Incidental Mutation 'R1664:Or5v1'
ID 187065
Institutional Source Beutler Lab
Gene Symbol Or5v1
Ensembl Gene ENSMUSG00000090894
Gene Name olfactory receptor family 5 subfamily V member 1
Synonyms GA_x6K02T2PSCP-1956307-1957260, Olfr110, MOR249-2
MMRRC Submission 039700-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.153) question?
Stock # R1664 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 37803359-37811098 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 37810316 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 258 (T258M)
Ref Sequence ENSEMBL: ENSMUSP00000149213 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168318] [ENSMUST00000216472]
AlphaFold A2RT31
Predicted Effect possibly damaging
Transcript: ENSMUST00000168318
AA Change: T258M

PolyPhen 2 Score 0.831 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000131089
Gene: ENSMUSG00000090894
AA Change: T258M

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 8.9e-54 PFAM
Pfam:7TM_GPCR_Srsx 35 286 1.9e-6 PFAM
Pfam:7tm_1 41 290 1.2e-26 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216472
AA Change: T258M

PolyPhen 2 Score 0.831 (Sensitivity: 0.84; Specificity: 0.93)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930596D02Rik T A 14: 35,533,772 (GRCm39) T45S probably benign Het
Ackr1 A G 1: 173,160,433 (GRCm39) F29L probably benign Het
Adgrf2 T A 17: 43,025,305 (GRCm39) S60C possibly damaging Het
Alpk2 A G 18: 65,482,944 (GRCm39) C355R probably damaging Het
Ankmy1 A C 1: 92,812,913 (GRCm39) D465E probably benign Het
Ankrd27 T A 7: 35,306,551 (GRCm39) D310E probably damaging Het
Ap3d1 G A 10: 80,553,571 (GRCm39) Q559* probably null Het
C4b T C 17: 34,951,952 (GRCm39) T1298A probably damaging Het
Casr T A 16: 36,330,327 (GRCm39) K336* probably null Het
Ccdc116 A T 16: 16,960,492 (GRCm39) D108E probably benign Het
Ccdc168 T A 1: 44,098,387 (GRCm39) I904F possibly damaging Het
Ccr7 A T 11: 99,036,517 (GRCm39) I135N possibly damaging Het
Cd96 A G 16: 45,938,364 (GRCm39) Y34H possibly damaging Het
Cdan1 T A 2: 120,550,987 (GRCm39) D1135V probably damaging Het
Cecr2 C A 6: 120,738,987 (GRCm39) T1210K probably damaging Het
Cep152 C A 2: 125,408,174 (GRCm39) A1390S probably benign Het
Chd9 T G 8: 91,749,418 (GRCm39) probably null Het
Cntnap5c G T 17: 58,600,985 (GRCm39) W776L probably benign Het
Col24a1 G A 3: 145,095,355 (GRCm39) probably null Het
Cpa2 G T 6: 30,554,314 (GRCm39) M311I probably damaging Het
Cpz A G 5: 35,664,087 (GRCm39) F483L probably damaging Het
Ddx19a A C 8: 111,716,130 (GRCm39) V90G probably damaging Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Fbxw7 A G 3: 84,876,478 (GRCm39) D213G possibly damaging Het
Fgd2 T C 17: 29,588,273 (GRCm39) F362L probably damaging Het
Fryl A G 5: 73,216,778 (GRCm39) Y2171H probably damaging Het
Gba2 T C 4: 43,578,080 (GRCm39) R90G probably benign Het
Gm10073 T C 8: 107,299,864 (GRCm39) E40G probably damaging Het
Grhl3 T C 4: 135,279,861 (GRCm39) I398V probably benign Het
Grip2 T A 6: 91,742,233 (GRCm39) H899L probably damaging Het
Grk2 T C 19: 4,337,268 (GRCm39) K644E possibly damaging Het
Iars1 A T 13: 49,865,251 (GRCm39) T576S probably damaging Het
Kif26b G A 1: 178,759,704 (GRCm39) V2084M probably damaging Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lrrc69 G A 4: 14,775,079 (GRCm39) T63M probably damaging Het
Lrrn4 A T 2: 132,711,886 (GRCm39) C646S probably damaging Het
Mtf2 C T 5: 108,252,342 (GRCm39) T457M probably damaging Het
Ncln A T 10: 81,323,555 (GRCm39) C531S probably benign Het
Ntn4 C T 10: 93,543,215 (GRCm39) R314W probably damaging Het
Or14j8 T C 17: 38,263,784 (GRCm39) I44V probably benign Het
Or8c11 A T 9: 38,289,548 (GRCm39) M124L possibly damaging Het
Otogl A G 10: 107,642,437 (GRCm39) V1331A probably benign Het
Palb2 A G 7: 121,723,615 (GRCm39) probably benign Het
Pcdh20 T C 14: 88,705,758 (GRCm39) E514G possibly damaging Het
Pclaf A G 9: 65,797,730 (GRCm39) N7S probably benign Het
