Incidental Mutation 'R1658:Adgrd1'
ID 186524
Institutional Source Beutler Lab
Gene Symbol Adgrd1
Ensembl Gene ENSMUSG00000044017
Gene Name adhesion G protein-coupled receptor D1
Synonyms Gpr133, E230012M21Rik
MMRRC Submission 039694-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1658 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 129173814-129281663 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 129255164 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Alanine at position 604 (S604A)
Ref Sequence ENSEMBL: ENSMUSP00000060307 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056617] [ENSMUST00000156437]
AlphaFold Q80T32
Predicted Effect probably benign
Transcript: ENSMUST00000056617
AA Change: S604A

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000060307
Gene: ENSMUSG00000044017
AA Change: S604A

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:Laminin_G_3 119 273 2.9e-18 PFAM
Pfam:Pentaxin 171 288 2.2e-7 PFAM
GPS 535 585 1.57e-14 SMART
Pfam:Dicty_CAR 590 856 1.2e-8 PFAM
Pfam:7tm_2 592 831 8e-58 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000156437
AA Change: S572A

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000121217
Gene: ENSMUSG00000044017
AA Change: S572A

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 92.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Apbb1 G A 7: 105,223,291 (GRCm39) P107S probably damaging Het
Baz2a T A 10: 127,960,252 (GRCm39) M1489K probably benign Het
Cd84 A G 1: 171,700,317 (GRCm39) T145A possibly damaging Het
Cdca2 A G 14: 67,915,148 (GRCm39) S704P possibly damaging Het
Cemip2 T C 19: 21,779,243 (GRCm39) V351A probably damaging Het
Chfr T C 5: 110,301,035 (GRCm39) I312T probably damaging Het
Csmd1 A G 8: 16,131,739 (GRCm39) V1662A possibly damaging Het
Dgkd T A 1: 87,853,990 (GRCm39) L611Q probably damaging Het
Dicer1 A G 12: 104,666,673 (GRCm39) V1376A probably benign Het
Elp2 C T 18: 24,750,470 (GRCm39) T269M probably benign Het
Ephb6 T A 6: 41,591,179 (GRCm39) V112E probably damaging Het
Fbxo11 A T 17: 88,320,086 (GRCm39) Y209N probably benign Het
Frem1 C T 4: 82,920,045 (GRCm39) R437Q probably damaging Het
G6pc2 A T 2: 69,057,413 (GRCm39) K353M probably damaging Het
Gabbr1 A G 17: 37,358,399 (GRCm39) T46A probably damaging Het
Gbp9 T A 5: 105,242,334 (GRCm39) Q135L probably damaging Het
Gstp1 A T 19: 4,087,375 (GRCm39) M20K probably damaging Het
Heatr6 A G 11: 83,649,193 (GRCm39) R183G probably damaging Het
Ints11 A G 4: 155,972,185 (GRCm39) K397E probably damaging Het
Intu A G 3: 40,647,211 (GRCm39) T695A probably benign Het
Kif21b T C 1: 136,099,023 (GRCm39) V1437A probably damaging Het
Klhl24 T A 16: 19,925,842 (GRCm39) Y123* probably null Het
Lipm C T 19: 34,093,847 (GRCm39) L255F probably benign Het
Max A T 12: 76,985,355 (GRCm39) M121K probably benign Het
