99
R6749:Myo10 UTSW 15 25,714,196 (GRCm39) missense probably damaging 1.00
R6819:Myo10 UTSW 15 25,781,496 (GRCm39) missense possibly damaging 0.80
R6875:Myo10 UTSW 15 25,805,745 (GRCm39) missense probably benign 0.00
R6908:Myo10 UTSW 15 25,804,469 (GRCm39) missense probably damaging 1.00
R6963:Myo10 UTSW 15 25,734,149 (GRCm39) missense probably benign 0.31
R7144:Myo10 UTSW 15 25,724,011 (GRCm39) missense probably damaging 1.00
R7266:Myo10 UTSW 15 25,783,067 (GRCm39) missense probably damaging 1.00
R7380:Myo10 UTSW 15 25,779,706 (GRCm39) missense probably benign 0.01
R7460:Myo10 UTSW 15 25,807,913 (GRCm39) missense probably damaging 1.00
R7614:Myo10 UTSW 15 25,701,709 (GRCm39) missense probably benign 0.00
R7618:Myo10 UTSW 15 25,726,561 (GRCm39) nonsense probably null
R7717:Myo10 UTSW 15 25,732,056 (GRCm39) missense probably benign 0.01
R7811:Myo10 UTSW 15 25,804,610 (GRCm39) missense probably damaging 1.00
R7830:Myo10 UTSW 15 25,738,057 (GRCm39) nonsense probably null
R7862:Myo10 UTSW 15 25,666,522 (GRCm39) missense probably damaging 1.00
R8232:Myo10 UTSW 15 25,804,400 (GRCm39) missense possibly damaging 0.89
R8264:Myo10 UTSW 15 25,800,195 (GRCm39) missense probably damaging 0.99
R8377:Myo10 UTSW 15 25,804,481 (GRCm39) missense possibly damaging 0.94
R8385:Myo10 UTSW 15 25,804,484 (GRCm39) missense probably damaging 1.00
R8426:Myo10 UTSW 15 25,799,576 (GRCm39) missense probably damaging 0.99
R8439:Myo10 UTSW 15 25,725,158 (GRCm39) missense probably benign 0.00
R8696:Myo10 UTSW 15 25,799,572 (GRCm39) missense probably damaging 1.00
R8775:Myo10 UTSW 15 25,800,145 (GRCm39) missense probably damaging 0.97
R8775-TAIL:Myo10 UTSW 15 25,800,145 (GRCm39) missense probably damaging 0.97
R8970:Myo10 UTSW 15 25,803,467 (GRCm39) missense possibly damaging 0.82
R9024:Myo10 UTSW 15 25,793,295 (GRCm39) missense possibly damaging 0.53
R9196:Myo10 UTSW 15 25,805,716 (GRCm39) missense probably damaging 0.96
R9224:Myo10 UTSW 15 25,808,081 (GRCm39) missense probably benign 0.33
R9308:Myo10 UTSW 15 25,781,862 (GRCm39) missense probably damaging 0.99
R9358:Myo10 UTSW 15 25,781,520 (GRCm39) missense possibly damaging 0.69
R9606:Myo10 UTSW 15 25,776,401 (GRCm39) frame shift probably null
R9722:Myo10 UTSW 15 25,801,227 (GRCm39) missense probably damaging 1.00
RF013:Myo10 UTSW 15 25,799,565 (GRCm39) missense probably damaging 0.99
Z1177:Myo10 UTSW 15 25,799,640 (GRCm39) critical splice donor site probably null
Z1177:Myo10 UTSW 15 25,781,487 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCCTATTCATCAGTGAGACCCCG -3'
(R):5'- AACAGGGTTCAGTCTCTCATCCGC -3'

Sequencing Primer
(F):5'- tgtttgtttgtttgtttgtttgtttg -3'
(R):5'- CGCCTCATGTCCACCTG -3'
Posted On 2014-05-09