Pdrg1 C T 2: 152,857,248 (GRCm39) probably benign Het
Phf8-ps T A 17: 33,285,492 (GRCm39) I437F probably damaging Het
Pik3r6 T A 11: 68,426,932 (GRCm39) D464E probably benign Het
Pkp3 A G 7: 140,667,560 (GRCm39) N454D probably damaging Het
Plekha7 C A 7: 115,734,269 (GRCm39) probably null Het
Ppip5k1 A G 2: 121,167,663 (GRCm39) V784A probably benign Het
Ppp1r36 T A 12: 76,483,028 (GRCm39) D205E possibly damaging Het
Prss35 A T 9: 86,637,700 (GRCm39) T157S probably benign Het
Ptprn2 T C 12: 117,125,329 (GRCm39) L621P probably damaging Het
Rasgrp3 A G 17: 75,831,172 (GRCm39) K524R probably damaging Het
Rasgrp4 T A 7: 28,839,688 (GRCm39) H133Q probably benign Het
Reln A T 5: 22,134,084 (GRCm39) Y2615N probably damaging Het
Rpf1 T A 3: 146,217,903 (GRCm39) T204S probably benign Het
Scgb2b3 T A 7: 31,058,464 (GRCm39) *113L probably null Het
Scn5a A C 9: 119,350,243 (GRCm39) L877R possibly damaging Het
Sh3pxd2a A T 19: 47,256,821 (GRCm39) D632E probably benign Het
Slc39a10 T C 1: 46,865,269 (GRCm39) H522R probably damaging Het
Spink2 A T 5: 77,354,855 (GRCm39) C19S probably damaging Het
Spsb4 A G 9: 96,878,266 (GRCm39) L19P possibly damaging Het
St7l T C 3: 104,778,214 (GRCm39) V117A probably damaging Het
Stac2 C T 11: 97,933,420 (GRCm39) S174N probably damaging Het
Sult4a1 A G 15: 83,970,818 (GRCm39) Y196H probably benign Het
Tex2 C T 11: 106,458,608 (GRCm39) probably benign Het
Tprg1l A T 4: 154,243,862 (GRCm39) V98D possibly damaging Het
Ttn G A 2: 76,548,369 (GRCm39) H31978Y probably damaging Het
Ttn T C 2: 76,658,853 (GRCm39) probably benign Het
Tyk2 C A 9: 21,031,649 (GRCm39) R447L probably damaging Het
Ucn3 T C 13: 3,991,634 (GRCm39) Y6C possibly damaging Het
Urb1 A T 16: 90,584,970 (GRCm39) probably null Het
Vmn2r94 G C 17: 18,464,406 (GRCm39) A628G probably damaging Het
Wdr95 C A 5: 149,518,752 (GRCm39) T389K probably damaging Het
Wrn A T 8: 33,770,794 (GRCm39) probably null Het
Xab2 T A 8: 3,669,068 (GRCm39) probably null Het
Zfp458 A T 13: 67,406,144 (GRCm39) N95K possibly damaging Het
Zfp672 T C 11: 58,208,138 (GRCm39) H61R probably damaging Het
Zfp942 C T 17: 22,147,420 (GRCm39) G403E possibly damaging Het
Other mutations in Or5v1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01954:Or5v1 APN 17 37,809,540 (GRCm39) utr 5 prime probably benign
IGL03088:Or5v1 APN 17 37,809,539 (GRCm39) utr 5 prime probably benign
F5426:Or5v1 UTSW 17 37,810,427 (GRCm39) missense probably damaging 1.00
R2883:Or5v1 UTSW 17 37,810,271 (GRCm39) missense probably damaging 1.00
R4011:Or5v1 UTSW 17 37,810,382 (GRCm39) missense possibly damaging 0.79
R4365:Or5v1 UTSW 17 37,810,270 (GRCm39) missense probably damaging 1.00
R4989:Or5v1 UTSW 17 37,810,017 (GRCm39) missense probably benign 0.10
R5442:Or5v1 UTSW 17 37,810,330 (GRCm39) missense probably damaging 1.00
R5577:Or5v1 UTSW 17 37,810,493 (GRCm39) missense probably benign 0.02
R6592:Or5v1 UTSW 17 37,809,988 (GRCm39) missense probably damaging 1.00
R7134:Or5v1 UTSW 17 37,809,776 (GRCm39) missense probably damaging 1.00
R7840:Or5v1 UTSW 17 37,809,868 (GRCm39) missense probably damaging 1.00
R8226:Or5v1 UTSW 17 37,809,560 (GRCm39) missense probably benign 0.16
R8304:Or5v1 UTSW 17 37,810,261 (GRCm39) missense probably damaging 1.00
R8310:Or5v1 UTSW 17 37,810,148 (GRCm39) missense probably benign 0.00
R8435:Or5v1 UTSW 17 37,809,676 (GRCm39) missense probably benign 0.01
R8779:Or5v1 UTSW 17 37,809,718 (GRCm39) missense probably damaging 1.00
R8852:Or5v1 UTSW 17 37,810,321 (GRCm39) missense probably benign 0.28
R8928:Or5v1 UTSW 17 37,809,583 (GRCm39) missense probably damaging 0.99
R8964:Or5v1 UTSW 17 37,809,664 (GRCm39) missense probably damaging 1.00
R9605:Or5v1 UTSW 17 37,810,331 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCTCAATGAACTGGCTTTGCTGTCC -3'
(R):5'- GCAAATTCAGCATGAGCGATGAACC -3'

Sequencing Primer
(F):5'- CTGGCTTTGCTGTCCATTGG -3'
(R):5'- CAATTAGGGTTCAGTGTGCCAAC -3'
Posted On 2014-05-09