Mga A T 2: 119,772,170 (GRCm39) I1677L possibly damaging Het
Msantd1 C A 5: 35,078,905 (GRCm39) L147M probably damaging Het
Msantd1 T A 5: 35,078,906 (GRCm39) L147Q probably benign Het
Mylk4 T C 13: 32,896,772 (GRCm39) D363G possibly damaging Het
Naaa T C 5: 92,420,300 (GRCm39) probably null Het
Ninl A G 2: 150,806,079 (GRCm39) Y381H probably damaging Het
Nwd2 A G 5: 63,964,589 (GRCm39) N1391S probably damaging Het
Or6k8-ps1 G A 1: 173,979,789 (GRCm39) A236T probably damaging Het
Or8g18 C T 9: 39,149,255 (GRCm39) C155Y probably benign Het
Phip A G 9: 82,753,551 (GRCm39) V1731A probably benign Het
Plxnb1 T A 9: 108,931,939 (GRCm39) C488* probably null Het
Rgs7 T C 1: 174,907,120 (GRCm39) I374V probably benign Het
Rin2 A T 2: 145,718,376 (GRCm39) M574L probably benign Het
Rps18 A T 17: 34,171,392 (GRCm39) D92E probably benign Het
Scrn1 T A 6: 54,497,791 (GRCm39) I267L probably benign Het
Stard9 T C 2: 120,532,023 (GRCm39) V67A probably benign Het
Syne1 T G 10: 5,317,616 (GRCm39) M493L probably benign Het
Tbc1d2 G A 4: 46,614,207 (GRCm39) R625C probably damaging Het
Tcerg1l A G 7: 137,995,909 (GRCm39) S200P probably damaging Het
Tet3 A T 6: 83,346,039 (GRCm39) V1331E probably benign Het
Ticrr A T 7: 79,345,297 (GRCm39) I1721F possibly damaging Het
Tjp2 T C 19: 24,090,311 (GRCm39) D577G probably damaging Het
Tmem38b A G 4: 53,840,713 (GRCm39) M43V probably benign Het
Trabd T A 15: 88,970,069 (GRCm39) probably null Het
Trpv5 C A 6: 41,651,216 (GRCm39) D277Y probably damaging Het
Tubb1 A C 2: 174,298,416 (GRCm39) D67A probably damaging Het
Ubxn7 A G 16: 32,200,054 (GRCm39) probably null Het
Ugp2 G A 11: 21,283,774 (GRCm39) P98S probably benign Het
Vmn2r66 G T 7: 84,656,955 (GRCm39) P150Q probably benign Het
Zbtb11 A T 16: 55,794,588 (GRCm39) H55L possibly damaging Het
Other mutations in Adgrd1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01084:Adgrd1 APN 5 129,216,656 (GRCm39) missense probably benign 0.06
IGL01384:Adgrd1 APN 5 129,174,273 (GRCm39) missense possibly damaging 0.47
IGL01636:Adgrd1 APN 5 129,219,516 (GRCm39) splice site probably benign
IGL01916:Adgrd1 APN 5 129,209,902 (GRCm39) missense probably benign 0.12
IGL01923:Adgrd1 APN 5 129,255,143 (GRCm39) missense possibly damaging 0.58
IGL02019:Adgrd1 APN 5 129,192,202 (GRCm39) missense probably benign 0.00
IGL02142:Adgrd1 APN 5 129,208,648 (GRCm39) missense probably benign
IGL02149:Adgrd1 APN 5 129,256,325 (GRCm39) missense probably damaging 1.00
IGL02190:Adgrd1 APN 5 129,217,788 (GRCm39) splice site probably benign
IGL02623:Adgrd1 APN 5 129,209,809 (GRCm39) missense probably damaging 0.99
IGL02696:Adgrd1 APN 5 129,217,918 (GRCm39) splice site probably benign
IGL02850:Adgrd1 APN 5 129,192,119 (GRCm39) missense probably damaging 1.00
IGL02976:Adgrd1 APN 5 129,208,661 (GRCm39) missense probably benign 0.00
IGL02988:Adgrd1 UTSW 5 129,221,074 (GRCm39) missense probably benign 0.00
PIT4458001:Adgrd1 UTSW 5 129,208,641 (GRCm39) missense probably damaging 1.00
R0081:Adgrd1 UTSW 5 129,255,146 (GRCm39) missense probably damaging 0.99
R0266:Adgrd1 UTSW 5 129,216,658 (GRCm39) missense probably benign 0.00
R0267:Adgrd1 UTSW 5 129,216,658 (GRCm39) missense probably benign 0.00
R0464:Adgrd1 UTSW 5 129,239,714 (GRCm39) missense probably damaging 1.00
R0625:Adgrd1 UTSW 5 129,248,995 (GRCm39) critical splice donor site probably null
R1288:Adgrd1 UTSW 5 129,206,071 (GRCm39) missense probably damaging 0.97
R1460:Adgrd1 UTSW 5 129,199,627 (GRCm39) missense possibly damaging 0.63
R1635:Adgrd1 UTSW 5 129,205,971 (GRCm39) missense probably damaging 1.00
R1709:Adgrd1 UTSW 5 129,256,292 (GRCm39) missense possibly damaging 0.95
R1897:Adgrd1 UTSW 5 129,206,065 (GRCm39) missense probably benign 0.01
R1976:Adgrd1 UTSW 5 129,217,861 (GRCm39) missense probably benign 0.06
R2049:Adgrd1 UTSW 5 129,192,159 (GRCm39) missense probably benign 0.01
R2259:Adgrd1 UTSW 5 129,189,375 (GRCm39) missense possibly damaging 0.92
R2295:Adgrd1 UTSW 5 129,199,570 (GRCm39) missense probably benign 0.13
R3076:Adgrd1 UTSW 5 129,206,169 (GRCm39) missense probably benign 0.20
R3077:Adgrd1 UTSW 5 129,206,169 (GRCm39) missense probably benign 0.20
R3078:Adgrd1 UTSW 5 129,206,169 (GRCm39) missense probably benign 0.20
R4581:Adgrd1 UTSW 5 129,279,595 (GRCm39) missense possibly damaging 0.68
R5024:Adgrd1 UTSW 5 129,248,959 (GRCm39) missense probably damaging 1.00
R5076:Adgrd1 UTSW 5 129,221,053 (GRCm39) nonsense probably null
R5227:Adgrd1 UTSW 5 129,199,647 (GRCm39) missense probably benign 0.00
R5453:Adgrd1 UTSW 5 129,256,647 (GRCm39) missense probably damaging 0.99
R6349:Adgrd1 UTSW 5 129,219,603 (GRCm39) splice site probably null
R6953:Adgrd1 UTSW 5 129,192,142 (GRCm39) nonsense probably null
R7300:Adgrd1 UTSW 5 129,174,411 (GRCm39) critical splice donor site probably null
R7583:Adgrd1 UTSW 5 129,256,652 (GRCm39) missense probably benign 0.42
R7622:Adgrd1 UTSW 5 129,216,688 (GRCm39) missense probably benign 0.27
R8205:Adgrd1 UTSW 5 129,192,175 (GRCm39) missense possibly damaging 0.94
R8716:Adgrd1 UTSW 5 129,265,435 (GRCm39) missense possibly damaging 0.94
R8780:Adgrd1 UTSW 5 129,174,138 (GRCm39) start gained probably benign
R8850:Adgrd1 UTSW 5 129,219,574 (GRCm39) missense probably benign 0.00
R9528:Adgrd1 UTSW 5 129,256,740 (GRCm39) missense probably benign 0.44
R9569:Adgrd1 UTSW 5 129,256,701 (GRCm39) missense possibly damaging 0.90
R9626:Adgrd1 UTSW 5 129,275,721 (GRCm39) missense probably damaging 1.00
X0067:Adgrd1 UTSW 5 129,265,416 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- CCTCTTTCTGTGAGGCAAGTCTTGG -3'
(R):5'- TGTCTAAAACCTGCTGACCCTACCC -3'

Sequencing Primer
(F):5'- CAAGTCTTGGAGGTTGGCATTAC -3'
(R):5'- CTGCACCTCAGATATGAAAGTG -3'
Posted On 2014-05-09